Faculty Profiles - KAMIOKA Hiroshi

重度の埋伏永久歯を牽引誘導した2症例 Reviewed

石川崇典, 星島光博, 川邉紀章, 上岡寛

岡山歯学会雑誌 37 ( 1 ) 9 - 13 2018.1

A case of adult cleft palate patient treatment with differential maxillary lateral expand distraction osteogenesis using combined expansion appliances Reviewed

Takeshi Yanagita, Hiroki Komori, Tomoyo Tanaka, Hiroshi Kamioka

Orthodontic Waves 77 176 - 188 2018

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ltd

A 34-year-old female patient who had undergone surgical treatment for a cleft in the soft palate during childhood received orthodontic treatment for crowding. She had a straight type facial profile and facial asymmetry with a concave area on the left side of the philtrum and mandibular deviation to the left. The surgical scar was observed on the center of the palate. She also had a severely constricted maxillary arch and unilateral cross bite on the left side. In this report, we suggest a novel method for uneven maxillary lateral expansion using a dento-osseous-supported expansion appliance in the frontal side of the maxilla and a modified dental-supported expansion appliance in the mid-palatal area. With this method, we achieved the optimal maxillary expansion in the maxillary frontal and molar areas. As a result of the surgically-assisted orthodontic treatment, facial asymmetry, the facial midline, and severe malocclusion were corrected. Furthermore, the resulting occlusion and facial symmetry were maintained over a 2-year retention period. Although attention must be paid regarding the retention of the expanded maxillary bone, our findings in the present study suggest that differential maxillary lateral expand distraction osteogenesis, which is performed using combined expansion appliances, can be successfully performed in patients with cleft palate.

DOI： 10.1016/j.odw.2018.04.003

骨細胞におけるPerlecan/HSPG2の発現部位は細胞の成熟とともに細胞体から細胞突起へと変化する

鳥原秀美, 大野充昭, 佐々木隆子, 上岡寛, 大橋俊孝

生命科学系学会合同年次大会 2017年度 [2P - 0326] 2017.12

Three-dimensional morphometry of collagen fibrils in membranous bone. Reviewed International journal

Mana Hashimoto, Noriyuki Nagaoka, Kaori Tabata, Tomoyo Tanaka, Ryuta Osumi, Naoya Odagaki, Toru Hara, Hiroshi Kamioka

Integrative biology : quantitative biosciences from nano to macro 9 ( 11 ) 868 - 875 2017.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ROYAL SOC CHEMISTRY

The collagen network acts as a scaffold for calcification and its three-dimensional structure influences bone strength. It is therefore important to observe the collagen network in detail and three-dimensionally. In this study, we observed the collagen network of chick embryonic calvariae in membranous bone three-dimensionally using orthogonally arranged FIB-SEM. A 25 × 25 μm area of chick embryonic calvaria was observed at a high resolution (25 nm per pixel). The inside of the bone (i.e. the primary calcified tissue), the bone cells (i.e. the osteoblasts and the osteocytes), the organelles, and the collagen fibrils were observed in detail. These structures were observed three-dimensionally using the Amira software program. In addition, the collagen fibrils of the bone were automatically extracted using the XTracing extension software program, and three-dimensional morphometry was performed. Almost all of the collagen fibrils ran along the longitudinal axis of the trabecular bone. We found that the regularity of the collagen fibril orientation was less remarkable in the osteoblast layer, which contained numerous osteoblasts. The collagen fibril orientation started to show regularity toward the central bone layer, which contained few bone cells.

DOI： 10.1039/c7ib00073a

Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats Reviewed

Teruko Takano-Yamamoto, Kiyo Sasaki, Goudarzi Fatemeh, Tomohiro Fukunaga, Masahiro Seiryu, Takayoshi Daimaruya, Nobuo Takeshita, Hiroshi Kamioka, Taiji Adachi, Hiroto Ida, Atsushi Mayama

SCIENTIFIC REPORTS 7 ( 1 ) 241 - 249 2017.10

Language：English Publishing type：Research paper (scientific journal) Publisher：NATURE PUBLISHING GROUP

Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-kappa B activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.

DOI： 10.1038/s41598-017-13541-7

Osteocyte Biologyアップデート骨細胞ネットワーク形成に与えるコラーゲン線維構築の関与

上岡寛, 橋本真奈, 長岡紀幸, 大嶋佑介, 飯村忠浩, 原徹

Journal of Oral Biosciences Supplement 2017 148 - 148 2017.9

A Novel Method to Detect 3D Mandibular Changes Related to Soft-Diet Feeding Reviewed

Kana Kono, Chihiro Tanikawa, Takeshi Yanagita, Hiroshi Kamioka, Takashi Yamashiro

FRONTIERS IN PHYSIOLOGY 8 ( AUG ) 64 - 79 2017.8

Language：English Publishing type：Research paper (scientific journal) Publisher：FRONTIERS MEDIA SA

Craniofacial morphology varies among individuals, which is regulated by the interaction between genes and the environment. Soft-diet feeding is a widely-used experimental model for studying the association between the skeletal morphology and muscle-related loading on the bone. Traditionally, these studies have been based on linear and angular measurements provided on two-dimensional (2D) radiographs in the lateral view. However, 2D observation is based on simplification of the anatomical structures and cannot detect three-dimensional (3D) changes in detail. In this study, we newly developed a modified surface-based analysis with micro-3D computed tomography (CT) to examine and detect the 3D changes in the mandible associated with soft-diet feeding. Mice at 3 weeks of age were fed a powdered soft-diet (SD) or hard-diet (HD) of regular rodent pellets until 9 weeks of age. Micro-CT images were taken at age 9 weeks to reconstruct the anatomical architecture images. A computer-generated averaged mandible was superimposed to directly visualize the morphological phenotypes. Gross observation revealed the apparent changes at the posterior body of the mandible, the angular process and the condyle between HD and SD mice. Significant differences in the mapping indicated the regions of significant displacement in the SD mice over the averaged 3D image of the HD mice. This map revealed that vertical displacement was most evident in 3D changes. We also noted a combination of vertical, transverse and anteroposterior directions of displacement in the condylar growth, resulting in complicated shape changes in the whole condylar process in SD mice. In contrast, transverse displacement was more significant in the coronoid process. The map analysis further showed the significant outward displacement of the inner surface of the alveolar process, which consequently resulted in thinning of the alveolar process.

DOI： 10.3389/fphys.2017.00567

Comparative evaluation of treatment outcomes between temporary anchorage devices and Class III elastics in Class III malocclusions Reviewed

Masahiro Nakamura, Noriaki Kawanabe, Tomoki Kataoka, Takashi Murakami, Takashi Yamashiro, Hiroshi Kamioka

AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS 151 ( 6 ) 1116 - 1124 2017.6

Language：English Publishing type：Research paper (scientific journal) Publisher：MOSBY-ELSEVIER

Introduction: Our objective was to elucidate the differences in treatment outcomes caused by the different mechanics of temporary anchorage devices (TADs) and Class III elastics in patients with Class III malocclusions. Methods: Records of 23 patients with Angle Class III malocclusion were selected retrospectively. All had been treated with nonextraction comprehensive orthodontic treatment; 11 were treated with TADs and 12 with Class III elastics. Pretreatment and posttreatment lateral cephalograms were used for evaluation of the treatment outcomes. A paired t test and a Student t test were used for statistical analysis. Results: In both groups, proper overjet and Class I molar relationships were achieved, and the occlusal plane was rotated counterclockwise. In the elastics group, distal tipping of the mandibular molars, extrusion of the mandibular incisors and maxillary molars, clockwise rotation of the mandibular plane angle, and increased ANB angle were observed. In the TADs group, distal tipping and intrusion of the mandibular molars, bodily movement of the mandibular incisors, and reduced mandibular plane angle were observed. Conclusions: In nonextraction treatment for Class III malocclusions, the mandibular plane angle was increased in the elastics group, whereas it was decreased in TADs group. Thus, we suggest that Class III elastics are preferred for low-angle, short-face patients, whereas TADs are preferred for high-angle, long-face patients.

DOI： 10.1016/j.ajodo.2016.10.040

CO2 low-level laser therapy has an early but not delayed pain effect during experimental tooth movement Reviewed

T. Deguchi, D. G. Kim, H. Kamioka

ORTHODONTICS & CRANIOFACIAL RESEARCH 20 ( 51 ) 172 - 176 2017.6

Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

Structured Abstract
ObjectivesTo test the hypothesis that the use of low-level laser therapy (LLLT) reduces elevated pain by controlling the release of neurochemicals during orthodontic tooth movement.
Setting and Sample PopulationDepartment of Orthodontics and Dentofacial Orthopedics, Okayama University. Sixty-five Sprague Dawley rats were subjected to tooth movement and LLLT.
Materials and MethodsAdult Sprague Dawley rats were used in this study. Groups included day 0 controls, irradiation only controls and with or without irradiation sacrificed at 1, 3, 5, 7 and 14days after tooth movement (n=5 each, total n=65). Tooth movement was achieved by insertion of an elastic module between molar teeth. Immunohistochemistry for CD-11b, GFAP and c-fos in the brain stem was performed. Stains were quantified by constructing a three-dimensional image using IMARIS, and counted using NEURON TRACER and WinROOF software. Two-way ANOVA followed by a Tukey's post hoc test (P<.05) was used for statistical comparison between groups.
ResultsC-fos expression was significantly increased at one and three days after tooth movement. LLLT significantly diminished this increase in c-fos expression only at one day after tooth movement CD-b11 and GFAP expression also significantly increased after tooth movement. No significant change was observed for CD-11b and GFAP expression in the central nervous system upon LLLT.
ConclusionLow-level laser therapy may reduce early neurochemical markers but have no effect on delayed pain neurochemical markers after tooth movement.

DOI： 10.1111/ocr.12158

岡山大学大学院歯科矯正学分野研究室における過去15年間および2013年から2016年の4年間の岡山大学の学生および職員に対する矯正相談の実態調査 Reviewed

田中智代, 村上隆, 石原嘉人, 中村政裕, 片岡伴記, 植田紘貴, 早野暁, 星島光博, 川邉紀章, 上岡寛

岡山歯学会雑誌 36 ( 2 ) 45 - 51 2017

歯科矯正用アンカースクリューを用いて多数埋伏歯の同時牽引を行った鎖骨頭蓋異骨症患者の1例 Reviewed

石本和也, 川邉紀章, Ei Hsu, Hlaing Ei, 片岡伴記, 村上隆, 上岡寛

岡山歯学会雑誌 36 ( 1 ) 7 - 12 2017

The different effects of intraoral vertical ramus osteotomy (IVRO) and sagittal split ramus osteotomy (SSRO) on mandibular border movement Reviewed

Hiroki Komori, Noriaki Kawanabe, Tomoki Kataoka, Yui Kato, Atsuro Fujisawa, Takashi Yamashiro, Hiroshi Kamioka

Cranio - Journal of Craniomandibular Practice 36 ( 4 ) 1 - 6 2017

Language：English Publishing type：Research paper (scientific journal)

© 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. Objectives: This study investigated the different effects of intraoral vertical ramus osteotomy (IVRO) and sagittal split ramus osteotomy (SSRO) on mandibular border movement. Methods: The participants included 22 patients receiving IVRO and 22 patients receiving SSRO who were treated at Okayama University Hospital. Their mandibular border movement was evaluated in three dimensions with 6° of freedom using an optical recording system. Results: A strong correlation between condylar and lower incisor movement was observed during maximum jaw protrusion and laterotrusion. Significant improvements in condylar and lower incisor movement were detected after orthognathic surgery during maximum jaw protrusion and laterotrusion in the IVRO group and during maximum jaw protrusion in the SSRO group. Discussion: IVRO likely achieves greater improvement in jaw movement than SSRO. Therefore, the application of IVRO could be considered in the treatment of patients with jaw deformities featuring temporomandibular joint problems.

DOI： 10.1080/08869634.2017.1317899

岡山大学歯科矯正学分野「歯の移動の臨床手技実習」における60分授業・クォーター制への対応 Reviewed

片岡伴記, 星島光博, 原規子, 中村政裕, 早野暁, 村上隆, 川邊紀章, 上岡寛

岡山歯学会雑誌 35 ( 2 ) 59 - 65 2017

Language：Japanese Publisher：岡山歯学会

当大学の歯科矯正学分野において、「歯の移動の臨床手技実習」における60分授業・クォーター制を導入し、導入前後の年度で学生と教職員にアンケートを実施した。学生アンケートでは、導入前の平成27年度の実習受講生53名と導入後の平成28年度の受講生46名を対象とした。教職員アンケートでは、平成28年度の実習で指導にあたった教職員7名と補助した医局員20名を対象とした。その結果、導入後では実習内容、指導法、実習書といった教育コンテンツの改善により学生の自修意欲が高まり、一定の成果を上げることができていた。また、ICTを活用した授業支援システム"WebClass"も予習・復習に積極的に利用されており、成果に貢献していた。しかし、実習時間の短縮への対応の点では問題が残り、「時間不足」を訴える意見が多く聞かれた。

骨格性下顎前突患者に対して上顎両側側切歯欠損部に下顎両側側切歯を移植し，カモフラージュ治療を行った一症例

下顎の垂直的な変化を制御するために歯科矯正用アンカースクリューとスライディングメカニクスを用い上下顎両側第二小臼歯を抜去して治療を行った上下顎前突症例 Reviewed

川邉紀章, 河野加奈, 片岡伴記, 中村政裕, 上岡寛

中・四国矯正歯科学会雑誌 29 ( 1 ) 27 - 36 2017

片岡伴記, 藤澤厚郎, 川邉紀章, 上岡寛

中・四国矯正歯科学会雑誌 29 ( 1 ) 17 - 26 2017

Language：English Publisher：中・四国矯正歯科学会

上顎両側側切歯欠如と下顎前歯叢生を伴う下顎前突患者に対して、上顎欠如部に下顎側切歯を移植してカモフラージュ治療を行い、良好な結果が得られたので報告する。初診時年齢33歳11ヵ月の女性で、受け口を主訴として来院した。側貌は直線型で骨格的には3級、オーバージェットは-3.2mm、オーバーバイトは-3.1mmであった。臼歯関係は両側III級で、上顎両側側切歯先天欠如およびそれに伴う上顎空隙歯列、下顎前歯の中等度の叢生を認めた。まず治療の第一段階として、上顎歯列幅径の拡大と上顎中切歯の唇側傾斜を行い、上顎の両側側切歯欠如部にそれぞれ6.0mmのスペースを作った。そして、下顎側切歯を抜去後、同部に移植して生着するのを待った。その後、下顎抜歯空隙の閉鎖と下顎前歯の舌側傾斜を行いつつ上下顎歯列のアーチコーディネートおよびディテーリングを行った。これらの治療により許容可能な咬合を得ることができた。今回の症例のように、上顎歯列に先天欠如があり、それによる空隙歯列を生じている下顎前突患者に対してカモフラージュ治療を行う場合、スペース閉鎖のために補綴処置を行うか、あるいは歯科矯正用アンカースクリュー等の固定源を用いて臼歯部を近心移動することによって、空隙を閉鎖する必要がある。また、下顎歯列に対しては、ストリッピングや抜歯を行って下顎前歯部を舌側傾斜させて対処することが多い。本症例では、下顎の側切歯を上顎の欠如部に移植することにより、上顎側切歯の欠如、空隙歯列および下顎前歯部叢生という3つの問題に対処すると同時に、下顎前突症例をカモフラージュ治療することができた。尚、側切歯部の移植歯は、移植処置を行ってから約10年、動的矯正治療終了時から8年経過した現在も何ら問題を生じていない。(著者抄録)

Modification of dentofacial growth associated with Goldenhar syndrome Reviewed

Ei Ei Hsu Hlaing, Yoshihito Ishihara, Chikako Hara, Hiroshi Kamioka

Acta Medica Okayama 71 ( 5 ) 437 - 443 2017

Language：English Publishing type：Research paper (scientific journal) Publisher：Okayama University

The rare developmental defect, Goldenhar syndrome is characterized by complex craniofacial and dentofacial anomalies. Here we describe the successful orthodontic treatment of a 5-year-old Japanese Goldenhar syndrome patient with mild facial asymmetry, right microtia, right-side hearing loss, and tongue-thrusting by a modification of dentofacial growth using a non-surgical orthopedic treatment approach. Improvement of the vertical discrepancies on the affected side and canted occlusal plane as well as mandibular deviation were achieved with a functional orthopaedic approach. Stable and acceptable occlusion were obtained over the 32-month post-retention period. A non-surgical orthodontic treatment approach offers satisfactory facial aesthetic outcomes in Goldenhar syndrome.

Orthognathic surgery during breast cancer treatment-A case report. International journal

Tsuyoshi Shimo, Norie Yoshioka, Masahiro Nakamura, Soichiro Ibaragi, Tatsuo Okui, Yuki Kunisada, Masanori Masui, Mayumi Yao, Koji Kishimoto, Shoko Yoshida, Akiyoshi Nishiyama, Hiroshi Kamioka, Akira Sasaki

International journal of surgery case reports 31 30 - 34 2017

Language：English Publishing type：Research paper (scientific journal)

INTRODUCTION: In recent years, patients with orthognathic surgery in middle-aged and elderly people have come to be a more frequent occurrence. Breast cancer is the most frequently diagnosed cancer in woman worldwide, and its prevalence rate is steadily increasing. PRESENTATION OF CASE: We report a case of a 47-year-old Japanese woman in whom left-side breast cancer (Stage 1) was unexpectedly found just before orthognathic surgery in April 2012. Breast-conserving surgery was performed (estrogen receptor+, progesterone receptor+, HER2 -, surgical margin+, sentinel lymph node +) that May. From June to August docetaxel (75mg/m2) and cyclophosphamide (600mg/m2) were administrated four times every 21days and thereafter radiotherapy (total 60Gy) was completed. The cancer surgeon declared the prognosis good and the patient had a strong desire to undergo orthognathic surgery, so in November we performed a bimaxillary osteotomy, and administration of tamoxifen began 6 weeks after the osteotomy. DISCUSSION: There are breast cancer cases in which the prognosis is sufficiently good for a planned orthognathic surgery to proceed. Good communication among surgeons and the patient is important. CONCLUSION: We experienced a case in which breast cancer was found just before the orthognathic surgery; we performed a bimaxillary osteotomy, including follow-up tamoxifen administration, during breast cancer treatment.

DOI： 10.1016/j.ijscr.2016.12.014

Involvement of multiple CCN family members in platelets that support regeneration of joint tissues Reviewed

Chikako Hara, Satoshi Kubota, Takashi Nishida, Miki Hiasa, Takako Hattori, Eriko Aoyama, Yoshinori Moriyama, Hiroshi Kamioka, Masaharu Takigawa

Modern Rheumatology 26 ( 6 ) 940 - 949 2016.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Taylor and Francis Ltd

Objectives: Platelet-rich plasma (PRP) has been widely used to enhance the regeneration of damaged joint tissues, such as osteoarthritic and rheumatoid arthritic cartilage. The aim of this study is to clarify the involvement of all of the CCN family proteins that are crucially associated with joint tissue regeneration. Methods: Cyr61-CTGF-NOV (CCN) family proteins in human platelets and megakaryocytic cells were comprehensively analyzed by Western blotting analysis. Production of CCN family proteins in megakaryocytes in vivo was confirmed by immunofluorescence analysis of mouse bone marrow cells. Effects of CCN family proteins found in platelets on chondrocytes were evaluated by using human chondrocytic HCS-2/8 cells. Results: Inclusion of CCN2, a mesenchymal tissue regenerator, was confirmed. Of note, CCN3, which counteracts CCN2, was newly found to be encapsulated in platelets. Interestingly, these two family members were not detectable in megakaryocytic cells, but their external origins were suggested. Furthermore, we found for the first time CCN5 and CCN1 that inhibits ADAMTS4 in both platelets and megakaryocytes. Finally, application of a CCN family cocktail mimicking platelets onto HCS-2/8 cells enhanced their chondrocytic phenotype. Conclusions: Multiple inclusion of CCN1, 2 and 3 in platelets was clarified, which supports the harmonized regenerative potential of PRP in joint therapeutics.

DOI： 10.3109/14397595.2016.1155255

A case of severe mandibular retrognathism with bilateral condylar deformities treated with Le Fort I osteotomy and two advancement genioplasty procedures Reviewed

Masahiro Nakamura, Takeshi Yanagita, Tatsushi Matsumura, Takashi Yamashiro, Seiji Iida, Hiroshi Kamioka

Korean Journal of Orthodontics 46 ( 6 ) 395 - 408 2016.11

Language：English Publishing type：Research paper (scientific journal) Publisher：Korean Association of Orthodontists

We report a case involving a young female patient with severe mandibular retrognathism accompanied by mandibular condylar deformity that was effectively treated with Le Fort I osteotomy and two genioplasty procedures. At 9 years and 9 months of age, she was diagnosed with Angle Class III malocclusion, a skeletal Class II jaw relationship, an anterior crossbite, congenital absence of some teeth, and a left-sided cleft lip and palate. Although the anterior crossbite and narrow maxillary arch were corrected by interceptive orthodontic treatment, severe mandibular hypogrowth resulted in unexpectedly severe mandibular retrognathism after growth completion. Moreover, bilateral condylar deformities were observed, and we suspected progressive condylar resorption (PCR). There was a high risk of further condylar resorption with mandibular advancement surgery
therefore, Le Fort I osteotomy with two genioplasty procedures was performed to achieve counterclockwise rotation of the mandible and avoid ingravescence of the condylar deformities. The total duration of active treatment was 42 months. The maxilla was impacted by 7.0 mm and 5.0 mm in the incisor and molar regions, respectively, while the pogonion was advanced by 18.0 mm. This significantly resolved both skeletal disharmony and malocclusion. Furthermore, the hyoid bone was advanced, the pharyngeal airway space was increased, and the morphology of the mandibular condyle was maintained. At the 30-month follow-up examination, the patient exhibited a satisfactory facial profile. The findings from our case suggest that severe mandibular retrognathism with condylar deformities can be effectively treated without surgical mandibular advancement, thus decreasing the risk of PCR.

DOI： 10.4041/kjod.2016.46.6.395