Papers - MASUYAMA Hisashi

[The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia].

Kosei Hasegawa, Yasushi Mizutani, Hiroyuki Kuramoto, Shoji Nagao, Hisashi Masuyama, Atsuhi Hongo, Jyunichi Kodama, Mitsuo Yoshinouchi, Yuji Hiramatsu, Takafumi Kudo, Hiroyuki Okuda

Gan to kagaku ryoho. Cancer & chemotherapy   29 ( 4 )   569 - 74   2002.4

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Language：Japanese   Publishing type：Research paper (scientific journal)  

Myalgia/arthralgia is a crucial side effect of paclitaxel, and may become the major dose-limiting side effect. However, this is a situation where there is little effective preventive treatment. L-Glutamine was reported as a neuroprotective agent for vincristine-induced neurotoxicity. In Japan, there have been reports on steroid and Shakuyaku-Kanzou-to (a herbal medicine) for paclitaxel-induced myalgia/arthralgia. This study aimed to compare the effect of L-Glutamine and Shakuyaku-Kanzou-to, and to discuss the validity of these agents for the paclitaxel-induced myalgia/arthralgia. Our results suggested that Shakuyaku-Kanzou-to showed no remarkable effects against paclitaxel-induced myalgia/arthralgia as had been reported before; however, both L-Glutamine and Shakuyaku-Kanzou-to decreased the duration of grade 2 toxicity (CALGB Expanded Common Toxicity Criteria) in comparison with those who were not treated. L-Glutamine and Shakuyaku-Kanzou-to might therefore a preventive effect against moderate or severer myalgia/arthralgia during paclitaxel-treated chemotherapy. Further trials are needed to confirm the value of these drugs.

PubMed

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共通肺静脈閉鎖の有無で児の予後が大きく左右した胎児複雑心奇形の2例

早田 桂, 井下 秀司, 石井 恵子, 中村 洋二郎, 橋本 一郎, 熊澤 一真, 増山 寿, 平松 祐司, 工藤 尚文

日本産科婦人科学会中国四国合同地方部会雑誌   50 ( 2 )   171 - 171   2002.2

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Language：Japanese   Publisher：中国四国産科婦人科学会  

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