Faculty Profiles - KAMIOKA Hiroshi

Papers - KAMIOKA Hiroshi

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Camouflage treatment for skeletal maxillary protrusion and lateral deviation with classic-type Ehlers-Danlos syndrome. Reviewed

Hoshijima M, Kawanabe N, Iida S, Yamashiro T, Kamioka H

Acta Medica Okayama 75 ( 2 ) 205 - 212 2021.4

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar "cigarette-paper" scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS.

DOI： 10.18926/AMO/61902

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岡山大学病院口唇裂・口蓋裂総合治療センター矯正歯科にて咬合管理を開始した患者動態について Reviewed

植田紘貴, 岡直毅, 中村政裕, 有村友紀, 徳山英二郎, 妹尾貴矢, 松村達志, 木股敬裕, 飯田征二, 上岡寛

日本口蓋裂学会雑誌 46 ( 2 ) 136 - 136 2021.4

Correction to: Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading (Journal of Bone and Mineral Metabolism, (2021), 39, 2, (148-159), 10.1007/s00774-020-01135-9) Reviewed

Ryuta Osumi, Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Tadahiro Iimura, Hiroshi Kamioka

Journal of Bone and Mineral Metabolism 39 ( 2 ) 160 - 162 2021.3

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Japan

In the original publication of the article, the left panel of Fig. 3 was published incorrectly. The correct version of Fig. 3 is provided below.The original article was updated.

DOI： 10.1007/s00774-020-01155-5

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Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading Reviewed

Ryuta Osumi, Ziyi Wang, Yoshihito Ishihara, Naoya Odagaki, Tadahiro Iimura, Hiroshi Kamioka

Journal of Bone and Mineral Metabolism 39 ( 2 ) 148 - 159 2021.3

Age-related changes in the effect of rapid maxillary expansion on the position of labially impacted maxillary canines: A case-control study Reviewed

Momoko Harada-Karashima, Yoshihito Ishihara, Hiroshi Kamioka, Ryuzo Kanomi

American Journal of Orthodontics and Dentofacial Orthopedics 159 ( 3 ) 305 - 311 2021.3

RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions Reviewed

Tomomi Mizukawa, Takashi Nishida, Sho Akashi, Kazumi Kawata, Sumire Kikuchi, Harumi Kawaki, Masaharu Takigawa, Hiroshi Kamioka, Satoshi Kubota

Journal of Cellular Physiology 2021.3

Simultaneous distal movement of the maxillary first and second premolars can be achieved by distal movement of the maxillary first molar using a headgear Reviewed

Junichi Miyano, Noriaki Kawanabe, Atsushi Fujishiro, Ryuzo Kanomi, Hiroshi Kamioka

Orthodontic Waves 79 ( 4 ) 171 - 178 2020.11

Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes Reviewed

Ziyi Wang, Yao Weng, Yoshihito Ishihara, Naoya Odagaki, Ei Ei Hsu Hlaing, Takashi Izawa, Hirohiko Okamura, Hiroshi Kamioka

PeerJ 8 e10244 - e10244 2020.11

Authorship：Last author,　Corresponding author Publishing type：Research paper (scientific journal) Publisher：PeerJ

<sec>
<title>Background</title>
In this study, we investigated the effect of the mechanical loading history on the expression of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in MLO-Y4 osteocyte-like cells.

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<sec>
<title>Methods</title>
Three hours after MLO-Y4 osteocytes were seeded, a continuous compressive force (CCF) of 31 dynes/cm² with or without additional CCF (32 dynes/cm²) was loaded onto the osteocytes. After 36 h, the additional CCF (loading history) was removed for a recovery period of 10 h. The expression of RANKL, OPG, RANKL/OPG ratio, cell numbers, viability and morphology were time-dependently examined at 0, 3, 6 and 10 h. Then, the same additional CCF was applied again for 1 h to all osteocytes with or without the gap junction inhibitor to examine the expression of RANKL, OPG, the RANKL/OPG ratio and other genes that essential to characterize the phenotype of MLO-Y4 cells. Fluorescence recovery after photobleaching technique was also applied to test the differences of gap-junctional intercellular communications (GJIC) among MLO-Y4 cells.

</sec>
<sec>
<title>Results</title>
The expression of RANKL and OPG by MLO-Y4 osteocytes without a loading history was dramatically decreased and increased, respectively, in response to the 1-h loading of additional weight. However, the expression of RANKL, OPG and the RANKL/OPG ratio were maintained at the same level as in the control group in the MLO-Y4 osteocytes with a loading history but without gap junction inhibitor treatment. Treatment of loading history significantly changed the capacity of GJIC and protein expression of connexin 43 (Cx43) but not the mRNA expression of Cx43. No significant difference was observed in the cell number or viability between the MLO-Y4 osteocyte-like cells with and without a loading history or among different time checkpoints during the recovery period. The cell morphology showed significant changes and was correlated with the expression of OPG, Gja1 and Dmp1 during the recovery period.

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<sec>
<title>Conclusion</title>
Our findings indicated that the compressive force-induced changes in the RANKL/OPG expression could be habituated within at least 11 h by 36-h CCF exposure. GJIC and cell morphology may play roles in response to loading history in MLO-Y4 osteocyte-like cells.

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DOI： 10.7717/peerj.10244

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Other Link： https://peerj.com/articles/10244.xml

Three-dimensional changes in the craniofacial complex associated with soft-diet feeding Reviewed

Kana Kono, Chihiro Tanikawa, Yuka Murata, Takeshi Yanagita, Hiroshi Kamioka, Takashi Yamashiro

European Journal of Orthodontics 42 ( 5 ) 509 - 516 2020.11

Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

<title>Summary</title>
<sec>
<title>Background and objectives</title>
The masticatory force affects craniofacial development. We aimed to quantify the topological deviation of the growing craniofacial structure due to soft-food diet feeding and to map the region where the phenotypes appeared on three-dimensional (3D) images.

</sec>
<sec>
<title>Material and methods</title>
Mice were fed a powdered soft diet (SD) or conventional hard diet (HD) of regular rodent pellets at 3 weeks of age until 9 weeks of age. The heads, excluding the mandibles, were scanned by micro-computed tomography. The topographic deviation of the bony surface was quantitatively assessed by a wire mesh fitting analysis. The actual displacement and significant differences were mapped and visualized in each x-, y-, and z-axis on the 3D craniofacial image. On these reconstructed images, two-dimensional linear measurements between the landmark points confirmed the 3D skeletal displacement.

</sec>
<sec>
<title>Results</title>
In the transverse direction, the zygomatic arches and the region in which the temporal muscle attaches to the parietal and temporal bones were narrow in the SD group. The temporal muscle attachment regions significantly shifted anteriorly, and consequently, the sagittal zygomatic arch shortened. Although the cranial sagittal length was not affected, the vertical height was also reduced in the SD group compared to the HD group.

</sec>
<sec>
<title>Conclusions</title>
Our 3D surface-based analysis demonstrated that SD feeding resulted in reduced 3D bony development at the region where the chewing muscles attach to the zygomatic arches and the temporal and parietal bones. Interestingly, SD feeding induced an anterior shift in the temporal and parietal bone regions, which can affect the skeletal inter-jaw relationship.

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DOI： 10.1093/ejo/cjaa007

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The expression and regulation of Wnt1 in tooth movement-initiated mechanotransduction. Reviewed International journal

Ei Ei Hsu Hlaing, Yoshihito Ishihara, Naoya Odagaki, Ziyi Wang, Mika Ikegame, Hiroshi Kamioka

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics 158 ( 6 ) e151 - e159 2020.10

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: The Wnt signaling pathway acts as a key regulator of skeletal development and its homeostasis. However, the potential role of Wnt1 in the mechanotransduction machinery of orthodontic tooth movement-initiated bone remodeling is still unclear. Hence, this study focused on the regulatory dynamics of the Wnt1 expression in both the periodontal ligament (PDL) and osteocytes in vivo and in vitro. METHODS: The Wnt1 expression in the orthodontically moved maxillary first molar in mice was assessed at 0, 1, and 5 days, on both the compression and tension sides. Primary isolated human PDL (hPDL) fibroblasts, as well as murine long-bone osteocyte-Y4 (MLO-Y4) cells, were exposed to continuous compressive force and static tensile force. RESULTS: The relative quantification of immunodetection showed that orthodontic tooth movement significantly stimulated the Wnt1 expression in both the PDL and alveolar osteocytes on the tension side on day 5, whereas the expression on the compression side did not change. This increase in the Wnt1 expression, shown in vivo, was also noted after the application of 12% static tensile force in isolated hPDL fibroblasts and 20% in MLO-Y4 cells. In contrast, a compressive force led to the attenuation of the Wnt1 gene expression in both hPDL fibroblasts and MLO-Y4 cells in a force-dependent manner. In the osteocyte-PDL coculture system, recombinant sclerostin attenuated Wnt1 in PDL, whereas the antisclerostin antibody upregulated its gene expression, indicating that mechanically-driven Wnt1 signaling in PDL might be regulated by osteocytic sclerostin. CONCLUSIONS: Our findings provide that Wnt1 signaling plays a vital role in tooth movement-initiated bone remodeling via innovative mechanotransduction approaches.

DOI： 10.1016/j.ajodo.2020.08.006

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Outer membrane vesicles derived from Porphyromonas gingivalis induced cell death with disruption of tight junctions in human lung epithelial cells Reviewed

Yuhan He, Noriko Shiotsu, Yoko Uchida-Fukuhara, Jiajie Guo, Yao Weng, Mika Ikegame, Ziyi Wang, Kisho Ono, Hiroshi Kamioka, Yasuhiro Torii, Akira Sasaki, Kaya Yoshida, Hirohiko Okamura

Archives of Oral Biology 118 104841 - 104841 2020.10

上下顎骨骨切り術により顎運動の改善が見られた顎関節症を併発する骨格性下顎前突症例 Reviewed

菅原康代, 石原嘉人, 上岡寛

中・四国矯正歯科学会雑誌 32 ( 1 ) 39 - 50 2020.8

下顎枝垂直骨切り術後に顎関節症状の改善と偏位側への側方滑走運動の改善を認めた顔面非対称症例 Reviewed

植田紘貴, 岡直毅, 上岡寛

中・四国矯正歯科学会雑誌 32 ( 1 ) 51 - 63 2020.8

Authorship：Corresponding author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：中・四国矯正歯科学会

本症例では、顎関節症状と下顎骨の左方偏位を伴う顔面非対称症例に対して、下顎枝垂直骨切り術を伴う外科的矯正治療を行い、顎関節症状の改善と偏位側への側方滑走運動の改善を認めたので報告する。患者は19歳女性で、下顎の左方偏位と右側顎関節の開閉口時の疼痛を主訴に来院した。上顎骨は標準範囲内で後方位傾向、下顎骨は標準範囲内で前方位傾向にあり、骨格性III級を示した。大臼歯関係はAngle III級で、上顎前歯歯軸は唇側傾斜、下顎前歯歯軸は標準範囲内で舌側傾斜傾向を示し、上下顎前歯部に叢生を認めた。顔面正中に対して上顎歯列正中は一致、下顎歯列正中は5.0mm左方に偏位していた。初診時の顎口腔機能検査所見では、左方への側方滑走運動の制限と左右下顎頭の開閉口路の不一致を認めた。以上から、上下顎前歯部叢生、下顎骨の左方偏位と偏位側への側方滑走運動の制限を伴う顔面非対称の骨格性下顎前突症例と診断し、下顎枝垂直骨切り術により遠位骨片を右側で6.0mm、左側で1.0mm後方移動し、顔面非対称が改善された。治療終了時の顎口腔機能検査所見では、右側下顎頭の疼痛が消退し、左右下顎頭と下顎前歯の運動経路のばらつきが減少するとともに、偏位側への側方滑走運動量が増加した。以上から、偏位側への側方滑走運動の制限を伴う顔面非対称症例において、下顎枝垂直骨切り術を伴う外科的矯正治療を行い、正貌・側貌の形態的改善だけでなく、顎関節症状や偏位側への側方滑走運動の改善等、機能的な改善が得られることが示された。(著者抄録)

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歯科矯正用アンカースクリューを用いて上顎前歯および臼歯の圧下を行ったガミースマイルを伴う過蓋咬合症例 Reviewed

早野暁, 宮本久美, 上岡寛

中・四国矯正歯科学会雑誌 32 ( 1 ) 17 - 24 2020.8

An investigation and treatment cases of hypodontia in Department of Orthodontics, Okayama University Hospital Reviewed

星島光博, 星島光博, 出射明美, 福井裕子, 鳥原秀美, 松田祐典, 上岡寛

岡山歯学会雑誌 39 ( 2 ) 19 - 25 2020.8

Comprehensive approach to simultaneous molar intrusion and canine retraction in the treatment of Class II anterior open bite using miniscrew anchorage Reviewed

Kaori Shirasaki, Yoshihito Ishihara, Hiroki Komori, Takashi Yamashiro, Hiroshi Kamioka

Dental Press Journal of Orthodontics 25 ( 3 ) 2020.5

Authorship：Last author,　Corresponding author Publishing type：Research paper (scientific journal) Publisher：FapUNIFESP (SciELO)

ABSTRACT Introduction: Anterior open bite is one of the most difficult malocclusions to correct in orthodontic treatment. Molar intrusion using miniscrew anchorage has been developed as a new strategy for open bite correction; however, this procedure still has an important concern about prolonged treatment duration in the patient with anteroposterior discrepancy due to the separate step-by-step movement of anterior and posterior teeth. Objective: This article illustrates a comprehensive orthodontic approach for dentoalveolar open bite correction of an adult patient, by using miniscrew. Case report: A woman 19 years and 5 months of age had chief complaints of difficulty chewing with the anterior teeth and maxillary incisor protrusion. An open bite of -2.0 mm caused by slight elongation of the maxillary molars was found. The patient was diagnosed with Angle Class II malocclusion with anterior open bite due to the vertical elongation of maxillary molars. After extraction of the maxillary first premolars, concurrent movements of molar intrusion and canine retraction were initiated with the combined use of sectional archwires, elastic chains and miniscrews. Results: At 4 months after the procedure, positive overbite was achieved subsequent to the intrusion of maxillary molars by 1.5 mm and without undesirable side effects. Class I canine relation was also achieved at the same time. The total active treatment period was 21 months. The resultant occlusion and satisfactory facial profile were maintained after 54 months of retention. Conclusion: The presented treatment shows the potential to shorten the treatment duration and to contribute to the long-term stability for open bite correction.

DOI： 10.1590/2177-6709.25.3.30.e1-12.onl

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Benzonaseを用いた新規骨芽細胞分離法の開発 Reviewed

浅野洋介, 松本佳則, Ziyi Wang, 佐田憲映, 上岡寛, 和田淳

日本骨形態計測学会雑誌 30 ( 1 ) S99 - S99 2020.5

核内受容体AhRはRANK/c-Fosシグナル伝達経路を介して破骨細胞の分化を制御する

井澤俊, 吉川友理, 石丸直澄, 上岡寛

日本骨形態計測学会雑誌 30 ( 1 ) S97 - S97 2020.5

Inhibitory effect of retinoic acid receptor agonists on in vitro chondrogenic differentiation. Reviewed

Yusuke Sumitani, Kenta Uchibe, Kaya Yoshida, Yao Weng, Jiajie Guo, Haoze Yuan, Mika Ikegame, Hiroshi Kamioka, Hirohiko Okamura

Anatomical science international 95 ( 2 ) 202 - 208 2020.3

Language：English Publishing type：Research paper (scientific journal)

Retinoic acid (RA), an active metabolite of vitamin A, plays pivotal roles in a wide variety of biological processes, such as body patterning, organ development, and cell differentiation and proliferation. RA signaling is mediated by nuclear retinoic acid receptors, α, β, and γ (RARα, RARβ, and RARγ). RA is a well-known regulator of cartilage and skeleton formation and RARs are also essential for skeletal growth and hypertrophic chondrocyte-specific gene expression. These important roles of RA and RARs in chondrogenesis have been widely investigated using in vivo mouse models. However, few reports are available on the function of each subtype of RARs on in vitro chondrocyte differentiation. Here, we examined the effect of specific agonists of RARs on chondrogenic differentiation of ATDC5 and C3H10T1/2 cells. Subtype-specific RAR agonists as well as RA decreased the expressions of chondrogenic differentiation marker genes and inhibited chondrogenic differentiation, which was accompanied with morphological change to spindle-shaped cells. Among RAR agonists, RARα and RARγ agonists revealed a strong inhibitory effect on chondrogenic differentiation. RARα and RARγ agonists also hampered viability of ATDC5 cells. These observations suggested that RARα and RARγ are dominant receptors of RA signaling that negatively regulate chondrogenic differentiation.

DOI： 10.1007/s12565-019-00512-3

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Orthodontic management of a non-syndromic patient with concomitant bimaxillary hypohyperdontia: a case report Reviewed International journal

Ei Ei Hsu Hlaing, Yoshihito Ishihara, Atsuro Fujisawa, Takashi Yamashiro, Hiroshi Kamioka

Dental Press Journal of Orthodontics 25 ( 1 ) 36 - 46 2020.1

Authorship：Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：FapUNIFESP (SciELO)

ABSTRACT Introduction: Tooth agenesis is one of the most common dental anomalies; however, the concomitant occurrence of opposite dental numerical variation of hypohyperdontia is extremely rare. Objective: To report the successful orthodontic management of a patient with non-syndromic concomitant bilateral agenesis of mandibular canines and two midline inverted supernumerary maxillary teeth. Case report: 21-year-old female patient with a chief complaint of protrusive right maxillary central incisor. The patient was diagnosed with a mild Class II skeletal base, Angle Class III molar relationship and increased overjet associated with hypohyperdontia. Anterior open bite accompanied with tongue-thrusting habit were also observed. Two temporary anchorage devices (TADs) were implanted at the buccal side of the maxillary molar region to control vertical height. Anterior teeth retraction was done after extraction of the maxillary first premolars, to improve the excessive overjet. The treatment mechanics involved lingual brackets system for the maxillary arch and transpalatal arch for anchorage control. Results: The total active treatment period was 35 months. Acceptable occlusion with increased bite force and contact area as well as functional excursion were established without interference, following complex orthodontic treatment with premolar substitution. The resultant occlusion and a satisfactory facial profile were maintained after 29 months of retention. Conclusion: The present case report provides implications regarding the orthodontic treatment of hypohyperdontia-associated substitution for missing teeth as an effective option for improving aesthetic and functional aspects.

DOI： 10.1590/2177-6709.25.1.036-046.oar

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Papers - KAMIOKA Hiroshi