Faculty Profiles - KAMIOKA Hiroshi

Papers - KAMIOKA Hiroshi

Division display 141 - 160 of about 196 ／ All the affair displays >>

岡山大学病院矯正歯科を受診しII期治療を開始した初診患者の実態調査

片岡伴記, 上岡寛, 川邊紀章, 本城正, 菅原康代, 村上隆, 柳田剛志, 石原嘉人, 山城隆

中四国矯正歯科学会雑誌 23 ( 1 ) 83 - 92 2011

Application of bioimaging to osteocyte biology

Hiroshi Kamioka, Taiji Adachi

Clinical Reviews in Bone and Mineral Metabolism 8 ( 4 ) 170 - 178 2010.12

Language：English

In a variety of scientific fields, it is helpful to visualize natural phenomena. Newly developed methods of visualization often lead to breakthroughs in scientific fields. Especially, in the bioscience field, it is significant to reveal temporal-spatial responses in cells while visualizing molecular phenomena. Such visualization may provide information to help understand cellular behavior in response to an extracellular stimulus. Although osteocytes are the most abundant cells in bone, it has been difficult to study their biological nature because they are embedded in hard bone tissue. So, the real 3D structure of osteocytes was not clarified until recently. On the other hand, a newly developed technique of visualization was recently introduced into bone cell biology. In this review, we introduce and review our application of a bioimaging technique to reveal the morphology of osteocytes as well as part of their biological nature. © Springer Science+Business Media, LLC 2010.

DOI： 10.1007/s12018-010-9077-z

Isolation of multipotent stem cells in human periodontal ligament using stage-specific embryonic antigen-4

Noriaki Kawanabe, Satoko Murata, Kaoru Murakami, Yoshihito Ishihara, Satoru Hayano, Hiroshi Kurosaka, Hiroshi Kamioka, Teruko Takano-Yamamoto, Takashi Yamashiro

DIFFERENTIATION 79 ( 2 ) 74 - 83 2010.2

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCI LTD

The periodontal ligament (PDL) comprises adult stem cells, which are responsible for periodontal tissue regeneration. In the present study, we investigated the specific profile of the stem cells in the human PDL. Microscopic analysis demonstrated that PDL cells showed a fibroblastic appearance, forming flat and loose aggregates. PDL cells expressed embryonic stem cell-associated antigens (SSEA-1, SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, OCT4, NANOG, SOX2, and REX1, and alkaline phosphatase activity), as well as conventional mesenchymal stem cell markers. When PDL cells were cultured in the presence of all-trans-retinoic acid, the numbers of SSEA-3+ and SSEA-4+ PDL cells were significantly decreased, while that of SSEA-1+ was increased. SSEA-4+ PDL cells showed a greater telomere length and growth rate. SSEA-4+ PDL cells exhibited the potential to generate specialized cells derived from three embryonic germ layers: mesodermal (adipocytes, osteoblasts, and chondrocytes), ectodermal (neurons), and endodermal (hepatocytes) lineages. Our findings demonstrated that SSEA-4, a major antigen to distinguish human embryonic stem cells, could also be used to identify multipotent stem cells in the PDL. Hence, SSEA-4+ human PDL cells appear to be a promising source of stem cells for regenerative medicine. (C) 2009 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.diff.2009.10.005

岡山大学病院矯正歯科における来院患者の実態調査

白賀のり子, 上岡寛, 片岡伴記, 植田紘貴, 安藤涼子, 石原嘉人, 柳田剛志, 村上隆, 黒坂寛, 菅原康代, 本城正, 川邉紀章, 山城隆

岡山歯学会雑誌 28 ( 2 ) 107 - 114 2009.12

Language：Japanese Publisher：岡山歯学会

岡山大学病院矯正歯科では2000年度から術前の顎機能検査とMRI検査を取り入れ、より精度の高い診断の基に個々の患者の様々な主訴に応じた治療を行っており、患者数も2001年度の184名から2008年度には209名に増加傾向を示した。2009年4月の1ヵ月間に来院した患者を対象に診療体制に関するアンケート調査を実施、回収された269名について分析した。その結果、対象の性別は女性が男性の1.5倍多く、年齢は成人患者が過半数を占め、矯正治療開始時の主訴は歯ならびの外観63.7%、顔や顎の形9.9%、噛み難い6.9%、発音し難い2.7%、顎関節疾患3.1%、虫歯や歯周病予防3.4%であった。来院のきっかけはかかりつけ医の紹介が35.1%と最も多く、来院動機は高度な専門医療が受けられると思うからが27.9%であった。以上より、岡山大学病院矯正歯科の特色であるインプラントアンカー治療や舌側矯正装置による治療を、地域との連携を深めながらより一層周知すること、さらなる技術の向上に努める必要性が示唆された。

Camouflage treatment using implant anchorage in a skeletal Class III patient

Hiroshi Kamioka, Noriko Shiraga, Teruko Takano-Yamamoto, Takashi Yamashiro

Orthodontic Waves 68 ( 4 ) 171 - 177 2009.12

Language：English Publishing type：Research paper (scientific journal)

This is a case report of a female patient (10 years 3 months) whose chief complaint was edge-to-edge bite. At the initial examination, the diagnosis was severe skeletal Class III. In first-phase treatment, growth modification was planned. Although forward and downward maxillary growth was observed, skeletal Class III still remained. In the second-phase treatment, implant anchorage was applied for distal movement of the mandibular teeth. A favorable occlusal relationship was achieved, and acceptable stomatognathic function was maintained after 2 years of retention. © 2009 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2009.05.001

Asymmetric intercellular communication between bone cells: propagation of the calcium signaling. Reviewed International journal

Taiji Adachi, Yuki Aonuma, Keisuke Taira, Masaki Hojo, Hiroshi Kamioka

Biochemical and biophysical research communications 389 ( 3 ) 495 - 500 2009.11

Language：English Publishing type：Research paper (scientific journal)

Bone functional adaptation by remodeling is achieved by harmonized activities of bone cells in which osteocytes in the bone matrix are believed to play critical roles in sensing mechanical stimuli and transmitting signals to osteoclasts/osteoblasts on the bone surface in order to regulate their bone remodeling activities through the lacuno-canalicular network with many slender osteocytic processes. In this study, we investigated the intercellular communication between bone cells, particularly focusing on its directionality, through in vitro observations of the calcium signaling response to mechanical stimulus and its propagation to neighboring cells (NCs). Direct mechanical stimulus was applied to isolated bone cells from chick calvariae, osteocytes (Ocys) and bone surface cells (BSCs) mainly containing osteoblasts, and the percentage of calcium signaling propagation from the stimulated cell to NCs was analyzed. The results revealed that, regardless of the type of stimulated cell, the signaling propagated to BSCs with a significantly higher percentage, implying that calcium signaling propagation between bone cells strongly depends on the type of receiver cell and not the transmitter cell. In addition, in terms of mutual communication between Ocys and BSCs, the percentage of propagation from Ocys to BSCs is significantly higher than that in the opposite direction, suggesting that the calcium signaling mainly propagates asymmetrically with a bias from Ocys in bone matrix to BSCs on bone surfaces. This asymmetric communication between Ocys and BSCs suggests that osteocytic mechanosensing and cellular communications, which significantly affect bone surface remodeling activities to achieve functional adaptation, seem to be well coordinated and active at the location of biologically suitable and mechanically sensitive regions close to the bone surfaces.

DOI： 10.1016/j.bbrc.2009.09.010

Osteocyte calcium signaling response to bone matrix deformation. Reviewed International journal

Taiji Adachi, Yuki Aonuma, Shin-ichi Ito, Mototsugu Tanaka, Masaki Hojo, Teruko Takano-Yamamoto, Hiroshi Kamioka

Journal of biomechanics 42 ( 15 ) 2507 - 12 2009.11

Language：English Publishing type：Research paper (scientific journal)

Osteocytes embedded in calcified bone matrix have been widely believed to play important roles in mechanosensing to achieve adaptive bone remodeling in a changing mechanical environment. In vitro studies have clarified several types of mechanical stimuli such as hydrostatic pressure, fluid shear stress, and direct deformation influence osteocyte functions. However, osteocyte response to mechanical stimuli in the bone matrix has not been clearly understood. In this study, we observed the osteocyte calcium signaling response to the quantitatively applied deformation in the bone matrix. A novel experimental system was developed to apply deformation to cultured bone tissue with osteocytes on a microscope stage. As a mechanical stimulus to the osteocytes in bone matrix, in-plane shear deformation was applied using a pair of glass microneedles to bone fragments, obtained from 13-day-old embryonic chick calvariae. Deformation of bone matrix and cells was quantitatively evaluated using an image correlation method by applying for differential interference contrast images of the matrix and fluorescent images of immunolabeled osteocytes, together with imaging of the cellular calcium transient using a ratiometric method. As a result, it was confirmed that the newly developed system enables us to apply deformation to bone matrix and osteocytes successfully under the microscope without significant focal plane shift or deviation from the observation view field. The system could be a basis for further development to investigate the mechanosensing mechanism of osteocytes in bone matrix through examination of various types of rapid biochemical signaling responses and intercellular communication induced by matrix deformation.

DOI： 10.1016/j.jbiomech.2009.07.006

A method for observing silver-stained osteocytes in situ in 3-microm sections using ultra-high voltage electron microscopy tomography. Reviewed International journal

Hiroshi Kamioka, Sakhr A Murshid, Yoshihito Ishihara, Naoko Kajimura, Toshiaki Hasegawa, Ryoko Ando, Yasuyo Sugawara, Takashi Yamashiro, Akio Takaoka, Teruko Takano-Yamamoto

Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 15 ( 5 ) 377 - 83 2009.10

Language：English Publishing type：Research paper (scientific journal)

Osteocytes are surrounded by hard bone matrix, and it has not been possible previously to directly observe the in situ architecture of osteocyte morphology in bone. Electron microscope tomography, however, is a technique that has the unique potential to provide three-dimensional (3D) visualization of cellular ultrastructure. This approach is based on reconstruction of 3D volumes from a tilt series of electron micrographs of cells, and resolution at the nanometer level has been achieved. We applied electron microscope tomography to thick sections of silver-stained osteocytes in bone using a Hitachi H-3000 ultra-high voltage electron microscope equipped with a 360 degrees tilt specimen holder, at an accelerating voltage of 2 MeV. Osteocytes with numerous processes and branches were clearly seen in the serial tilt series acquired from 3-microm-thick sections. Reconstruction of young osteocytes showed the 3D topographic morphology of the cell body and processes at high resolution. This morphological data on osteocytes should provide useful information to those who study osteocyte physiology and the several models used to explain their mechanosensory properties.

DOI： 10.1017/S1431927609990420

Corrigendum to "botulinum toxin type A (150 kDa) decreases exaggerated neurotransmitter release from trigeminal ganglion neurons and relieves neuropathy behaviors induced by infraorbital nerve constriction" [Neuroscience 159 (2009) 1422-1429] (DOI:10.1016/j.neuroscience.2009.01.066) Reviewed

Y. Kitamura, Y. Matsuka, I. Spigelman, Y. Ishihara, Y. Yamamoto, W. Sonoyama, H. Kamioka, T. Yamashiro, T. Kuboki, K. Oguma

Neuroscience 161 ( 3 ) 950 2009.7

Bimaxillary protrusion with masseter muscle hypertrophy treated with titanium screw anchorage and masseter surgical reduction

Takashi Hashimoto, Shingo Kuroda, Hiroshi Kamioka, Katsuaki Mishima, Toshio Sugahara, Teruko Takano-Yamamoto

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS 135 ( 4 ) 536 - 548 2009.4

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

This case report describes the treatment of a patient with bimaxillary protrusion and masseter muscle hypertrophy. At age 21 years 7 months, this woman had temporomandibular disorder (TMD) symptoms, severe bimaxillary protrusion, and a prominent mandibular angle with facial asymmetry. After an attempt to alleviate the TMD symptoms with occlusal splint stabilization, portions of the masseter muscle and the mandible were surgically removed. Titanium screws were placed bilaterally in both arches, and a retraction force was applied. After active treatment for 38 months, the convexity of the facial profile with lip protrusion was improved remarkably, and good occlusion was achieved. The prominent mandibular angle with facial asymmetry was improved as a result of the surgical reduction of the masseter muscle and the modeling ostectomy near the masseteric tuberosity. The TMD symptoms disappeared, and the jaw movement pattern became normal. Therefore, our results suggest that this combination treatment would be useful for masseter muscle hypertrophy for morphologic and functional problems. (Am J Orthod Dentofacial Orthop 2009; 135:536-48)

DOI： 10.1016/j.ajodo.2006.10.043

上下顎移動術を適応した顎偏位を伴う骨格性下顎前突症例

本城正, 上岡寛, 黒坂寛, 山本照子, 山城隆

中・四国矯正歯科学会雑誌 21 ( 1 ) 41 - 53 2009

[Osteocytes and mechanical stress]. Reviewed

Hiroshi Kamioka, Takashi Yamashiro

Clinical calcium 18 ( 9 ) 1287 - 93 2008.9

Language：Japanese Publishing type：Research paper (scientific journal)

A number of fascinating studies suggest that osteocytes play an important role in bone metabolism, especially in its regulation by mechanical stimuli. However, it has been still discussed how the osteocytes were activated by mechanical stimuli. For example, direct mechanical load applied to cells at levels measured to occur in humans in vivo do not affect bone cells in vitro . In order to solve the contradiction, theories based on fluid flow-induced shear stress stimulation around osteocytes in bone have appeared with the most prominence. In addition, I would like to introduce recent hypothesis to mechanically stimulate osteocyte, such as strain amplification by radial hoop strains, flow induced integrin mediated signaling, and osteocyte lacuna strain. To validate the availability of these hypothesis, it is important to observe 3-dimensional osteocyte morphology as well as its interaction with pericellular matrix.

Other Link： http://orcid.org/0000-0002-4419-9643

【メカニカルストレスと骨】骨細胞とメカニカルストレス

上岡寛, 山城隆

Clinical Calcium 18 ( 9 ) 1287 - 1293 2008.8

Language：Japanese Publisher：(株)医薬ジャーナル社

骨は機械的刺激を受けマクロな変化を遂げる。その結果は、骨に存在する細胞群が引き起こすミクロな変化の集積である。このような変化を生じるためには、骨の細胞は何らかの方法で機械的刺激を感知しなければならない。実際に、骨の形態を変化させるのは骨芽細胞および破骨細胞であるが、機械的刺激を感知し、これらの細胞の役割を調節しているのが骨細胞であると考えられている。骨細胞は骨基質に囲まれている特異な環境のために、実際にどのようにして機械的刺激を感知しているのかは明らかではない。しかしながら、近年、生体工学的な試みにより、さまざまな骨細胞の機械的刺激の受容機構が提案されてきた。そこで、本稿ではこれらの説を紹介するとともに、骨細胞およびその周囲骨基質の三次元構造を求めることの重要性について解説していきたい。(著者抄録)

The alteration of a mechanical property of bone cells during the process of changing from osteoblasts to osteocytes. Reviewed International journal

Yasuyo Sugawara, Ryoko Ando, Hiroshi Kamioka, Yoshihito Ishihara, Sakhr A Murshid, Ken Hashimoto, Noriyuki Kataoka, Katsuhiko Tsujioka, Fumihiko Kajiya, Takashi Yamashiro, Teruko Takano-Yamamoto

Bone 43 ( 1 ) 19 - 24 2008.7

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE INC

Osteocytes acquire their stellate shape during the process of changing from osteoblasts in bone. Throughout this process, dynamic cytoskeletal changes occur. In general, changes of the cytoskeleton affect cellular mechanical properties. Mechanical properties of living cells are connected with their biological functions and physiological processes. In this study, we for the first time analyzed elastic modulus, a mechanical property of bone cells. Bone cells in embryonic chick calvariae and in isolated culture were identified using fluorescently labeled phalloidin and OB7.3, a chick osteocyte-specific monoclonal antibody, and then observed by confocal laser scanning microscopy. The elastic modulus of living cells was analyzed with atomic force microscopy. To examine the consequences of focal adhesion formation on the elastic modulus, cells were pretreated with GRGDS and GRGES, and then the elastic modulus of the cells was analyzed. Focal adhesions in the cells were visualized by immunofluorescence of vinculin. From fluorescence images, we could distinguish osteoblasts, osteoid osteocytes and mature osteocytes both in vivo and in vitro. The elastic modulus of peripheral regions of cells in all three populations was significantly higher than in their nuclear regions. The elastic modulus of the peripheral region of osteoblasts was 12053+/-934 Pa, that of osteoid osteocytes was 7971+/-422 Pa and that of mature osteocytes was 4471+/-198 Pa. These results suggest that the level of elastic modulus of bone cells was proportional to the stage of changing from osteoblasts to osteocytes. The focal adhesion area of osteoblasts was significantly higher than that of osteocytes. The focal adhesion area of osteoblasts was decreased after treatment with GRGDS, however, that of osteocytes was not. The elastic modulus of osteoblasts and osteoid osteocytes were decreased after treatment with GRGDS. However, that of mature osteocytes was not changed. There were dynamic changes in the mechanical property of elastic modulus and in focal adhesions of bone cells.

DOI： 10.1016/j.bone.2008.02.020

Other Link： http://orcid.org/0000-0002-4419-9643

Comparison of the intrusion effects on the maxillary incisors between implant anchorage and J-hook headgear

Toru Deguchi, Takashi Murakami, Shingo Kuroda, Toshinori Yabuuchi, Hiroshi Kamioka, Teruko Takano-Yamamoto

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS 133 ( 5 ) 654 - 660 2008.5

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

Introduction: Recently, miniscrews have been used to provide anchorage during orthodontic treatment, especially for incisor intrusion. Miniscrews during incisor intrusion are commonly used in implant orthodontics. Traditionally, effective incisor intrusion has been accomplished with J-hook headgear. In this study, we compared the effect of incisor intrusion, force vector, and amount of root resorption between implant orthodontics and J-hook headgear. Methods: Lateral cephalometric radiographs from 8 patients in the implant group and 10 patients in the J-hook headgear group were analyzed for incisor retraction. The estimated force vector was analyzed in the horizontal and vertical directions in both groups. Root resorption was also measured on periapical radiographs. Results: In the implant group, significant reductions in overjet, overbite, maxillary incisor to palatal plane, and maxillary incisor to upper lip were observed after intrusion of the incisors. In the J-hook headgear group, significant reductions in overjet, overbite, maxillary incisor to upper lip, and maxillary incisor to SN plane were observed after intrusion of the incisors. There were significantly greater reductions in overbite, maxillary incisor to palatal plane, and maxillary incisor to upper lip in the implant group than in the J-hook headgear group. Estimated force analysis resulted in significantly more force in the vertical direction and less in the horizontal direction in the implant group. Furthermore, significantly less root resorption was observed in the implant group compared with the J-hook headgear group. Conclusions: The maxillary incisors were effectively intruded by using miniscrews as orthodontic anchorage without patient cooperation. The amount of root resorption was not affected by activating the ligature wire from the miniscrew during incisor intrusion.

DOI： 10.1016/j.ajodo.2006.04.047

Hormonal, pH, and calcium regulation of connexin 43-mediated dye transfer in osteocytes in chick calvaria. Reviewed International journal

Yoshihito Ishihara, Hiroshi Kamioka, Tadashi Honjo, Hirotaka Ueda, Teruko Takano-Yamamoto, Takashi Yamashiro

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 23 ( 3 ) 350 - 60 2008.3

Language：English Publishing type：Research paper (scientific journal) Publisher：AMER SOC BONE & MINERAL RES

UNLABELLED: Gap junctional intercellular communication among osteocytes in chick calvaria, their natural 3D environment, was examined using FRAP analysis. Cell-cell communication among osteocytes in chick calvaria was mediated by Cx43 and was regulated by extracellular pH, extracellular calcium ion concentration, and PTH. INTRODUCTION: The intercellular network of communication among osteocytes is mediated by gap junctions. Gap junctional intercellular communication (GJIC) is thought to play an important role in integration and synchronization of bone remodeling. We hypothesized that extracellular pH (pH(o)) and extracellular calcium ion concentration ([Ca2+](e)), both of which are dynamically altered by osteoclasts during bone remodeling, affect GJIC among osteocytes. Using fluorescence replacement after photobleaching (FRAP) analysis, we examined the effect of changes in pH(o) and [Ca2+](e) and addition of PTH on GJIC in osteocytes in chick calvaria. Additionally, we examined the role of intracellular calcium on the regulation of GJIC among osteocytes. MATERIALS AND METHODS: Anti-Connexin43 (Cx43) immunolabeling was used to localize gap junctions in chick calvaria. GJIC among osteocytes in chick calvariae was assessed using FRAP. RESULTS: Cx43 immunoreactivity was detected in most of the osteocyte processes. FRAP analysis showed dye-coupling among osteocytes in chick calvariae. In untreated osteocytes, fluorescence intensity recovered 43.7 +/- 2.2% within 5 min after photobleaching. Pretreatment of osteocytes with 18 alpha-GA, a reversible inhibitor of GJIC, significantly decreased fluorescence recovery to 10.7 +/- 2.2%. When pH(o) was decreased from 7.4 to 6.9, fluorescence recovery significantly decreased from 43.3 +/- 2.9% to 19.7 +/- 2.3%. Conversely, when pH(o) was increased from 7.4 to 8.0, fluorescence recovery was significantly increased to 61.9 +/- 4.5%. When [Ca2+](e) was increased from 1 to 25 mM, fluorescence recovery was significantly decreased from 47.0 +/- 6.1% to 16.1 +/- 2.1%. In bone fragments exposed to 1.0-10 nM rPTH for 3 h, replacement of fluorescence was significantly increased to 60.7 +/- 7.2%. Chelating intracellular calcium ions affected GJIC regulation by [Ca2+](e) and PTH. CONCLUSIONS: Our study of cell-cell communication between osteocytes in chick calvaria showed for the first time that GJIC among osteocytes is regulated by the extracellular environment and by hormonal stimulation during bone remodeling. This method may be more biologically relevant to living bone than current methods.

DOI： 10.1359/JBMR.071102

岡山大学大学院顎顔面口腔矯正学分野における過去6年間の矯正相談の実態について

菅原康代, 上岡寛, 薮内利憲, 山城隆

岡山歯学会雑誌 27 ( 1 ) 29 - 34 2008

過去10年間に岡山大学医学部・歯学部附属病院矯正歯科に来院した矯正患者の実態調査

柳田剛志, 上岡寛, 本城正, 山城隆

岡山歯学会雑誌 27 ( 1 ) 35 - 42 2008

著しいオトガイ後退を伴う顎顔面の変形に対し、オトガイ形成術とベニアグラフトを併用した症例

志茂剛, 西山明慶, 上岡寛, 酒井雄一, 川邉紀章, 銅前昇平, 小野達生, 岸本晃治, 目瀬浩, 山城隆, 佐々木朗

岡山歯学会雑誌 26 ( 2 ) 147 - 151 2007.12

Language：Japanese Publisher：岡山歯学会

17歳女性。斜頸による舌骨上筋群および下筋群の高度緊張を認めた著しいオトガイ後退を伴う顎顔面の変形をきたした症例で、オトガイ部の後退に対する形態改善の目的で受診となった。顔貌所見にて正貌で眼瞼下垂、側貌でconvex type、口腔内所見にて両側Angel class II、overjet 3.7mm、overbite -2.5mm、前歯部は開咬を示していた。セファロ分析ではオトガイの劣成長を認め、舌骨が下方へ位置していた。CTデータをOsiriX Medical Imaging Softwareを用いた3Dおよび再構築CT画像においては、両側下顎犬歯から両側第二大臼歯部にかけて舌側皮質骨に溝状の凹みと同部の骨の非薄を認めた。骨非薄部の厚みは最も薄いところで約3mmであった。下顎後退症の臨床診断で、オトガイ形成術とベニアグラフトを併用して治療を行った。術後の側貌においてはlabiomental foldが明瞭化し、オトガイから頸部にかけての審美的改善が認められた。術後経過は良好で、骨片のずれや吸収等は認められない。

Surgical orthodontic treatment for a patient with unilateral cleft lip and palate and temporomandibular disorder

Hiroshi Kamioka, Yoshihito Ishihara, Masahide Inoue, Teruko Takano-Yamamoto

Orthodontic Waves 66 ( 3 ) 90 - 98 2007.9

Language：English Publishing type：Research paper (scientific journal)

The patient was a 12-year-old female who presented with unilateral cleft lip and palate, facial asymmetry, mandibular protrusion, resorption of condyle heads, and transverse maxillary deficiency. At the age of 13 years 10 months, maxillary expansion and autogenous bone graft were performed to improve the maxillary collapsed arch. Aged 14 years 10 months, she described symptoms of temporomandibular joint pain and dysfunction. Segmental Le Fort I osteotomy and intraoral vertical ramus osteotomy (IVRO) were performed at the age of 15 years 11 months. Segmental Le Fort I osteotomy resulted in improved sagittal and transverse discrepancy of the maxilla. After IVRO, facial symmetry, a good facial profile, and disappearance of TMD symptoms were achieved. The occlusion and esthetics were stable after 5 years of retention. © 2007 Elsevier Ltd and the Japanese Orthodontic Society.

DOI： 10.1016/j.odw.2007.06.002

　 PREV - NEXT 　

1
2
3
4
5
6
7
8
9
10