Faculty Profiles - MASUYAMA Hisashi

Papers - MASUYAMA Hisashi

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糖代謝異常妊婦における母体体組成量および安静時代謝量と出生児体重の関係

衛藤英理子, 横畑理美, 牧尉太, 増山寿

糖尿病と妊娠 21 ( 3 ) S - 104 2021.11

耐糖能異常妊婦における妊娠後期・分娩直後・産後2ヵ月でのインスリン分泌能の変化

渡邉真由, 牧尉太, 衛藤英理子, 江口潤, 増山寿, 和田淳

糖尿病と妊娠 21 ( 3 ) S - 103 2021.11

糖代謝異常妊婦における母体体組成量および安静時代謝量と出生児体重の関係

衛藤英理子, 横畑理美, 牧尉太, 増山寿

糖尿病と妊娠 21 ( 3 ) S - 104 2021.11

【産科医療におけるME機器-正しい使い方とトラブルシューティング-】体脂肪計体重コントロールの工夫、体脂肪計を用いての栄養評価

衛藤英理子, 増山寿

周産期医学 51 ( 11 ) 1667 - 1670 2021.11

糖尿病マウスにおけるProtein kinase Cを介した血管新生因子及び抗血管新生因子の産生

光井崇, 増山寿

糖尿病と妊娠 21 ( 3 ) S - 105 2021.11

Inflammation of the adipose tissue in the retroperitoneal cavity adjacent to pelvic endometriosis. International journal

Kotaro Kubo, Yasuhiko Kamada, Toru Hasegawa, Ai Sakamoto, Mikiya Nakatsuka, Takashi Matsumoto, Hisashi Masuyama

The journal of obstetrics and gynaecology research 47 ( 10 ) 3598 - 3606 2021.10

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

AIM: Peritoneal endometriosis is a chronic inflammatory disease particularly associated with macrophages. Of note, adipose tissues with fibrotic changes in the context of peritoneal endometriotic lesions are often observed during surgery. However, the characteristics of fibrotic adipose tissues in endometriosis are still unknown. In this study, we investigated the inflammatory status of retroperitoneal adipose tissues adjacent to pelvic endometriotic lesions. METHODS: Thirty-two patients who underwent surgical treatment were assigned to either the endometriosis (n = 16) or the control (n = 16) groups. Retroperitoneal adipose tissues around the uterus were collected from patients in both groups. Fibrosis was evaluated via Masson's trichrome staining. Macrophage infiltration, the expression of fatty acid-binding protein 4 (FABP4), and angiogenesis in the retroperitoneal adipose tissues were evaluated via immunohistochemistry. The mRNA expression levels of cytokines was also evaluated in the adipose tissues using real-time PCR. RESULTS: There was more fibrosis and angiogenesis in the adipose tissues adjacent to the endometriotic lesions with a significantly higher level of infiltration of macrophages and a predominance of the M1 type in the endometriosis group compared to the control group. In addition, FABP4 positivity in the adipose tissues of the peritoneum was significantly higher in the endometriosis group versus the control group. Moreover, the mRNA expression levels of FABP4, VEGF, and proinflammatory cytokines were also significantly higher in the endometriosis group. CONCLUSION: Altogether, our results showed that the adipose tissue adjacent to endometriotic lesions are inflamed with fibrosis and angiogenesis.

DOI： 10.1111/jog.14958

Evaluation of the clinical performance of noninvasive prenatal testing at a Japanese laboratory. International journal

Yuna Sasaki, Takahiro Yamada, Shiro Tanaka, Akihiko Sekizawa, Tatsuko Hirose, Nobuhiro Suzumori, Takashi Kaji, Satoshi Kawaguchi, Yasuyuki Hasuo, Haruki Nishizawa, Keiichi Matsubara, Haruka Hamanoue, Akimune Fukushima, Masayuki Endo, Masayuki Yamaguchi, Yoshimasa Kamei, Hideaki Sawai, Kiyonori Miura, Masaki Ogawa, Shinya Tairaku, Hiroaki Nakamura, Ayako Sanui, Masahito Mizuuchi, Yoko Okamoto, Michihiro Kitagawa, Yukie Kawano, Hisashi Masuyama, Jun Murotsuki, Hisao Osada, Ryuhei Kurashina, Osamu Samura, Mayuko Ichikawa, Rumi Sasaki, Kazuhisa Maeda, Yasuyo Kasai, Tomomi Yamazaki, Reiko Neki, Naoki Hamajima, Yukiko Katagiri, Shunichiro Izumi, Setsuko Nakayama, Norio Miharu, Yuko Yokohama, Masaya Hirose, Kosuke Kawakami, Kiyotake Ichizuka, Masakatsu Sase, Kohei Sugimoto, Takeshi Nagamatsu, Tomomi Shiga, Lena Tashima, Takeshi Taketani, Mariko Matsumoto, Hironori Hamada, Takafumi Watanabe, Tetsuya Okazaki, Sadahiko Iwamoto, Daisuke Katsura, Nobuo Ikenoue, Toshiyuki Kakinuma, Hiromi Hamada, Makiko Egawa, Atsushi Kasamatsu, Akinori Ida, Naohiko Kuno, Naoaki Kuji, Mika Ito, Hiroko Morisaki, Shinji Tanigaki, Hiromi Hayakawa, Akinori Miki, Shoko Sasaki, Makoto Saito, Naoki Yamada, Toshiyuki Sasagawa, Toshitaka Tanaka, Fumiki Hirahara, Shinji Kosugi, Haruhiko Sago

The journal of obstetrics and gynaecology research 47 ( 10 ) 3437 - 3446 2021.10

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

AIM: We aimed to evaluate the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of noninvasive prenatal testing (NIPT) in high-risk pregnant women. METHODS: Pregnant women who underwent GeneTech NIPT, the most commonly used NIPT in Japan, between January 2015 and March 2019, at Japan NIPT Consortium medical sites were recruited for this study. The exclusion criteria were as follows: pregnant women with missing survey items, multiple pregnancy/vanishing twins, chromosomal abnormalities in the fetus other than the NIPT target disease, and nonreportable NIPT results. Sensitivity and specificity were calculated from the obtained data, and maternal age-specific PPV and NPV were estimated. RESULTS: Of the 45 504 cases, 44 263 cases fulfilling the study criteria were included. The mean maternal age and gestational weeks at the time of procedure were 38.5 years and 13.1 weeks, respectively. Sensitivities were 99.78% (95% confidence interval [95% CI]: 98.78-99.96), 99.12% (95% CI: 96.83-99.76), and 100% (95% CI: 88.30-100) for trisomies 21, 18, and 13, respectively. Specificities were more than 99.9% for trisomies 21, 18, and 13, respectively. Maternal age-specific PPVs were more than 93%, 77%, and 43% at the age of 35 years for trisomies 21, 18, and 13, respectively. CONCLUSION: The GeneTech NIPT data showed high sensitivity and specificity in the detection of fetal trisomies 21, 18, and 13 in high-risk pregnant women, and maternal age-specific PPVs were obtained. These results could provide more accurate and improved information regarding NIPT for genetic counseling in Japan.

DOI： 10.1111/jog.14954

【帝王切開-明日からできる工夫と留意点-】術前に判明している場合 6.子宮筋腫合併

増山寿, 衛藤英理子, 谷村吏香

産科と婦人科 88 ( 10 ) 1191 - 1196 2021.10

Language：Japanese Publisher：(株)診断と治療社

子宮筋腫は婦人科疾患の中で最も一般的であり、子宮筋腫合併妊娠の頻度は、超音波検査の診断技術向上と晩産化に伴い、最近の報告では10%を超えている。まず、妊娠初期の子宮筋腫の評価(個数、大きさ、位置)が大切である。そのうえで妊娠中や分娩・産褥期に起こり得る合併症に注意を払う必要がある。子宮筋腫合併妊娠の帝王切開では、子宮筋腫および胎盤の正確な位置把握に基づく娩出ルート設定による安全な児娩出が最優先である。さらに適切な手術操作での同時の子宮筋腫摘出術も十分可能である。(著者抄録)

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当院における小児・思春期女性に対する妊孕性温存

樫野千明, 久保光太郎, 長谷川徹, 光井崇, 鎌田泰彦, 中塚幹也, 増山寿

日本生殖医学会雑誌 66 ( 4 ) 395 - 395 2021.10

PRODUCTION OF ANGIOGENIC AND ANTIANGIOGENIC FACTORS VIA THE ACTIVATION OF PROTEIN KINASE C IN THE PLACENTA OF PREGNANT DIABETIC MICE

Takashi Mitsui, Sakurako Mishima, Kazumasa Tani, Hisashi Masuyama

PLACENTA 114 145 - 145 2021.10

PRODUCTION OF ENDOTHELIN-1 VIA PLACENTAL (PRO)RENIN RECEPTOR IN PREECLAMPSIA MODEL MICE

Sakurako Mishima, Takashi Mitsui, Kazumasa Tani, Tomohiro Mitoma, Satomi Yokohata, Akiko Ohira, Jota Maki, Satoe Kirino, Eriko Eto, Kei Hayata, Hisashi Masuyama

PLACENTA 114 148 - 148 2021.10