Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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ブルガダ症候群との合併例と考えられた先天性QT延長症候群(LQT3)の1例

橘元見, 森田宏, 上岡亮, 三好章仁, 久保元基, 中川晃志, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

Pilsicainid負荷試験にて著明なQRSの延長を示し,経時的に増悪がみられたBrugada症候群の一例

松本菜見子, 上岡亮, 森田宏, 杉山弘恭, 久保元基, 中川晃志, 三好亨, 西井伸洋, 永瀬聡, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 104th 2014

酵素補充療法により病理学的な変化の有無を確認できたファブリー病の1例

杉山弘恭, 時岡浩二, 中川晃志, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 中村陽一, 由谷親夫, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

繰り返す失神を主訴とする右腕頭動脈狭窄に対して血管内治療を施行した1例

戸田洋伸, 河合勇介, 江尻健太郎, 山中俊明, 中川晃志, 麻植浩樹, 赤木達, 吉田賢司, 杉山洋樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

心房中隔欠損症に合併した心房細動に対するカテーテルアブレーションの有用性

中川晃志, 赤木禎治, 永瀬聡, 木島康文, 河野晋久, 中村一文, 森田宏, 佐野俊二, 伊藤浩

日本成人先天性心疾患学会雑誌(Web) 3 ( 1 ) 2014

両心室ペーシング(CRT)により心機能の改善を得た修正大血管転位の1例

越智香織, 戸田洋伸, 河合勇介, 中川晃志, 麻植浩樹, 赤木達, 吉田賢司, 杉山洋樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

ハイリスク症例に対するペースメーカーリード抜去術について

久保元基, 西井伸洋, 河合勇介, 中川晃志, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩, 増田善逸, 佐野俊二, 竹中祐樹

日本循環器学会中国地方会(Web) 104th 2014

Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-bridge Formation in Hypertrophied Rat Hearts

Kazufumi Nakamura, Hironobu Toda, Toru Miyoshi, Hiroshi Ito

JOURNAL OF CARDIAC FAILURE 19 ( 10 ) S121 - S121 2013.10

Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-Bridge Formation in Hypertrophied Rat Hearts Induced by Chronic beta-Adrenergic Stimulation

Wakako Sumita Yoshikawa, Kazufumi Nakamura, Daiji Miura, Juichiro Shimizu, Ken Hashimoto, Noriyuki Kataoka, Hiroko Toyota, Hiroshi Okuyama, Toru Miyoshi, Hiroshi Morita, Kengo Fukushima Kusano, Tatsuhito Matsuo, Miyako Takaki, Fumihiko Kajiya, Naoto Yagi, Tohru Ohe, Hiroshi Ito

CIRCULATION JOURNAL 77 ( 3 ) 741 - 748 2013.3

Language：English Publisher：JAPANESE CIRCULATION SOC

Background: Left ventricular (LV) hypertrophy is often present in patients with diastolic heart failure. However, stiffness of hypertrophied cardiomyocytes in the transverse direction has not been fully elucidated. The aim of this study was to assess passive cardiomyocyte stiffness of hypertrophied hearts in the transverse direction and the influence of actin-myosin cross-bridge formation on the stiffness.
Methods and Results: Wistar rats received a vehicle (control) or isoproterenol (ISO) subcutaneously. After 7 days, compared with the controls, ISO administration had significantly increased heart weight and LV wall thickness and had decreased peak early annular relaxation velocity (e') assessed by echocardiography. Elastic modulus of living cardiomyocytes in the transverse direction assessed by an atomic force microscope was significantly higher in the ISO group than in controls. We added butanedione monoxime (BDM), an inhibitor of actin-myosin interaction, and blebbistatin, a specific myosin II inhibitor, to the medium. BDM and blebbistatin significantly reduced the elastic modulus of cardiomyocytes in the ISO group. X-ray diffraction analysis showed that the reflection intensity ratio (I-(1,I-0)/I-(1,I-1)) at diastole was not different before and after treatment with BDM, which induces complete relaxation, in control hearts, but that I-(1,I-0)/I-(1,I-1) was significantly increased after BDM treatment in the ISO group, indicating residual cross-bridge formation in hypertrophied hearts.
Conclusions: Passive cardiomyocyte stiffness in the transverse direction is increased in hearts with ISO-induced hypertrophy and this is caused by residual actin-myosin cross-bridge formation. (Circ J 2013; 77: 741-748)

DOI： 10.1253/circj.CJ-12-0779

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新薬の最近の話題イマチニブ

中村一文, 赤木達, 伊藤浩

分子呼吸器病 17 ( 1 ) 118 - 120 2013.3

カテコラミン誘発性多形性心室頻拍1家系3人

田渕勲, 草野研吾, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 伊藤浩, 増田拓郎, 高石篤志

日本循環器学会中国地方会(Web) 102nd 2013

流出路起源を示す心電図波形でValsalva洞から離れた左室前中隔心内膜側での焼灼が有効であった特発性心室頻拍の1例

和田匡史, 永瀬聡, 中川晃志, 西井伸洋, 河野晋久, 森田宏, 中村一文, 伊藤浩

日本不整脈学会カテーテルアブレーション委員会公開研究会プログラム・抄録集 25th 2013

濃厚な家族歴を有し,神経疾患及び冠攣縮性狭心症を合併したProgressive Cardiac Conduction Diseaseの1例

戸田洋伸, 森田宏, 杉山洋樹, 中川晃志, 麻植浩樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 103rd 2013

Hedgehog Interacting Protein Controls Age-Dependent Angiogenic Activity in Human Cardiac Progenitor Cells Through Insulin-Like Growth Factor-1 Receptor Signaling

Masashi Yoshida, Suguru Tarui, Junko Kobayashi, Masataka Hirata, Yasufumi Kijima, Tohru Miyoshi, Kazufumi Nakamura, Kengo Kusano, Youhei Maeshima, Shunji Sano, Hiroshi Ito, Hidemasa Oh

CIRCULATION 126 ( 21 ) 2012.11