Faculty Profiles - MASUYAMA Hisashi

Papers - MASUYAMA Hisashi

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救急救命士の処置拡大に向けた医師の指示下でのFAST検査におけるSim教育の効果実証

中藤光里, 大平安希子, 牧尉太, 三苫智裕, 三島桜子, 上田浩平, 桐野智江, 衛藤英理子, 中尾篤典, 増山寿

超音波医学 50 ( Suppl. ) S691 - S691 2023.4

デジタル田園健康特区での移動車両内遠隔超音波検査伝送による遠隔診断の有効性の調査

三苫智裕, 牧尉太, 大羽輝, 上田浩平, 桐野智江, 大平安希子, 谷和祐, 衛藤英理子, 中尾篤典, 増山寿

超音波医学 50 ( Suppl. ) S691 - S691 2023.4

救急救命士の処置拡大に向けた医師の指示下でのFAST検査におけるSim教育の効果実証

中藤光里, 大平安希子, 牧尉太, 三苫智裕, 三島桜子, 上田浩平, 桐野智江, 衛藤英理子, 中尾篤典, 増山寿

超音波医学 50 ( Suppl. ) S691 - S691 2023.4

妊娠25週で発覚した胎児無水脳症の一例

三島桜子, 佐藤麻夕子, 谷和祐, 衛藤英理子, 早田桂, 奈良井哲, 梶俊策, 河原義文, 増山寿

超音波医学 50 ( Suppl. ) S757 - S757 2023.4

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer. International journal

Keiichiro Nakamura, Kunitoshi Shigeyasu, Kazuhiro Okamoto, Hirofumi Matsuoka, Hisashi Masuyama

Scientific reports 13 ( 1 ) 4720 - 4720 2023.3

Language：English Publishing type：Research paper (scientific journal)

Adenosine deaminase acting on RNA 1 (ADAR1), a recently described epigenetic modifier, is believed to play a critical oncogenic role in human cancers. However, its functional role and clinical significance in cervical cancer (CC) remain unclear. ADAR1 knockdown was performed to investigate its oncogenic functions in SiHa (HPV16), HeLa (HPV18), and Yumoto (non-HPV) CC cell lines. Cytoplasmic and nuclear ADAR1 expression were examined to clarify their correlation with clinicopathological parameters and prognosis in patients with CC. This resulted in increased apoptosis and necroptosis in HPV16 -type SiHa, HPV18-type HeLa, and non-HPV-type Yumoto CC cell lines. Progression-free survival (PFS) rates of patients exhibiting high cytoplasmic and nuclear ADAR1 expression were poorer than those in the other groups (P = 0.016). Multivariate analysis indicated that the combination of higher cytoplasmic and nuclear ADAR1 expression was an independent predictor of prognosis in patients with CC (P = 0.017). ADAR1 could be a potential therapeutic target for HPV-positive or HPV-negative CC. The combination of cytoplasmic and nuclear ADAR1 comprises a better prognostic factor for CC.

DOI： 10.1038/s41598-023-30452-y

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産科領域の播種性血管内凝固症候群(DIC) 暫定版産科DIC診断基準

板倉敦夫, 芹沢麻里子, 竹田純, 竹田善治, 二井理文, 兵藤博信, 牧野真太郎, 増山寿, 松永茂剛, 森川守

日本産婦人科・新生児血液学会誌 32 ( 2 ) 43 - 49 2023.3

Language：Japanese Publisher：日本産婦人科・新生児血液学会

前回の総説(日産婦新生児血会誌.2022;31:81-8.)では、産科DIC診断基準(スコア)の背景と改訂の必要性、その際の注意点などを記した。2022年6月に日本産婦人科・新生児血液学会ワーキンググループと日本産科婦人科学会周産期委員会の合同委員会によって、暫定版産科DIC診断基準を策定・公開した。本総説では作成のその経緯と今後取り組むべき課題などについてまとめた。(著者抄録)

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Therapeutic plasma exchange in postpartum HELLP syndrome: a case report. International journal

Nana Kojima, Kosuke Kuroda, Makiko Tani, Tomoyuki Kanazawa, Kazuyoshi Shimizu, Jota Maki, Hisashi Masuyama, Hiroshi Morimatsu

JA clinical reports 9 ( 1 ) 9 - 9 2023.2

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Postpartum hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is more difficult to treat than HELLP syndrome during pregnancy. We describe a case of postpartum HELLP syndrome that responded to plasma exchange (PE) therapy. CASE PRESENTATION: A 30-year-old primipara woman was hospitalized for gestational hypertension at 33 weeks of gestation and underwent an emergent cesarean section at 36 weeks and 6 days of gestation due to rapidly progressing pulmonary edema. After delivery, liver dysfunction and a rapid decrease in platelet count were observed, and the patient was diagnosed with severe HELLP syndrome. She experienced multiple organ failure despite intensive care, and PE therapy was initiated. Her general condition dramatically stabilized within a few hours of PE therapy. CONCLUSION: It is controversial whether PE therapy should be used primarily in the management of HELLP syndrome, but early initiation of PE therapy could be effective for severe HELLP syndrome.

DOI： 10.1186/s40981-023-00602-2

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Protocol for a randomised, placebo-controlled, double-blinded clinical trial on the effect of oestrogen replacement on physical performance to muscle resistance exercise for older women with osteoarthritis of knee joint: the EPOK trial International journal

Tomohiro Mitoma, Jota Maki, Hikaru Ooba, Eriko Eto, Kasumi Takahashi, Tsunemasa Kondo, Tomohiro Ikeda, Yoko Sakamoto, Toshiharu Mitsuhashi, Hisashi Masuyama

BMC Geriatrics 23 ( 1 ) 104 - 104 2023.2

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Knee osteoarthritis (KOA) is highly prevalent in older women, and previous studies suggest the involvement of hormonal factors play a role in the pathogenesis of osteoarthritis. KOA causes musculoskeletal impairment, resulting in decreased physical activity, muscle mass, and strength, which leads to sarcopenia and further increases the burden on healthcare systems. Oestrogen replacement therapy (ERT) improves joint pain and muscle performance in early menopausal women. Muscle resistance exercise (MRE) is a non-pharmacological method that preserves the physical functions of patients with KOA. However, data on short-term oestrogen administration combined with MRE in postmenopausal women, especially in those aged > 65 years, are limited. Therefore, this study presents a protocol of a trial aimed to examine the synergistic effect of ERT and MRE on lower-limb physical performance in older women with KOA.

Methods

We will conduct a double-blinded, randomised placebo-controlled trial in 80 Japanese women aged > 65 years living independently with knee pain. The participants will be randomly categorised into two groups: (1) 12-week MRE programme with transdermal oestrogen gel containing 0.54 mg oestradiol per push and (2) 12-week MRE programme with placebo gel. The primary outcome measured using the 30-s chair stand test, and secondary outcomes (body composition, lower-limb muscle strength, physical performance, self-reported measure of knee pain, and quality of life) will be measured at baseline, 3 months, and 12 months, and these outcomes will be analysed based on the intention-to-treat.

Discussion

The EPOK trial is the first study to focus on the efficacy of ERT on MRE among women aged > 65 years with KOA. This trial will provide an effective MRE to prevent KOA-induced lower-limb muscle weakness, confirming the benefit of short-term oestrogen administration.

Trial registration

Japan Registry of Clinical Trials: jRCTs061210062. Registered 17th December 2021, https://jrct.niph.go.jp/en-latest-detail/jRCTs061210062.

DOI： 10.1186/s12877-023-03828-y

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Other Link： https://link.springer.com/article/10.1186/s12877-023-03828-y/fulltext.html

有棘縫合糸を用いて安全に妊娠中の子宮筋腫核出術を行った1例

根来柚衣, 城道久, 牧尉太, 苔原つばさ, 岡田十三, 増山寿, 吉田茂樹

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 563 2023.2

腹腔鏡下McCall縫合を併用した骨盤臓器脱に対する術式の工夫

久保光太郎, 牧尉太, 衛藤英理子, 鎌田泰彦, 増山寿

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 380 2023.2

ART妊娠では胎盤遺残,特に単純癒着胎盤のリスクがある

末森彩乃, 早田桂, 大羽輝, 三苫智裕, 三島桜子, 大平安希子, 桐野智江, 谷和祐, 牧尉太, 衛藤英理子, 増山寿

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 408 2023.2

妊娠21週に前期破水を認めた全前置癒着胎盤に対して子宮動脈塞栓術後に妊娠子宮全摘出術を施行した一例

杉原百芳, 谷和祐, 大羽輝, 三苫智裕, 三島桜子, 大平安希子, 牧尉太, 桐野智江, 衛藤英理子, 早田桂, 増山寿

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 407 2023.2

子宮頸癌に対し放射線治療後骨盤骨折発生の多施設共同後ろ向きコホート研究

白河伸介, 長尾昌二, 入江恭平, 岡本和浩, 松岡敬典, 依田尚之, 原賀順子, 小川千加子, 中村圭一郎, 依光正枝, 児玉順一, 永坂久子, 中西美惠, 今福紀章, 山本暖, 増山寿, IPFAR

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 450 2023.2

初回進行卵巣癌に対するPARP阻害剤維持療法の施行状況と安全性の検討

松岡敬典, 白河伸介, 入江恭平, 岡本和浩, 依田尚之, 原賀順子, 久保光太郎, 小川千加子, 中村圭一郎, 長尾昌二, 増山寿

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 291 2023.2

マウス卵における染色体凝集塊形成手法を用いた新規核置換法の開発

岡本遼太, 鎌田泰彦, 増山寿, 大月純子

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 257 2023.2

性成熟期での腟狭窄を伴う総排泄腔遺残 2例の報告(Persistent cloaca with vaginal stenosis at sexual maturity: A report of two cases)

Kamada Yasuhiko, Okamoto Ryota, Kashino Chiaki, Kubo Kotaro, Mitsui Takashi, Masuyama Hisashi

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 232 2023.2

Wunderlich症候群の根治術として子宮鏡下子宮中隔切除術を施行した一例

鎌田泰彦, 岡本遼太, 樫野千明, 久保光太郎, 光井崇, 増山寿

日本子宮鏡研究会雑誌 4 ( 1 ) 98 - 98 2023.2

ART妊娠では胎盤遺残,特に単純癒着胎盤のリスクがある

末森彩乃, 早田桂, 大羽輝, 三苫智裕, 三島桜子, 大平安希子, 桐野智江, 谷和祐, 牧尉太, 衛藤英理子, 増山寿

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 408 2023.2

有棘縫合糸を用いて安全に妊娠中の子宮筋腫核出術を行った1例

根来柚衣, 城道久, 牧尉太, 苔原つばさ, 岡田十三, 増山寿, 吉田茂樹

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 563 2023.2

腹腔鏡下McCall縫合を併用した骨盤臓器脱に対する術式の工夫

久保光太郎, 牧尉太, 衛藤英理子, 鎌田泰彦, 増山寿

日本産科婦人科学会雑誌 75 ( 臨増 ) S - 380 2023.2

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Papers - MASUYAMA Hisashi