Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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Application of Real-Time Three-Dimensional Transesophageal Echocardiography Using a Matrix Array Probe for Transcatheter Closure of Atrial Septal Defect

Manabu Taniguchi, Teiji Akagi, Nobuhisa Watanabe, Yoshio Okamoto, Koji Nakagawa, Yasufumi Kijima, Norihisa Toh, Shinichi Ohtsuki, Kengo Kusano, Shunji Sano

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 22 ( 10 ) 1114 - 1120 2009.10

Language：English Publishing type：Book review, literature introduction, etc. Publisher：MOSBY-ELSEVIER

Background: The aim of this study was to demonstrate the utility of real-time three-dimensional (3D) transesophageal echocardiography (RT3D-TEE) using a matrix array 3D transesophageal echocardiographic probe for morphologic evaluation and guidance of transcatheter closure of atrial septal defects (ASDs).
Methods: Forty-eight consecutive patients scheduled for the intervention were included. Two-dimensional (2D) transesophageal echocardiography (2D-TEE) and RT3D-TEE were performed before and during the procedures. Measurements of maximal ASD diameter and surrounding rims obtained on RT3D-TEE were compared with those obtained on 2D-TEE.
Results: In 46 patients (96%), optimal 3D images for the morphologic evaluation of ASDs were obtained. RT3D-TEE facilitated the evaluation of ASD morphology and surrounding rims and was able to provide intra-procedural information clearly. A Bland-Altman plot showed a mean maximal diameter difference of -0.12 mm between the means (95% limits of agreement, -2.2 to 2.5 mm).
Conclusion: RT3D-TEE is a clinically useful, complementary option to 2D-TEE for evaluation of ASD morphology and for interventional guidance. (J Am Soc Echocardiogr 2009; 22: 1114-20.)

DOI： 10.1016/j.echo.2009.06.008

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4-Hydroxy-2-nonenal Induces Calcium Overload via the Generation of Reactive Oxygen Species in Isolated Rat Cardiac Myocytes

Kazufumi Nakamura, Daiji Miura, Kengo Fukushima Kusano, Yoshihisa Fujimoto, Wakako Sumita-Yoshikawa, Soichiro Fuke, Nobuhiro Nishii, Satoshi Nagase, Yoshiki Hata, Hiroshi Morita, Hiromi Matsubara, Tohru Ohe, Hiroshi Ito

JOURNAL OF CARDIAC FAILURE 15 ( 8 ) 709 - 716 2009.10

Language：English Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS

Background: It has been reported that that the amount of 4-hydroxy-2-nonenal (FINE), which is a major lipid peroxidation product and a cytotoxic aldehyde, is increased in the human failing myocardium. This study was designed to determine whether FINE has a pro-oxidant effect in cardiac myocytes and whether FINE causes Ca(2+) overload.
Methods and Results: Exposure to FINE for 10 minutes in the presence of ferric nitrilotriacetate induced the production of hydroxyl radical (.OH) in the rat myocardium as assessed by electron spin resonance spectroscopy, and FINE induced the generation of reactive oxygen species (ROS) in a dose-dependent manner as assessed by 2', 7'-dichlorofluorescein diacetate fluorescence. FINE increased intracellular Ca(2+) concentration ([Ca(2+)](i)) as assessed by fura-2 ratio in a dose- and time-dependent manner. After 20 minutes of FINE (400 mu mol/L) exposure, hypercontracture was induced in 67% of the cells. Catalase, an antioxidative enzyme that can decompose hydrogen peroxide (H(2)O(2)), significantly attenuated the increase in [Ca(2+)](i) and completely inhibited hypercontracture. Carvedilol, a beta-blocker with potent antioxidant activity, also significantly attenuated the increase in [Ca(2+)](i) and completely inhibited hypercontracture, but propranolol had no effect on either [Ca(2+)](i) increase or hypercontracture.
Conclusions: FINE induces the formation of ROS, especially H(2)O(2) and .OH, in cardiomyocytes and subsequently ROS cause intracellular Ca(2+) overload. FINE formation may play an important role as a mediator of oxidative stress in heart failure. (J Cardiac Fail 2009;15:709-716)

DOI： 10.1016/j.cardfail.2009.04.008

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A novel KCNH2 mutation as a modifier for short QT interval

Hideki Itoh, Tomoko Sakaguchi, Takashi Ashihara, Wei-Guang Ding, Iori Nagaoka, Yuko Oka, Yuko Nakazawa, Takenori Yao, Hikari Jo, Makoto Ito, Kazufumi Nakamura, Tohru Ohe, Hiroshi Matsuura, Minoru Horie

INTERNATIONAL JOURNAL OF CARDIOLOGY 137 ( 1 ) 83 - 85 2009.9

Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：ELSEVIER IRELAND LTD

In a 34-year-old man showing short QT interval (QTc 329 ms), we identified a novel C-terminal KCNH2 mutation, R1135H. Using a heterologous expression system with CHO cells, the mutant channels were found to display a significantly slow deactivation, which resulted in a gain-of-function for reconstituted 'I(Kr)' channels. This mutation could modify clinical phenotypes for this patient. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijcard.2008.05.050

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Abnormal transmural repolarization process in patients with Brugada syndrome

Mutsuko Sangawa, Hiroshi Morita, Takaaki Nakatsu, Nobuhiro Nishii, Daiji Miura, Aya Miura, Takeshi Tada, Masato Murakami, Shigeki Hiramatsu, Satoshi Nagase, Kazufumi Nakamura, Takefumi Oka, Shinji Toyonaga, Keiichi Mashima, Shozo Kusachi, Kazuhide Yamamoto, Tohru Ohe, Kengo F. Kusano

HEART RHYTHM 6 ( 8 ) 1163 - 1169 2009.8

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND Repolarization abnormality, especially during bradycardia, might be critical for initiation of ventricular fibrillation (VF) in patients with Brugada syndrome (BrS), but the contribution of the rate-dependent repolarization dynamics to the occurrence of VF is still unknown.
OBJECTIVE The aim of our study was to determine the differences in rate-dependent repolarization dynamics between BrS with and without spontaneous VF and between BrS with and without SCN5A mutation.
METHODS The subjects were 37 BrS patients with VF (VF(+) group: 10 mate subjects) and without VF (VF(-) group: 27 mate subjects) and 20 control subjects. Genetic analysis of SCN5A was performed in all 37 BrS patients. The relationships between QT, QTp, Tp-e, and RR intervals were obtained from Hotter recordings as first Linear regression tines, and the slopes of QT/RR, QTp/RR, and Tp-e/RR Linear regression Lines as the sensitivity of rate-dependent repolarization dynamics were compared.
RESULTS QT/RR and Tp-e/RR slopes showed toss of a rate-dependent property in the VF(+) group compared with those in the VF(-) and control groups. There was no significant difference in QTp/RR slope among the VF(+), VF(-) and control groups. The Tp-e interval had a negative correlation with the RR interval in the VF(+) group and a positive correlation with the RR interval in the VF(-) and control groups. There was no significant difference in QT/RR, QTp/RR, and Tp-e/RR slopes. between BrS patients with SCN5A mutation and those without SCN5A mutation.
CONCLUSIONS Loss of rate-dependent QT dynamics may be associated with occurrence of VF in BrS.

DOI： 10.1016/j.hrthm.2009.04.037

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Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome

Hiroshi Morita, Satoshi Nagase, Daiji Miura, Aya Miura, Shigeki Hiramatsu, Takeshi Tada, Masato Murakami, Nobuhiro Nishii, Kazufumi Nakamura, Shiho T. Morita, Takefumi Oka, Kengo F. Kusano, Tohru Ohe

HEART RHYTHM 6 ( 4 ) 487 - 492 2009.4

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND Premature ventricular contractions (PVCs) do not occur frequently but can induce ventricular fibrillation (VF) in patients with Brugada syndrome. The effect of SCN5A mutation on the onset of ventricular arrhythmias is unknown.
OBJECTIVE The purpose of this study was to evaluate PVC morphology and onset of VF in patients with Brugada syndrome.
METHODS Morphology of PVCs was evaluated by 12-lead ECG in 32 patients with Brugada syndrome. Patients had spontaneous ventricular arrhythmia (n = 17) or sodium channel blocker-induced ventricular arrhythmia (n = 19). Patients were classified into two groups according to the existence of SCN5A mutation (22 mutation negative, 10 mutation positive).
RESULTS Patients without mutation often had PVCs of left bundle branch block (LBBB) morphology (82%), especially with inferior axis (77%). Patients with mutation had PVCs of both right bundle branch block (36%) and LBBB (64%) morphologies. Only two patients with mutation had PVCs of LBBB, inferior-axis morphology.
CONCLUSION Patients without SCN5A mutation often had PVCs of LBBB, inferior-axis morphology, suggesting a right ventricular outflow tract origin. Patients with SCN5A mutations had PVCs that originated from both the right and left ventricles.

DOI： 10.1016/j.hrthm.2009.01.031

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Transcatheter Closure of Atrial Septal Defect in Elderly Patients With Permanent Atrial Fibrillation

Manabu Taniguchi, Teiji Akagi, Shinichi Ohtsuki, Yoshio Okamoto, Yasuharu Tanabe, Nobuhisa Watanabe, Koji Nakagawa, Norihisa Toh, Kengo Kusano, Shunji Sano

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS 73 ( 5 ) 682 - 686 2009.4

Language：English Publisher：WILEY-LISS

Objectives: The aim of this study is to evaluate the feasibility and efficacy of device closure of atrial septal defect (ASD) in elderly patients with permanent atrial fibrillation. Background: Little is known about the feasibility of device closure of ASD in those patients. Methods: Nine consecutive patients (mean age 68.1 years) with permanent atrial fibrillation (>1 year persistent) underwent catheter closure using the Amplatzer septal occluder. Transthoracic echocardiography and plasma B-type natriuretic peptide (BNP) level were assessed before and at 24 hours; and 1, 3, and >6 months after the closure. Before the procedure, appropriate dose of warfarin was used in all, diuretics was used in 8/9. Same amount of medications were continued after the procedure. Results: ASD could be closed in all (mean device size 27.3 mm) without hemodynamic and thromboembolic complications. New York Heart Association (NYHA) functional classification was significantly improved in all patients after device closure. No hemodynamic and thromboembolic complications were observed during the follow-up period (mean 10.6 months). Although permanent atrial fibrillation did not change in all after the procedure, resting heart rate decreased from 76.2 +/- 16.0 to 68.3 +/- 13.2 beats/min (P = 0.015). There was statistically significant improvement in right ventricular/left ventricular diameter ratio (1.08 +/- 0.16 to 0.73 +/- 0.10, P = 0.008) and plasma BNP level (183.7 +/- 90.5 to 94.6 +/- 47.4 pg/mL, P = 0.008) after >6 months device closure. Conclusions: Even in the patients complicated with permanent fibrillation, transcatheter closure of ASD can contribute to symptomatic improvement as well as cardiac geometric remodeling. (C) 2009 Wiley-Liss, Inc.

DOI： 10.1002/ccd.21870

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FRS-116 Frequency of Single Nucleotide Polymorphisms in Japanese Patients with Brugada Syndrome(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Miura Daiji, Nakamura Kazufumi, Morita Hiroshi, Miura Aya, Sumita Wakako, Taniyama Makiko, Iwasaki Jun, Urakawa Shigemi, Kimura Hideo, Banba Kimikazu, Watanabe Atsuyuki, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 73 169 - 169 2009.3

FRS-023 Red Cell Distribution Width as a Prognostic Marker in Patients with Nonischemic Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Kijima Yasufumi, Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Ohe Tohru, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 140 - 141 2009.3

PE-514 Red Blood Cell Distribution Width Reflects Heart Failure Status in Patients with Idiopathic Pulmonary Arterial Hypertension(PE086,Pulmonary Circulation (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)

Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Hata Yoshiki, Morita Hiroshi, Ohe Tohru, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 529 - 529 2009.3

OE-151 Conduction Abnormality within QRS Complex Detected by Wavelet Transform of SAECG in Patients with Brugada Syndorme(OE26,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nosaka Kazumasa, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 212 - 212 2009.3

PE-246 Serum Cyctatin C Reflects Cardiac Diastolic Dysfunction in Patients with Heart Failure(PE042,Cardiac Function (Clinical) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nosaka Kazumasa, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 461 - 461 2009.3

OE-198 Increased Cardiomyocyte Elasticity in the Transverse Direction in Hypertrophied Rat Hearts Induced by Chronic β-Adrenergic Stimulation(OE34,Cardiac Function (Basic) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nakamura Kazufumi, Sumita Wakako, Hashimoto Ken, Miura Daiji, Nishii Nobuhiro, Nagase Satoshi, Morita Hiroshi, Hata Yoshiki, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 73 223 - 223 2009.3

PJ-608 Comparison of Clinical Characteristics between the Patients with Connective Tissue Disease and Idiopathic Pulmonary Arterial Hyptertension(PJ102,Pulmonary Circulation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Hirota Minoru, Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Ohe Tohru, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 698 - 699 2009.3

DPJ-006 Differential Effects of Genotype on the Initiation of Ventricular Arrhythmia in Patients with Brugada Syndrome(DPJ01,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Morita Hiroshi, Miura Daiji, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 73 377 - 377 2009.3

非Brugada型特発性心室細動12例の検討(原著）

平松茂樹, 森田宏, 中川晃志, 田中正道, 村上正人, 多田毅, 西井伸洋, 永瀬聡

心臓 41 ( 3 ) 54 - 60 2009

Language：Japanese Publisher：(公財)日本心臓財団

特発性心室細動(IVF)には、Brugada症候群の心電図特徴を示さない例がある。原因や病態は複数と思われ、潜在性の心筋炎の可能性も考えられている。今回、当院で経験されたBrugada症候群が否定的なIVF12例について、その特徴を検討した。年齢は38±12歳、男性が8名(67%)。右室流出路起源の心室性期外収縮(PVC)から心室細動(VF)を起こした者が3名。連結期の短いPVCを認める者が3名。いずれも認めない者が6名であった。12誘導心電図で有意な所見は認めず、遅延電位は陰性。冠動脈に有意狭窄はなく、左室造影も正常。心臓電気生理学的検査(EPS)において、2例のみ右室の一部に軽度の異常電位を認めたが、その他の症例では認めていない。プログラム刺激による心室頻拍/心室細動(VT/VF)の誘発では、全例で持続するVT/VFは誘発されなかった。上記のことからIVFには器質的な異常は認めず、機能的な異常が原因となっている可能性が高いと考えられる。(著者抄録)

DOI： 10.11281/shinzo.41.S3_54

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2009&ichushi_jid=J00679&link_issn=&doc_id=20090807210010&doc_link_id=10.11281%2Fshinzo.41.S3_54&url=https%3A%2F%2Fdoi.org%2F10.11281%2Fshinzo.41.S3_54&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

酸化ストレスと拡張機能障害(共著）

谷山真規子, 中村一文

医学のあゆみ 231 ( 8 ) 815 - 817 2009

治療(2)】急性心筋炎における大量免疫グロブリン療法-有効性は確かか？(共著）

柚木佳, 中村一文

心臓 41 ( 11 ) 1201 - 1204 2009