研究者詳細 - 鉄永　智紀

論文 - 鉄永　智紀

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腰仙椎の癒合がpincer lesionの原因と考えられた若年アスリートに発症した大腿骨寛骨臼インピンジメントの1例

山田和希, 鉄永智紀, 佐藤嘉洋, 廣瀬一樹, 小浦卓, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S131 - S131 2021年11月

発育性股関節形成不全に対するSalter innominate osteotomyの短期成績

廣瀬一樹, 鉄永智紀, 山田和希, 佐藤嘉洋, 小浦卓, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 3 ) S84 - S84 2021年11月

変形性肩関節症モデルとしてのCCN3過剰発現マウス

廣瀬一樹, 服部高子, 中田英二, 鉄永智紀, 山田和希, 佐藤嘉洋, 桑原実穂, 尾崎敏文, 滝川正春, 久保田聡

日本骨代謝学会学術集会プログラム抄録集 39回 151 - 151 2021年10月

Mechanical stretching induces calcification and cartilage matrix metabolism, causing degeneration of the acetabular labrum 査読国際誌

Yoshi Kawamura, Tomonori Tetsunaga, Kazuki Yamada, Tomoaki Sanki, Yoshihiro Sato, Aki Yoshida, Takayuki Furumatsu, Toshifumi Ozaki

HIP International 11207000211044675 - 11207000211044675 2021年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications

<sec><title>Purpose:</title> The acetabular labrum plays an important role in joint lubrication, and damage to this structure leads to osteoarthritis. This study aimed to histologically classify the degree of degeneration of the acetabular labrum and to investigate the changes in gene expression induced by mechanical stretching.

</sec><sec><title>Methods:</title> We obtained acetabular labrum cells from patients with hip osteoarthritis during total hip arthroplasty ( n?=?25). The labrum was stained with safranin O, and images were histologically evaluated using a new parameter, the red/blue (R/B) value. The samples were divided into the degenerated group (D group: n?=?18) and the healthy group (H group: n?=?7) in accordance with the Kellgren-Lawrence (KL) grade. The cultured acetabular labral cells were subjected to loaded uniaxial cyclic tensile strain (CTS). After CTS, changes in gene expression were examined in both groups.

</sec><sec><title>Results:</title> Spearman’s correlation analysis revealed that the R/B value was significantly correlated with the KL grade and the Krenn score. The expression levels of genes related to cartilage metabolism, osteogenesis and angiogenesis significantly increased after CTS in the H group, while gene expression in the D group showed weaker changes after CTS than that in the H group compared to the nonstretched control group.

</sec><sec><title>Conclusions:</title> The degree of labral degeneration could be classified histologically using the R/B value and the KL grade. Mechanical stretching caused changes in gene expression that support the pathological features of labral degeneration.

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DOI： 10.1177/11207000211044675

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その他リンク： http://journals.sagepub.com/doi/pdf/10.1177/11207000211044675

Cognitive factors associated with locomotive syndrome in chronic pain patients: A retrospective study 査読国際誌

Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Keiichiro Nishida, Toshifumi Ozaki

Journal of Orthopaedic Science 26 ( 5 ) 896 - 901 2021年9月

Comparison of the accuracy of CT- and accelerometer-based navigation systems for cup orientation in total hip arthroplasty 査読国際誌

Tomonori Tetsunaga, Kazuki Yamada, Tomoko Tetsunaga, Takayuki Furumatsu, Tomoaki Sanki, Yoshi Kawamura, Toshifumi Ozaki

HIP International 31 ( 5 ) 603 - 608 2021年9月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications

<sec><title>Background:</title> The accuracies of various navigation systems in total hip arthroplasty (THA) have been described; however, the accuracy of cup orientation with an accelerometer-based navigation system has not been reported. The purpose of this study was to compare the accuracies of computed tomography (CT)- and accelerometer-based navigation systems for cup orientation in THA.

</sec><sec><title>Methods:</title> In this prospective study, 30 patients who underwent cementless THA via anterolateral approach in the lateral decubitus position were analysed. A CT-based navigation system (30 hips) and an accelerometer-based navigation system (30 hips) were used simultaneously. The accuracy of cup orientation (absolute difference between intraoperative vs. postoperative measurements) was compared between the navigation systems using postoperative CT.

</sec><sec><title>Results:</title> The accuracy of cup inclination was 3.2?±?2.4° in the CT-based navigation group and 4.1?±?3.7° in the accelerometer-based navigation group ( p?=?0.3035). The accuracy of cup anteversion was 3.0°?±?2.5° in the CT-based navigation group and 6.8°?±?4.8° in the accelerometer-based navigation group. Cup anteversion was significantly more accurate with the CT-based navigation system than with accelerometer-based navigation ( p?=?0.0009). Multiple regression analysis demonstrated that the malposition in cup anteversion was positively correlated with the change in pelvic tilt and loosening of the reference antenna.

</sec><sec><title>Conclusions:</title> Although, these results are only true for this specific accelerometer system, cup positioning was significantly more accurate with the CT-based navigation system than an accelerometer-based navigation in the lateral decubitus position. This is because of considerable discrepancies in the sagittal pelvic tilt, resulting in variability in cup anteversion angle with the use of an accelerometer-based navigation system.

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DOI： 10.1177/1120700020904940

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その他リンク： http://journals.sagepub.com/doi/pdf/10.1177/1120700020904940

当院で施行したキアリ骨盤骨切り術の術後成績査読

廣瀬一樹, 鉄永智紀, 山田和希, 佐藤嘉洋, 尾﨑敏文

Hip Joint 47 ( 1 ) 365 - 369 2021年8月

股関節唇の Safranin O 染色性の局在と影響を与える因子査読

佐藤嘉洋, 鉄永智紀, 河村涌志, 山田和希, 廣瀬一樹, 尾﨑敏文

Hip Joint 47 ( 2 ) 737 - 739 2021年8月

寛骨臼回転骨切り術における恥骨骨切り面の接触評価 - 恥骨骨切り面の接触面積は恥骨偽関節発生に関与する - 査読

山田和希, 遠藤裕介, 鉄永智紀, 三喜知明, 河村涌志, 佐藤嘉洋, 廣瀬一樹, 尾﨑敏文

Hip Joint 47 ( 1 ) 386 - 390 2021年8月

変形性肩関節症とCCN3発現上昇との相関について

廣瀬一樹, 中田英二, 服部高子, 鉄永智紀, 山田和希, 佐藤嘉洋, 桑原実穂, 滝川正春, 久保田聡, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1506 - S1506 2021年8月

変形性肩関節症とCCN3発現上昇との相関について

廣瀬一樹, 中田英二, 服部高子, 鉄永智紀, 山田和希, 佐藤嘉洋, 桑原実穂, 滝川正春, 久保田聡, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1506 - S1506 2021年8月

Recombinant human FGF-2 for the treatment of early-stage osteonecrosis of the femoral head: TRION, a single-arm, multicenter, Phase II trial 査読国際誌

Yutaka Kuroda, Takeyuki Tanaka, Takaki Miyagawa, Hidetoshi Hamada, Hiroyasu Abe, Toshiko Ito-Ihara, Ryuta Asada, Yusuke Fujimoto, Daisuke Takahashi, Tomonori Tetsunaga, Ayumi Kaneuji, Michiaki Takagi, Yutaka Inaba, Satoshi Morita, Nobuhiko Sugano, Sakae Tanaka, Shuichi Matsuda, Haruhiko Akiyama, Tsuyoshi Asano, Juji Ito, Hirofumi Oshima, Taizo Kaneko, Yoko Fukasawa, Hyonmin Choe, Shusuke Ueda, Kayoko Enomoto, Harue Tada, Akiko Kuroda, Yasuhiko Tabata, Yaichiro Okuzu, Toshiyuki Kawai, Koji Goto, Manabu Nankaku, Masaki Takao, Wataru Ando, Kazuki Yamada, Michio Yamamoto, Takashi Sakai, Yasuhiro Ishidou, Shigeru Yamada, Hidetsugu Ohara, Hiroshi Fujita, Hirotsugu Ohashi, Hirokazu Iida, Takashi Nakamura

Regenerative Medicine 16 ( 6 ) 535 - 548 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Future Medicine Ltd

Aim: This study aimed to evaluate the 2-year outcomes from a clinical trial of recombinant human FGF-2 (rhFGF-2) for osteonecrosis of the femoral head (ONFH). Patients & methods: Sixty-four patients with nontraumatic, precollapse?and large ONFHs were percutaneously administered with 800 μg rhFGF-2 contained in gelatin hydrogel. Setting the end point of radiological collapse, we analyzed the joint preservation period of the historical control. Changes in two validated clinical scores, bone regeneration?and safety were evaluated. Results: Radiological joint preservation time was significantly higher in the rhFGF-2 group than in the control group. The ONFHs tended to improve to smaller ONFHs. The postoperative clinical scores significantly improved. Thirteen serious adverse events showed recovery. Conclusion: rhFGF-2 treatment increases joint preservation time with clinical efficacy, radiological bone regeneration and safety.

DOI： 10.2217/rme-2021-0049

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DDH治療後の腸腰筋断面積の検討査読

佐藤嘉洋, 鉄永智紀, 山田和希, 廣瀬一樹, 尾﨑敏文

日本小児整形外科学会雑誌 30 ( 1 ) 44 - 46 2021年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本小児整形外科学会

発育性股関節形成不全(以下、DDH)に対して、当院では観血的整復術(広範囲展開法:田邊法、以下、OR)の適応を保存的整復不成功例や歩行開始後の診断遅延例とし、ORで腸腰筋前方移行を行っている。本研究の目的は、腸腰筋の断面積をOR群とRiemenbuegel装具による保存的整復(以下、CR)群で比較し、ORにおける腸腰筋前方移行の影響を明らかにすることである。対象はDDH症例26例26股(女:男23:3)。OR群13例、CR群13例、CT axial viewで、S2椎間孔、臼蓋上縁、恥骨結合の各高位で腸腰筋断面積の健側に対する患側の割合(以下、%Area)を求め、OR群とCR群で比較した。結果、各高位の%Area(%)はOR群で有意に小さく、腸腰筋前方移行により長期的には腸腰筋のボリュームが低下していた。腸腰筋の機能として股関節屈曲、腰椎屈曲、側屈に加え姿勢制御がある。最終観察時に症状はなかったが、長期的には腰痛等生じる可能性はあり、注意深い経過観察が必要である。(著者抄録)

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Femoral head collapse rate among Japanese patients with pre-collapse osteonecrosis of the femoral head 査読国際誌

Ryuta Asada, Hiroyasu Abe, Hidetoshi Hamada, Yusuke Fujimoto, Hyonmin Choe, Daisuke Takahashi, Shusuke Ueda, Yutaka Kuroda, Takaki Miyagawa, Kazuki Yamada, Takeyuki Tanaka, Juji Ito, Satoshi Morita, Michiaki Takagi, Tomonori Tetsunaga, Ayumi Kaneuji, Yutaka Inaba, Sakae Tanaka, Shuichi Matsuda, Nobuhiko Sugano, Haruhiko Akiyama

Journal of International Medical Research 49 ( 6 ) 3000605211023336. - 3000605211023336. 2021年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications

<sec><title>Objective</title> In this study, we aimed to elucidate the relationship between the duration from diagnosis to femoral head collapse and the collapse rate among patients with pre-collapse osteonecrosis of the femoral head (ONFH).

</sec><sec><title>Methods</title> In this retrospective, observational, multicenter study, we analyzed 268 patients diagnosed with ONFH and classified them using the Japanese Investigation Committee classification. The primary endpoint was duration from the time of diagnosis to femoral head collapse for each type of ONFH.

</sec><sec><title>Results</title> The 12-, 24-, and 36-month collapse rates among participants were 0%, 0%, and 0% for type A, respectively; 0%, 2.0%, and 10.8% for type B, respectively; 25.5%, 40.8%, and 48.5% for type C-1, respectively; and 57.4%, 70.3%, and 76.7% for type C-2 ONFH, respectively. A comparison of unilateral and bilateral ONFH, using Kaplan?Meier survival curves demonstrated similar collapse rates.

</sec><sec><title>Conclusions</title> The lowest collapse rate was observed for ONFH type A, followed by types B, C-1, and C-2. Additionally, a direct association was observed between the collapse rate and location of the osteonecrotic lesion on the weight-bearing surface.

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DOI： 10.1177/03000605211023336

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PubMed

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その他リンク： http://journals.sagepub.com/doi/pdf/10.1177/03000605211023336

DDH治療後の腸腰筋断面積の検討

佐藤嘉洋, 鉄永智紀, 山田和希, 廣瀬一樹, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 1 ) 44 - 46 2021年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本小児整形外科学会

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運動器疼痛を対象とした医療体制腰痛に対するチームアプローチ査読

鉄永倫子, 鉄永智紀, 西田圭一郎