Faculty Profiles - MASUYAMA Hisashi

Papers - MASUYAMA Hisashi

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Interaction between orexin A and bone morphogenetic protein system on progesterone biosynthesis by rat granulosa cells Reviewed

Shiho Fujita, Toru Hasegawa, Yuki Nishiyama, Satoshi Fujisawa, Yasuhiro Nakano, Takahiro Nada, Nahoko Iwata, Yasuhiko Kamada, Hisashi Masuyama, Fumio Otsuka

Journal of Steroid Biochemistry and Molecular Biology 181 73 - 79 2018.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ltd

The involvement of orexins in reproductive function has been gradually uncovered. However, the functional role of orexins in ovarian steroidogenesis remains unclear. In the present study, we investigated the effects of orexin A on ovarian steroidogenesis by using rat primary granulosa cells that express both OX1 and OX2 receptors for orexins. Treatment with orexin A enhanced progesterone, but not estradiol, biosynthesis induced by FSH, whereas it did not affect basal levels of progesterone or estradiol. In accordance with the effects on steroidogenesis, orexin A increased the mRNA levels of progesterogenic enzymes, including StAR, P450scc and 3βHSD, but not P450arom, and cellular cAMP synthesis induced by FSH. Under the condition of blockage of endogenous BMP actions by noggin or BMP-signaling inhibitors, orexin A failed to increase levels of progesterone synthesis induced by FSH treatment, suggesting that endogenous BMP activity in granulosa cells might be involved in the enhancement of progesterone synthesis by orexin A. Treatment with orexin A impaired Smad1/5/9 activation as well as Id-1 mRNA expression stimulated by BMP-6 and BMP-7, the latter of which was reversed by treatment with an OX1 antagonist. It was also found that orexin A suppressed the mRNA expression of both type-I and -II receptors for BMPs and increased that of inhibitory Smad6 and Smad7 in granulosa cells. On the other hand, treatments with BMP-6 and -7 suppressed the expression of OX1 and OX2. Collectively, the results indicated that orexin A enhances FSH-induced progesterone production, at least in part, by downregulating BMP signaling in granulosa cells. Thus, a new role of orexin A in facilitating progesterone synthesis and functional interaction between the orexin and BMP systems in granulosa cells were revealed.

DOI： 10.1016/j.jsbmb.2018.03.004

Assessment of resting energy expenditure and body composition in Japanese pregnant women with diabetes. Reviewed

Eriko Eto, Jota Maki, Shoko Tamada, Takashi Mitsui, Kei Hayata, Yuji Hiramatsu, Hisashi Masuyama

Journal of diabetes investigation 9 ( 4 ) 959 - 966 2018.7

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

AIMS/INTRODUCTION: To measure longitudinal changes in resting energy expenditure and body composition of Japanese pregnant women with or without diabetes. MATERIALS AND METHODS: The study population consisted of women who had delivered a live singleton neonate after 22 weeks' gestation at Okayama University Hospital from July 2013 to June 2017. Resting energy expenditure and body composition were measured in the first trimester, second trimester, third trimester and postpartum. RESULTS: A total of 144 women participated in this study: 103 with normal glucose tolerance and 41 with diabetes. The resting energy expenditure (kcal/day) of pregnant women with normal glucose tolerance was significantly higher in the third trimester (1,644 ± 234) than in the first (1,461 ± 215) and second trimesters (1,491 ± 219), and postpartum (1,419 ± 254), whereas that of pregnant women with diabetes did not significantly change during all periods (1,568 ± 404, 1,710 ± 332, 1,716 ± 251, 1,567 ± 249). The resting energy expenditure of women with good glycemic control was lower than that of women with poor control. Fat-free mass was closely correlated with resting energy expenditure. CONCLUSIONS: The resting energy expenditure of Japanese pregnant women with normal glucose tolerance was significantly increased in the third trimester. The resting energy expenditure of women with good glycemic control was lower than that of women with poor control. Resting energy expenditure and fat-free mass are potential indexes for medical nutrition therapy in pregnant women with diabetes.

DOI： 10.1111/jdi.12795

この症例をどうするか?:妊娠、出産へのアプローチ Fontan手術後に挙児希望をされているが、低酸素血症が持続している1症例 Reviewed

杜徳尚, 赤木禎治, 黒子洋介, 馬場健児, 板谷慶一, 牧尉太, 小谷恭弘, 大月審一, 増山寿, 笠原真悟, 伊藤浩

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 156 2018.7

【妊娠糖尿病まるわかり妊娠中・分娩時・産後&新生児の管理に関する最新アプローチ】産婦が意識消失、どう対応する? 母体急変対応 Reviewed

牧尉太, 増山寿

ペリネイタルケア 37 ( 7 ) 652 - 656 2018.7

成人先天性心疾患センターにおけるハイリスク妊娠に対するアプローチ妊娠中の抗凝固療法管理はどうあるべきか?

赤木禎治, 杜徳尚, 高橋生, 増山寿, 伊藤浩

日本小児循環器学会雑誌 34 ( Suppl.1 ) s1 - 191 2018.7

血糖モニター(リアルタイムCGM)を用いた糖代謝異常妊婦の陣痛発来後の血糖動態および血糖管理方法の検討 Reviewed

牧尉太, 谷和祐, 玉田祥子, 江口武志, 光井崇, 衛藤英理子, 早田桂, 平松祐司, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 655 - 655 2018.6

全前脳胞症に22q11.2欠失症候群を合併した1例 Reviewed

谷和祐, 牧尉太, 江口武志, 玉田祥子, 岡村朋香, 光井崇, 衛藤英理子, 早田桂, 鷲尾洋介, 吉本順子, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 720 - 720 2018.6

糖尿病合併妊婦と妊娠糖尿病妊婦の妊娠経過に伴う安静時代謝量の変化 Reviewed

衛藤英理子, 谷和祐, 牧尉太, 江口武志, 玉田祥子, 早田桂, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 656 - 656 2018.6

新ACC/AHA高血圧ガイドラインにおける高血圧ステージ分類における周産期予後の検討

江口武志, 谷和祐, 牧尉太, 玉田祥子, 光井崇, 衛藤英理子, 早田桂, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 549 - 549 2018.6

帝王切開時筋腫核出術を施行した子宮下部巨大筋腫合併妊娠の一例

谷村吏香, 衛藤英理子, 牧尉太, 玉田祥子, 光井崇, 早田桂, 増山寿

現代産婦人科 66 ( 2 ) 243 - 247 2018.6

Language：Japanese Publisher：中国四国産科婦人科学会

帝王切開時筋腫核出術を施行した子宮下部巨大筋腫合併妊娠の一例を経験したので報告する。症例は31歳、4妊1産、自然妊娠成立し初期から近医で妊娠管理されていた。妊娠25週5日に性器出血を認め、翌日前医へ母体搬送となった。子宮下部に巨大筋腫を認め、出血も持続するため周産期管理目的に妊娠26週4日当院へ転院となった。初診時の経腟超音波検査では子宮前壁の頸部から体下部にかけて14cm径の子宮筋腫を認め、子宮頸管は圧迫により強く引き延ばされていた。経腹超音波検査では胎児は横位で推定体重970g(+0.04SD)であった。胎盤は子宮後壁に付着し、上縁は子宮底部、下縁は筋腫上端の高さに位置していた。入院後も筋腫は次第に増大し、上腹部圧迫感が増悪していった。妊娠34週5日選択帝王切開術+子宮筋腫核出術を施行した。子宮筋腫の上端から3cm離れた位置で子宮体部横切開を行い、骨盤位で児を娩出した。体重1888gの男児でアプガースコア8/9点であった。晩出部位の子宮筋層を縫合した後、筋腫一塊として核出した。手術時間は1時間58分、出血量は2320mlであった。術後7日目に退院し、産褥1ヵ月健診で異常所見は認めなかった。当院で過去に経験した筋腫合併妊娠症例をあわせて報告する。(著者抄録)

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低用量アスピリン内服による妊娠高血圧症候群発症予防についての後方視的検討

玉田祥子, 谷和祐, 牧尉太, 江口武志, 光井崇, 衛藤英理子, 早田桂, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 703 - 703 2018.6

妊娠高血圧症候群の病態におけるプロレニンの影響

光井崇, 谷和祐, 牧尉太, 江口武志, 玉田祥子, 衛藤英理子, 早田桂, 増山寿

日本周産期・新生児医学会雑誌 54 ( 2 ) 552 - 552 2018.6

Fetal cell-free DNA fraction in maternal plasma for the prediction of hypertensive disorders of pregnancy. Reviewed International journal

Nobuhiro Suzumori, Akihiko Sekizawa, Takeshi Ebara, Osamu Samura, Aiko Sasaki, Rina Akaishi, Seiji Wada, Haruka Hamanoue, Fumiki Hirahara, Haruna Izumi, Hideaki Sawai, Hiroaki Nakamura, Takahiro Yamada, Kiyonori Miura, Hideaki Masuzaki, Takahiro Yamashita, Takashi Okai, Yoshimasa Kamei, Akira Namba, Jun Murotsuki, Tomohiro Tanemoto, Akimune Fukushima, Kazufumi Haino, Shinya Tairaku, Keiichi Matsubara, Kazutoshi Maeda, Takashi Kaji, Masanobu Ogawa, Hisao Osada, Haruki Nishizawa, Yoko Okamoto, Takeshi Kanagawa, Aiko Kakigano, Michihiro Kitagawa, Masaki Ogawa, Shunichiro Izumi, Yukiko Katagiri, Naoki Takeshita, Yasuyo Kasai, Katsuhiko Naruse, Reiko Neki, Hisashi Masuyama, Maki Hyodo, Yukie Kawano, Takashi Ohba, Kiyotake Ichizuka, Takeshi Nagamatsu, Atsushi Watanabe, Nahoko Shirato, Junko Yotsumoto, Miyuki Nishiyama, Tatsuko Hirose, Haruhiko Sago

European journal of obstetrics, gynecology, and reproductive biology 224 165 - 169 2018.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

OBJECTIVE: The purpose of this study is to compare the fetal fractions during non-invasive prenatal testing (NIPT) in singleton pregnancies according to gestational age and maternal characteristics to evaluate the utility of this parameter for the prediction of pregnancy complications including gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP). STUDY DESIGN: This study was a multicenter prospective cohort study. The present data were collected from women whose NIPT results were negative. The relationships between the fetal fractions and the gestational age, maternal weight and height, and incidences of miscarriage, preterm delivery, and pregnancy complications including GDM, HDP and placental abruption were assessed. RESULTS: A total of 5582 pregnant women with verified NIPT negative results were registered in the study. The demographic characteristics of the study populations were statistically analyzed, and the women with HDP tended to have a low fetal fraction in samples taken during early gestation. The area under the curve (AUC) in a receiver operating characteristic curve (ROC) analysis was 0.608 for women with HDP. CONCLUSION: A low fetal fraction on NIPT might be correlated with future HDP. However, predicting HDP during early pregnancy in women with a low fetal fraction might be difficult.

DOI： 10.1016/j.ejogrb.2018.03.048

Lynch症候群子宮体癌におけるMMR statusとLynch症候群関連腫瘍家族歴との相関

原賀順子, 永坂岳司, 春間朋子, 西田傑, 入谷大洋, 母里淑子, 小川千加子, 中村圭一郎, 藤原俊義, 増山寿

日本外科系連合学会誌 43 ( 3 ) 401 - 401 2018.5

Treatment of premenstrual mood changes in a patient with schizophrenia using dienogest: A case report Reviewed

Yasuhiko Kamada, Ai Sakamoto, Sayoko Kotani, Hisashi Masuyama

Journal of Obstetrics and Gynaecology Research 44 ( 4 ) 797 - 800 2018.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Blackwell Publishing

Dienogest is a fourth-generation progestin that is used for the treatment of endometriosis. We report a case of premenstrual mood changes in a patient with schizophrenia who was unresponsive to conventional treatment but successfully managed with dienogest. A 37-year-old Japanese woman with schizophrenia was referred to our hospital and diagnosed with premenstrual exacerbation of schizophrenia or coexisting premenstrual dysphoric disorder with schizophrenia. She had already taken maximal doses of selective serotonin reuptake inhibitors and combined oral contraceptives produced intolerable side effects. Gonadotropin-releasing hormone agonist treatment was effective but was not suitable for long-term use. Dienogest was initiated to treat pelvic endometriosis and produced subsequent improvements in mental status. The patient was able to return to work and did not indicate any adverse effects. This case suggests that dienogest may be useful for managing premenstrual mood changes in patients with schizophrenia, that it can be safely administered over long periods of time.

DOI： 10.1111/jog.13578

Clinical impact of endometrial cancer stratified by genetic mutational profiles, pole mutation, and microsatellite instability Reviewed

Tomoko Haruma, Takeshi Nagasaka, Keiichiro Nakamura, Junko Haraga, Akihiro Nyuya, Takeshi Nishida, Ajay Goel, Hisashi Masuyama, Yuji Hiramatsu

PLoS ONE 13 ( 4 ) e0195655 2018.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Public Library of Science

Background The molecular characterization of endometrial cancer (EC) can facilitate identification of various tumor subtypes. Although EC patients with POLE mutations reproducibly demonstrate better prognosis, the outcome of patients with microsatellite instability (MSI) remains controversial. This study attempted to interrogate whether genetic stratification of EC can identify distinct subsets with prognostic significance. Materials and methods A cohort of 138 EC patients who underwent surgical resection with curative intent was enrolled. Sanger sequencing was used to evaluate mutations in the POLE and KRAS genes. MSI analysis was performed using four mononucleotide repeat markers and methylation status of the MLH1 promoter was measured by a fluorescent bisulfite polymerase chain reaction (PCR). Protein expression for mismatch repair (MMR) proteins was evaluated by immunohistochemistry (IHC). Results Extensive hypermethylation of the MLH1 promoter was observed in 69.6% ECs with MLH1 deficiency and 3.5% with MMR proficiency, but in none of the ECs with loss of other MMR genes (P &lt
.0001). MSI-positive and POLE mutations were found in 29.0% and 8.7% EC patients, respectively. Our MSI analysis showed a sensitivity of 92.7% for EC patients with MMR deficiency, and a specificity of 97.9% for EC patients with MMR proficiency. In univariate and multivariate analyses, POLE mutations and MSI status was significantly associated with progression-free survival (P = 0.0129 and 0.0064, respectively) but not with endometrial cancer-specific survival. Conclusions This study provides significant evidence that analyses of proofreading POLE mutations and MSI status based on mononucleotide repeat markers are potentially useful biomarkers to identify EC patients with better prognosis.

DOI： 10.1371/journal.pone.0195655

前置胎盤症例に対する術中経腟エコーの有用性について Reviewed

早田桂, 牧尉太, 谷和祐, 江口武志, 玉田祥子, 光井崇, 衛藤英理子, 増山寿

超音波医学 45 ( Suppl. ) S731 - S731 2018.4