Faculty Profiles - MASUYAMA Hisashi

Papers - MASUYAMA Hisashi

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The Combination of D-dimer and Glasgow Prognostic Score Can Be Useful in Predicting VTE in Patients with Stage IIIC and IVA Ovarian Cancer.

Kotaro Kubo, Keiichiro Nakamura, Kazuhiro Okamoto, Hirofumi Matsuoka, Naoyuki Ida, Tomoko Haruma, Chikako Ogawa, Hisashi Masuyama

Acta medica Okayama 76 ( 2 ) 129 - 135 2022.4

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann-Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.

DOI： 10.18926/AMO/63406

COVID-19 妊産婦緊急搬送補助システム"iPicss"を用いた救急隊との搬送連携/災害発生後やCOVID-19妊婦の連携体制の構築

牧尉太, 三苫智裕, 横畑理美, 三島桜子, 大平安希子, 谷和祐, 衛藤英理子, 早田桂, 増山寿

日本周産期・新生児医学会雑誌 57 ( 4 ) 826 - 828 2022.4

胎児診断された胎児卵巣嚢腫茎捻転の一例

谷和祐, 三苫智裕, 横畑理美, 三島桜子, 大平安希子, 桐野智江, 牧尉太, 衛藤英理子, 早田桂, 増山寿

超音波医学 49 ( Suppl. ) S719 - S719 2022.4

COVID-19 妊産婦緊急搬送補助システム"iPicss"を用いた救急隊との搬送連携/災害発生後やCOVID-19妊婦の連携体制の構築

牧尉太, 三苫智裕, 横畑理美, 三島桜子, 大平安希子, 谷和祐, 衛藤英理子, 早田桂, 増山寿

日本周産期・新生児医学会雑誌 57 ( 4 ) 826 - 828 2022.4

胎児心エコーにおけるストレイン値の機種間誤差に関する検討

大平安希子, 早田桂, 三苫智裕, 横畑理美, 三島桜子, 谷和祐, 牧尉太, 桐野智江, 衛藤英理子, 増山寿

超音波医学 49 ( Suppl. ) S729 - S729 2022.4

大動脈縮窄症および左上大静脈遺残を伴った1例妊娠14週のHDlive Flow所見

小柳彩, 秦利之, 高吉理子, 中井祐一郎, 三宅貴仁, 谷和祐, 早田桂, 増山寿

超音波医学 49 ( Suppl. ) S752 - S752 2022.4

胎児心エコーにおけるストレイン値の機種間誤差に関する検討

大平安希子, 早田桂, 三苫智裕, 横畑理美, 三島桜子, 谷和祐, 牧尉太, 桐野智江, 衛藤英理子, 増山寿

超音波医学 49 ( Suppl. ) S729 - S729 2022.4

胎児診断された胎児卵巣嚢腫茎捻転の一例

谷和祐, 三苫智裕, 横畑理美, 三島桜子, 大平安希子, 桐野智江, 牧尉太, 衛藤英理子, 早田桂, 増山寿

超音波医学 49 ( Suppl. ) S719 - S719 2022.4

大動脈縮窄症および左上大静脈遺残を伴った1例妊娠14週のHDlive Flow所見

小柳彩, 秦利之, 高吉理子, 中井祐一郎, 三宅貴仁, 谷和祐, 早田桂, 増山寿

超音波医学 49 ( Suppl. ) S752 - S752 2022.4

摂食調節ホルモンによる卵胞ステロイド合成への影響とその機序の検討

中野靖浩, 樫野千明, 長谷川徹, 岩田菜穂子, 副島佳晃, 須山敦仁, 山本紘一郎, 増山寿, 大塚文男

日本内分泌学会雑誌 97 ( 5 ) 1363 - 1363 2022.3

摂食調節ホルモンによる卵胞ステロイド合成への影響とその機序の検討

中野靖浩, 樫野千明, 長谷川徹, 岩田菜穂子, 副島佳晃, 須山敦仁, 山本紘一郎, 増山寿, 大塚文男

日本内分泌学会雑誌 97 ( 5 ) 1363 - 1363 2022.3

【産婦人科診療に必要な遺伝カウンセリングの基本知識と実際】がんゲノム医療検査前遺伝カウンセリング

小川千加子, 依田尚之, 増山寿, 平沢晃

産婦人科の実際 71 ( 2 ) 155 - 160 2022.2

Language：Japanese Publisher：金原出版(株)

＜文献概要＞・がんゲノム医療とは,狭義の意味ではがん遺伝子パネル検査を指すこと多いが,本質的は未発症者のがん予防も含めた医療であり,薬剤選択に加え,予測される予後や他のがんのリスクを個別に評価し管理することも含んでいる。・がんゲノム医療における遺伝カウンセリングでは,疾患への遺伝医学的な理解を促し,クライエントを全人的に捉え心理面や社会経済面での問題にも対応することで,がん予防やQOLに貢献する。・婦人科領域ではgermline findingsが比較的高率に検出される。特に遺伝性乳癌卵巣癌(HBOC)とLynch症候群が同定される頻度が高い。

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Obesity's Influence on Insulin Resistance in Pregnant Women with Polycystic Ovary Syndrome.

Eriko Eto, Kazumasa Tani, Jota Maki, Kei Hayata, Hisashi Masuyama

Acta medica Okayama 76 ( 1 ) 51 - 56 2022.2

Language：English Publishing type：Research paper (scientific journal) Publisher：OKAYAMA UNIV MED SCHOOL

Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder that is associated with high insulin resistance and obesity. However, ~70% of women with PCOS in Japan are non-obese. We retrospectively analyzed the cases of 163 Japanese women with PCOS who visited our Ob/Gyn department in 2006-2018 to determine which has a greater effect on insulin resistance: PCOS or obesity. We reviewed the women's medical records and calculated their insulin resistance and insulin secretion. The women's mean age and pre-pregnancy body mass index (BMI) were 30±5.8 years and 24.8±5.6 kg/m2, respectively; their mean ± SD fasting plasma glucose, 94.1±13.7 mg/dL; HOMA-IR, 2.1±2.0; QUICKI, 0.4±0.0; and HOMA-β, 108.9±88.0%. Sixtyeight women were pregnant, and 37% (n=25) were obese (BMI ≥ 25 kg/m2). Obesity had a greater effect on insulin resistance: fasting plasma glucose F(1, 53)=6.134, p<0.05; fasting insulin F(1, 53)=31.606, p<0.01; HOMA-IR F(1, 53)=31.670, p<0.01; QUICKI F(1, 53)=16.156, p<0.01. There was no significant difference in values other than QUICKI and testosterone between the women with and without PCOS. Obesity thus had a greater effect on increased insulin resistance in pregnant women with PCOS. Further studies of the insulin resistance of non-obese women with PCOS is needed, as non-obese women with PCOS are common in Asia.

DOI： 10.18926/AMO/63209

Plus One Seminar 2021 多視点映像と実況中継による参加型オンライン分娩シミュレーションへの挑戦

三苫智裕, 横畑理美, 三島桜子, 大平安希子, 桐野智江, 谷和祐, 牧尉太, 衛藤英理子, 早田桂, 増山寿

日本産科婦人科学会雑誌 74 ( 臨増 ) S - 590 2022.2