Faculty Profiles - EKUNI Daisuke

MISC - EKUNI Daisuke

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職域成人における口腔内所見および口腔保健行動とメタボリックシンドロームとの関係

林浩範, 江國大輔, 米田俊樹, 水谷慎介, 赤澤百合子, 森田学

産業衛生学雑誌 56 ( 臨増 ) 429 - 429 2014.5

若年者における血圧と歯周炎との関連についてのコホート研究

川端勇也, 江國大輔, 友藤孝明, 東哲司, 丸山貴之, 水谷慎介, 米田俊樹, 町田達哉, 片岡広太, 山根真由, 佐久本雅美, 大森智栄, 森田学

口腔衛生学会雑誌 64 ( 2 ) 175 - 175 2014.4

口腔常在菌叢による歯周組織への影響

入江浩一郎, ダービュ・リチャード, 友藤孝明, 江國大輔, 森田学, 嶋崎義浩

日本歯周病学会会誌 56 ( 春季特別 ) 120 - 120 2014.4

肥満と歯周病進行との関連

米田俊樹, 江國大輔, 水谷慎介, 児島梓, 友藤孝明, 入江浩一郎, 東哲司, 森田学

口腔衛生学会雑誌 64 ( 3 ) 316 - 316 2014.4

大学生における第二大臼歯の埋伏状況と口腔内の他の因子との関係

大森智栄, 江國大輔, 片岡広太, 山根真由, 水谷慎介, 東哲司, 友藤孝明, 森田学

口腔衛生学会雑誌 64 ( 3 ) 315 - 315 2014.4

若年者における口腔乾燥感と歯周病との関連

水谷慎介, 江國大輔, 友藤孝明, 東哲司, 片岡広太, 山根真由, 森田学

口腔衛生学会雑誌 64 ( 3 ) 312 - 312 2014.4

咬合異常によるストレスはアポリポタンパクE欠損ラットの動脈硬化を増悪する

江國大輔, 米田俊樹, 遠藤康正, 粕山健太, 入江浩一郎, 水谷慎介, 東哲司, 友藤孝明, 森田学

口腔衛生学会雑誌 64 ( 2 ) 230 - 230 2014.4

口腔常在菌に対する宿主防御機構への影響

入江浩一郎, 友藤孝明, 江國大輔, 森田学, 嶋崎義浩

口腔衛生学会雑誌 64 ( 2 ) 181 - 181 2014.4

歯周病による全身の酸化ストレスへの影響酸化ストレス可視化マウスを用いた検討

片岡広太, 江國大輔, 粕山健太, 川端勇也, 山根真由, 遠藤康正, 米田俊樹, 友藤孝明, 森田学

口腔衛生学会雑誌 64 ( 2 ) 181 - 181 2014.4

Anti-ageing effects of dentifrices containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina (R)) on gingival collagen degradation in rats

Koichiro Irie, Takaaki Tomofuji, Daisuke Ekuni, Yasumasa Endo, Kenta Kasuyama, Tetsuji Azuma, Naofumi Tamaki, Toshiki Yoneda, Manabu Morita

ARCHIVES OF ORAL BIOLOGY 59 ( 1 ) 60 - 65 2014.1

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Objective: Previous studies have demonstrated the relationship between ageing and oxidative stress. In this study, we examined the effects of topical application of a dentifrice containing anti-oxidative, anti-inflammatory, and anti-bacterial agents (Tomarina (R)) to the gingival surface on gingival collagen degradation in rats.
Design: Fischer 344 male rats (4 or 8 months old) were divided into two groups: experimental group and control group. Tomarina (R) (the experimental group) or control dentifrice (the control group) was applied 5 days per week for 2 months.
Results: In the control group, gingival collagen density decreased with ageing. In the experimental group, the collagen density did not change with ageing, and was greater than that in the control group at 10 months of age (p < 0.0083). In addition, the control group showed an increase in serum oxidative stress with ageing. The experimental group also showed increased serum oxidative stress, but the value was lower than the control group at 10 months of age (p < 0.0083). Furthermore, low expressions of protein oxidative damage in the periodontal tissue were observed in the experimental group, compared to the control group at 6 months and 10 months.
Conclusion: These findings indicate that Tomarina (R) might suppress the effects of ageing on gingival collagen degradation, by decreasing oxidative stress in the rat model. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.archoralbio.2013.09.008

Factors related to the formation of buccal mucosa ridging in university students International journal

Shinsuke Mizutani, Daisuke Ekuni, Takaaki Tomofuji, Tetsuji Azuma, Koichiro Irie, Tatsuya Machida, Toshiki Yoneda, Yoshiaki Iwasaki, Manabu Morita

ACTA ODONTOLOGICA SCANDINAVICA 72 ( 1 ) 58 - 63 2014.1

Language：English Publisher：TAYLOR & FRANCIS LTD

Objective. Buccal mucosa ridging (BMR) is known as a clinical sign of clenching, which is one of the major manifestations of bruxism. However, there are few reports about the formation of BMR and no data regarding the association between BMR and factors such as malocclusion. The purpose of the current study was to investigate the relationship between BMR and factors such as the number of teeth present, gender, body mass index (BMI), occlusion and clenching habit in university students. Materials and methods. A total of 2101 students (1164 males, 937 females), aged 18-29 years old, were included in the study. BMR and the number of teeth present were recorded and malocclusion was defined using a modified version of the Index of Orthodontic Treatment Need. Additional information regarding gender, clenching habit and BMI was collected via a questionnaire. Results. Forty-six per cent of the subjects had BMR and the prevalence of BMR in females was significantly higher than that of males (chi square test, p < 0.001). According to logistic regression analysis, the probability of BMR was significantly associated with female gender (OR = 1.501, 95% CI = 1.259-1.790, p < 0.001), crowding (OR = 2.102, 95% CI = 1.706-2.590, p < 0.001) and overjet (OR = 0.585, 95% CI = 0.418-0.818, p = 0.002). On the other hand, BMR was not associated with awareness of clenching habit and BMI. Conclusions. Gender, crowding and overjet were related to the formation of BMR in university students. When evaluating BMR as a clinical sign of clenching, one might have to take factors such as gender and crowding into consideration.

DOI： 10.3109/00016357.2013.797102

Periodontitis and Atherosclerosis.

Ekuni D, Tomofuji T, Morita M

Studies on Periodontal Disease 183 - 195 2014

Effects of Antioxidants on Periodontal Disease.

Tomofuji T, Ekuni D, Mizutani S, Morita M

Studies on Periodontal Disease 279 - 305 2014

Periodontitis and Liver Diseases.

Irie K, Ekuni D, Tomofuji T, Morita M

Studies on Periodontal Disease 197 - 209 2014

Association between oxidative stress and periodontal diseases in animal model studies

Morita M, Ekuni D, Tomofuji T

Springer 2014

Longitudinal Relationship between Plasma Reactive Oxygen Metabolites and Periodontal Condition in the Maintenance Phase of Periodontal Treatment

Tatsuya Machida, Takaaki Tomofuji, Daisuke Ekuni, Mayu Yamane, Toshiki Yoneda, Yuya Kawabata, Kota Kataoka, Naofumi Tamaki, Manabu Morit

DISEASE MARKERS 2014 489292 - 489292 2014

Language：English Publisher：HINDAWI PUBLISHING CORPORATION

Aim. The present cohort study describes the longitudinal relationship between plasma oxidative status and periodontitis progression during the maintenance phase of treatment. Materials and Methods. Forty-five patients (mean age 58.8 years) were monitored from 2008 to 2013. Periodontal conditions, including probing pocket depth (PPD) and clinical attachment level (CAL), were recorded. Measurements of plasma reactive oxygen metabolites (ROM) and biologic antioxidant potential (BAP) were performed to evaluate plasma oxidative status. The patients were assigned into 2 groups as low and high plasma ROM level using a cut-off value which was median of plasma ROM level at baseline. Results. In the subjects with low plasma ROM level at baseline, changes in mean CAL were positively correlated with changes in plasma ROM levels, bleeding on probing, and plaque control record, but not with PPD. In the subjects with high plasma ROM at baseline, changes in CAL were significantly associated with only PPD at baseline. On the other hands there were no significant associations between changes in CAL and those in plasma BAP levels. Conclusions. When plasma ROM level in periodontitis patients was low, increases in plasma ROM level were associated with those in CAL during the maintenance phase of treatment.

DOI： 10.1155/2014/489292

Association Between Oxidative Stress and Periodontal Diseases in Animal Model Studies.

Morita M, Ekuni D, Tomofuji T

Studies on Periodontal Disease 33 - 51 2014

Effects of antioxidants on periodontal disease.

Tomofuji T, Ekuni D, Mizutani S, Morita M

Springer 2014

Effects of Periodontal Therapy on Circulating Oxidative Stress.