Faculty Profiles - NAKAMURA Kazufumi

Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice

Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Kei Yunoki, Yasushi Koyama, Minoru Satoh, Megumi Kondo, Kazuhiro Osawa, Omer F. Hatipoglu, Toru Miyoshi, Masashi Yoshida, Hiroshi Morita, Hiroshi Ito

PLOS ONE 12 ( 8 ) 159 - 166 2017.8

Language：English Publisher：PUBLIC LIBRARY SCIENCE

Background
The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However, the effects of EPA on arterial calcification have not been fully elucidated. The aim of this study was to determine the effect of EPA on arterial calcification in klotho mutant mice.
Methods and results
Four-week-old klotho mutant mice and wild-type (WT) mice were given a diet containing 5% EPA (EPA food, klotho and WT: n = 12, each) or not containing EPA (control food, klotho and WT: n = 12, each) for 4 weeks. Calcium volume scores of thoracic and abdominal aortas assessed by computed tomography were significantly elevated in klotho mice after 4 weeks of control food, but they were not elevated in klotho mice after EPA food or in WT mice. Serum levels of EPA and resolvin E1, an active metabolite of EPA, in EPA food-fed mice were significantly increased compared to those in control food-fed mice. An oxidative stress PCR array followed by quantitative PCR revealed that NADPH oxidase-4 (NOX4), an enzyme that generates superoxide, gene expression was up-regulated in arterial smooth muscle cells (SMCs) of klotho mice. Activity of NOX was also significantly higher in SMCs of klotho mice than in those of WT mice. EPA decreased expression levels of the NOX4 gene and NOX activity. GPR120, a receptor of n-3 fatty acids, gene knockdown by siRNA canceled effects of EPA on NOX4 gene expression and NOX activity in arterial SMCs of klotho mice.
Conclusions
EPA prevents arterial calcification together with reduction of NOX gene expression and activity via GPR120 in klotho mutant mice.

DOI： 10.1371/journal.pone.0181009

Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy

Yoichi Takaya, Kengo Kusano, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito

INTERNATIONAL JOURNAL OF CARDIOLOGY 240 302 - 306 2017.8

Language：English Publisher：ELSEVIER IRELAND LTD

Background: Little is known about the suitability of implantable cardioverter defibrillator (ICD) implantation in patients with cardiac sarcoidosis (CS). We evaluated the efficacy of ICD implantation in patients with CS, including suspected CS, compared with those with idiopathic dilated cardiomyopathy (DCM).
Methods: A total of 102 consecutive patients with definite CS, suspected CS, or DCM who underwent ICD implantation were enrolled. The endpoint was the first documentation of appropriate ICD therapy for ventricular tachyarrhythmias. The follow-up started after ICD implantation.
Results: Appropriate ICD therapies occurred in 15 (56%) of 27 patients with definite CS, 17 (68%) of 25 with suspected CS, and 16 (32%) of 50 with DCM. The rate of appropriate ICD therapies was higher in patients with definite CS and those with suspected CS than in those with DCM (log-rank test, p= 0.010). After ICD implantation, five or more appropriate ICD therapies occurred in 5 (19%) patients with definite CS and 10 (40%) with suspected CS, but in only 1 (2%) with DCM. Cox proportional hazard analysis showed that CS, including suspected CS, was independently associated with appropriate ICD therapies. For primary prevention, the rate of appropriate ICD therapies was higher in patients with CS than in those with DCM(log-rank test, p= 0.034). More than half of patients with CS received appropriate ICD therapies.
Conclusions: Patients with CS receive appropriate ICD therapies for ventricular tachyarrhythmias at a higher rate, compared with those with DCM, suggesting that ICD implantation should be performed in patients with CS.

DOI： 10.1016/j.ijcard.2017.04.044

Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid

Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito

NUTRIENTS 9 ( 8 ) 17574 - 17582 2017.8

Language：English Publisher：MDPI AG

Vascular medial calcification is often observed in patients with arteriosclerosis. It is also associated with systolic hypertension, wide pulse pressure, and fluctuation of blood pressure, which results in cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular calcification in previous animal experiments. We investigated the inhibitory effects of EPA on Wnt signaling, which is one of the important signaling pathways involved in vascular calcification. Intake of food containing 5% EPA resulted in upregulation of the mRNA expression of Klotho, an intrinsic inhibitor of Wnt signaling, in the kidneys of wild-type mice. Expression levels of beta-catenin, an intracellular signal transducer in the Wnt signaling pathway, were increased in the aortas of Klotho mutant (kl/kl) mice compared to the levels in the aortas of wild-type mice. Wnt3a or BIO, a GSK-3 inhibitor that activates beta-catenin signaling, upregulated mRNA levels of AXIN2 and LEF1, Wnt signaling marker genes, and RUNX2 and BMP4, early osteogenic genes, in human aorta smooth muscle cells. EPA suppressed the upregulation of AXIN2 and BMP4. The effect of EPA was cancelled by T0070907, a PPAR gamma inhibitor. The results suggested that EPA could suppress vascular calcification via the inhibition of Wnt signaling in osteogenic vascular smooth muscle cells via PPAR gamma activation.

DOI： 10.3390/nu9080858

Complete right bundle branch block and QRS-T discordance can be the initial clue to detect S-ICD ineligibility

Motomi Tachibana, Nobuhiro Nishii, Yoshimasa Morimoto, Satoshi Kawada, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

JOURNAL OF CARDIOLOGY 70 ( 1-2 ) 23 - 28 2017.7

Language：English Publisher：ELSEVIER SCIENCE BV

Background: In order to minimize inappropriate shocks of subcutaneous implantable cardioverter-defibrillators (S-ICD), it is important to recognize who is suitable for S-ICD indication. This study aimed to clarify what types of cardiac disease are likely to fulfill the S-ICD screening criteria and ineligible factors for S-ICD in the standard 12-lead electrocardiogram (ECG).
Methods: A total of 348 patients with heart disease were enrolled. They were assessed by supine and standing ECG recording to simulate the 3 S-ICD sensing vectors and standard 12-lead ECG, simultaneously. Clinical and ECG characteristics were analyzed to compare the patients who are eligible and ineligible with S-ICD screening ECG indication.
Results: The mean age of study patients was 49 21 years and 244 (70%) were men. Nineteen percent of patients were unsuitable for S-ICD. There was no significant difference in ineligibility for S-ICD among cardiac diseases (p = 0.48). Univariate analysis showed complete right bundle branch block (CRBBB), QRS-T discordance in lead II, and QRS-T discordance in 3 leads (I, II, and aVF) were more frequent in patients who were ineligible for S-ICD than in the eligible group. Multivariate regression analysis showed CRBBB and QRST discordance in 3 leads were independent predictors for ineligibility of S-ICD.
Conclusion: There are no differences in eligibility of S-ICD among types of cardiac diseases. CRBBB and QRS-T discordance were independent predictors for ineligibility. (C) 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jjcc.2016.11.014

High Frequency of Acute Adverse Cardiovascular Events After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Receiving Preoperative Long-Term Intravenous Prostacyclin

Satoshi Akagi, Takahiro Oto, Motomu Kobayashi, Kentaroh Miyoshi, Seiichiro Sugimoto, Masaomi Yamane, Kazufumi Nakamura, Toshihiro Sarashina, Shinichiro Miyoshi, Hiroshi Ito

INTERNATIONAL HEART JOURNAL 58 ( 4 ) 557 - 561 2017.7

Language：English Publisher：INT HEART JOURNAL ASSOC

Adverse cardiovascular events after lung transplantation (LT) increase the mortality in patients with pulmonary arterial hypertension (PAH). Long-term intravenous prostacyclin is the usual treatment in severe patients with PAH, but it may increase the risk of hemorrhage due to its antiplatelet aggregation effect or thrombocytopenia. We investigated the impact of length of intravenous prostacyclin therapy on acute adverse cardiovascular events including hemorrhagic complication after LT. We retrospectively compared the incidence of adverse events (death, intrathoracic hematoma and bleeding, cardiac congestion or shock, cerebral infarction and pulmonary embolism) within 30 days after LT between no/short-term (median 0.6 years, n = 13) and long-term (median 3.7 years, n = 15) intravenous prostacyclin groups. There were no differences in the dose of intravenous prostacyclin and pulmonary artery pressure between the two groups. Among 22 adverse events (0.8 +/- 1.1 events/patient), 4 events occurred in the no/short-term intravenous prostacyclin group and 18 occurred in the long-term intravenous prostacyclin group. The event rate per patient in the long-term intravenous prostacyclin group (1.2 +/- 1.3 events/patient) was significantly higher than that in the no/short-term intravenous prostacyclin group (0.3 +/- 0.5 events/patient) (P < 0.05). Intrathoracic hematoma and bleeding was the most frequent adverse event (9 events, 41%). Preoperative long-term intravenous prostacyclin therapy increases acute adverse cardiovascular events after LT in patients with PAH.

DOI： 10.1536/ihj.16-389

Epicardially placed implantable cardioverter-defibrillator for a child with congenital long QT syndrome

Hirotaro Sugiyama, Motomi Tachibana, Hiroshi Morita, Nobuhiro Nishii, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Ito

Journal of Arrhythmia 33 ( 3 ) 237 - 239 2017.6

Language：English Publisher：Elsevier B.V.

A 7-year-old boy presented at our hospital with syncope. At birth, electrocardiography had shown a long QT interval with torsade de pointes (TdP). Congenital long QT syndrome (LQTS) had been diagnosed by genetic testing, and was successfully controlled with oral propranolol. At age 7, TdP had recurred with syncope. Electrocardiography revealed a prominent long QT interval with T-wave alternans. The propranolol dose was increased, but TdP remained uncontrolled. A cardioverter-defibrillator (ICD) was implanted epicardially, and TdP completely resolved with atrial pacing. We report this rare case of ICD implantation in a child with LQTS.

DOI： 10.1016/j.joa.2016.10.561

Effect of remote ischemia or nicorandil on myocardial injury following percutaneous coronary intervention in patients with stable coronary artery disease: A randomized controlled trial

Toru Miyoshi, Kentaro Ejiri, Kunihisa Kohno, Makoto Nakahama, Masayuki Doi, Mitsuru Munemasa, Masaaki Murakami, Atsushi Takaishi, Yusuke Kawai, Tetsuya Sato, Katsumasa Sato, Takefumi Oka, Natsuki Takahashi, Satoru Sakuragi, Atsushi Mima, Kenki Enko, Shingo Hosogi, Seiji Nanba, Ryoichi Hirami, Kazufumi Nakamura, Hiroshi Ito

INTERNATIONAL JOURNAL OF CARDIOLOGY 236 36 - 42 2017.6

Language：English Publisher：ELSEVIER IRELAND LTD

Background: The effect of remote ischemic preconditioning (RIPC) and nicorandil on periprocedural myocardial injury (pMI) in patients with planned percutaneous coronary intervention (PCI) remains controversial. The aim of this randomized trial was to evaluate the effect of RIPC or nicorandil on pMI following PCI in patients with stable coronary artery disease (CAD) compared with a control group.
Methods: Patients with stable CAD who planned to undergo PCI were assigned to a 1: 1: 1 ratio to control, RIPC, or intravenous nicorandil (6mg/h). Automated RIPC was performed by a device, which performs intermittent arm ischemia through three cycles of 5min of inflation and 5min of deflation of a pressure cuff. The primary outcome was the incidence of pMI, determined by an elevation in high-sensitive troponin T or creatine kinase myocardial band at 12 or 24 h after PCI. The secondary outcomes were ischemic events during PCI and adverse clinical events at 8 months after PCI.
Results: A total of 391 patients were enrolled. The incidence of pMI following PCI was not significantly different between the control group (48.9%) and RIPC group (39.5%; p = 0.14), or between the control group and nicorandil group (40.3%; p = 0.17). There were no significant differences in ischemic events during PCI or adverse clinical events within 8 months after PCI among the three groups.
Conclusions: This study demonstrated moderate reductions in biomarker release and pMI by RIPC or intravenous nicorandil prior to the PCI consistently, but may have failed to achieve statistical significance because the study was underpowered. (C) 2017 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.ijcard.2017.02.028

Comparable effect of aliskiren or a diuretic added on an angiotensin II receptor blocker on augmentation index in hypertension: A multicentre, prospective, randomised study

Toru Miyoshi, Takashi Murakami, Satoru Sakuragi, Masayuki Doi, Seiji Nanba, Atsushi Mima, Youkou Tominaga, Takafumi Oka, Yutaka Kajikawa, Kazufumi Nakamura, Hiroshi Ito

Open Heart 4 ( 1 ) 296 - 301 2017.3

Language：English Publisher：BMJ Publishing Group

Background The effects of antihypertensive drug combination therapy on central blood pressure (BP) and augmentation index (AI) have not been fully elucidated. We investigated the effects of the direct renin inhibitor, aliskiren, or a diuretic added to an angiotensin II receptor blocker on AI in patients with essential hypertension. Methods A 24-week, prospective, multicentre, randomised, open-label study enrolled 103 patients already treated with valsartan. Participants were randomly allocated to receive either valsartan with aliskiren (V+A), or valsartan with trichlormethiazide (V+T). The primary outcome was the change in AI derived from radial artery tonometry. Secondary outcome measures included systolic and diastolic BP, cardio-ankle vascular index (CAVI, which reflects arterial stiffness) and urinary 8-hydroxydeoxyguanosine concentration. Results After 24 weeks, systolic and diastolic BP were significantly reduced in both groups to a broadly comparable extent. There was no significant difference in AI at the end of the study between the V+A group and the V+T group (between-group difference: -2.3%, 95% CI -6.9% to 2.2%, p=0.31). Central BP at the end of the study also did not differ between the two groups (p=0.62). There was no significant difference in the CAVI between the groups at the end of the study. Urinary 8-hydroxydeoxyguanosine concentration was significantly lower in the V+A group than in the V+T group (p &lt
0.01), suggesting that V+A attenuated oxidative stress more than V+T. Conclusion The combination of valsartan and aliskiren had an effect on AI comparable with that of the combination of valsartan and trichlormethiazide.

DOI： 10.1136/openhrt-2017-000591

Reverse Right Ventricular Remodeling After Lung Transplantation in Patients With Pulmonary Arterial Hypertension Under Combination Therapy of Targeted Medical Drugs

Toshihiro Sarashina, Kazufumi Nakamura, Satoshi Akagi, Takahiro Oto, Hiroki Oe, Kentaro Ejiri, Koji Nakagawa, Nobuhiro Nishii, Hiromi Matsubara, Motomu Kobayashi, Hiroshi Morimatsu, Shinichiro Miyoshi, Hiroshi Ito

CIRCULATION JOURNAL 81 ( 3 ) 383 - 390 2017.3

Language：English Publisher：JAPANESE CIRCULATION SOC

Background: Patients with pulmonary arterial hypertension (PAH) are currently treated with combination therapy of PAH-targeted drugs. Reverse right ventricular (RV) remodeling after lung transplantation (LTx) in patients with end-stage PAH despite combination therapy of PAH-targeted drugs has not been fully elucidated.
Methods and Results: A total of 136 patients, including 32 with PAH, underwent LTx from 1998 to 2014. We enrolled 12 consecutive patients with PAH treated with combination therapy of PAH-targeted drugs who underwent LTx and retrospectively analyzed the temporal and serial changes in hemodynamics and echocardiography before LTx and at 3 and 12 months after LTx. Before LTx, the RV was markedly dilated with substantially reduced RV fractional area change (RVFAC). At 3 months after LTx, pulmonary artery pressure, pulmonary vascular resistance and RV stroke work index were significantly decreased, while left ventricular stroke work index was increased. RV size assessed by echocardiography also significantly decreased and RVFAC improved. At 12 months after LTx, RVFAC was further increased and RV wall thickness was decreased significantly.
Conclusions: Although severe RV dysfunction and dilation were observed in patients with end-stage PAH despite combination therapy of PAH-targeted drugs, RV function and morphology were improved after reduction of RV pressure load by LTx.

DOI： 10.1253/circj.CJ-16-0838

Local Left Ventricular Epicardial J Waves and Late Potentials in Brugada Syndrome Patients with Inferolateral Early Repolarization Pattern

Satoshi Nagase, Masamichi Tanaka, Hiroshi Morita, Koji Nakagawa, Tadashi Wada, Masato Murakami, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito, Tohru Ohe, Kengo F. Kusano

FRONTIERS IN PHYSIOLOGY 8 ( JAN ) 947 - 60 2017.1

Language：English Publisher：FRONTIERS MEDIA SA

Background: Brugada syndrome (BrS) is characterized by J-point or ST-segment elevation on electrocardiograms (ECGs) and increased risk of ventricular fibrillation (VF). In BrS, epicardial depolarization abnormality with delayed potential on the right ventricular outflow tract is reportedly the predominant mechanism underlying VF. Yet VF occurrence is also associated with early repolarization (ER) pattern in the inferolateral ECG leads, which may represent the inferior and/or left lateral ventricular myocardium. The aim of this study was to examine epicardial electrograms recorded directly at the left ventricle (LV) in BrS patients after VF episodes.
Methods: In 12 BrS patients who had experienced VF episodes and 17 control subjects, a multipolar catheter was introduced into the left lateral coronary vein for unipolar and bipolar electrogram recordings at the LV epicardium. Both inferior and lateral ER patterns on ECG were observed in three BrS patients and six control subjects.
Results: In the epicardium, prominent J waves were detected using unipolar recording, and potentials after the QRS complex were detected using bipolar recording in three of the 12 BrS patients. These three patients also showed both inferior and lateral ER patterns on ECG. Neither prominent J waves nor potentials after the QRS complex were recorded at the endocardium of the LV in any of these three patients; nor were they seen at the epicardium in any of the control subjects. These features were accentuated on pilsicainide administration (n = 2) but diminished on constant atrial pacing (n = 3) and isoproterenol administration (n = 1). The J waves observed through unipolar recording coincided with the potentials after QRS complex observed through bipolar recording and with the inferolateral ER patterns on ECG.
Conclusions: We recorded prominent J waves in unipolar electrogram and potentials after QRS complex in bipolar electrogram at the LV epicardium in BrS patients with global ER pattern. The prominent J waves coincided with the potentials after QRS complex and the inferolateral ER pattern on ECG. The characteristics of the inferolateral ER pattern on ECG in these patients primarily represent depolarization feature.

DOI： 10.3389/fphys.2017.00014

治療に難渋した壊死性好酸球性心筋炎の1例(共著）

小出祐嗣, 中村一文, 木村朋生, 中川晃志, 三好亨, 西井伸洋, 伊藤浩, 大澤晋, 笠原慎吾, 田中健大, 柳井広之, 安藤翠, 大郷恵子, 山中俊明

心臓 49 ( Suppl1 ) 159 - 167 2017

Progression of pulmonary artery dilatation in patients with pulmonary hypertension coexisting with a pulmonary artery aneurysm

Satoshi Akagi, Kazufumi Nakamura, Toshihiro Sarashina, Kentaro Ejiri, Shingo Kasahara, Hiroshi Ito

Journal of Cardiology 571 - 579 2017

Serum cystatin C levels are associated with coronary artery calcification in women without chronic kidney disease

Hiroyasu Sugiyama, Toru Miyoshi, Kazuhiro Osawa, Takashi Miki, Yuji Koide, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

Journal of Cardiology 283 - 289 2017

ACE阻害薬、ARB(共著）

谷本匡史, 中村一文

薬局 68 ( 7 ) 54 - 59 2017

特集肺高血圧症－診断と治療の新展開－肺動脈性肺高血圧症基礎研究の進歩(共著）

中村一文, 江尻健太郎, 赤木達

最新医学 72 ( 8 ) 49 - 53 2017

Analysis of arrhythmic events is useful to detect lead failure earlier in patients followed by remote monitoring

Nobuhiro Nishii, Akihito Miyoshi, Motoki Kubo, Masakazu Miyamoto, Yoshimasa Morimoto, Satoshi Kawada, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

Journal of Cardiovascular Electrophysiology, Journal of Electrophysiology, Clinical Progress in Electrophysiology and Pacing, Clinical Progress in Pacing and Electrophysiology 379 - 386 2017

Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter defibrillator in patients with Brugada syndrome

Motomi Tachibana, Nobuhiro Nishii, Hiroshi Morita, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Ito

Journal of Cardiovascular Electrophysiology, Journal of Electrophysiology, Clinical Progress in Electrophysiology and Pacing, Clinical Progress in Pacing and Electrophysiology 38 - 44 2017

Identification of electrocardiographic risk markers for the initial and recurrent episodes of ventricular fibrillation in patients with Brugada syndrome

Hiroshi Morita, Atsuyuki Watanabe, Satoshi Kawada, Masakazu Miyamoto, Yoshimasa Morimoto, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito

Journal of Cardiovascular Electrophysiology, Journal of Electrophysiology, Clinical Progress in Electrophysiology and Pacing, Clinical Progress in Pacing and Electrophysiology 20 - 33 2017

His束近傍の副伝導路に対して,Freezor Xtraにより根治しえた一例

森本芳正, 渡邊敦之, 川田哲史, 橘元見, 中川晃志, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 110th 2017

胸椎圧迫骨折が病態悪化に関与したと考えられた心房中隔欠損症によるPlatypnea-Orthodeoxia Syndromeの一例

原田洸, 大塚寛昭, 中川晃志, 高谷陽一, 渡邊敦之, 三好亨, 西井伸洋, 衛藤弘城, 赤木禎治, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 110th 2017

Single Chamber ICDによりshock作動を起こした頻拍を,心臓電気生理学的検査にて上室頻拍と診断しえた1例

森本芳正, 西井伸洋, 森田宏, 三好章仁, 川田哲史, 杉山弘恭, 橘元見, 中川晃志, 渡邊敦之, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 110th 2017

心肺停止に至ったQT短縮症候群の1例

山岡英功, 森田宏, 大塚寛昭, 戸田洋伸, 寺西仁, 杜徳尚, 中川晃志, 渡邊敦之, 西井伸洋, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 111th 2017

肺高血圧症患者の肺移植後右室リバースリモデリング:特異的肺動脈性肺高血圧症治療薬の併用療法後の検討

更科俊洋, 中村一文, 赤木達, 江尻健太郎, 中川晃志, 西井伸洋, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 110th 2017

ペースメーカリード抜去術後に発症した,たこつぼ心筋症の1例

寺西仁, 西井伸洋, 宮本真和, 森本芳正, 川田哲史, 更科俊洋, 高谷陽一, 杜徳尚, 中川晃志, 赤木達, 吉田賢司, 谷山真規子, 渡邊敦之, 三好亨, 赤木禎治, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 111th 2017

MRIで示唆された心筋障害部位への通電により房室副伝導路の離断,および持続性心室頻拍,心室性期外収縮を根治しえた1例

森本芳正, 中川晃志, 渡邊敦之, 川田哲史, 橘元見, 西井伸洋, 中村一文, 森田宏, 伊藤浩

心臓 49 2017

大動脈側周囲縁欠損心房中隔欠損症に対するカテーテル治療:Occlutech Figulla Flex IIの有用性

中川晃志, 赤木禎治, 高谷陽一, 中村一文, 森田宏, 伊藤浩

日本Pediatric Interventional Cardiology学会学術集会プログラム抄録集 28th 2017

His束近傍起源ATP感受性心房頻拍をentrainment pacingを指標に根治しえた1例

森本芳正, 中川晃志, 渡邊敦之, 川田哲史, 橘元見, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 110th 2017

Coronary Plaque Erosionが原因と考えられたAMIの1例

戸田洋伸, 網岡尚史, 吉田雅言, 中川晃志, 渡邉敦之, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 110th 2017

運動負荷試験中にwide QRS tachycardiaを来したBrugada症候群の1例

宮本真和, 森田宏, 森本芳正, 三好章仁, 川田哲史, 寺西仁, 中川晃志, 西井伸洋, 渡邊敦之, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 111th 2017

Late R’ Wave Axis of Complete Right Bundle Branch Block Represents Conduction Disturbance within Right Ventricle in Brugada Syndrome

森本芳正, 森田宏, 川田哲史, 橘元見, 中川晃志, 渡辺敦之, 西井伸洋, 中村一文, 伊藤浩

日本循環器学会学術集会(Web) 81st 2017

Measurement of epicardial fat thickness by transthoracic echocardiography for predicting high-risk coronary artery plaques

Motomi Tachibana, Toru Miyoshi, Kazuhiro Osawa, Norihisa Toh, Hiroki Oe, Kazufumi Nakamura, Takanori Naito, Shuhei Sato, Susumu Kanazawa, Hiroshi Ito

HEART AND VESSELS 31 ( 11 ) 1758 - 1766 2016.11

Language：English Publisher：SPRINGER

Epicardial adipose tissue (EAT) volume is reported to be associated with coronary plaques. We evaluated whether non-invasive measurement of EAT thickness by echocardiography can predict high-risk coronary plaque characteristics determined independently by coronary computed tomography (CT) angiography. We enrolled 406 patients (mean age 63 years, 57 % male) referred for 64-slice CT. EAT was measured on the right ventricle free wall from a parasternal long-axis view at the end of systole. High-risk coronary plaques were defined as low-density plaques (< 30 Hounsfield units) with positive remodeling (remodeling index > 1.05). Patients were divided into thin or thick EAT groups using a cutoff value derived from receiver operator characteristic curve analysis for discriminating high-risk plaques. The receiver operator characteristic cutoff value was 5.8 mm with a sensitivity of 83 % and specificity of 64 % (area under the curve 0.77, 95 % confidence interval 0.70-0.83, p < 0.01). Compared with the thin EAT group, the thick EAT group had a high prevalence of low-density plaques (4 vs. 24 %, p < 0.01), positive remodeling (39 vs. 60 %, p < 0.01), and high-risk plaques (3 vs. 17 %, p < 0.01). Multiple logistic analysis revealed that thick EAT was a significant predictor of high-risk plaques (odds ratio 7.98, 95 % confidence interval 2.77-22.98, p < 0.01) after adjustment for covariates, including conventional risk factors, visceral adipose tissue area, and medications. The measurement of EAT thickness by echocardiography may provide a non-invasive option for predicting high-risk coronary plaques.

DOI： 10.1007/s00380-016-0802-5

Intratracheal Administration of Prostacyclin Analogue-incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension

Satoshi Akagi, Kazufumi Nakamura, Hiromi Matsubara, Megumi Kondo, Daiji Miura, Tetsuya Matoba, Kensuke Egashira, Hiroshi Ito

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 67 ( 4 ) 290 - 298 2016.4

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

Nanoparticles (NPs) have been used as novel drug delivery systems. Drug-incorporated NPs for local delivery might optimize the efficacy and minimize the side effects of drugs. Intravenous prostacyclin improves long-term survival in patients with pulmonary arterial hypertension (PAH), but it causes serious side effects such as catheter-related infections. We investigated the efficacy and safety of intratracheal administration of a prostacyclin analogue, beraprost (BPS), incorporated NPs in Sugen-hypoxia-normoxia and monocrotaline rat models of PAH and in human PAH pulmonary arterial smooth muscle cells (PASMCs). After a single administration, BPS NPs significantly decreased right ventricular pressure, right ventricular hypertrophy, and pulmonary artery muscularization in the 2 rat models. BPS NPs significantly improved the survival rate in the monocrotaline rat model. No infiltration of inflammatory cells, hemorrhage, or fibrosis was found in the liver, kidney, spleen, and heart after the administration of BPS NPs. No liver or kidney dysfunction was found in the blood examinations. BPS and BPS NPs significantly inhibited the proliferation of human PAH PASMCs after 24 hours of treatment. BPS NPs significantly continued to inhibit the proliferation of human PAH PASMCs at 24 hours after the removal of BPS NPs. BPS NPs significantly induced apoptosis in PAH PASMCs compared to that in non-PAH PASMCs. Intratracheal administration of BPS NPs ameliorates pulmonary hypertension in PAH rat models by a sustained antiproliferative effect and a proapoptotic effect on PAH PASMCs.

DOI： 10.1097/FJC.0000000000000352

Association between coronary artery calcification and left ventricular diastolic dysfunction in elderly people

Kazuhiro Osawa, Toru Miyoshi, Hiroki Oe, Shuhei Sato, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Morita, Susumu Kanazawa, Hiroshi Ito

HEART AND VESSELS 31 ( 4 ) 499 - 507 2016.4

Language：English Publisher：SPRINGER

Coronary artery calcification (CAC) is associated with the incidence of congestive heart failure. We evaluated the association between CAC and left ventricular diastolic dysfunction (LVDD) in elderly patients without coronary artery disease. Coronary computed tomography was performed in 1,021 consecutive patients > 55 years of age who were suspected of having coronary artery disease. A total of 530 patients (age, 70 +/- A 8 years; 56 % men) with a LV ejection fraction > 50 % and without obstructive coronary artery disease and a history of coronary artery disease were included in the analysis. LVDD was defined according to a standard algorithm by echocardiography (septal e' < 8, lateral e' < 10, and left atrial volume index a parts per thousand yen34 mL/m(2)). A total of 224 of 530 patients had LVDD. CAC scores in patients with LVDD were higher than those in patients without LVDD (p < 0.01). The prevalence of LVDD in patients with CAC scores a parts per thousand yen400 was greater than that in patients with CAC scores of 0-9 (58 vs. 34 %, p < 0.01). After adjustment for confounding factors, the CAC score was associated with LVDD, with an odds ratio of 1.96 (95 % confidence interval: 1.11-3.43, p = 0.02) for a CAC score a parts per thousand yen400 compared with a CAC score of 0-9. A CAC score a parts per thousand yen400 was associated with LVDD in elderly patients without CAD in this population. Further prospective studies are needed to evaluate the clinical relevance of CAC as a risk of heart failure with preserved ejection fraction.

DOI： 10.1007/s00380-015-0645-5

Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension

Nobutoshi Nawa, Hidekazu Ishida, Shinichi Katsuragi, Hiroki Baden, Kunihiko Takahashi, Ryota Higeno, Fumiko Torigoe, Seiko Mihara, Jun Narita, Kohji Miura, Kazufumi Nakamura, Shigetoyo Kogaki, Keiichi Ozono

Molecular Therapy - Methods and Clinical Development 3 16044 - 16044 2016.3

Language：English Publisher：Elsevier Inc

We recently found a constitutively active mutant of natriuretic peptide receptor 2 (caNPR2
V883M), which synthesizes larger amounts of cyclic guanosine monophosphate (cGMP) intracellularly without any ligand stimulation than existing drugs. The aim of this study was to investigate the therapeutic effects of gene transduction using caNPR2 for pulmonary arterial hypertension (PAH). In vitro gene transduction into human pulmonary arterial smooth muscle cells using Sendai virus (SeV) vectors carrying caNPR2 induced 10,000-fold increases in the synthesis of cGMP without ligand stimulation, and the proliferation of caNPR2-expressing cells was significantly attenuated. The PAH model rats generated by hypoxia and the administration of SU5416 were then treated with SeV vectors through a direct injection into the left pulmonary artery. Right ventricular systolic pressure was significantly decreased 2 weeks after the treatment, while systemic blood pressure remained unchanged. Histological analyses revealed that the medial wall thickness and occlusion rate of pulmonary arterioles were significantly improved in caNPR2-treated lungs. Neither the systemic integration of virus vectors nor side effects were observed. The massive stimulation of cGMP synthesis by gene therapy with caNPR2 was safe and effective in a PAH rat model and, thus, has potential as a novel therapy for patients with severe progressive PAH.

DOI： 10.1038/mtm.2016.44

Postprandial hyperlipidemia as a potential residual risk factor

Kazufumi Nakamura, Toru Miyoshi, Kei Yunoki, Hiroshi Ito

JOURNAL OF CARDIOLOGY 67 ( 3-4 ) 335 - 339 2016.3

Language：English Publishing type：Book review, literature introduction, etc. Publisher：ELSEVIER SCIENCE BV

Statin therapy targeting reduction of low-density lipoprotein cholesterol (LDL-C) decreases the risk of coronary heart disease (CHD) and all-cause mortality. However, a substantial number of cases of CHD are not prevented and residual risk factors remain unsettled. A high triglyceride (TG) level is considered to be an important and residual risk factor. Postprandial hyperlipidemia is a condition in which TG-rich chylomicron remnants are increased during the postprandial period and hypertriglycedemia is protracted. Postprandial hyperlipidemia evokes atherogenesis during the postprandial period. Several prospective studies have revealed that nonfasting serum TG levels predict the incidence of CHD. Values of TG, remnant lipoprotein cholesterol, and remnant lipoprotein TG after fat loading were significantly higher in diabetes patients with insulin resistance than in diabetes patients without insulin resistance.
Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD. Postprandial hyperlipidemia (postprandial hypertriglyceridemia) is involved in the production of proinflammatory cytokines, recruitment of neutrophils, and generation of oxidative stress, resulting in endothelial dysfunction in healthy subjects, hypertriglyceridemic patients, or type 2 diabetic patients.
Effective treatment has not been established till date. Ezetimibe or omega-3 fatty acids significantly decrease postprandial TG elevation and postprandial endothelial dysfunction. Ezetimibe or omega-3 fatty acids added to statin therapy reduce serum TG levels and result in good outcomes in patients with CHD.
In conclusion, postprandial hyperlipidemia is an important and residual risk factor especially in patients with insulin resistance syndrome (metabolic syndrome) and diabetes mellitus. Further studies are needed to establish effective treatment. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jjcc.2015.12.001

Celsior preserves cardiac mechano-energetics better than University of Wisconsin solution by preventing oxidative stress

Takahiko Kiyooka, Yu Oshima, Waso Fujinaka, Gentaro Iribe, Juichiro Shimizu, Satoshi Mohri, Kazufumi Nakamura

INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY 22 ( 2 ) 168 - 175 2016.2

Language：English Publisher：OXFORD UNIV PRESS

OBJECTIVES: Identity of the optimal heart preservation solution remains unknown. Because oxidative stress contributes to contractile failure in the ischaemic/reperfused myocardium and the main characteristic of Celsior is its antioxidant effect, it is important to elucidate the relationship between the inhibitory effect on oxidative stress and cardiac mechano-energetics. We therefore evaluated the efficacy of Celsior from both aspects by comparison with the University of Wisconsin solution (UWS).
METHODS: We used 18 excised cross-circulated canine hearts. Excised hearts were preserved with UWS (n = 6) or Celsior (n = 6) for 3 h at 4 degrees C; the remaining six served as controls. Hearts were then cross-circulated and rewarmed. The end-systolic pressure-volume ratio (LV E-max) and the ventricular pressure-volume area, which is a measure of total mechanical energy, were assessed after reperfusion. Biopsies were taken from the endocardium after excising the heart, before reperfusion, after reperfusion and 4 h after reperfusion to assess the inhibitory effect of each agent on oxidative stress. Endo-myocardial biopsy samples were studied immunohistochemically for expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product.
RESULTS: E-max in the UWS group was significantly smaller than in the control group, whereas the E-max in the Celsior group was preserved. Oxygen cost of E-max in the UWS group was significantly higher than in the Celsior group. Myocardial HNE-modified protein levels increased gradually, both under preservation and after reperfusion in the UWS group. Myocardial HNE-modified protein levels in the Celsior group were lower, mainly before and 4 h after reperfusion compared with the UWS group.
CONCLUSIONS: Celsior may maintain cardiac contractility and conserve oxygen cost by inhibiting oxidative stress.

DOI： 10.1093/icvts/ivv324

Clinical characteristics of responders to treatment with tolvaptan in patients with acute decompensated heart failure: Importance of preserved kidney size

Hironobu Toda, Kazufumi Nakamura, Makoto Nakahama, Tadashi Wada, Atsuyuki Watanabe, Bkatsushi Hashimoto, Ritsuko Terasaka, Koji Tokioka, Nobuhiro Nishii, Toru Miyoshi, Kunihisa Kohno, Yusuke Kawai, Kohei Miyaji, Yuji Koide, Motomi Tachibana, Ryo Yoshioka, Hiroshi Ito

JOURNAL OF CARDIOLOGY 67 ( 1-2 ) 177 - 183 2016.1

Language：English Publisher：ELSEVIER SCIENCE BV

Background: Recent clinical trials have demonstrated the efficacy of short-term treatment with tolvaptan, an oral vasopressin V2 receptor antagonist, in patients with heart failure. However, the response to tolvaptan varies among patients. The aim of this study was to determine factors associated with response to tolvaptan in patients with acute decompensated heart failure (ADHF).
Methods: The Tolvaptan Registry, a prospective, observational, multicenter cohort study performed in Japan, aims to determine factors affecting the responsiveness of tolvaptan in patients with ADHF. We enrolled ADHF patients treated with tolvaptan and they were divided into two groups: responders and non-responders. Responders were defined as subjects who met all of the following three conditions: (1) increasing urine volume during a 24-hour period after the start of tolvaptan treatment; (2) improvement in New York Heart Association functional class; and (3) decrease in cardiothoracic ratio assessed by chest X-ray on day 3 of tolvaptan administration.
Results: Among the 114 patients, treatment with tolvaptan improved three conditions of heart failure in more than half of all the cohorts (71 patients, 62%). As for baseline characteristics, estimated glomerular filtration rate, urine osmolality, and kidney size were significantly greater in responders than in non responders. Multivariate logistic analysis revealed that kidney size was independently associated with responders (odds ratio: 1.083, p = 0.001, 95% confidence interval 1.031-1.137).
Conclusions: The main clinical characteristic of responders to treatment with tolvaptan is that kidney size is preserved. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.jjcc.2015.04.017

Treatment for pulmonary hypertension due to left heart diseases

Kazufumi Nakamura

HYPERTENSION RESEARCH 39 ( 1 ) 6 - 7 2016.1

PCPS管理にて経過良好で後遺症なく独歩退院できた劇症型心筋炎の一例

大塚寛昭, 中村一文, 網岡尚史, 木村朋生, 中川晃志, 赤木達, 笠原真悟, 清水一好, 渡邊謙, 伊藤浩

日本循環器学会中国地方会(Web) 109th 2016

肺高血圧症の基礎研究から臨床研究への橋渡し（共著）

中村一文, 赤木達

呼吸と循環 64 ( 6 ) 582 - 587 2016

Translational research on pulmonary hypertension（共著）

Kazufumi Nakamura, Satoshi Akagi

Respiration and Circulation 64 ( 6 ) 582 - 587 2016

Feasibility of repairing defects followed by treatment with pulmonary hypertension-specific drugs (repair and treat) in patients with pulmonary hypertension associated with atrial septal defect（共著）

Satoshi Akagi, Kazufumi Nakamura, Teiji Akagi, Koji Nakagawa, Yoichi Takaya, Toshihiro Sarashina, Kentaro Ejiri, Hiroshi Ito

Acta Medica Okayama, Acta. Medica Okayama, Acta medicinae Okayama, Acta medica Okayama 70 ( 5 ) 397 - 400 2016

初期スクリーニング・病態評価における心エコー検査の意義・現時点での限界・将来性（共著）

更科俊洋, 赤木達, 麻植浩樹, 中村一文, 伊藤浩

内科 117 ( 3 ) 383 - 390 2016

心拍数（共著）

杉山洋樹, 中村一文

日本臨床 74 ( 4 ) 284 - 287 2016

肥大型心筋症と診断されていたミトコンドリア心筋症の1例

小橋宗一郎, 中村一文, 木村朋生, 中川晃志, 西井伸洋, 三好亨, 森田宏, 伊藤浩, 小坂田宗倫, 大郷恵子

日本循環器学会中国地方会(Web) 109th 2016

右冠動脈ステント内閉塞を繰り返した冠動脈肉腫の一例

吉田雅言, 中村一文, 増田善逸, 中川晃志, 麻植浩樹, 赤木達, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 渡辺敦之, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 108th 2016

卵円孔開存による労作時低酸素血症を合併したEbstein奇形に対し経皮的閉鎖術を施行した一例

川名伸一, 三木崇史, 赤木禎治, 高谷陽一, 麻植浩樹, 中川晃志, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 108th 2016

家族性高コレステロール血症を背景としたPolyvascular diseaseに対して血行再建術を施行した1例

原田圭, 戸田洋伸, 赤木達, 中川晃志, 麻植浩樹, 吉田賢司, 谷山真規子, 渡邊敦之, 三好亨, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 109th 2016

治療に難渋した壊死性好酸球性心筋炎(一部巨細胞浸潤を伴う)の一例

小出祐嗣, 中村一文, 中川晃志, 麻植浩樹, 三好亨, 西井伸洋, 森田宏, 大澤晋, 笠原真悟, 山中俊明, 伊藤浩

日本循環器学会中国地方会(Web) 108th 2016

血管炎をbaseにした進行性の腎動脈狭窄に対して血管内治療を施行した1例

戸田洋伸, 江尻健太郎, 中川晃志, 渡邊敦之, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 109th 2016

家族性高コレステロール血症を基礎に持つ,下行大動脈狭窄に対してEVTを行った1例

戸田洋伸, 吉田雅言, 中川晃志, 西井伸洋, 渡邊敦之, 中村一文, 伊藤浩

脈管学(Web) 56 ( supplement ) 2016

治療開始20年後に再発を認めたカテコラミン誘発性多形性心室頻拍の一例

川北祝史, 森田宏, 上岡亮, 津島翔, 橘元見, 中川晃志, 三好亨, 渡辺敦之, 西井伸洋, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 108th 2016

左冠動脈主幹部に起始異常を認め物理的圧迫による心筋虚血にて長期間失神を繰り返した若年者の一症例

網岡尚史, 渡辺敦之, 大塚寛昭, 赤木達, 麻植浩樹, 中川晃志, 中村一文, 森田宏, 小谷恭弘, 新井禎彦, 笠原真悟, 佐野俊二, 伊藤浩

日本循環器学会中国地方会(Web) 109th 2016

Incidence and Clinical Significance of Brugada Syndrome Masked by Complete Right Bundle-Branch Block

Tadashi Wada, Satoshi Nagase, Hiroshi Morita, Koji Nakagawa, Nobuhiro Nishii, Kazufumi Nakamura, Kunihisa Kohno, Hiroshi Ito, Kengo F. Kusano, Tohru Ohe

CIRCULATION JOURNAL 79 ( 12 ) 2568 - + 2015.11

Language：English Publisher：JAPANESE CIRCULATION SOC

Background: Brugada syndrome (BrS)-type electrocardiogram (ECG) is concealed by complete right bundle-branch block (CRBBB) in some cases of BrS. Clinical significance of BrS masked by CRBBB is not well known.
Methods and Results: We reviewed an ECG database of 326 BrS patients who had type 1 ECG with or without pilsicainide. "BrS masked by CRBBB" was defined on ECG as <2-mm elevation of the J point at the time of CRBBB in the right precordial leads, and BrS-type J-point elevation >= 2 mm at the time of normalized QRS complex on relieved CRBBB. We identified 25 BrS patients (7.7%) with persistent (n=12) or intermittent CRBBB (n=13). Relief of CRBBB by pacing was performed in patients with persistent CRBBB. The prevalence of BrS masked by CRBBB was 3.1% (10/326 patients). Three patients had type 1 ECG, and 7 patients had type 2 or 3 ECG on relief of CRBBB. Two of these 10 patients had lethal arrhythmic events during the follow-up period (mean, 86.4+/-57.2 months). There was no prognostic difference between BrS masked by CRBBB and other BrS.
Conclusions: In a small BrS population, CRBBB can completely mask typical BrS-type ECG. BrS masked by CRBBB is associated with the same risk of fatal ventricular tachyarrhythmia as other BrS.

DOI： 10.1253/circj.CJ-15-0618

Prognostic significance of endothelial dysfunction in patients undergoing percutaneous coronary intervention in the era of drug-eluting stents

Motoki Kubo, Toru Miyoshi, Hiroki Oe, Yuko Ohno, Kazufumi Nakamura, Hiroshi Ito

BMC CARDIOVASCULAR DISORDERS 15 ( 1 ) 102 - 102 2015.9

Language：English Publisher：BIOMED CENTRAL LTD

Background: Endothelial function is a prognostic predictor in patients undergoing percutaneous coronary intervention (PCI). However, in an era with widespread use of drug-eluting stents, the clinical relevance of endothelial dysfunction on restenosis in patients undergoing PCI has not been fully evaluated.
Methods: This study included 80 patients with stable angina pectoris. Flow-mediated dilation (FMD) of the brachial artery was examined 1 week after PCI. Patients were retrospectively followed-up for an average of 21 months after PCI. The primary endpoints included cardiac death, nonfatal myocardial infarction, stroke, coronary revascularization, and critical limb ischemia.
Results: A drug-eluting stent was used in 58 patients and a cardiovascular event was recorded in 34 patients during follow-up. The incidence of all cardiovascular diseases was significantly greater in the low FMD (median FMD <4.2 %) than the high FMD (median FMD >= 4.2 %) group (60 % vs. 25 %, p <0.01). Furthermore, the incidence of coronary revascularization was significantly higher in the low than the high FMD group (p = 0.02), while the incidence of in-stent restenosis did not differ between the two groups. Cox regression analysis showed that low FMD was an independent predictor of cardiovascular events (hazard ratio: 2.77, 95 % confidence interval: 1.23 to 6.19, p = 0.01).
Conclusions: Impaired brachial artery FMD independently predicts long-term cardiovascular events after PCI in the era of drug-eluting stents.

DOI： 10.1186/s12872-015-0096-z

Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker

Yukihiro Saito, Kazufumi Nakamura, Masashi Yoshida, Hiroki Sugiyama, Tohru Ohe, Junko Kurokawa, Tetsushi Furukawa, Makoto Takano, Satoshi Nagase, Hiroshi Morita, Kengo F. Kusano, Hiroshi Ito

PLOS ONE 10 ( 9 ) e0138193-e0138193 2015.9

Language：English Publisher：PUBLIC LIBRARY SCIENCE

Background
Establishment of a biological pacemaker is expected to solve the persisting problems of a mechanical pacemaker including the problems of battery life and electromagnetic interference. Enhancement of the funny current (If) flowing through hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and attenuation of the inward rectifier K+ current (I-K1) flowing through inward rectifier potassium (K-ir) channels are essential for generation of a biological pacemaker. Therefore, we generated HCN4-overexpressing mouse embryonic stem cells (mESCs) and induced cardiomyocytes that originally show poor I-K1 currents, and we investigated whether the HCN4-overexpressing mESC-derived cardiomyocytes (mESC-CMs) function as a biological pacemaker in vitro.
Methods and Results
The rabbit Hcn4 gene was transfected into mESCs, and stable clones were selected. mESC-CMs were generated via embryoid bodies and purified under serum/glucose-free and lactate-supplemented conditions. Approximately 90% of the purified cells were troponin I-positive by immunostaining. In mESC-CMs, expression level of the Kcnj2 gene encoding K(ir)2.1, which is essential for generation of I-K1 currents that are responsible for stabilizing the resting membrane potential, was lower than that in an adult mouse ventricle. HCN4-overexpressing mESC-CMs expressed about a 3-times higher level of the Hcn4 gene than did non-overexpressing mESC-CMs. Expression of the Cacna1h gene, which encodes T-type calcium channel and generates diastolic depolarization in the sinoatrial node, was also confirmed. Additionally, genes required for impulse conduction including Connexin40, Connexin43, and Connexin45 genes, which encode connexins forming gap junctions, and the Scn5a gene, which encodes sodium channels, are expressed in the cells. HCN4-overexpressing mESC-CMs showed significantly larger I-f currents and more rapid spontaneous beating than did non-overexpressing mESC-CMs. The beating rate of HCN4-overexpressing mESC-CMs responded to ivabradine, an I-f inhibitor, and to isoproterenol, a beta-adrenergic receptor agonist. Co-culture of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with aggregates composed of mESC-CMs resulted in synchronized contraction of the cells. The beating rate of hiPSC-CMs co-cultured with aggregates of HCN4-overexpressing mESC-CMs was significantly higher than that of nontreated hiPSC-CMs and that of hiPSC-CMs co-cultured with aggregates of non-overexpressing mESC-CMs.
Conclusions
We generated HCN4-overexpresssing mESC-CMs expressing genes required for impulse conduction, showing rapid spontaneous beating, responding to an I-f inhibitor and beta-adrenergic receptor agonist, and having pacing ability in an in vitro co-culture system with other excitable cells. The results indicated that these cells could be applied to a biological pacemaker.

DOI： 10.1371/journal.pone.0138193

Impact of Ezetimibe Alone or in Addition to a Statin on Plasma PCSK9 Concentrations in Patients with Type 2 Diabetes and Hypercholesterolemia: A Pilot Study

Toru Miyoshi, Keigo Nakamura, Masayuki Doi, Hiroshi Ito

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS 15 ( 3 ) 213 - 219 2015.6

Language：English Publisher：ADIS INT LTD

Background and Aim The increase in proprotein convertase subtilisin/kexin type 9 (PCSK9) leads to low-density lipoprotein (LDL) receptor degradation. Statins significantly reduce LDL-cholesterol levels, but upregulate PCSK9. This study evaluated the effect of ezetimibe monotherapy or ezetimibe in combination with a statin on serum levels of PCSK9 in patients with type 2 diabetes and hypercholesterolemia.
Methods Ezetimibe treatment was given to ten patients with diabetes without statin therapy and ten patients with statin therapy. Plasma levels of PCSK9 were examined at baseline and 24 weeks after treatment.
Results At baseline, PCSK9 concentrations in patients with statin therapy were significantly higher than those in patients without statin use and in control subjects [median (25th-75th percentile) 411 (272-467) and 382 (356-453) ng/mL, respectively, p<0.01]. After ezetimibe treatment for 24 weeks, LDL-cholesterol, triglyceride and remnant-like lipoprotein cholesterol were significantly decreased in both groups. However, PCSK9 concentration did not change compared with baseline measurements in both groups. The percentage change in LDL-cholesterol after ezetimibe therapy for 24 weeks was not correlated with the percentage change in PCSK9 concentration.
Conclusion Ezetimibe may reduce LDL-cholesterol levels without affecting PCSK9 in patients with type 2 diabetes and hypercholesterolemia.

DOI： 10.1007/s40256-015-0119-2

Nonalcoholic Hepatic Steatosis Is a Strong Predictor of High-Risk Coronary-Artery Plaques as Determined by Multidetector CT

Kazuhiro Osawa, Toru Miyoshi, Kentarou Yamauchi, Yasushi Koyama, Kazufumi Nakamura, Shuhei Sato, Susumu Kanazawa, Hiroshi Ito

PLOS ONE 10 ( 6 ) e0131138-e0131138 2015.6

Language：English Publisher：PUBLIC LIBRARY SCIENCE

Background
Nonalcoholic fatty liver disease is associated with a risk of coronary artery disease (e.g., diabetes mellitus, dyslipidemia, metabolic syndrome). We evaluated whether nonalcoholic hepatic steatosis is associated with high-risk plaques as assessed by multidetector computed tomography (CT).
Methods
This retrospective study involved 414 participants suspected of having coronary artery disease. Nonalcoholic hepatic steatosis was defined as a liver-to-spleen fat ratio of <1.0 and the presence and appropriate characteristics of coronary-artery plaques as assessed by coronary CT angiography. High-risk plaques were identified, as were low-density plaques, positive remodeling, and spotty calcification.
Results
Compared with patients who did not have nonalcoholic hepatic steatosis, patients with nonalcoholic hepatic steatosis had more low-density plaques (21% vs. 44%, p<0.01), positive remodeling (41% vs. 58%, p = 0.01), and spotty calcification (12% vs. 36%, p<0.01). The number of high-risk plaques in patients with nonalcoholic hepatic steatosis was greater than in those without nonalcoholic hepatic steatosis (p<0.01). Patients with nonalcoholic hepatic steatosis were more likely to have high-risk plaques than were those with only an elevated level of visceral adipose tissue (>= 86 cm(2); 35% vs. 16%, p<0.01). Multivariate analyses that included nonalcoholic hepatic steatosis, amount of visceral adipose tissue, and the presence/absence of traditional risk factors demonstrated that nonalcoholic hepatic steatosis was an independent predictor of high-risk plaques (odds ratio: 4.60; 95% confidence interval: 1.94-9.07, p<0.01).
Conclusions
Diagnosis of nonalcoholic hepatic steatosis may be of value when assessing the risk of coronary artery disease.

DOI： 10.1371/journal.pone.0131138

Comparison of effects of sitagliptin and voglibose on left ventricular diastolic dysfunction in patients with type 2 diabetes: results of the 3D trial

Hiroki Oe, Kazufumi Nakamura, Hajime Kihara, Kenei Shimada, Shota Fukuda, Tsutomu Takagi, Toru Miyoshi, Kumiko Hirata, Junichi Yoshikawa, Hiroshi Ito

CARDIOVASCULAR DIABETOLOGY 14 83 - 83 2015.6

Language：English Publisher：BIOMED CENTRAL LTD

Background: Left ventricular ( LV) diastolic dysfunction is frequently observed in patients with type 2 diabetes. Dipeptidyl peptidase-4 inhibitor ( DPP-4i) attenuates postprandial hyperglycemia ( PPH) and may have cardio-protective effects. It remains unclear whether DPP-4i improves LV diastolic function in patients with type 2 diabetes, and, if so, it is attributable to the attenuation of PPH or to a direct cardiac effect of DPP-4i. We compared the effects of the DPP-4i, sitagliptin, and the alpha-glucosidase inhibitor, voglibose, on LV diastolic function in patients with type 2 diabetes.
Methods: We conducted a prospective, randomized, open-label, multicenter study of 100 diabetic patients with LV diastolic dysfunction. Patients received sitagliptin ( 50 mg/day) or voglibose ( 0.6 mg/day). The primary endpoints were changes in the e' velocity and E/e' ratio from baseline to 24 weeks later. The secondary efficacy measures included HbA1c, GLP-1, lipid profiles, oxidative stress markers and inflammatory markers.
Results: The study was completed with 40 patients in the sitagliptin group and 40 patients in the voglibose group. There were no significant changes in the e' velocity and E/e' ratio from baseline to 24 weeks later in both groups. However, analysis of covariance demonstrated that pioglitazone use is an independent factor associated with changes in the e' and E/e' ratio. Among patients not using pioglitazone, e' increased and the E/e' ratio decreased in both the sitagliptin and voglibose groups. GLP-1 level increased from baseline to 24 weeks later only in the sitagliptin group ( 4.8 +/- 4.7 vs. 7.3 +/- 5.5 pmol/L, p < 0.05). The reductions in HbA1c and body weight were significantly greater in the sitagliptin group than in the voglibose group (-0.7 +/- 0.6 % vs. -0.3 +/- 0.4, p < 0.005; -1.3 +/- 3.2 kg vs. 0.4 +/- 2.8 kg, p < 0.05, respectively). There were no changes in lipid profiles and inflammatory markers in both groups.
Conclusions: Our trial showed that sitagliptin reduces HbA1c levels more greatly than voglibose does, but that neither was associated with improvement in the echocardiographic parameters of LV diastolic function in patients with diabetes.

DOI： 10.1186/s12933-015-0242-z

Comparison of Outcomes in Patients With Probable Versus Definite Cardiac Sarcoidosis

Yoichi Takaya, Kengo F. Kusano, Kazufumi Nakamura, Hiroshi Ito

AMERICAN JOURNAL OF CARDIOLOGY 115 ( 9 ) 1293 - 1297 2015.5

Language：English Publisher：EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

Patients with probable cardiac sarcoidosis (CS) who satisfy only clinical cardiac findings for CS are not uncommon. The aim of this study was to compare outcomes between patients with probable CS and those with definite CS treated with steroids. The study population consisted of 101 consecutive patients who satisfied clinical cardiac findings for CS. Patients with definite CS were defined as having histologic or clinical confirmation of CS according to the guidelines and were treated with steroids. Patients with probable CS were defined as having only clinical cardiac findings but not definite CS because of no histologic confirmation or extracardiac sarcoidosis and were not treated with steroids. The end point was major adverse cardiac events. Forty-seven patients had definite CS, and the other 54 had probable CS. Except for serum angiotensin-converting enzyme levels and left ventricular dysfunction, clinical characteristics were similar between the 2 groups. Over a median follow-up period of 15 months, major adverse cardiac events occurred more frequently in patients with probable CS than in those with definite CS (74% vs 53%, p = 0.029). The event-free survival rate was worse in patients with probable CS than in those with definite CS (log-rank test, p = 0.006). Cox proportional-hazards analysis showed that probable CS was an independent predictor of major adverse cardiac events. In conclusion, outcomes were worse in patients with probable CS than in those with definite CS treated with steroids. The initiation of steroid treatment may be considered for patients who satisfy only clinical cardiac findings for CS. (C) 2015 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.amjcard.2015.01.562

Outcomes in Patients With High-Degree Atrioventricular Block as the Initial Manifestation of Cardiac Sarcoidosis

Yoichi Takaya, Kengo Fukushima Kusano, Kazufumi Nakamura, Hiroshi Ito

AMERICAN JOURNAL OF CARDIOLOGY 115 ( 4 ) 505 - 509 2015.2

Language：English Publisher：EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC

Although high-degree atrioventricular block (AVB) is a common initial manifestation of cardiac sarcoidosis, little is known about the outcomes. The aim of this study was to assess outcomes in patients with AVB as an initial manifestation of cardiac sarcoidosis compared with those in patients with ventricular tachyarrhytlunia (VT) and/or heart failure (HF). Fifty-three consecutive patients with cardiac sarcoidosis, who had high-degree AVB (n = 22) or VT and/or HF (n = 31), were enrolled. The end point was defined as major adverse cardiac events, including cardiac death, ventricular fibrillation, sustained VT, and hospitalization for HF. Over a median follow-up period of 34 months, the outcomes of major adverse cardiac events were better in patients with high-degree AVB than in those with VT and/or HF (log-rank test, p = 0.046). However, this difference was due mainly to HF hospitalization. The outcomes of fatal cardiac events, including cardiac death, ventricular fibrillation, and sustained VT, were comparable between the 2 groups (log-rank test, p = 0.877). The fatal cardiac events in patients with high-degree AVB were not associated with the initiation of steroid treatment or left ventricular dysfunction. In conclusion, the outcomes of major adverse cardiac events are better in patients with high-degree AVB than in those with VT and/or HF. However, patients with high-degree AVB have a high rate of fatal cardiac events, similar to those with VT and/or HF. An indication for an implantable cardioverter-defibrillator, but not a pacemaker system, can be considered in patients with cardiac sarcoidosis manifested by high-degree AVB. (C) 2015 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.amjcard.2014.11.028

Remote ischemic preconditioning reduces contrast-induced acute kidney injury in patients with ST-elevation myocardial infarction: A randomized controlled trial

Toshiaki Yamanaka, Yusuke Kawai, Toru Miyoshi, Tsutomu Mima, Kenji Takagaki, Saori Tsukuda, Yukio Kazatani, Kazufumi Nakamura, Hiroshi Ito

INTERNATIONAL JOURNAL OF CARDIOLOGY 178 136 - 141 2015.1

Language：English Publisher：ELSEVIER IRELAND LTD

Background: Contrast medium-induced acute kidney injury (CI-AKI) is a cardiovascular complication after myocardial infarction treated with emergency percutaneous coronary intervention. The aim of this randomized, sham-controlled trial was to evaluate the impact of remote ischemic preconditioning (RIPC) on CI-AKI in patients with ST-elevation myocardial infarction who received emergency primary percutaneous coronary intervention.
Methods and results: Patients with a suspected ST-elevation myocardial infarction were randomly assigned at a 1: 1 ratio to receive percutaneous coronary intervention eitherwith (n = 63) or without (n = 62) RIPC (intermittent arm ischemia through three cycles of 5 min of inflation and 5 min of deflation of a blood pressure cuff). A total of 47 RIPC patients and 47 control patients met all study criteria. The primary endpoint was the incidence of CI-AKI, which was defined as an increase in serum creatinine >0.5 mg/dL or N25% over the baseline value 48-72 h after administration of contrast medium. The incidence of CI-AKI was 10% (n = 5) in the RIPC group and 36% (n = 17) in the control group (p = 0.003). The odds ratio of CI-AKI in patients who received RIPC was 0.18 (95% confidence interval: 0.05-0.64; p = 0.008).
Conclusions: In patients with ST-elevation myocardial infarction, RIPC before percutaneous coronary intervention reduced the incidence of CI-AKI. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijcard.2014.10.135

ナノ粒子を用いたDrug Delivery System(共著）

赤木達, 中村一文

Medical Practice 32 ( 12 ) 2001 - 2003 2015

右室機能を考えなおす右室後負荷は、どのくらい重要か(共著）

中村一文, 時岡浩二, 更科俊洋, 赤木達, 伊藤浩

呼吸と循環 63 ( 8 ) S19-S20 2015

日本から世界に向けて肺高血圧症の基礎研究をどう発信していくか? PGI2封入ナノ粒子を用いた肺高血圧症の新規治療法(共著）

赤木達, 中村一文, 更科俊洋, 江頭健輔, 伊藤浩

呼吸と循環 63 ( 8 ) S12-S12 2015

特発性・遺伝性肺動脈性肺高血圧症に対する薬物治療(共著）

中村一文, 更科俊洋, 江尻健太郎, 赤木達

Angiology Frontier 14 ( 2 ) 11 - 17 2015

門脈圧亢進症の病態と治療基礎から臨床へ門脈圧亢進症における心肺機能と酸化ストレスについての検討(共著）

高木章乃夫, 寺尾正子, 安中哲也, 白羽英則, 中村進一郎, 麻植浩樹, 中村一文, 岡田裕之

日本門脈圧亢進症学会雑誌 21 ( 3 ) 67 - 67 2015

肺高血圧症患者におけるドプラ法を用いた肺血管抵抗推定の有用性(共著）

麻植浩樹, 池田まどか, 赤木達, 大野佑子, 更科俊洋, 渡辺修久, 中村一文, 森田宏, 伊藤浩

呼吸と循環 63 ( 8 ) S42-S42 2015

Basiginは血管平滑筋細胞増殖を促進し、肺高血圧症を悪化させる(共著）

佐藤公雄, 鈴木康太, 大村淳一, 菊池順裕, 矢尾板信裕, 杉村宏一郎, 福本義弘, 中村一文, 伊藤浩, 下川宏明

呼吸と循環 63 ( 8 ) S35-S36 2015

肺高血圧症の血管リモデリングとその治療(共著）

中村一文, 更科俊洋, 赤木達

呼吸と循環 63 ( 8 ) S30-S30 2015

A case of cardiac amyloidosis with ventricular flutter of first symptom

Ono Tamaki, Morita Hiroshi, Kimura Tomonari, Tokioka Koji, Nakagawa Kouji, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazuhumi, Ito Hiroshi, Tanaka Takehiro, Yanai Hiroyuki, Ando Midori, Yutani Chikao

Shinzo 47 ( suppl-1 ) 33 - 37 2015

肺高血圧症～肺高血圧症におけるバイオマーカー測定の意義～(共著）

更科俊洋, 江尻健太郎, 赤木達, 中村一文

Heart View 19 ( 12 ) 77 - 82 2015

目でみる肺高血圧症肺高血圧症の電子顕微鏡像(共著）

中村一文, 赤木達, 三浦綾, 伊藤浩

Pulmonary Hypertension Update 1 ( 2 ) 4 - 8 2015

巨大右室を必須緩徐伝導路とするマクロリエントリー性心室頻拍を合併した成人Ebstein奇形の一例(共著）

永瀬聡, 中川晃志, 久保元基, 上岡亮, 高谷陽一, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本成人先天性心疾患学会雑誌 4 ( 1 ) 172 - 172 2015

心房中隔欠損症患者における心房細動カテーテルアブレーション後の欠損孔の変化(共著）

中川晃志, 赤木禎治, 永瀬聡, 高谷陽一, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本成人先天性心疾患学会雑誌 4 ( 1 ) 118 - 118 2015

重症不整脈源性右室心筋症に対するFontan手術の検討(共著）

三好章仁, 永瀬聡, 中川晃志, 久保元基, 上岡亮, 西井伸洋, 中村一文, 森田宏, 伊藤浩, 佐野俊二

日本成人先天性心疾患学会雑誌 4 ( 1 ) 107 - 107 2015

肺高血圧に対する薬物治療(共著）

更科俊洋, 斎藤幸弘, 中村一文

Heart View 19 ( 3 ) 76 - 82 2015

一瀬論文に対するEditorial Comment

中村一文

心臓 47 ( 9 ) 1117 - 1117 2015

動脈グラフト周囲脂肪の炎症に関する検討(共著）

横田武典, 三隅祐輔, 桝田浩禎, 時岡浩二, 中村一文, 伊藤浩, 正井崇史

日本心臓血管外科学会雑誌 44 ( suppl ) 380 - 380 2015

心臓サルコイドーシスにおける加算平均心電図による心室遅延電位 (LP : Late Potential) の特徴(共著）

寒川睦子, 森田宏, 中川晃志, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 伊藤浩, 草野研吾, 大江透

心電図 35 ( suppl-1 ) 5023 - 5023 2015

肺動脈性肺高血圧症治療剤「マシテンタン（オプスミットR錠）」のインパクト(共著）

更科俊洋, 赤木達, 中村一文

PHARM STAGE 15 ( 5 ) 35 - 39 2015

肺高血圧を伴う心房中隔欠損症例の経カテーテル閉鎖術の治療効果(共著）

渡辺修久, 麻植浩樹, 赤木禎治, 更科俊洋, 高谷陽一, 木島康文, 赤木達, 中村一文, 岡田健, 伊藤浩

呼吸と循環 63 ( 8 ) S53-S54 2015

ボセンタン継続例とアンブリセンタンへ変更例での治療効果の検討(共著）

更科俊洋, 赤木達, 麻植浩樹, 中村一文, 伊藤浩

呼吸と循環 63 ( 8 ) S42-S42 2015

循環器病の診断と治療に関するガイドライン(2008年度合同研究班報告)【ダイジェスト版】急性および慢性心筋炎の診断・治療に関するガイドライン(2009年改訂版)(共著）

和泉徹, 磯部光章, 河合祥雄, 川名正敏, 木村一雄, 許俊鋭, 小玉誠, 佐地勉, 廣江道昭, 松崎益徳, 松森昭, 森本紳一郎, 由谷親夫, 石井正浩, 猪又孝元, 奥村謙, 倉林正彦, 友池仁暢, 今中(吉田)恭子, 植田初江, 大倉裕二, 岡本洋, 佐藤衛, 塩井哲雄, 高野博之, 寺崎文生, 中村一文, 中村浩士, 西尾亮介, 西川俊郎, 布田伸一, 矢崎善一, 吉川勉, 山科章, 吉村道博

日本心臓血管外科学会雑誌 44 ( 5 ) 1 - 9 2015

Delivery of imatinib-incorporated nanoparticles into lungs suppresses the development of monocrotaline-induced pulmonary arterial hypertension(共著）

Akagi S, Nakamura K, Miura D, Saito Y, Matsubara H, Ogawa A, Matoba T, Egashira K, Ito H

Int Heart J 56 ( 3 ) 354 - 359 2015

Epoprostenol sodium for treatment of pulmonary arterial hypertension. International journal

Yukihiro Saito, Kazufumi Nakamura, Satoshi Akagi, Toshihiro Sarashina, Kentaro Ejiri, Aya Miura, Aiko Ogawa, Hiromi Matsubara, Hiroshi Ito

Vascular health and risk management 11 265 - 70 2015

Language：English

The release of endogenous prostacyclin (PGI2) is depressed in patients with pulmonary arterial hypertension (PAH). PGI2 replacement therapy by epoprostenol infusion is one of the best treatments available for PAH. Here, we provide an overview of the current clinical data for epoprostenol. Epoprostenol treatment improves symptoms, exercise capacity, and hemodynamics, and is the only treatment that has been shown to reduce mortality in patients with idiopathic PAH (IPAH) in randomized clinical trials. We have reported that high-dose epoprostenol therapy (>40 ng/kg/min) also results in marked hemodynamic improvement in some patients with IPAH. High-dose epoprostenol has a pro-apoptotic effect on PAH-PASMCs via the IP receptor and upregulation of Fas ligand (FasL) in vitro. However, long-term intravenous administration of epoprostenol is sometimes associated with catheter-related infections and leads to considerable inconvenience for the patient. In the future, the development of new routes of administration or the development of powerful PGI2 analogs, IP-receptor agonists, and gene and cell-based therapy enhancing PGI2 production with new routes of administration is required.

DOI： 10.2147/VHRM.S50368

Epoprostenol Therapy for Pulmonary Arterial Hypertension(共著）

Akagi S, Nakamura K, Matsubara H, Ogawa A, Sarashina T, Ejiri K, Ito H

Acta Med Okayama 69 ( 3 ) 129 - 136 2015

左室内血栓を伴い,心筋への好酸球顆粒の沈着にて診断された好酸球性心内膜炎の一例

木村朋生, 中村一文, 橘元見, 中川晃志, 麻植浩樹, 森田宏, 伊藤浩, 安藤翠, 田中健大, 大郷恵子

日本血管生物医学会学術集会プログラム・抄録集 23rd 2015

3cm大のvegetationを認めるも開胸することなく全抜去に成功したデバイス感染の一例

三好章仁, 西井伸洋, 久保元基, 中川晃志, 永瀬聡, 中村一文, 森田宏, 伊藤浩, 宮本陽介, 笠原真悟, 佐野俊二

日本循環器学会中国地方会(Web) 106th 2015

化学・放射線療法が奏功した原発性肺動脈血管内膜肉腫の1症例

山中俊明, 中川晃志, 西井伸洋, 中村一文, 豊田容輔, 田端雅弘, 伊藤浩

日本循環器学会中国地方会(Web) 106th 2015

当院で経験したPaget-Schroetter syndrome(PSS)の2例

小野環, 戸田洋伸, 中川晃志, 西井伸洋, 三好亨, 森田宏, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 106th 2015

ファロー四徴症術後遠隔期にカテコラミン誘発性多形性心室頻拍の合併が疑われICD植込みを行った1例

橘元見, 森田宏, 西井伸洋, 上岡亮, 中川晃志, 永瀬聡, 中村一文, 伊藤浩, 重光裕輔, 永徳隆裕, 大月審一, 笠原真吾, 佐野俊二

日本循環器学会中国地方会(Web) 106th 2015

先天性QT延長症候群の小児に対しICD植込みを行った1例

杉山博太郎, 橘元見, 森田宏, 上岡亮, 中川晃志, 西井伸洋, 永瀬聡, 中村一文, 伊藤浩, 重光裕輔, 永徳隆裕, 大月審一, 笠原真吾, 佐野俊二

日本循環器学会中国地方会(Web) 106th 2015

platypnea-orthodeoxia syndromeの患者に対して精査し,肝肺症候群・動静脈瘻に起因すると考えられた一例。

川北祝史, 高谷陽一, 中川晃志, 赤木禎治, 麻植浩樹, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 106th 2015

Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats.（共著）

Miyoshi T, Nakamura K, Yoshida M, Miura D, Oe H, Akagi S, Sugiyama H, Akazawa K, Yonezawa T, Wada J, Ito H

Cardiovasc Diabetol. 13 43 - 43 2014

DPP-4 inhibitor and alpha-glucosidase inhibitor equally improve endothelial function in patients with type 2 diabetes: EDGE study.（共著）

Nakamura K, Oe H, Kihara H, Shimada K, Fukuda S, Watanabe K, Takagi T, Yunoki K, Miyoshi T, Hirata K, Yoshikawa J, Ito H

Cardiovasc Diabetol. 13 110 - 110 2014

心サルコイドーシスに対しステロイドパルス療法が有効だった一例

木村朋生, 中村一文, 西井伸洋, 時岡浩二, 三好章仁, 中川晃志, 吉田賢司, 麻植浩樹, 谷山麻規子, 三好亨, 永瀬聡, 河野晋久, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 104th 2014

両大血管右室起始・Fontan術後でチアノーゼが残存している挙児希望をもつ女性に対するアセスメントについて

越智香織, 戸田洋伸, 中川晃志, 赤木達, 河合勇介, 杉山洋樹, 吉田賢司, 谷山真規子, 麻植浩樹, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩, 笠原真悟, 赤木禎治, 佐野俊二

日本循環器学会中国地方会(Web) 104th 2014

冠攣縮性狭心症が原因と疑われた心肺停止蘇生例にICD植込み術を施行した1例

杉山弘恭, 西井伸洋, 三好章仁, 久保元基, 中川晃志, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 104th 2014

エキシマレーザーと開心術で,感染デバイス抜去術とTOF完全修復術を施行した1例

三好章仁, 西井伸洋, 久保元基, 木島康文, 中川晃志, 森田宏, 中村一文, 伊藤浩, 増田善逸, 笠原真悟, 佐野俊二, 庄田守男

日本循環器学会中国地方会(Web) 104th 2014

幼少時に心室細動にて蘇生歴があり,挙児希望のある女性に対する治療方針は?

戸田洋伸, 森田宏, 中川晃志, 赤木達, 河合勇介, 杉山洋樹, 吉田賢司, 麻植浩樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩, 平松茂樹

日本循環器学会中国地方会(Web) 104th 2014

当院における植え込み型デバイスリード抜去の経験

西井伸洋, 久保元基, 三好章仁, 時岡浩二, 木島康文, 中川晃志, 永瀬聡, 中村一文, 森田宏, 河野晋久, 伊藤浩, 増田善逸, 笠原真悟, 佐野俊二, 庄田守男

日本循環器学会中国地方会(Web) 104th 2014

Treat and Repairに成功した重症肺高血圧症を合併した心房中隔欠損症の1例

更科俊洋, 赤木禎治, 高谷陽一, 中川晃志, 赤木達, 麻植浩樹, 西井伸洋, 中村一文, 伊藤浩, 風谷幸男

日本循環器学会中国地方会(Web) 105th 2014

ブルガダ症候群との合併例と考えられた先天性QT延長症候群(LQT3)の1例

橘元見, 森田宏, 上岡亮, 三好章仁, 久保元基, 中川晃志, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

Pilsicainid負荷試験にて著明なQRSの延長を示し,経時的に増悪がみられたBrugada症候群の一例

松本菜見子, 上岡亮, 森田宏, 杉山弘恭, 久保元基, 中川晃志, 三好亨, 西井伸洋, 永瀬聡, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 104th 2014

酵素補充療法により病理学的な変化の有無を確認できたファブリー病の1例

杉山弘恭, 時岡浩二, 中川晃志, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 中村陽一, 由谷親夫, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

繰り返す失神を主訴とする右腕頭動脈狭窄に対して血管内治療を施行した1例

戸田洋伸, 河合勇介, 江尻健太郎, 山中俊明, 中川晃志, 麻植浩樹, 赤木達, 吉田賢司, 杉山洋樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

心房中隔欠損症に合併した心房細動に対するカテーテルアブレーションの有用性

中川晃志, 赤木禎治, 永瀬聡, 木島康文, 河野晋久, 中村一文, 森田宏, 佐野俊二, 伊藤浩

日本成人先天性心疾患学会雑誌(Web) 3 ( 1 ) 2014

両心室ペーシング(CRT)により心機能の改善を得た修正大血管転位の1例

越智香織, 戸田洋伸, 河合勇介, 中川晃志, 麻植浩樹, 赤木達, 吉田賢司, 杉山洋樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 105th 2014

ハイリスク症例に対するペースメーカーリード抜去術について

久保元基, 西井伸洋, 河合勇介, 中川晃志, 永瀬聡, 河野晋久, 中村一文, 森田宏, 伊藤浩, 増田善逸, 佐野俊二, 竹中祐樹

日本循環器学会中国地方会(Web) 104th 2014

Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-bridge Formation in Hypertrophied Rat Hearts

Kazufumi Nakamura, Hironobu Toda, Toru Miyoshi, Hiroshi Ito

JOURNAL OF CARDIAC FAILURE 19 ( 10 ) S121 - S121 2013.10

Increased Passive Stiffness of Cardiomyocytes in the Transverse Direction and Residual Actin and Myosin Cross-Bridge Formation in Hypertrophied Rat Hearts Induced by Chronic beta-Adrenergic Stimulation

Wakako Sumita Yoshikawa, Kazufumi Nakamura, Daiji Miura, Juichiro Shimizu, Ken Hashimoto, Noriyuki Kataoka, Hiroko Toyota, Hiroshi Okuyama, Toru Miyoshi, Hiroshi Morita, Kengo Fukushima Kusano, Tatsuhito Matsuo, Miyako Takaki, Fumihiko Kajiya, Naoto Yagi, Tohru Ohe, Hiroshi Ito

CIRCULATION JOURNAL 77 ( 3 ) 741 - 748 2013.3

Language：English Publisher：JAPANESE CIRCULATION SOC

Background: Left ventricular (LV) hypertrophy is often present in patients with diastolic heart failure. However, stiffness of hypertrophied cardiomyocytes in the transverse direction has not been fully elucidated. The aim of this study was to assess passive cardiomyocyte stiffness of hypertrophied hearts in the transverse direction and the influence of actin-myosin cross-bridge formation on the stiffness.
Methods and Results: Wistar rats received a vehicle (control) or isoproterenol (ISO) subcutaneously. After 7 days, compared with the controls, ISO administration had significantly increased heart weight and LV wall thickness and had decreased peak early annular relaxation velocity (e') assessed by echocardiography. Elastic modulus of living cardiomyocytes in the transverse direction assessed by an atomic force microscope was significantly higher in the ISO group than in controls. We added butanedione monoxime (BDM), an inhibitor of actin-myosin interaction, and blebbistatin, a specific myosin II inhibitor, to the medium. BDM and blebbistatin significantly reduced the elastic modulus of cardiomyocytes in the ISO group. X-ray diffraction analysis showed that the reflection intensity ratio (I-(1,I-0)/I-(1,I-1)) at diastole was not different before and after treatment with BDM, which induces complete relaxation, in control hearts, but that I-(1,I-0)/I-(1,I-1) was significantly increased after BDM treatment in the ISO group, indicating residual cross-bridge formation in hypertrophied hearts.
Conclusions: Passive cardiomyocyte stiffness in the transverse direction is increased in hearts with ISO-induced hypertrophy and this is caused by residual actin-myosin cross-bridge formation. (Circ J 2013; 77: 741-748)

DOI： 10.1253/circj.CJ-12-0779

心臓からみた心腎連関 (特集心腎連鎖の克服を目指した糖尿病腎症の治療) -- (心腎連関とは)

新薬の最近の話題イマチニブ

中村一文, 赤木達, 伊藤浩

分子呼吸器病 17 ( 1 ) 118 - 120 2013.3

カテコラミン誘発性多形性心室頻拍1家系3人

田渕勲, 草野研吾, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 伊藤浩, 増田拓郎, 高石篤志

日本循環器学会中国地方会(Web) 102nd 2013

流出路起源を示す心電図波形でValsalva洞から離れた左室前中隔心内膜側での焼灼が有効であった特発性心室頻拍の1例

和田匡史, 永瀬聡, 中川晃志, 西井伸洋, 河野晋久, 森田宏, 中村一文, 伊藤浩

日本不整脈学会カテーテルアブレーション委員会公開研究会プログラム・抄録集 25th 2013

濃厚な家族歴を有し,神経疾患及び冠攣縮性狭心症を合併したProgressive Cardiac Conduction Diseaseの1例

戸田洋伸, 森田宏, 杉山洋樹, 中川晃志, 麻植浩樹, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 伊藤浩

日本循環器学会中国地方会(Web) 103rd 2013

Hedgehog Interacting Protein Controls Age-Dependent Angiogenic Activity in Human Cardiac Progenitor Cells Through Insulin-Like Growth Factor-1 Receptor Signaling

Masashi Yoshida, Suguru Tarui, Junko Kobayashi, Masataka Hirata, Yasufumi Kijima, Tohru Miyoshi, Kazufumi Nakamura, Kengo Kusano, Youhei Maeshima, Shunji Sano, Hiroshi Ito, Hidemasa Oh

CIRCULATION 126 ( 21 ) 2012.11

SIGNIFICANCE OF IMIDAPRIL IN THE DIRECT INHIBITION OF MATRIX METALLOPROTEINASES IN EXPEIMENTAL ABDOMINAL AORTIC ANEURYSM; COMPARISON WITH LOSARTAN

Toru Miyoshi, Kazufumi Nakamura, Hiroshi Morita, Kengo Kusano, Hiroshi Ito

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 59 ( 13 ) E2061 - E2061 2012.3

中村一文, 伊藤浩

糖尿病 4 ( 2 ) 21 - 24 2012.2

Characteristics of pulmonary artery smooth muscle cells and endothelial cells in IPAH

240 ( 1 ) 36 - 40 2012.1

Treatment with Imatinib for Refractory IPAH

60 ( 1 ) 27 - 31 2012.1

LQT3型が疑われたQT延長症候群の1例

鈴木秀行, 森田宏, 重歳正尚, 永瀬聡, 中村一文, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 100th 2012

N-3系多価不飽和脂肪酸はブルガダ症候群患者における心室細動の抑制に関連している

田中正道, 中村一文, 和田匡史, 中川晃志, 西井伸洋, 永瀬聡, 森田宏, 河野晋久, 草野研吾, 由谷親夫, 伊藤浩

日本循環器学会中国地方会(Web) 101st 2012

約5年前からリエントリー性心室調律が持続していた重症右心不全を伴う成人Ebstein奇形の1例

高谷陽一, 永瀬聡, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 橋本克史, 中村一文, 河野晋久, 森田宏, 草野研吾, 佐野俊二, 伊藤浩

日本循環器学会中国地方会(Web) 101st 2012

呼吸不全に関する調査研究特発性肺動脈性肺高血圧に関する研究

草野研吾, 中村一文, 赤木達, 三浦綾, 伊藤浩

呼吸不全に関する調査研究平成23年度研究報告書 2012

心室遅延電位とJ波高の日内変動の特徴を検討し得た特発性心室細動の一例

寒川睦子, 森田宏, 大澤和宏, 鵜川聡子, 湯本晃久, 永瀬聡, 河野晋久, 中村一文, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 100th 2012

冠動脈CT撮像におけるコアベータの安全性と有効性の検討

大澤和宏, 三好亨, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 100th 2012

固形物の嚥下時に出現する心房期外収縮,心房頻拍に対してアブレーションを施行した1例

時岡浩二, 永瀬聡, 西井伸洋, 橋本克史, 中村一文, 森田宏, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 101st 2012

一次予防目的にICD(CRTD)植え込み後,運転中に心室頻拍が出現しICDが作動した肥大型心筋症の一例

鵜川聡子, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 101st 2012

呼吸不全に関する調査研究特発性肺動脈性肺高血圧に関する研究

草野研吾, 中村一文, 赤木達, 三浦綾, 伊藤浩

呼吸不全に関する調査研究平成23年度研究報告書 2012

左脚後枝遠位部通電後より軸が様々に変化し多源性QRS波形を呈した特発性左室起源心室頻拍の一例

田中正道, 永瀬聡, 中川晃志, 西井伸洋, 中村一文, 森田宏, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 100th 2012

肺高血圧症患者の肺移植前後における心電図変化の検討

時岡浩二, 中村一文, 赤木達, 河野晋久, 草野研吾, 伊藤浩, 大藤剛宏, 三好新一郎, 小川愛子, 宮地克維, 松原広己

日本循環器学会中国地方会(Web) 100th 2012

致死的デバイス感染に対し,リード抜去およびtotal managementにて救命しえた1例

森本芳正, 西井伸洋, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 100th 2012

複数のモダリティーが診断及び治療方針決定に有用であった冠動脈瘤及び冠動脈肺動脈瘻の1症例

大澤和宏, 橋本克史, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 101st 2012

Use of Intravenous Amiodarone in the Treatment of Nifekalant-Resistant Arrhythmia: A Review of 11 Consecutive Cases with Severe Heart Failure

Koji Nakagawa, Kazufumi Nakamura, Kengo Fukushima Kusano, Satoshi Nagase, Takeshi Tada, Masato Murakami, Yoshiki Hata, Hiroshi Morita, Kunihisa Kohno, Kazumasa Hina, Tohru Ujihira, Tohru Ohe, Hiroshi Ito

PHARMACEUTICALS 4 ( 6 ) 794 - 803 2011.6

Language：English Publishing type：Book review, literature introduction, etc. Publisher：MDPI

Background: Both nifekalant hydrochloride (NIF), a selective I-Kr blocker, and intravenous amiodarone (AMD), a multi-channel (including I-Kr blocking) blocker, have been reported to be efficacious for refractory arrhythmias. However, the optimal use of those antiarrhythmic drugs for refractory arrhythmia with severe heart failure has not been established. Intravenous AMD might be effective for arrhythmias refractory to NIF in patients with severe heart failure. Here, we report that intravenous amiodarone was effective in the treatment of nifekalant-resistant in a group of arrhythmia patients with severe heart failure. Methods: Eleven severe heart failure patients who had received intravenous AMD for treatment of NIF-resistant arrhythmias were included in this study, and retrospective analysis was performed. Clinical efficacy (terminative and preventive effects on arrhythmia) of intravenous AMD was evaluated. Results: All cases were emergent cases and had depressed left ventricular ejection fraction (30 +/- 13%). Clinical arrhythmias were ventricular fibrillation (VF) in four patients, ventricular tachycardia (VT) in six patients, and atrial fibrillation (AF) in one patient. NIF was administered to all patients by intravenous injection. After administration of NIF, VT/VF/AF was terminated in seven of the 10 patients, but a preventive effect was not obtained in any of the patients (NIF-resistance). Intravenous AMD (maintenance dose: 484 +/- 166 mg/day) was effective both in termination (80%) and in prevention (80%) of VT/VF events in those patients. It was also effective in termination (80%) and prevention (60%) of AF events refractory to NIF. During continuous AMD administration, no significant adverse effects or proarrhythmic effects were observed in any of the patients. Five patients died within one month, but there was no arrhythmic deaths. Conclusions: Intravenous AMD was effective in NIF-resistant lethal arrhythmias and was relatively safe in emergent cases with severe heart failure.

DOI： 10.3390/ph4060794

肺動脈のreverse remodeling―肺高血圧症患者の肺動脈平滑筋細胞を用いた検討―

植え込み型除細動器による心腔内除細動は心不全患者の心機能を低下させ,血行動態の回復を遅延させる

杜徳尚, 西井伸洋, 中村一文, 渡辺修久, 田辺康治, 麻植浩樹, 谷口学, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本心エコー図学会学術集会抄録集 22nd 2011

Noonan症候群に僧帽弁逸脱症による重症僧帽弁閉鎖不全,および心機能低下を合併した一例

森本芳正, 麻植浩樹, 武寛, 杜徳尚, 吉田賢司, 三好亨, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 98th 2011

携帯心電計貸与2年後に多形性心室頻拍をとらえ冠攣縮性狭心症を診断し得た1例

時岡浩二, 森田宏, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 98th 2011

診断に苦慮した若年性Platypnea Orthodeoxia Syndromeの1症例

大澤和宏, 草野研吾, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 99th 2011

OptiVolによって観察し得たPMSの1例

久保元基, 西井伸洋, 三好亨, 森田宏, 中村一文, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 99th 2011

シルデナフィルによる血管反応試験が治療選択に有用だった門脈圧亢進に伴う肺高血圧症の一例

赤木達, 中村一文, 福家聡一郎, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 98th 2011

Brugada型症候群に伴った持続性心室性頻拍の4例

武寛, 森田宏, 杜徳尚, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 草野研吾, 大江透, 伊藤浩

日本循環器学会中国地方会(Web) 99th 2011

左上大静脈違残を伴うUnroofed coronary sinusと診断した心房中隔欠損の一例

武寛, 杜徳尚, 谷口学, 西井伸洋, 永瀬聡, 大塚頼隆, 中村一文, 河野晋久, 森田宏, 草野研吾, 赤木禎治, 佐野俊二, 伊藤浩

日本循環器学会中国地方会(Web) 98th 2011

努責により再現性をもって発作性房室ブロックが確認できた1例

上枝弘雄, 三好章仁, 久保元基, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 99th 2011

頸部食道癌術後ルビエールリンパ節転移に起因し,仰臥位にても失神を繰り返した重症起立性低血圧の一例

寒川睦子, 森田宏, 森本芳正, 吉田賢司, 三好亨, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 99th 2011

心室頻拍の治療に難渋した拡張型心筋症の1例

森本芳正, 草野研吾, 麻植浩樹, 杜徳尚, 吉田賢司, 谷山真規子, 三好亨, 西井伸洋, 橋本克史, 永瀬聡, 中村一文, 河野晋久, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 99th 2011

慢性腎臓病は安定狭心症患者における左冠動脈主幹部病変と関連する

旦一宏, 三好亨, 西井伸洋, 永瀬聡, 中村一文, 河野晋久, 森田宏, 草野研吾, 上枝正幸, 伊藤浩

日本循環器学会中国地方会(Web) 98th 2011

呼吸不全に関する調査研究特発性肺動脈性肺高血圧に関する研究

草野研吾, 三浦綾, 赤木達, 中村一文, 伊藤浩

呼吸不全に関する調査研究平成22年度研究報告書 2011

呼吸不全に関する調査研究特発性肺動脈性肺高血圧に関する研究

草野研吾, 三浦綾, 赤木達, 中村一文, 伊藤浩

呼吸不全に関する調査研究平成22年度研究報告書 2011

中村一文, 赤木達, 小川愛子, 草野研吾, 伊藤浩

日本心臓病学会誌 5 ( Supplement 1 ) 140 2010.8

特発性肺動脈性肺高血圧症において高用量エポプロステノール療法は血行動態を著しく改善する

赤木達, 中村一文, 小川愛子, 草野研吾, 宮地克維, 松原広己, 伊藤浩

日本心臓病学会誌 5 ( Supplement 1 ) 232 2010.8

Drug-induced long QT syndrome

Respiration and circulation 58 ( 5 ) 511 - 516 2010.5

肺動脈性肺高血圧症の病理学的特徴

中村一文, 三浦綾, 由谷親夫

循環器内科 67 ( 5 ) 469 - 474 2010

分子標的治療薬 (imatinib) の肺高血圧症における効果

小川愛子, 中村一文, 松原広己

循環器内科 67 ( 5 ) 525 - 529 2010

Flecainideが著効したカテコラミン誘発性多形性心室頻拍の一例

杉山洋樹, 森田宏, 久保元基, 永瀬聡, 河野晋久, 中村一文, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 97th 2010

先天性QT延長症候群1型,2型における再分極相の変動に対するβ遮断薬の効果

武寛, 森田宏, 野田崇, 中村一文, 草野研吾, 鎌倉史郎, 大江透, 伊藤浩, 清水渉

日本循環器学会中国地方会(Web) 97th 2010

二次性徴に伴い二回目に行ったピルジカイニド負荷でBrugada様波形を認めたLQT3の一例

武寛, 森田宏, 西井伸洋, 永瀬聡, 河野晋久, 中村一文, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 97th 2010

HELLP症候群に伴い産褥期に認めたカテコラミン心筋症の一例

時岡浩二, 武寛, 杜徳尚, 西井伸洋, 永瀬聡, 中村一文, 森田宏, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 97th 2010

植え込み型除細動器による心腔内除細動は一過性に心機能を低下させる

杜徳尚, 西井伸洋, 森田宏, 谷口学, 永瀬聡, 中村一文, 河野晋久, 草野研吾, 伊藤浩

日本心エコー図学会学術集会抄録集 21st 2010

呼吸不全に関する調査研究特発性肺動脈性肺高血圧に関する研究

草野研吾, 赤木達, 中村一文, 伊藤浩

呼吸不全に関する調査研究班平成21年度研究報告書 2010

呼吸不全に関する調査研究特発性肺動脈性肺高血圧に関する研究

草野研吾, 赤木達, 中村一文, 伊藤浩

呼吸不全に関する調査研究班平成21年度研究報告書 2010

失神にて植込み型除細動器植込み術を行い,1年後に心室細動を認めた一例

久保元基, 西井伸洋, 三好亨, 森田宏, 中村一文, 河野晋久, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 97th 2010

Relationship between circulating levels of monocyte chemoattractant protein-1 and systolic dysfunction in patients with hypertrophic cardiomyopathy

Jun Iwasaki, Kazufumi Nakamura, Hiromi Matsubara, Yoichi Nakamura, Nobuhiro Nishii, Kimikazu Banba, Masato Murakami, Keiko Ohta-Ogo, Hideo Kimura, Norihisa Toh, Satoshi Nagase, Takefumi Oka, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe

CARDIOVASCULAR PATHOLOGY 18 ( 6 ) 317 - 322 2009.11

Language：English Publisher：ELSEVIER SCIENCE INC

Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism of the transition from hypertrophy to dysfunction has not been elucidated. It has been reported that circulating levels of monocyte chemoattractant protein-1 (MCP-1), which is a major factor promoting the accumulation of macrophages, are increased in patients with congestive heart failure. We measured circulating levels of MCP-1 in patients with HCM and examined whether MCP-1 was expressed in the myocardium of HCM patients. We also examined whether circulating levels of MCP-1 were correlated with left ventricular dysfunction. Methods: Circulating levels of MCP-1 were measured by an enzyme immunoassay in 26 patients with HCM (60 2 years old) and 20 control subjects (57 2 years old). Cardiac function was evaluated by two-dimensional echocardiography and cardiac catheterization. Results: HCM patients had significantly elevated levels of MCP-1 (HCM: 309+/-30 vs. control: 178+/-8 pg/ml, P<001). MCPI levels in patients with systolic dysfunction were significantly higher than those in patients without systolic dysfunction (P<05) and were also significantly higher than those in patients with outflow obstruction (P<05). Immunohistochemical analysis revealed that MCP-1 was expressed in endomyocardial biopsy samples obtained from HCM patients with systolic dysfunction. Furthermore, MCP-1 levels were inversely correlated with fractional shortening (r=-.4011, P<05) and correlated with left ventricular end-diastolic pressure (r=-.579, P<01). Conclusion: These results show that MCP-1 is associated with, and might be involved in the pathogenesis of, left ventricular systolic dysfunction in patients with HCM. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.carpath.2008.12.004

Application of Real-Time Three-Dimensional Transesophageal Echocardiography Using a Matrix Array Probe for Transcatheter Closure of Atrial Septal Defect

Manabu Taniguchi, Teiji Akagi, Nobuhisa Watanabe, Yoshio Okamoto, Koji Nakagawa, Yasufumi Kijima, Norihisa Toh, Shinichi Ohtsuki, Kengo Kusano, Shunji Sano

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 22 ( 10 ) 1114 - 1120 2009.10

Language：English Publishing type：Book review, literature introduction, etc. Publisher：MOSBY-ELSEVIER

Background: The aim of this study was to demonstrate the utility of real-time three-dimensional (3D) transesophageal echocardiography (RT3D-TEE) using a matrix array 3D transesophageal echocardiographic probe for morphologic evaluation and guidance of transcatheter closure of atrial septal defects (ASDs).
Methods: Forty-eight consecutive patients scheduled for the intervention were included. Two-dimensional (2D) transesophageal echocardiography (2D-TEE) and RT3D-TEE were performed before and during the procedures. Measurements of maximal ASD diameter and surrounding rims obtained on RT3D-TEE were compared with those obtained on 2D-TEE.
Results: In 46 patients (96%), optimal 3D images for the morphologic evaluation of ASDs were obtained. RT3D-TEE facilitated the evaluation of ASD morphology and surrounding rims and was able to provide intra-procedural information clearly. A Bland-Altman plot showed a mean maximal diameter difference of -0.12 mm between the means (95% limits of agreement, -2.2 to 2.5 mm).
Conclusion: RT3D-TEE is a clinically useful, complementary option to 2D-TEE for evaluation of ASD morphology and for interventional guidance. (J Am Soc Echocardiogr 2009; 22: 1114-20.)

DOI： 10.1016/j.echo.2009.06.008

4-Hydroxy-2-nonenal Induces Calcium Overload via the Generation of Reactive Oxygen Species in Isolated Rat Cardiac Myocytes

Kazufumi Nakamura, Daiji Miura, Kengo Fukushima Kusano, Yoshihisa Fujimoto, Wakako Sumita-Yoshikawa, Soichiro Fuke, Nobuhiro Nishii, Satoshi Nagase, Yoshiki Hata, Hiroshi Morita, Hiromi Matsubara, Tohru Ohe, Hiroshi Ito

JOURNAL OF CARDIAC FAILURE 15 ( 8 ) 709 - 716 2009.10

Language：English Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS

Background: It has been reported that that the amount of 4-hydroxy-2-nonenal (FINE), which is a major lipid peroxidation product and a cytotoxic aldehyde, is increased in the human failing myocardium. This study was designed to determine whether FINE has a pro-oxidant effect in cardiac myocytes and whether FINE causes Ca(2+) overload.
Methods and Results: Exposure to FINE for 10 minutes in the presence of ferric nitrilotriacetate induced the production of hydroxyl radical (.OH) in the rat myocardium as assessed by electron spin resonance spectroscopy, and FINE induced the generation of reactive oxygen species (ROS) in a dose-dependent manner as assessed by 2', 7'-dichlorofluorescein diacetate fluorescence. FINE increased intracellular Ca(2+) concentration ([Ca(2+)](i)) as assessed by fura-2 ratio in a dose- and time-dependent manner. After 20 minutes of FINE (400 mu mol/L) exposure, hypercontracture was induced in 67% of the cells. Catalase, an antioxidative enzyme that can decompose hydrogen peroxide (H(2)O(2)), significantly attenuated the increase in [Ca(2+)](i) and completely inhibited hypercontracture. Carvedilol, a beta-blocker with potent antioxidant activity, also significantly attenuated the increase in [Ca(2+)](i) and completely inhibited hypercontracture, but propranolol had no effect on either [Ca(2+)](i) increase or hypercontracture.
Conclusions: FINE induces the formation of ROS, especially H(2)O(2) and .OH, in cardiomyocytes and subsequently ROS cause intracellular Ca(2+) overload. FINE formation may play an important role as a mediator of oxidative stress in heart failure. (J Cardiac Fail 2009;15:709-716)

DOI： 10.1016/j.cardfail.2009.04.008

A novel KCNH2 mutation as a modifier for short QT interval

Hideki Itoh, Tomoko Sakaguchi, Takashi Ashihara, Wei-Guang Ding, Iori Nagaoka, Yuko Oka, Yuko Nakazawa, Takenori Yao, Hikari Jo, Makoto Ito, Kazufumi Nakamura, Tohru Ohe, Hiroshi Matsuura, Minoru Horie

INTERNATIONAL JOURNAL OF CARDIOLOGY 137 ( 1 ) 83 - 85 2009.9

Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：ELSEVIER IRELAND LTD

In a 34-year-old man showing short QT interval (QTc 329 ms), we identified a novel C-terminal KCNH2 mutation, R1135H. Using a heterologous expression system with CHO cells, the mutant channels were found to display a significantly slow deactivation, which resulted in a gain-of-function for reconstituted 'I(Kr)' channels. This mutation could modify clinical phenotypes for this patient. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijcard.2008.05.050

Abnormal transmural repolarization process in patients with Brugada syndrome

Mutsuko Sangawa, Hiroshi Morita, Takaaki Nakatsu, Nobuhiro Nishii, Daiji Miura, Aya Miura, Takeshi Tada, Masato Murakami, Shigeki Hiramatsu, Satoshi Nagase, Kazufumi Nakamura, Takefumi Oka, Shinji Toyonaga, Keiichi Mashima, Shozo Kusachi, Kazuhide Yamamoto, Tohru Ohe, Kengo F. Kusano

HEART RHYTHM 6 ( 8 ) 1163 - 1169 2009.8

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND Repolarization abnormality, especially during bradycardia, might be critical for initiation of ventricular fibrillation (VF) in patients with Brugada syndrome (BrS), but the contribution of the rate-dependent repolarization dynamics to the occurrence of VF is still unknown.
OBJECTIVE The aim of our study was to determine the differences in rate-dependent repolarization dynamics between BrS with and without spontaneous VF and between BrS with and without SCN5A mutation.
METHODS The subjects were 37 BrS patients with VF (VF(+) group: 10 mate subjects) and without VF (VF(-) group: 27 mate subjects) and 20 control subjects. Genetic analysis of SCN5A was performed in all 37 BrS patients. The relationships between QT, QTp, Tp-e, and RR intervals were obtained from Hotter recordings as first Linear regression tines, and the slopes of QT/RR, QTp/RR, and Tp-e/RR Linear regression Lines as the sensitivity of rate-dependent repolarization dynamics were compared.
RESULTS QT/RR and Tp-e/RR slopes showed toss of a rate-dependent property in the VF(+) group compared with those in the VF(-) and control groups. There was no significant difference in QTp/RR slope among the VF(+), VF(-) and control groups. The Tp-e interval had a negative correlation with the RR interval in the VF(+) group and a positive correlation with the RR interval in the VF(-) and control groups. There was no significant difference in QT/RR, QTp/RR, and Tp-e/RR slopes. between BrS patients with SCN5A mutation and those without SCN5A mutation.
CONCLUSIONS Loss of rate-dependent QT dynamics may be associated with occurrence of VF in BrS.

DOI： 10.1016/j.hrthm.2009.04.037

Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome

Hiroshi Morita, Satoshi Nagase, Daiji Miura, Aya Miura, Shigeki Hiramatsu, Takeshi Tada, Masato Murakami, Nobuhiro Nishii, Kazufumi Nakamura, Shiho T. Morita, Takefumi Oka, Kengo F. Kusano, Tohru Ohe

HEART RHYTHM 6 ( 4 ) 487 - 492 2009.4

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND Premature ventricular contractions (PVCs) do not occur frequently but can induce ventricular fibrillation (VF) in patients with Brugada syndrome. The effect of SCN5A mutation on the onset of ventricular arrhythmias is unknown.
OBJECTIVE The purpose of this study was to evaluate PVC morphology and onset of VF in patients with Brugada syndrome.
METHODS Morphology of PVCs was evaluated by 12-lead ECG in 32 patients with Brugada syndrome. Patients had spontaneous ventricular arrhythmia (n = 17) or sodium channel blocker-induced ventricular arrhythmia (n = 19). Patients were classified into two groups according to the existence of SCN5A mutation (22 mutation negative, 10 mutation positive).
RESULTS Patients without mutation often had PVCs of left bundle branch block (LBBB) morphology (82%), especially with inferior axis (77%). Patients with mutation had PVCs of both right bundle branch block (36%) and LBBB (64%) morphologies. Only two patients with mutation had PVCs of LBBB, inferior-axis morphology.
CONCLUSION Patients without SCN5A mutation often had PVCs of LBBB, inferior-axis morphology, suggesting a right ventricular outflow tract origin. Patients with SCN5A mutations had PVCs that originated from both the right and left ventricles.

DOI： 10.1016/j.hrthm.2009.01.031

Transcatheter Closure of Atrial Septal Defect in Elderly Patients With Permanent Atrial Fibrillation

Manabu Taniguchi, Teiji Akagi, Shinichi Ohtsuki, Yoshio Okamoto, Yasuharu Tanabe, Nobuhisa Watanabe, Koji Nakagawa, Norihisa Toh, Kengo Kusano, Shunji Sano

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS 73 ( 5 ) 682 - 686 2009.4

Language：English Publisher：WILEY-LISS

Objectives: The aim of this study is to evaluate the feasibility and efficacy of device closure of atrial septal defect (ASD) in elderly patients with permanent atrial fibrillation. Background: Little is known about the feasibility of device closure of ASD in those patients. Methods: Nine consecutive patients (mean age 68.1 years) with permanent atrial fibrillation (>1 year persistent) underwent catheter closure using the Amplatzer septal occluder. Transthoracic echocardiography and plasma B-type natriuretic peptide (BNP) level were assessed before and at 24 hours; and 1, 3, and >6 months after the closure. Before the procedure, appropriate dose of warfarin was used in all, diuretics was used in 8/9. Same amount of medications were continued after the procedure. Results: ASD could be closed in all (mean device size 27.3 mm) without hemodynamic and thromboembolic complications. New York Heart Association (NYHA) functional classification was significantly improved in all patients after device closure. No hemodynamic and thromboembolic complications were observed during the follow-up period (mean 10.6 months). Although permanent atrial fibrillation did not change in all after the procedure, resting heart rate decreased from 76.2 +/- 16.0 to 68.3 +/- 13.2 beats/min (P = 0.015). There was statistically significant improvement in right ventricular/left ventricular diameter ratio (1.08 +/- 0.16 to 0.73 +/- 0.10, P = 0.008) and plasma BNP level (183.7 +/- 90.5 to 94.6 +/- 47.4 pg/mL, P = 0.008) after >6 months device closure. Conclusions: Even in the patients complicated with permanent fibrillation, transcatheter closure of ASD can contribute to symptomatic improvement as well as cardiac geometric remodeling. (C) 2009 Wiley-Liss, Inc.

DOI： 10.1002/ccd.21870

OE-151 Conduction Abnormality within QRS Complex Detected by Wavelet Transform of SAECG in Patients with Brugada Syndorme(OE26,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

FRS-116 Frequency of Single Nucleotide Polymorphisms in Japanese Patients with Brugada Syndrome(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Miura Daiji, Nakamura Kazufumi, Morita Hiroshi, Miura Aya, Sumita Wakako, Taniyama Makiko, Iwasaki Jun, Urakawa Shigemi, Kimura Hideo, Banba Kimikazu, Watanabe Atsuyuki, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 73 169 - 169 2009.3

FRS-023 Red Cell Distribution Width as a Prognostic Marker in Patients with Nonischemic Cardiomyopathy(FRS5,Novel Biomarkers in Heart Failure (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Kijima Yasufumi, Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Ohe Tohru, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 140 - 141 2009.3

PE-514 Red Blood Cell Distribution Width Reflects Heart Failure Status in Patients with Idiopathic Pulmonary Arterial Hypertension(PE086,Pulmonary Circulation (H),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)

Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Hata Yoshiki, Morita Hiroshi, Ohe Tohru, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 529 - 529 2009.3

Nosaka Kazumasa, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 212 - 212 2009.3

PE-246 Serum Cyctatin C Reflects Cardiac Diastolic Dysfunction in Patients with Heart Failure(PE042,Cardiac Function (Clinical) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nosaka Kazumasa, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 461 - 461 2009.3

OE-198 Increased Cardiomyocyte Elasticity in the Transverse Direction in Hypertrophied Rat Hearts Induced by Chronic β-Adrenergic Stimulation(OE34,Cardiac Function (Basic) (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Nakamura Kazufumi, Sumita Wakako, Hashimoto Ken, Miura Daiji, Nishii Nobuhiro, Nagase Satoshi, Morita Hiroshi, Hata Yoshiki, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 73 223 - 223 2009.3

PJ-608 Comparison of Clinical Characteristics between the Patients with Connective Tissue Disease and Idiopathic Pulmonary Arterial Hyptertension(PJ102,Pulmonary Circulation 2 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Hirota Minoru, Fuke Soichiro, Nishii Nobuhiro, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Morita Hiroshi, Ohe Tohru, Kusano Kengo

Circulation journal : official journal of the Japanese Circulation Society 73 698 - 699 2009.3

DPJ-006 Differential Effects of Genotype on the Initiation of Ventricular Arrhythmia in Patients with Brugada Syndrome(DPJ01,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 1 (A),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

Morita Hiroshi, Miura Daiji, Nagase Satoshi, Hata Yoshiki, Nakamura Kazufumi, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 73 377 - 377 2009.3

Simvastain Inhibits Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells from Patients with Idiopathic Pulmonary Arterial Hypertension

中村一文

分子心血管病 10 ( 3 ) 96 - 97 2009

無症候性Brugada症候群におけるEPSの適応－岡山大学での適応の変遷－(共著）

森田宏, 草野研吾, 永瀬聡, 西井伸洋, 多田毅, 村上正人, 平松茂樹

Japanese Journal of Electrocardiology 29 ( 4 ) S-4-50-S-4-55 2009

Intravenous Amiodarone in Patients with Ventricular Tachycardia/Fibrillation Resistant to Nifekalant

KUSANO Kengo F., NAKAGAWA Koji, TADA Takeshi, NAGASE Satoshi, NAKAMURA Kazufumi, MORITA Hiroshi, NISHII Nobuhiro, FUKE Soichiro, HATA Yoshiki, OHE Tohru

Japanese Journal of Electrocardiology 29 ( 1 ) 26 - 33 2009

エポプロステノール治療による血管病変へのアプローチ(共著）

松原広己, 赤木達, 中村一文, 佐久間聖仁, 京谷晋吾

PROGRESS IN MEDICINE 29 ( 2 ) 529 - 534 2009

Effects of combined treatment with angiotensin II type 1 receptor blocker and statin on stent restenosis.(共著）

Yoshikawa M, Nakamura K, Nagase S, Sakuragi S, Kusano KF, Matsubara H

J Cardiovasc Pharmacol. 53 ( 2 ) 179 - 186 2009

非Brugada型特発性心室細動12例の検討(原著）

平松茂樹, 森田宏, 中川晃志, 田中正道, 村上正人, 多田毅, 西井伸洋, 永瀬聡

心臓 41 ( 3 ) 54 - 60 2009

Language：Japanese Publisher：(公財)日本心臓財団

特発性心室細動(IVF)には、Brugada症候群の心電図特徴を示さない例がある。原因や病態は複数と思われ、潜在性の心筋炎の可能性も考えられている。今回、当院で経験されたBrugada症候群が否定的なIVF12例について、その特徴を検討した。年齢は38±12歳、男性が8名(67%)。右室流出路起源の心室性期外収縮(PVC)から心室細動(VF)を起こした者が3名。連結期の短いPVCを認める者が3名。いずれも認めない者が6名であった。12誘導心電図で有意な所見は認めず、遅延電位は陰性。冠動脈に有意狭窄はなく、左室造影も正常。心臓電気生理学的検査(EPS)において、2例のみ右室の一部に軽度の異常電位を認めたが、その他の症例では認めていない。プログラム刺激による心室頻拍/心室細動(VT/VF)の誘発では、全例で持続するVT/VFは誘発されなかった。上記のことからIVFには器質的な異常は認めず、機能的な異常が原因となっている可能性が高いと考えられる。(著者抄録)

DOI： 10.11281/shinzo.41.S3_54

Other Link： https://search.jamas.or.jp/default/link?pub_year=2009&ichushi_jid=J00679&link_issn=&doc_id=20090807210010&doc_link_id=10.11281%2Fshinzo.41.S3_54&url=https%3A%2F%2Fdoi.org%2F10.11281%2Fshinzo.41.S3_54&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

心臓MRIにて遅延造影を認め電気生理検査で伝導遅延所見を認めたBrugada症候群の1例(共著）

永瀬聡, 多田毅, 西井伸洋, 村上正人, 平松茂樹, 宮地晃平, 三浦大志, 中村一文, 森田宏, 岡岳文, 草野研吾, 大江透

臨床心臓電気生理 32 265 - 272 2009

Language：Japanese Publisher：臨床心臓電気生理研究会

症例は61歳、男性。うめき声を伴う夜間の苦悶様呼吸およびBrugada型心電図を認め精査目的で当院入院。心エコー・両心室造影・心筋組織生検ではとくに明らかな異常を認めなかったが、加算平均心電図で心室遅延電位を認め、心臓MRIでは形態的異常を認めないものの、遅延造影delayed enhancementを心室中隔に認めた。心臓電気生理検査では、心室中隔などに局所電位のwideningが主体の異常電位を認め、プログラムペーシングで心室細動が誘発された。右室早期刺激による心室内伝導時間の検討でも伝導遅延の存在が示唆された。植込み型除細動器の植込みを行い、現在外来経過観察中である。心臓MRIにて遅延造影delayed enhancementを認めたBrugada症候群の報告はこれまでなく、心臓電気生理検査所見と併せて報告する。(著者抄録)

治療(2)】急性心筋炎における大量免疫グロブリン療法-有効性は確かか？(共著）

酸化ストレスと拡張機能障害(共著）

谷山真規子, 中村一文

医学のあゆみ 231 ( 8 ) 815 - 817 2009

柚木佳, 中村一文

心臓 41 ( 11 ) 1201 - 1204 2009

後天性にBrugada型心電図を呈した5例(共著）

森田宏, 西井伸洋, 永瀬聡, 中村一文, 幡芳樹, 草野研吾

Journal of Arrhythmia 25 333 2009

長期間のDDD pacingで左室流出路圧較差が改善した閉塞性肥大型心筋症の1例(共著）

高谷陽一, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 森田宏, 草野研吾

Journal of Arrhythmia 25 343 2009

家族内集積を認めた左室緻密化障害を合併した完全房室ブロックの1例(共著）

野坂和正, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 森田宏, 草野研吾

Journal of Arrhythmia 25 484 2009

特別座談会企画「大規模臨床試験から何を学か」大規模臨床試験が語ること(共著）

草野研吾, 中村一文, 前島洋平

血圧 16 ( 1 ) 9 - 14 2009

「心不全と不整脈」心不全をめぐる最近の話題

中村一文

メディカル・ビューポイント 31 ( 1 ) 2 2009

肺動脈性肺高血圧症における肺動脈平滑筋細胞の特性(共著）

赤木達, 小川愛子, 中村一文

血栓と循環 17 ( 3 ) 263 - 268 2009

薬剤負荷心電図で診断されたカテコラミン誘発性多形性心室頻拍の1例(共著）

木島康文, 平松茂樹, 多田毅, 村上正人, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 森田宏, 草野研吾

Journal of Arrhythmia 25 499 2009

Fulminant eosinophilic myocarditis associated with visceral larva migrans caused by Toxocara canis infection(共著）

Enko K, Tada T, Ohgo KO, Nagase S, Nakamura K, Ohta K, Ichiba S, Ujike Y, Nawa Y, Maruyama H, Ohe T, Kusano KF

Circ J 73 ( 7 ) 1344 - 1348 2009

Spironolactone and Chlorthalidone in Uncontrolled Elderly Hypertensive Patients Treated with Calcium Antagonists and Angiotensin II Receptor-Blocker: Effects on Endothelial Function, Inflammation, and Oxidative Stress

Hiroshi Yamanari, Kazufumi Nakamura, Daiji Miura, Shuichi Yamanari, Tohru Ohe

CLINICAL AND EXPERIMENTAL HYPERTENSION 31 ( 7 ) 585 - 594 2009

Language：English Publisher：TAYLOR & FRANCIS INC

The side effects of thiazide-type diuretics include metabolic abnormality and increased oxidative stress, which might cause endothelial dysfunction despite blood pressure reduction. In hypertensive patients with heart failure, treatment with an aldosterone antagonist resulted in improvements in endothelial function and significant blood pressure reduction. The purpose of the present study was to evaluate the differences between spironolactione and chlorthalidone in hypertensive elderly patients treated with calcium antagonists and angiotensin II receptor blockers.
Fourteen uncontrolled hypertensive patients treated with amlodipine and candesartan were included in this study. The study was an open-label randomized crossover comparison of 16 weeks treatment with spironolactone against chlorthalidone added to amlodipine and candesartan. blood pressure significantly decreased in patients treated with both spironolactone and chlorthalidone. Chlortalidone reduced flow-mediated dilation significantly compared to the baseline condition and spironolactone. serum highsensitively C-reactive protein and uric acid increased significantly in chlorthalidone-treated patients compared to spironolactonetreated patients. We conclude that spironolactone may be a more useful add-on therapy than chlorthalidone in hypertensive patients inadequately controlled on candesartan and amlodipine, because spironolactone preserves endothelial function and reduces inflammation compared to chlorthalidone.

DOI： 10.3109/10641960902929438

急性心筋炎に伴う多剤抵抗性心室頻拍に対してアミオダロン静注が有効であった乳児の1例

Are adrenergic receptor blockers effective or contraindicated in pulmonary arterial hypertension?(共著）

Nakamura K, Fujio H

Circ J. 73 ( 12 ) 2212 - 2213 2009

植込み型除細動器植込み術時における除細動閾値テストの心機能に与える影響についての検討（共著）

杜徳尚, 西井伸洋, 森田宏, 谷口学, 永瀬聡, 中村一文, 草野研吾

Journal of Arrhythmia 25 407 2009

非虚血性心筋症に伴う心室頻拍に対するカテーテル・アブレーションの検討(共著）

永瀬聡, 村上正人, 平松茂樹, 多田毅, 西井伸洋, 中村一文, 幡芳樹, 森田宏, 草野研吾, 大江透

Journal of Arrhythmia 25 221 2009

中川晃志, 細木信吾, 伴場主一, 多田毅, 西井伸洋, 永瀬聡, 中村一文, 幡芳樹, 森田宏, 草野研吾, 大江透

PROGRESS IN MEDICINE 29 ( Suppl.1 ) 609 - 613 2009

Language：Japanese Publisher：(株)ライフ・サイエンス

18ヵ月女児。発熱、嘔吐、下痢が出現した。哺乳がなくなり、ぐったりしているために近医を受診し、心電図にて頻脈性不整脈を指摘され、紹介受診した。発熱・腸炎などの感染症状や全周性の左室壁運動低下、急性心不全、さらに心筋逸脱酵素の上昇や頻脈性不整脈といった所見から、急性心筋炎と診断した。頻脈性不整脈のコントロールが困難で、血行動態は次第に不安定となったため、鎮静ならびに人工呼吸管理を行い、経皮的心肺補助装置を留置した。アミオダロンを開始し、頻拍は速やかに停止し、洞調律への復帰を認めた。急性心筋炎の治療としては、γグロブリン大量療法とステロイドパルス療法を施行した。徐脈傾向とQT延長の遷延に対して恒久的ペースメーカーを植え込み、軽快退院した。

心室細動の一次予防に植込み型除細動器植込み術を施行した筋強直性ジストロフィーの1例(共著）

尾上豪, 西井伸洋, 永瀬聡, 中村一文, 幡芳樹, 森田宏, 草野研吾

Journal of Arrhythmia 25 406 2009

QT延長を伴わないNifekalantによる心室頻拍の催不整脈作用を認めた1例(共著）

川合晴朗, 森田宏, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 草野研吾

Journal of Arrhythmia 25 524 2009

ミトコンドリア心筋症に複数の副伝導路を認めアブレーションにて根治し得た1例(共著）

田中正道, 木島康文, 多田毅, 村上正人, 平松茂樹, 西井伸洋, 永瀬聡, 中村一文, 幡芳樹, 森田宏, 草野研吾, 由谷親夫, 大江透

Journal of Arrhythmia 25 287 2009

症候性Brugada症候群におけるSCN5A遺伝子異常とベプリジルの有用性の関連についての検討(共著）

村上正人, 多田毅, 平松茂樹, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 森田宏, 草野研吾

Journal of Arrhythmia 25 292 2009

植込み型除細動器を植込まれたBrugada症候群患者における適切作動, 不適切作動の検討(共著）

西井伸洋, 森田宏, 中川晃志, 田中正道, 平松茂樹, 多田毅, 村上正人, 永瀬聡, 中村一文, 幡芳樹, 草野研吾

Journal of Arrhythmia 25 293 2009

Brugada症候群の再分極異常とVF発症との関連性の検討(共著）

寒川睦子, 中津高明, 豊永慎二, 間島圭一, 森田宏, 西井伸洋, 三浦大志, 多田毅, 村上正人, 平松茂樹, 永瀬聡, 中村一文, 幡芳樹, 草野研吾, 草地省蔵, 大江透

Journal of Arrhythmia 25 376 2009

左室後乳頭筋起源と考えられた心室期外収縮に対しアブレーションを施行した1例

多田毅, 永瀬聡, 平松茂樹, 村上正人, 田中正道, 中川晃志, 西井伸洋, 幡芳樹, 中村一文, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 94th 2009

デバイス設定変更にてT波オーバーセンスを回避できた1例

西井伸洋, 多田毅, 村上正人, 永瀬聡, 中村一文, 幡芳樹, 河野晋久, 森田宏, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 95th 2009

貧血と房室ブロックの重症度に相関が見られた一例

森田宏, 西井伸洋, 永瀬聡, 中村一文, 幡芳樹, 草野研吾, 伊藤浩

日本循環器学会中国地方会(Web) 95th 2009

心室頻拍に対し抗頻拍ペーシングが入りICDでdetectできない心室細動様波形となった重症拡張型心筋症の1例

柚木佳, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 森田宏, 草野研吾

日本循環器学会中国地方会(Web) 94th 2009

II度房室ブロックを指摘され,植込み型除細動器植込み術を施行された筋強直性ジストロフィーの1例

尾上豪, 西井伸洋, 永瀬聡, 幡芳樹, 中村一文, 森田宏, 草野研吾

日本循環器学会中国地方会(Web) 94th 2009

Home monitoringシステムによる植込み型除細動器正常作動の検出経験

西井伸洋, 平松茂樹, 多田毅, 村上正人, 永瀬聡, 中村一文, 幡芳樹, 河野晋久, 森田宏, 草野研吾

日本循環器学会中国地方会(Web) 94th 2009

Radial augmentation index associated with increase in B-type natriuretic peptide in patients with hypertension

Satoru Sakuragi, Takeshi Maruo, Manabu Taniguchi, Satoshi Nagase, Kazufumi Nakamura, Kengo Fukushima Kusano, Tohru Ohe

INTERNATIONAL JOURNAL OF CARDIOLOGY 130 ( 3 ) 414 - 419 2008.11

Language：English Publisher：ELSEVIER IRELAND LTD

Brain natriuretic peptide (BNP) level has been used as a marker of left ventricular (LV) systolic dysfunction (LVSD), even though some patients with atherosclerosis have a high BNP level irrespective of LV function. In this study, we investigate whether augmentation index (AI), which is an index of wave reflection, is involved in increasing BNP level in hypertensive patients without LVSD. Sixty treated hypertensive patients were enrolled in this study. Radial AI (r-AI) was measured in all patients. The patients were classified into tertiles on the basis of r-AI to identify the characteristics of the patients with a high r-AI.
BNP level was significantly higher in the patients classified into the highest tertile of r-AI. In echocardiography, e ', which is index of left ventricular (LV) diastolic function, decreased and LV mass index (LVMI) increased gradually with r-AI, whereas there was no difference in LV ejection fraction ( LVEF). r-AI significantly correlated with LVMI (r=0.35, p < 0.01) and e ' (r=-0.30, p < 0.05). In univariate analysis, age, heart rate, r-AI, LVEF, e ' and LVMI were significantly correlated with BNP level, whereas multivariate analysis demonstrated that only r-AI and LVEF correlated with BNP level. In conclusion, an increase in r-AI was significantly associated with an increase in BNP level in hypertensive patients without LVSD. LV hypertrophy and diastolic dysfunction associated with increase in r-AI may be involved in increase in BNP level. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijcard.2007.08.129

85) SLEに伴う重症二次性肺高血圧が正常化した一例(第92回日本循環器学会中国・四国合同地方会)

119) 右房内に巨大血栓を認めた一例(第92回日本循環器学会中国・四国合同地方会)

森あい子, 川田哲史, 永瀬聡, 中村一文, 森田宏, 武田賢治, 岡岳文, 草野研吾, 大江透, 佐野俊二, 豊永慎二

Circulation journal : official journal of the Japanese Circulation Society 72 1042 - 1042 2008.10

廣田稔, 草野研吾, 赤木達, 福家聡一郎, 永瀬聡, 中村一文, 森田宏, 岡岳文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 1038 - 1038 2008.10

171) Pergolide投与中に僧帽弁閉鎖不全による心不全を呈した1例(第92回日本循環器学会中国・四国合同地方会)

杉山洋樹, 武田賢治, 永瀬聡, 中村一文, 岡岳文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 1048 - 1048 2008.10

157) AED(自動体外式除細動器)の有効性と限界(第92回日本循環器学会中国・四国合同地方会)

尾上豪, 森田宏, 永瀬聡, 中村一文, 岡岳文, 草野研吾, 大江透, 氏家良人

Circulation journal : official journal of the Japanese Circulation Society 72 1046 - 1046 2008.10

50) 両心不全の原因が全身性硬化症による二次性心筋症であると考えられた一症例(第92回日本循環器学会中国・四国合同地方会)

野坂和正, 草野研吾, 尾上豪, 福家聡一郎, 永瀬聡, 中村一文, 森田宏, 武田賢治, 岡岳文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 1034 - 1034 2008.10

Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 ECG in patients with Brugada syndrome

NAGASE Satoshi, FUKUSHIMA KUSANO Kengo, MORITA Hiroshi, NISHII Nobuhiro, HIRAMATSU Shigeki, NAKAMURA Kazufumi, OHE Tohru

28 ( 5 ) 428 - 428 2008.10

Update on genetic analysis in Brugada syndrome

Daiji Miura, Kazufumi Nakamura, Tohru Ohe

HEART RHYTHM 5 ( 10 ) 1495 - 1496 2008.10

Fragmented QRS as a Marker of Conduction Abnormality and a Predictor of Prognosis of Brugada Syndrome

Hiroshi Morita, Kengo F. Kusano, Daiji Miura, Satoshi Nagase, Kazufumi Nakamura, Shiho T. Morita, Tohru Ohe, Douglas P. Zipes, Jiashin Wu

CIRCULATION 118 ( 17 ) 1697 - 1704 2008.10

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

Background-Conduction abnormalities serve as a substrate for ventricular fibrillation (VF) in patients with Brugada syndrome (BS). Signal-averaged electrograms can detect late potentials, but the significance of conduction abnormalities within the QRS complex is still unknown. The latter can present as multiple spikes within the QRS complex (fragmented QRS [f-QRS]). We hypothesized that f-QRS could indicate a substrate for VF and might predict a high risk of VF for patients with BS.
Methods and Results-In study 1, we analyzed the incidence of f-QRS in 115 patients with BS (13 resuscitated from VF, 28 with syncope, and 74 asymptomatic). f-QRS was observed in 43% of patients, more often in the VF group (incidence of f-QRS: VF 85%, syncope 50%, and asymptomatic 34%, P < 0.01). SCN5A mutations occurred more often in patients with f-QRS (33%) than in patients without f-QRS (5%). In patients with syncope or VF, only 6% without f-QRS experienced VF during follow-up (43 +/- 25 months), but 58% of patients with f-QRS had recurrent syncope due to VF (P < 0.01). In study 2, to investigate the mechanism of f-QRS, we studied in vitro models of BS in canine right ventricular tissues (n = 4) and optically mapped multisite action potentials. In the experimental model of BS, ST elevation resulted from a large phase 1 notch of the action potential in the epicardium, and local epicardial activation delay reproduced f-QRS in the transmural ECG.
Conclusions-f-QRS appears to be a marker for the substrate for spontaneous VF in BS and predicts patients at high risk of syncope. (Circulation. 2008; 118: 1697-1704.)

DOI： 10.1161/CIRCULATIONAHA.108.770917

Expression of monocyte chemoattractant protein-1 in idiopathic dilated cardiomyopathy

Makoto Kobayashi, Kazufumi Nakamura, Kengo Fukushima Kusano, Yoichi Nakamura, Keiko Ohta-Ogo, Satoshi Nagase, Satoru Sakuragi, Tohru Ohe

INTERNATIONAL JOURNAL OF CARDIOLOGY 126 ( 3 ) 427 - 429 2008.6

Language：English Publishing type：Rapid communication, short report, research note, etc. (scientific journal) Publisher：ELSEVIER IRELAND LTD

Immunological factors have been involved in the pathogenesis of dilated cardiomyopathy (DCM). The cytotoxic action of macrophages is one of the main factors causing cardiac myocyte damage. Monocyte chemoattractant protein-1 (MCP-1) is a major signal for the accumulation of monocytes/macrophages. We examined whether MCP-1 was expressed in the myocardium of DCM patients and whether the expression level was correlated with the degree of impairment of cardiac function. The expression of MCP-1 in the myocardium was determined by immunohistochemistry in endomyocardial biopsy samples from 13 patients. The expression of MCP-1 was found in all myocardial samples from DCM patients but not in those from control subjects. Positive staining for MCP-1 was distinct in cardiac myocytes, interstitium and infiltrating cells. Semi-quantitative analysis revealed that the expression of MCP-1 was inversely correlated with left ventricular ejection fraction. In conclusion, the expression level of MCP-1 in the myocardium was correlated with the degree of impairment of cardiac function in patients with DCM. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijcard.2007.01.109

Repolarization heterogeneity in the right ventricular outflow tract: Correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model

Hiroshi Morita, Douglas P. Zipes, Kengo Fukushima-Kusano, Satoshi Nagase, Kazufumi Nakamura, Shiho T. Morita, Tohru Ohe, Jiashin Wu

HEART RHYTHM 5 ( 5 ) 725 - 733 2008.5

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND Brugada syndrome (BrS) is characterized by repolarization abnormality with ST-segment elevation in the right ventricular outflow tract (RVOT).
OBJECTIVE Although action potential (AP) heterogeneity is associated with induction of ventricular arrhythmias (VA) in BrS, clinical evidence and its experimental correlations are still absent and are the focus of this study.
METHODS We evaluated repolarization heterogeneity in 15 patients with BrS using body surface mapping and in 8 pairs of isolated canine RVOT and right ventricular anteroinferior (RVAI) preparations having drug-induced BrS using optical mapping.
RESULTS Patients had large J-ST-segment elevation and long QT interval in the RVOT at baseline. Administration of pilsicainide (1 mg/kg) exaggerated J-ST-segment elevation, caused simultaneous Long and short QT intervals in the RVOT, and induced polymorphic ventricular tachycardia (VT) and T wave alternans (TWA). Dispersion of QT within the RVOT after pilsicainide was greater in patients that had syncope or ventricutar fibrillation than those that did not. Ventricular arrhythmias originated from the RVOT along with local electrocardiogram changes and TWA. Repolarization heterogeneity was much Less in areas outside the RVOT. Inducing BrS increased AP heterogeneity (with and without spike-and-dome) within the RVOT epicardium. Phase 2 reentry and TWA originated from the epicardium in 88% and 50% of RVOT preparations, respectively. In contrast, the RVOT endocardium and RVAI had Little AP heterogeneity, with neither reentry nor TWA.
CONCLUSION The instability and heterogeneity of repolarization within the epicardium of the RVOT seem to be associated with arrhythmogenesis in both patients and in the in vitro tissue models of BrS.

DOI： 10.1016/j.hrthm.2008.02.028

50) メキシレチン投与によりQT間隔延長が著明に軽減した先天性QT延長症候群の一例(第91回日本循環器学会中国地方会)

尾上豪, 福家聡一郎, 岡岳文, 永瀬聡, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 954 - 954 2008.4

41) 左心耳起源心房頻拍に対しnon-contact mapping法を用いてablationを行った一例(第91回日本循環器学会中国地方会)

宮地晃平, 永瀬聡, 村上正人, 多田毅, 平松茂樹, 西井伸洋, 中村一文, 森田宏, 岡岳文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 953 - 953 2008.4

54) 重複僧帽弁口を伴った孤立性左室緻密化障害にWPW症候群を合併した一例(第91回日本循環器学会中国地方会)

福家聡一郎, 中川晃志, 谷口学, 渡辺敦之, 永瀬聡, 中村一文, 森田宏, 岡岳文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 955 - 955 2008.4

60) 失神原因精査に携帯型イベントホルター心電図が有用であった発作性完全房室ブロックの1例(第91回日本循環器学会中国地方会)

山脇均, 福家聡一郎, 武田賢治, 岡岳文, 永瀬聡, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 955 - 955 2008.4

7) 入浴中にST上昇・VFを来たしたことが捉えられたBrugada症候群の一例(第91回日本循環器学会中国地方会)

野坂和正, 草野研吾, 田中正道, 福家聡一郎, 永瀬聡, 中村一文, 武田賢治, 岡岳文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 950 - 950 2008.4

85) 部分的肺静脈還流異常に原発性肺高血圧症を合併した一例(第91回日本循環器学会中国地方会)

森あい子, 草野研吾, 圓光賢希, 杉山洋樹, 永瀬聡, 中村一文, 森田宏, 岡岳文, 福康志, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 958 - 958 2008.4

44) 洞不全症候群を合併した無症候性ブルガダ心電図の一症例(第91回日本循環器学会中国地方会)

多田毅, 草野研吾, 永瀬聡, 西井伸洋, 宮地晃平, 平松茂樹, 村上正人, 中村一文, 森田宏, 岡岳文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 954 - 954 2008.4

61) 精巣摘出によりBrugada型心電図が消失した心筋ナトリウムチャネル遺伝子変異を有する一例(第91回日本循環器学会中国地方会)

森田宏, 草野研吾, 三浦大志, 永瀬聡, 中村一文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 956 - 956 2008.4

OE-381 Clinical Features of and Effects of Angiotensin System Antagonists on Amiodarone-Induced Pulmonary Toxicity(Arrhythmia, therapy(04)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Nikaido Akira, Kusano Kengo, Morita Hiroshi, Nakamura Kazufumi, Oka Takefumi, Nagase Satoshi, Nishii Nobuhiro, Fuke Soichiro, Enkoh Kenki, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 276 - 276 2008.3

OJ-008 Usefulness of the Hot-Bath Test in Brugada Sydrome(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Mori Aiko, Tanaka Masamichi, Kusano Kengo, Nosaka Kazumasa, Nakagawa Koji, Sugiyama Hiroki, Yamawaki Hitoshi, Onoue Go, Fuke Soichiro, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Takeda Kenji, Oka Takefumi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 289 - 290 2008.3

OJ-011 Characteristics and Diagnosis of Patients with Inherited Bidirectional Ventricular Tachycardia(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Sugiyama Hiroki, Morita Hiroshi, Takeda Kenji, Nagase Satoshi, Nakamura Kazufumi, Oka Takefumi, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 290 - 290 2008.3

OJ-007 Blunted QT Prolongation to Sudden R-R Prolongation in Brugada Syndrome Patients with Coved ST Elevation(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tada Takeshi, Kusano Kengo, Nagase Satoshi, Nishii Nobuhiro, Hiramatsu Shigeki, Miyaji Kohei, Murakami Masato, Tanaka Masamichi, Nakagawa Koji, Miura Daiji, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 289 - 289 2008.3

OJ-056 Outcome After Implantable Cardioverter-Defibrillator in Brugada Syndrome(Arrhythmia, therapy(06)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Nishii Nobuhiro, Kusano Kengo, Miyaji Kohei, Hiramatsu Shigeki, Tada Takeshi, Murakami Masato, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru, Miura Daiji, Miura Aya

Circulation journal : official journal of the Japanese Circulation Society 72 301 - 301 2008.3

FRS-106 Fragmented QRS, a Marker of Intraventricular Conduction Abnormality and Predictor of Prognosis of Brugada Syndrome(New Horizon in Diagnosis and Pathophysiology of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Morita Hiroshi, Kusano Kengo, Miura Daiji, Nagase Satoshi, Nakamura Kazufumi, Oka Takefumi, Wu Jiashin, Zipes Douglas P, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 172 - 173 2008.3

6 Anti-KCNH2 Antibody-induced Long QT Syndrome : Novel Acquired Form of LQT Syndrome(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Nakamura Kazufumi, Katayama Yusuke, Morita Hiroshi, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 20 - 20 2008.3

PJ-745 Clinical Usefulness of the Non-invasive Stroke Volume Measurement System, the Task Force[○!R] Monitor, in Patients with Pulmonary Hypertension(Pulmonary circulation(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Fuke Soichiro, Kusano Kengo, Mizoguchi Hiroki, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 699 - 699 2008.3

Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome

Satoshi Nagase, Kengo Fukushima Kusano, Hiroshi Morita, Nobuhiro Nishii, Kimikazu. Banba, Atsuyuki Watanabe, Shigeki Hiramatsu, Kazufumi Nakamura, Satoru Sakuragi, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51 ( 12 ) 1154 - 1161 2008.3

Language：English Publisher：ELSEVIER SCIENCE INC

Objectives We examined the relationship between repolarization abnormality and coved-type ST-segment elevation with terminal inverted T-wave (type 1 electrocardiogram [ECG]) in patients with Brugada syndrome (BrS).
Background Recent experimental studies have suggested that accentuation of the right ventricular action potential (AP) notch preferentially prolongs epicardial AP causing inversion of the T-wave.
Methods In 19 patients with BrS and 3 control subjects, activation-recovery intervals (ARIs) and repolarization times (RTs) in the epicardium and endocardium were directly examined with the use of local unipolar electrograms at the right ventricular outflow tract. Surface ECG, ARI, and RT were examined before and after administration of pilsicainide.
Results Type 1 ECG was observed in 10 of the 19 BrS patients before the administration of pilsicainide and in all of the 19 patients after the administration of pilsicainide. We found that ARI and RT in the epicardium were shorter than those in the endocardium in all 9 BrS patients without type 1 ECG under baseline conditions and in all control subjects regardless of pilsicainide administration. However, longer epicardial ARI than endocardial ARI was observed in 8 of the 10 BrS patients manifesting type 1 ECG under baseline conditions and in all of the BrS patients after the administration of pilsicainide. Also, epicardial RT was longer than endocardial RT in all patients manifesting type 1 ECG regardless of pilsicainide administration.
Conclusions Our data provide support for the hypothesis that the negative T-wave associated with type 1 BrS ECG is due to a preferential prolongation of the epicardial AP secondary to accentuation of the AP notch in the region of the right ventricular outflow tract.

DOI： 10.1016/j.jacc.2007.10.059

Atrial fibrillation in patients with Brugada syndrome - Relationships of gene mutation, electrophysiology, and clinical backgrounds

Kengo F. Kusano, Makiko Tamyama, Kazufumi Nakamura, Daiji Miura, Kimikazu Banba, Satoshi Nagase, Hiroshi Morita, Nobuhlro Nishil, Atsuyuki Watanabe, Takeshi Tada, Masato Murakarm, Kohei Miyaji, Shigeki Hiramatsu, Koji Nakagawa, Masamichi Tanaka, Aya Miura, Hideo Kimura, Soichiro Fuke, Wakako Sumita, Satoru Sakuragi, Shigern Urakawa, Jun Iwasaki, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51 ( 12 ) 1169 - 1175 2008.3

Language：English Publisher：ELSEVIER SCIENCE INC

Objectives The goal of our work was to examine the relationships of atrial fibrillation (AF) with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS).
Background Atrial fibrillation is often observed in patients with BrS and indicates that electrical abnormality might exist in the atrium as well as in the ventricle. SCN5A, a gene encoding the cardiac sodium channel, has been reported to be causally related to BrS. However, little is known about the relationships of atrial arrhythmias with genetic, clinical, and electrophysiological backgrounds of BrS.
Methods Seventy-three BrS patients (49 +/- 12 years of age, men/women = 72/1) were studied. The existence of SCN5A mutation and clinical variables (syncopal episode, documented ventricular fibrillation [VF], and family history of sudden death) were compared with spontaneous AF episodes. Genetic and clinical variables were also compared with electrophysiologic (EP) parameters: atrial refractory period, interatrial conduction time (CT), repetitive atrial firing, and AF induction by atrial extra-stimulus testing.
Results Spontaneous AF occurred in 10 (13.7%) of the BrS patients and SCN5A mutation was detected in 15 patients. Spontaneous AF was associated with higher incidence of syncopal episodes (60.0% vs. 22.2%, p < 0.03) and documented VF (40.0% vs. 14.3%, p < 0.05). SCN5A mutation was associated with prolonged CT (p < 0.03) and AF induction (p < 0.05) in EP study, but not related to the spontaneous AF episode and other clinical variables. In patients with documented VF, higher incidence of spontaneous AF (30.8% vs. 10.0%, p < 0.05), AF induction (53.8% vs. 20.0%, p < 0.03), and prolonged CT was observed.
Conclusions Spontaneous AF and VF are closely linked clinically and electrophysiologically in BrS patients. Patients with spontaneous AF have more severe clinical backgrounds in BrS. SCN5A mutation is associated with electrical abnormality but not disease severity.

DOI： 10.1016/j.jacc.2007.10.060

Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome

Takeshi Tada, Kengo Fukushima Kusano, Satoshi Nagase, Kimikazu Banba, Daiji Miura, Nobuhiro Nishii, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Tohru Ohe

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 19 ( 1 ) 56 - 61 2008.1

Language：English Publisher：BLACKWELL PUBLISHING

Clinical Significance of Macroscopic T-Wave Alternans. Introduction: Macroscopic T-wave alternans (TWA) is sometimes observed after sodium channel blocker administration in patients with Brugada syndrome (BS), but little is known about the association between occurrence of TWA and clinical characteristics in BS patients. We investigated the association between spontaneous ventricular fibrillation (VF) occurrence and TWA after pilsicainide, a sodium channel blocker administration in BS patients.
Methods and Results: We administered pilsicainide at a dose of 1 mg/kg to 77 BS patients (76 males and one female; mean age, 48.4 years) and examined the association between TWA after pilsicainide administration and clinical characteristics, including age, spontaneous VF, syncope, family history of sudden death, spontaneous coved ST elevation, late potentials (LP), induction of VF by programmed electrical stimulation, and SCN5A mutation. None of the patients had TWA before pilsicainide administration, but TWA became apparent in 17 (22.1%) of the patients after pilsicainide administration. Patients with TWA had a significantly higher incidence of spontaneous VF (52.9% vs 8.3%, P < 0.001) and syncope (58.8% vs 26.7%, P < 0.05) than did patients without TWA. Then, we focused on the association between spontaneous VF and clinical characteristics. Patients with spontaneous VF had a significantly higher incidence of TWA (64.3% vs 12.7%, P < 0.001) and LP positive (92.9% vs 56.5%, P < 0.01) than did patients without spontaneous VF. In multivariate analysis, TWA (P = 0.001) and LP (P = 0.047) appeared as the independent predictor for spontaneous VF.
Conclusion: TWA after pilsicainide administration is associated with a high risk of clinical VF in patients with BS.

DOI： 10.1111/j.1540-8167.2007.00967.x

163)治療抵抗性の原発性肺高血圧症に対しSildenafil併用が著効した成人男性の一例(第90回日本循環器学会中国・四国合同地方会)

特集致死性不整脈をきたす疾患-診断と治療-特殊な機序によるQT延長症候群－HERGチャネルに対する自己抗体.

杉山洋樹, 中村一文, 大江透, 片山祐介

Heart View 12 ( 9 ) 1117 - 1121 2008

抗KCNH2抗体による自己免疫性QT延長症候群－後天性QT延長症候群の新しい発症機序－

中村一文, 片山祐介, 大江透

循環器専門医 16 ( 2 ) 231 - 236 2008

頻回な心室性不整脈を呈したBrugada症候群に対する低用量Isoproterenolの治療効果の検討

渡邊敦之, 草野研吾, 森田宏, 三浦大二, 角田和歌子, 平松茂樹, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 大江透

岡山医学会雑誌 12 ( 9 ) 95 - 99 2008

Topics 心不全の基礎と臨床酸化ストレスと心不全.

中村一文

循環器フォーラム2008 心不全Up-to-date記録集 2 - 3 2008

座談会心不全と不整脈心不全患者の不整脈をどう治療するか.

大江透, 鵜野起久也, 栗田隆志, 庄田守男, 中村一文

不整脈News&Views 26 3 - 9 2008

シンポジウム：肺高血圧症に対する経口治療薬の位置づけと最新の知見5 肺動脈性肺高血圧症治療における最新の知見.

松原広己, 宮地克維, 赤木達, 中村一文

Therapeutic Research 29 ( 10 ) 1780 - 1782 2008

Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

Nakamura K, Shimizu J, Kataoka N, Hashimoto K, Ikeda T, Fujio H, Ohta-Ogo K, Ogawa A, Miura A, Mohri S, Nagase S, Morita H, Kusano KF, Date H, Matsubara H, Mochizuki S, Hashimoto K, Kajiya F, Ohe T

Int J Cardiol 2008

Arterial Stiffening is Associated with Exercise Intolerance and Hyperventilatory Response in Patients with Coronary Artery Disease.

Enko K, Sakuragi S, Kakishita M, Ohkawa K, Nagase S, Nakamura K, Kusano KF, Ohe T

Cardiology 2 41 - 48 2008

Usefulness of a long-straight sheath for atrial lead insertion at the right atrial septum.

Nishii N, Kusano KF, Miyaji K, Hiramatsu S, Tada T, Murakami M, Banba K, Sakai Y, Nagase S, Nakamura K, Sakuragi S, Ohe T

Circ J 72 ( 2 ) 262 - 267 2008

28.?? Topics 心不全の基礎と臨床酸化ストレスと心不全.

中村一文

循環器フォーラム2008 心不全Up-to-date記録集 2 - 3 2008

Clinical features of and effects of angiotensin system antagonists on amiodarone-induced pulmonary toxicity.

Nikaido A, Tada T, Nakamura K, Murakami M, Banba K, Nishii N, Fuke S, Nagase S, Sakuragi S, Morita H, Ohe T, Kusano KF

Int J Cardiol 2008

A novel KCNH2 mutation as a modifier for short QT interval.

Itoh H, Sakaguchi T, Ashihara T, Ding WG, Nagaoka I, Oka Y, Nakazawa Y, Yao T, Jo H, Ito M, Nakamura K, Ohe T, Matsuura H, Horie M

Int J Cardiol 2008

Brugada症候群における遺伝子型と表現型の相関

中村一文, 三浦大志, 三浦大志, 大守伊織, 清水憲二, 森田宏, 草野研吾, 谷山真紀子, 大江透, 大江透

日本人類遺伝学会大会プログラム・抄録集 53rd 2008

日本人Brugada症候群患者における新規SCN5A遺伝子変異

三浦大志, 三浦大志, 中村一文, 谷山真規子, 大守伊織, 清水憲二, 森田宏, 草野研吾, 大江透, 大江透

日本人類遺伝学会大会プログラム・抄録集 53rd 2008

臨床経過において心筋肥大の著明な退縮が確認できたacromegalic cardiomyopathyの1例

村上正人, 中村一文, 大郷恵子, 草野研吾, 大江透, 由谷親夫

循環器科 64 ( 2 ) 2008

頻回な心室性不整脈を呈したBrugada症候群に対する低用量Isoproterenolの治療効果の検討

渡邊敦之, 草野研吾, 森田宏, 三浦大二, 角田和歌子, 平松茂樹, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 大江透

岡山医学会雑誌 120 ( 1 ) 2008

中川晃志, 田中正道, 多田毅, 永瀬聡, 中村一文, 櫻木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 975 - 975 2007.10

50)不整脈源性右室心筋症と診断されていた心サルコイドーシスの一例(第90回日本循環器学会中国・四国合同地方会)

小倉可奈子, 草野研吾, 二階堂暁, 大郷恵子, 福家聡一郎, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 962 - 962 2007.10

107)CRT-Dを施行した修正大血管転位症(C-TGA)の一例(第90回日本循環器学会中国・四国合同地方会)

圓光賢希, 草野研吾, 岡岳文, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 969 - 969 2007.10

196)拡張相肥大型心筋症に合併した難治性心室頻拍に対し開胸下cryoablationを行った一例(第90回日本循環器学会中国・四国合同地方会)

二階堂暁, 草野研吾, 福家聡一郎, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 979 - 979 2007.10

161)PH crisisに対してNO吸入で対応し,緊急生体肺移植を行った原発性肺高血圧症の1例(第90回日本循環器学会中国・四国合同地方会)

岡岳文, 円光賢希, 溝口博喜, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 伊達洋至, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 975 - 975 2007.10

160)心房中隔欠損症の肺高血圧合併患者で,epoprostenol治療中にカテーテル感染からBOOP様経過をたどった一例(第90回日本循環器学会中国・四国合同地方会)

福家聡一郎, 草野研吾, 小倉加奈子, 赤木達, 溝口博喜, 永瀬聡, 中村一文, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 975 - 975 2007.10

Relationship between arrhythmogenesis and disease activity in cardiac sarcoidosis

Kimikazu Banba, Kengo Fukushima Kusano, Kazufumi Nakamura, Hiroshi Morita, Aiko Ogawa, Fuyo Ohtsuka, Keiko Ohta Ogo, Nobuhiro Nishii, Atsuyuki Watanabe, Satoshi Nagase, Satoru Sakuragi, Tohru Ohe

HEART RHYTHM 4 ( 10 ) 1292 - 1299 2007.10

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND In patients with cardiac sarcoidosis, ventricular arrhythmias and/or conduction disturbances are frequently observed and sometimes fatal. However, few reports on disease activity and arrhythmic events in cardiac sarcoidosis are available.
OBJECTIVE The purpose of this study was to investigate the relationship between disease activity and arrhythmic events in cardiac sarcoidosis and the effect of corticosteroid therapy.
METHODS The study population consisted of 15 cardiac sarcoidosis patients with new-onset symptomatic arrhythmia, including eight patients admitted once for complete atrioventricular block (CAVB), five patients admitted once for sustained ventricular tachycardia (VT), and two patients admitted twice for two arrhythmic events (one for CAVB and the other for sustained VT). Disease activity was evaluated by gallium-67 citrate (Ga) scintigraphy. All patients with positive Ga uptake were treated with corticosteroids, and arrhythmic events were evaluated by repeat Hotter recordings.
RESULTS Positive uptake of Ga was observed in 8 (80%) of the 10 CAVB events and in 1 (14%) of the 7 sustained VT events (80% vs 14%, P =.02). Corticosteroids abolished myocardial Ga uptake in all nine patients with positive Ga uptake. After corticosteroid therapy was started, AV conduction improved in 5 of 9 CAVB patients (including 8 patients with new-onset CAVB and one patient with history of CAVB). However, ventricular arrhythmias were not improved after corticosteroid therapy.
CONCLUSION In cardiac sarcoidosis patients, CAVB develops mainly during the active phase of the disease. Early treatment with corticosteroids might improve AV conduction disturbance. However, sustained VT is not closely linked with disease activity and frequently develops in the advanced stage of disease.

DOI： 10.1016/j.hrthm.2007.06.006

Anti-KCNH2 antibody-induced long QT syndrome: Novel acquired form of long QT syndrome

Kazufumi Nakamura, Yusuke Katayama, Kengo F. Kusano, Kayo Haraoka, Yoshinori Tani, Satoshi Nagase, Hiroshi Morita, Daiji Miura, Yoshihisa Fujimoto, Tetsushi Furukawa, Kazuo Ueda, Yoshiyasu Aizawa, Akinori Kimura, Yoshihisa Kurachi, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 50 ( 18 ) 1808 - 1809 2007.10

T75M-KCNJ2 mutation causing Andersen-Tawil syndrome enhances inward rectification by changing Mg2+ sensitivity

Yoshinori Tani, Daiji Miura, Junko Kurokawa, Kazufumi Nakamura, Mamoru Ouchida, Kenji Shimizu, Tohru Ohe, Tetsushi Furukawa

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 43 ( 2 ) 187 - 196 2007.8

Language：English Publisher：ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Andersen-Tawil syndrome (ATS) is a multisystem inherited disease exhibiting periodic paralysis, cardiac arrhythmias, and dysmorphic features. In this study, we characterized the KCNJ2 channels with an ATS mutation (T75M) which is associated with cardiac phenotypes of bidirectional ventricular tachycardia, syncope, and QT(c) prolongation. Confocal imaging of GFP-KCNJ2 fusion proteins showed that the T75M mutation impaired membrane localization of the channel protein, which was restored by co-expression of WT channels with T75M channels. Whole-cell patch-clamp experiments in CHO-K1 cells showed that the T75M mutation produced a loss-of-function of the channel. When both WT and the T75M were co-expressed, the T75M mutation showed dominant-negative effects on inward rectifier K+ current densities, with prominent suppression of outward currents at potentials between 0 mV and + 80 mV over the E-K. Inside-out patch experiments in HEK293T cells revealed that co-expression of WT and the T75M channels enhanced voltage-dependent block of the channels by internal Mg2+, resulting in enhanced inward rectification at potentials 50 mV more positive than the EK. We suggest that the T75M mutation causes dominant-negative suppression of the co-expressed WT KCNJ2 channels. In addition, the T75M mutation caused alteration of gating kinetics of the mutated KCNJ2 channels, i.e., increased sensitivity to intracellular Mg2+ and resultant enhancement of inward rectification. The data presented suggest that the mutation may influence clinical features, but it does not directly show this. (c) 2007 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.yjmcc.2007.05.005

The role of autonomic nervous activity on arrhythmogenesis of Brugada syndrome

SANGAWA Mutsuko, NAKATSU Takaaki, TOYONAGA Shinji, MASHIMA Keiichi, KUSACHI Shozo, WATANABE Atsuyuki, BANBA Kimikazu, NISHII Nobuhiro, TADA Takeshi, NAGASE Satoshi, MORITA Hiroshi, NAKAMURA Kazufumi, KUSANO Kengo, OHE Tohru

44 ( 3 ) 156 - 165 2007.6

71)WPW症候群を合併した家族性肥大型心筋症の一例(第89回日本循環器学会中国地方会)

赤木達, 大田恵子, 中川晃志, 多田毅, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 858 - 858 2007.4

36)心臓再同期療法後より頻発する心室頻拍に対し高周波カテーテルアブレーションを施行した一例(第89回日本循環器学会中国地方会)

二階堂暁, 酒井芳昭, 赤木進, 福家聡一郎, 西井伸洋, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 854 - 854 2007.4

89)原発性肺高血圧症の心房中隔欠損合併例にepoprostenolを導入した2症例(第89回日本循環器学会中国地方会)

福家聡一郎, 二階堂暁, 圓光賢希, 赤木達, 溝口博喜, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 860 - 860 2007.4

68)ステロイド投与が有用であった好酸球性心筋炎の一症例(第89回日本循環器学会中国地方会)

圓光賢希, 桜木悟, 大郷恵子, 永瀬聡, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 857 - 857 2007.4

3)ヒト冠動脈平滑筋細胞におけるPioglitazoneの効果 : 遊走・増殖・活性酸素発生の抑制効果の検討(第89回日本循環器学会中国地方会)

吉川昌樹, 中村一文, 永瀬聡, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 71 850 - 850 2007.4

FRS-087 Relationship between SCN5A Mutation and Atrial Vulnerability in Brugada Syndrome(Arrhythmia (clinical) ; Pathophysiology of Atrial Fibrillation, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Taniyama Makiko, Kusano Kengo, Banba Kimikazu, Morita Hiroshi, Nishii Nobuhiro, Watanabe Atsuyuki, Miura Daiji, Sumida Wakako, Iwasaki Jun, Urakawa Shigemi, Kimura Hideo, Miura Aya, Kobayashi Kaoru, Nagase Satoshi, Nakamura Kazufumi, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 71 141 - 141 2007.3

心不全(下）－最新の基礎・臨床研究の進歩－XXIII 心不全での合併症－成因・病態・治療－不整脈心不全に用いられる抗不整脈薬

中村一文, 西井伸洋, 大江透

日本臨床 65 ( 5 ) 369 - 374 2007

Efficacy and safety of the additional bepridil treatment in patients with atrial fibrillation refractory to class I antiarrhythmic drugs.

Miyaji K, Tada H, Fukushima Kusano K, Hashimoto T, Kaseno K, Hiramatsu S, Tadokoro K, Naito S, Nakamura K, Oshima S, Taniguchi K, Ohe T

Circ J 71 ( 8 ) 1250 - 1257 2007

異常Purkinje線維の興奮と多源性心室性不整脈の発生機序に関し検討を行った特発性心室細動の1例

伴場主一, 草野研吾, 永瀬聡, 西井伸洋, 渡邊敦之, 平松茂樹, 多田毅, 村上正人, 大郷恵子, 酒井芳昭, 中村一文, 櫻木悟, 大江透

臨床心臓電気生理 30 237 - 245 2007

Language：Japanese Publisher：臨床心臓電気生理研究会

29歳の女性。Short-coupled variant of torsade de pointesとして植込み型除細動器(ICD)植込みをされている。電気生理学的検査開始時より心室期外収縮はさまざまな連結期で出現し、波形もさまざまであった。この多源性の心室期外収縮は、左室内中部中隔に配置した多極カテーテルからの記録によって常にPurkinje電位(PP)が同じ場所で同じ興奮順序で記録された。興味あることにこのPPが出現する周期を検討すると、副収縮を呈していた。PPの連結期とPP-心室期外収縮間隔について検討を行うとPP-心室期外収縮間の興奮伝導様式には遅延伝導と減衰伝導特性が存在し、Purkinje network内あるいはPurkinje-心筋間でのブロックの変化によって多源性の心室期外収縮様のQRS波形を呈しているものと考えられた。心室期外収縮連発時も各々のQRS波形に先行してPPが記録され、PPを標的に高周波アブレーションを施行し、心室期外収縮は消失した。(著者抄録)

原発性肺高血圧症の進行メカニズムの解明と治療薬の開発

小川愛子, 中村一文, 松原広己, 藤尾栄起, 池田哲也, 宮地克維, 三浦大志, 三浦綾, 永瀬聡, 草野研吾, 伊達洋至, 大江透

岡山医学会雑誌 118 ( 3 ) 187 - 192 2007

循環器症候群（第2版）Ⅰ－その他の循環器疾患を含めて－Ⅲ. 不整脈二次性QT延長症候群

原岡佳代, 中村一文, 大江透

別冊日本臨床新領域別症候群シリーズ 4 221 - 224 2007

イオン感応性電界効果トランジスタ（ISFET）を用いた迅速・簡便な細胞活性測定システムの開発

合田典子, 中村通宏, 山本尚武, 中村一文

中谷電子計測技術振興財団年報 21 53 - 57 2007

救命しえた劇症型好酸球性心筋炎の1例

大郷恵子, 圓光賢希, 草野研吾, 櫻木悟, 永瀬聡, 中村一文, 柳井広之, 大森昌子, 大家政志, 難波靖治, 津田佳穂, 大江透

心臓 39 ( 3 ) 112 - 117 2007

Language：Japanese Publisher：(公財)日本心臓財団

症例は19歳、男性。主訴は胸苦・胸痛。2006年4月29日午前2時ころ、胸苦・胸痛のため近医を受診、心電図上広範囲のST-T変化を認め急性心膜炎の疑いで入院となった。30日午前4時ころより血圧低下がみられたためdopamine点滴を開始され当科転院となった。転院時、血圧80mmHg、脈拍130/分で、奇脈、III音、頸静脈怒張を認めた。心エコーでの左室壁厚増大とびまん性の高度壁運動低下(左室駆出率23.8%)、多量の心嚢液貯留、CPKの上昇などから劇症型心筋炎による心原性ショックと診断した。機械的循環補助を行った上で、心臓カテーテル検査により冠動脈疾患を否定し、右室心内膜心筋生検を施行した。5月2日好酸球性心筋炎との組織診断によりステロイド投与を開始した。そのころより心機能の急速な回復がみられ、補助循環が離脱可能となった(離脱時に脳出血を合併)。その後ステロイドを漸減中止したが好酸球性心筋炎の再発やLoeffler心内膜炎への移行は認めていない。原因検索の結果、イヌ回虫に対する抗体が陽性であり、寄生虫感染に関連した好酸球性心筋炎と考えられた。今回著者等は劇症型心筋炎がイヌ回虫感染に伴う好酸球性心筋炎によるという稀な1例を経験し、ステロイド投与と機械的循環補助により救命しえたので報告する。(著者抄録)

DOI： 10.11281/shinzo1969.39.Supplement3_112

Other Link： https://search.jamas.or.jp/default/link?pub_year=2007&ichushi_jid=J00679&link_issn=&doc_id=20070820320022&doc_link_id=10.11281%2Fshinzo1969.39.Supplement3_112&url=https%3A%2F%2Fdoi.org%2F10.11281%2Fshinzo1969.39.Supplement3_112&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Brugada症候群における電気的異常についての検討

草野研吾, 永瀬聡, 森田宏, 中村一文, 伴場主一, 西井伸洋, 大江透

Journal of Cardiology 50 ( Supplement 1 ) 2007

4-hydroxy-2-nonenal induces calcium overload via NADPH oxidase-derived reactive oxygen species in isolated rat cardiac myocytes

Kazufumi Nakamura, Daiji Miura, Hiromi Matsubara, Wakako Sumita, Satoshi Nagase, Satoru Sakuragi, Kengo F. Kusano, Tohru Ohe

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 41 ( 6 ) 1050 - 1050 2006.12

Aldosterone synthesis and cytokine production in human peripheral blood mononuclear cells

Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Katsushi Hashimoto, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tetsuro Emori, Kazuhiko Ishihara, Tohru Ohe

JOURNAL OF PHARMACOLOGICAL SCIENCES 102 ( 3 ) 288 - 295 2006.11

Language：English Publisher：JAPANESE PHARMACOLOGICAL SOC

Previously, we reported that spironolactone reduced cytokine production in cultured human peripheral blood mononuclear cells (PBMCs) with angiotensin (Ang) II stimulation. To address the mechanisms underlying this effect, we examined the contribution of aldosterone to cytokine production in cultured human PBMCs with Ang II stimulation. PBMCs expressed the messenger RNA (mRNA) of Ang II type I receptor (ATIR) and mineralocorticoid receptor (MR) both spontaneously and after Ang II stimulation, but expressed Ang II type 2 receptor (AT2R) under neither condition. After 24 h of incubation, exogenous Ang II induced the expression of CYP11B2 (a key enzyme of aldosterone synthesis) mRNA and caused aldosterone synthesis. CV-11974 (an AT1R antagonist) reduced Ang II-induced aldosterone synthesis, whereas PD-123319 (an AT2R antagonist) had no effect. The concentration of aldosterone peaked earlier than those of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha). After 48 h of incubation (under the influence of synthesized aldosterone), CV-11974 and spironolactone significantly reduced the Ang II-enhanced production of MCP-1 and TNF-alpha, whereas PD-123319 also had no effect. In conclusion, Ang II induces aldosterone synthesis through AT1R and enhances cytokine production through an AT1R-dependent mechanism and, at least partly, through a MR-dependent mechanism in human PBMCs.

DOI： 10.1254/jphs.FP0060801

188)Narrow QRSに対し心臓再同期療法を施行した2症例(第88回日本循環器学会中国・四国合同地方会)

西井伸洋, 草野研吾, 多田毅, 大田恵子, 村上正人, 平松茂樹, 渡辺敦之, 伴場主一, 永瀬聡, 中村一文, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1169 - 1169 2006.10

136)デスミン蓄積が原因と考えられた拡張型心筋症の一例(第88回日本循環器学会中国・四国合同地方会)

大郷恵子, 多田毅, 草野研吾, 酒井芳昭, 伴場主一, 西井伸洋, 渡辺敦之, 平松茂樹, 永瀬聡, 中村一文, 桜木悟, 由谷親夫, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1164 - 1164 2006.10

66)異常Purkinje線維の興奮が不整脈発生に関与したshort-coupled variant of torsades de pointesの一症例(第88回日本循環器学会中国・四国合同地方会)

伴場主一, 永瀬聡, 西井伸洋, 渡辺敦之, 村上正人, 多田毅, 大田恵子, 酒井芳昭, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1156 - 1156 2006.10

78)左上肺静脈局所起源発作性心房頻拍が心房細動の発生,維持に関係した一例(第88回日本循環器学会中国・四国合同地方会)

酒井芳昭, 伴場主一, 西井伸洋, 平松茂樹, 渡辺敦之, 村上正人, 永瀬聡, 桜木悟, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1157 - 1157 2006.10

142)肥大型心筋症患者の収縮不全における酸化ストレスによるDNA傷害の関与(第88回日本循環器学会中国・四国合同地方会)

木村英夫, 中村一文, 永瀬聡, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1165 - 1165 2006.10

4-hydroxy-2-nonenal induces calcium overload via NADPH oxidase-derived reactive oxygen species in isolated rat cardiac myocytes

Kazufumi Nakamura, Daiji Miura, Wakako Sumita, Makiko Taniyama, Satoshi Nagase, Satoru Sarkuragi, Kengo F. Kusano, Tohru Ohe, Hiromi Matsubara

CIRCULATION 114 ( 18 ) 207 - 207 2006.10

Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells

Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe, Kazuhiko Ishihara

JOURNAL OF PHARMACOLOGICAL SCIENCES 101 ( 3 ) 256 - 259 2006.7

Language：English Publisher：JAPANESE PHARMACOLOGICAL SOC

We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. Specifically, 10 mu M of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

DOI： 10.1254/jphs.SC0060049

Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome

A Watanabe, KF Kusano, H Morita, D Miura, W Sumida, S Hiramatsu, K Banba, N Nishii, S Nagase, K Nakamura, S Sakuragi, T Ohe

EUROPEAN HEART JOURNAL 27 ( 13 ) 1579 - 1583 2006.7

Language：English Publisher：OXFORD UNIV PRESS

Aims Arrhythmic storm or repetitive ventricular arrhythmia (VA) has been occasionally observed in Brugada syndrome (BS). A beta-adrenergic stimulator [isoproterenol (ISP)] has been reported to suppress this arrhythmic storm in sporadic cases. Accordingly, we investigated the antiarrhythmic effects of ISP infusion in consecutive BS patients with arrhythmic storm or repetitive VA.
Methods and results Seven BS patients with arrhythmic storm were studied. Intravenous ISP was administered as a bolus injection (1-2 mu g), followed by continuous infusion (0.15 mu g/min). Arrhythmic storm or repetitive VA was suppressed immediately after the bolus administration of ISP, which was followed by continuous infusion of low-dose ISP for 1-3 days. In all patients, ST-elevation decreased in right precordial leads. In six of the seven patients, VA subsided after the discontinuance of ISP. RR interval was shortened and ST-elevation in right precordial leads was decreased after ISP bolus injection. ST-elevation in right precordial leads remained decreased during continuous ISP infusion, whereas the RR interval returned to the control level.
Conclusion Continuous administration of low-dose ISP may be effective for the suppression of repetitive VA occurrence in patients with BS.

DOI： 10.1093/eurheartj/ehl060

246)自己免疫機序による慢性心筋炎が病因と考えられた左室機能不全の一例(第87回日本循環器学会中国・四国合同地方会)

特発性肺動脈高血圧症に対するスタチンの効果

池田哲也, 中村一文, 小川愛子, 三浦大志, 永瀬聡, 桜木悟, 草野研吾, 大江透, 伊達洋至, 松原広己, 藤尾栄起

Circ J 70 ( Supplement 2 ) 1077 2006.4

大郷恵子, 多田毅, 三浦綾, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透, 由谷親夫

Circulation journal : official journal of the Japanese Circulation Society 70 1078 - 1078 2006.4

90) Brugada症候群におけるSCN5A遺伝子の変異と電気生理学的検査における検討(第87回日本循環器学会中国・四国合同地方会)

伴場主一, 草野研吾, 中村一文, 永瀬聡, 三浦大志, 平松茂樹, 西井伸洋, 渡辺敦之, 岩崎淳, 浦川茂美, 谷山真規子, 角田和歌子, 三浦綾, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1061 - 1061 2006.4

92) Pilsicainide負荷時の高位肋間のみでBrugada型心電図を呈したSCN5A異常を有する1例(第87回日本循環器学会中国・四国合同地方会)

平松茂樹, 渡辺敦之, 西井伸洋, 伴場主一, 三浦大志, 永瀬聡, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1061 - 1061 2006.4

88)左室起源リエントリ性心室頻拍にて発見されたSCN5A遺伝子変異を認めるBrugada症候群の一例(第87回日本循環器学会中国・四国合同地方会)

酒井芳昭, 永瀬聡, 平松茂樹, 西井伸洋, 伴場主一, 渡辺敦之, 細木信吾, 三浦大志, 谷山真規子, 木村英夫, 岩崎淳, 浦川茂美, 角田和歌子, 三浦綾, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1060 - 1060 2006.4

59)β刺激薬負荷で誘発された冠攣縮性狭心症の一例(第87回日本循環器学会中国・四国合同地方会)

三宅智博, 和田匡史, 細木信吾, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1057 - 1057 2006.4

94)多種類の薬剤が心室性不整脈の抑制に有効であったAndersen症候群の2例(第87回日本循環器学会中国・四国合同地方会)

和田匡史, 永瀬聡, 細木信吾, 多田毅, 村上正人, 溝口博喜, 大郷恵子, 伴場主一, 酒井芳昭, 中村一文, 櫻木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1061 - 1061 2006.4

PJ-157 Changes of Late Potentials after Administration of Sodium Channel Blocker in Brugada Syndrome(ECG/Body surface potential mapping/Holter-6 () PJ27,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Watanabe Atsuyuki, Kusano Kengo, Hiramatsu Shigeki, Tada Takeshi, Murakami masato, Banba Kimikazu, Nishii Nobuhiro, Hosogi Shingo, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Sakuragi Satoru, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 70 528 - 528 2006.3

Brugada Syndrome(Morning Lecture 9 (ML9) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Kusano Kengo, Kusano Kengo F., Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Sakuragi Satoru, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 70 100 - 100 2006.3

PE-598 Detection of T Wave Abnormality in Brugada Syndrome : Usefulness of Vector Electrocardiograms and Body Surface Mapping(ECG/Body surface potential mapping/Holter-4 (A) PE60,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Hiramatsu Shigeki, Kusano Kengo, Murakami Masato, Tada Takeshi, Watanabe Atsuyuki, Banba Kimikazu, Nishii Nobuhiro, Hosogi Shingo, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Sakuragi Satoru, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 70 424 - 424 2006.3

肺動脈性肺高血圧症の診断・治療と経過の検討

小川愛子, 草野研吾, 松原広己, 宮地克維, 永瀬聡, 中村一文, 桜木悟, 伊達洋至, 大江透

日本内科学会雑誌 95 179 2006.2

冠動脈造影により診断できた若年発症心室細動の2症例．

伴場主一, 草野研吾, 永瀬聡, 平松茂樹, 宮地晃平, 木村英夫, 西井伸洋, 中村一文, 桜木悟, 大江透

心臓 38,3,105-111 2006

SCN5A遺伝子変異を有するBrugada症候群の心電図および電気生理学的特徴－ピルジカイニド負荷試験を中心に－

伴場主一, 草野研吾, 中村一文, 永瀬聡, 渡邊敦之, 西井伸洋, 三浦大志, 森田宏, 櫻木悟, 大江透

Japanese Journal of Electrocardiology 26,4,S-4-97-S-4-101 2006

Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure.

Kono Y, Nakamura K, Kimura H, Nishii N, Watanabe A, Banba K, Miura A, Nagase S, Sakuragi S, Kusano KF, Matsubara H, Ohe T

Circulation Journal 2006

特論致死的不整脈への対応．

村上正人, 中村一文, 大江透

日本臨床 64,5,985-989 2006

心機能低下例における不整脈の薬物療法－上流治療ならびに抗不整脈薬の効果－

中村一文, 岩崎淳

医学のあゆみ 218,14,1213-1216 2006

KCNJ2の遺伝子変異を認めるAndersen症候群 (LQT7) における心臓電気生理学的検討．

永瀬聡, 柚木佳, 三浦大志, 吉田賢司, 西井伸洋, 伴場主一, 中村一文, 斎藤博則, 草野研吾, 大江透

臨床心臓電気生理 29,257-264 2006

Carvedilol inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

Fujio H, Nakamura K, Matsubara H, Kusano KF, Miyaji K, Nagase S, Ikeda T, Ogawa A, Ohta-Ogo K, Miura D, Miura A, Miyazaki M, Date H, Ohe T

J Cardiovasc Pharmacol 2006

特集/薬物によるQT延長の諸問題：遺伝子からICHまで 6. 後天性QT延長症候群の臨床的特徴．

草野研吾, 中村一文, 大江透

臨床薬理 37,4,227-230 2006

サイファーステント留置後, 再狭窄をきたした1症例(第86回日本循環器学会中国地方会)

吉川昌樹, 細木信吾, 武寛, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 907 - 907 2005.10

SCN5A遺伝子に異常を認めた Brugada 症候群-LQT3の2症例(第86回日本循環器学会中国地方会)

吉田賢司, 柚木佳, 三浦大志, 木村英夫, 平松茂樹, 渡辺敦之, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透, 宮地晃平

Circulation journal : official journal of the Japanese Circulation Society 69 910 - 910 2005.10

巨大MACの一例(第86回日本循環器学会中国地方会)

杜徳尚, 村上正人, 谷口学, 丸尾健, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透, 宮地克維

Circulation journal : official journal of the Japanese Circulation Society 69 914 - 914 2005.10

原発性肺高血圧症 (PPH) と特発性血小板減少性紫斑病 (ITP) を合併した一例(第86回日本循環器学会中国地方会)

溝口博喜, 谷口学, 宮地克維, 藤尾栄起, 小川愛子, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 915 - 915 2005.10

T波の oversensing によるICD誤作動を繰り返した1例(第86回日本循環器学会中国地方会)

村上正人, 宮地剛, 角田和歌子, 西井伸洋, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 911 - 911 2005.10

心房細動に対して, 電気的 substarate ablation を行った2症例(第86回日本循環器学会中国地方会)

武寛, 西井伸洋, 永瀬聡, 草野研吾, 村上正人, 溝口博喜, 谷口学, 平松茂樹, 渡辺敦之, 伴場主一, 中村一文, 齋藤博則, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 910 - 910 2005.10

急性心筋炎後心室頻拍の乳児に対してアミオダロン持続静注が極めて有効であった1症例(第86回日本循環器学会中国地方会)

細木信吾, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 911 - 911 2005.10

Equivalence of flow velocities through bilateral pulmonary vein anastomoses in bilateral living-donor lobar lung transplantation

K Miyaji, H Matsubara, K Nakamura, KF Kusano, K Goto, H Date, T Ohe

JOURNAL OF HEART AND LUNG TRANSPLANTATION 24 ( 7 ) 860 - 864 2005.7

Language：English Publisher：ELSEVIER SCIENCE INC

Background: Intraoperative transesophageal echocardiography (TEE) during lung transplantation is useful for monitoring cardiac condition and pulmonary vascular anastomoses to detect vascular complications, but the parameters for evaluation by TEE during lung transplantation have not been established.
Methods: We performed intraoperative TEE on 17 patients during living-donor lobar lung transplantation (LDLLT) and investigated the usefulness of measurement of peak flow velocities through bilateral pulmonary vein (PV) anastomoses and evaluation of the equivalence.
Results: The peak flow velocities through bilateral PV anastomoses were almost equivalent in 14 patients without complications and were not equivalent in 3 patients with complications such as vascular stenosis and peripheral atelectasis.
Conclusions: The flow velocities through the bilateral PV anastomoses are shown to be nearly equivalent during bilateral LDLLT, and the equivalence may be one factor for predicting the success of LDLLT.

DOI： 10.1016/j.healun.2004.05.021

Therapeutic Effect of Beta-Stimulant on Patients with Brugada Syndrom(Arrhythmia, Pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Watanabe Atsuyuki, Morita Hiroshi, Sumida Wakako, Banba Kimikazu, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 69 536 - 536 2005.3

The Use of Low Dose Quinidine Test to Differentiate between Symptomatic and Asymptomatic Patients with Brugada Syndrome (Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Watanabe Atsuyuki, Morita Hiroshi, Sumida Wakako, Banba Kimikazu, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 69 290 - 290 2005.3

Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy

K Nakamura, KF Kusano, H Matsubara, Y Nakamura, A Miura, N Nishii, K Banba, S Nagase, K Miyaji, H Morita, H Saito, T Emori, T Ohe

JOURNAL OF CARDIAC FAILURE 11 ( 2 ) 117 - 123 2005.3

Language：English Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS

Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism is not known. We examined whether oxidative stress was elevated in myocardia of HCM patients and whether the levels were correlated with left ventricular dilatation and systolic dysfunction.
Methods and Results: Endomyocardial biopsy samples obtained from the right ventricular side of the septum of 31 patients with HCM, and 10 control subjects were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with HCM. Expression was distinct in the cytosol of cardiomyocytes. The expression levels in patients with HCM were significantly increased compared with those in control subjects (P = .0005). The expression levels in patients with HCM were correlated with left ventricular end-diastolic diameter (r = 0.483, P = .0053) and end-systolic diameter (r = 0.500, P = .0037) determined by echocardiography. The expression levels were inversely con-elated with left ventricular ejection fraction determined by left ventriculography (r = -0.640, P = .0001).
Conclusion: Oxidative stress was elevated in myocardia of HCM patients and the levels were correlated with left ventricular dilatation and systolic dysfunction. Oxidative stress is involved in the pathogenesis of heart failure in patients with HCM.

DOI： 10.1016/j.cardfail.2004.05.005

94) 原発性肺高血圧症患者におけるMCP-1(第84回日本循環器学会中国地方会)

Risk of alveolar hemorrhage in patients with primary pulmonary hypertension -anticoagulation and epoprostenol therapy-

Ogawa A, Matsubara H, Fujio H, Miyaji K, Nakamura K, Morita H, Saito H, Kusano FK, Emori T, Date H, Ohe T

Circulation Journal 2005

Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia.

Yumoto A, Kusano FK, Nakamura K, Hashimoto K, Aoki M, Morishita R, Kaneda Y, Ohe T

Acta Med. Okayama 2005

Prednisolone inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

Ogawa A, Nakamura K, Matsubara H, Fujio H, Ikeda T, Kobayashi K, Miyazaki I, Asanuma M, Miyaji K, Miura D, Kusano FK, Date H, Ohe T

Circulation 2005

頻回の心室細動発作に対してキニジンが著効したBrugada症候群の1例

渡辺敦之, 森田宏, 草野研吾, 角田和歌子, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 斎藤博則, 大江透

心臓 37,SUPPL.3,68-72 2005

臨床心臓の病気・病態での突然死 QT延長症候群

渡辺敦之, 中村一文, 森田宏, 草野研吾, 大江透

日本臨床 63,7,1171-1177 2005

Para-hisian accessory pathwayに対しアブレーションを施行した肥大型心筋症の2例

永瀬聡, 草野研吾, 西井伸洋, 渡辺敦之, 伴場主一, 平松茂樹, 中村一文, 斉藤博則, 大江透

不整脈 21 ( 2 ) 2005

右室心尖部以外に留置された植込み型除細動器の心室リードの安全性について

西井伸洋, 草野研吾, 平松茂樹, 村上正人, 渡辺敦之, 伴場主一, 永瀬聡, 中村一文, 斉藤博則

不整脈 21 ( 2 ) 2005

橋本克史, 中村一文, 藤尾栄起, 永瀬聡, 宮地克維, 森田宏, 齋藤博則, 草野研吾, 江森哲郎, 大江透, 松原広己

Circulation journal : official journal of the Japanese Circulation Society 68 948 - 948 2004.10

65) 院内AEDによる除細動にて救命された2症例(第84回日本循環器学会中国地方会)

斉藤博則, 江森哲郎, 森田宏, 中村一文, 大江透, 林峰栄, 氏家良人

Circulation journal : official journal of the Japanese Circulation Society 68 945 - 945 2004.10

8) マラソン中に心肺停止をきたした右冠動脈起始異常の一症例(第84回日本循環器学会中国地方会)

伴場主一, 宮地晃平, 清藤哲司, 永瀬聡, 中村一文, 森田宏, 齋藤博則, 村上充, 江森哲郎, 大江透, 谷本耕司郎

Circulation journal : official journal of the Japanese Circulation Society 68 939 - 939 2004.10

72) 高齢にて発症したQT延長症候群の一例(第84回日本循環器学会中国地方会)

三浦大志, 中村一文, 久松研一, 永瀬聡, 森田宏, 竹中志保, 斉藤博則, 江森哲郎, 大江透, 西内崇将, 幡芳樹, 水尾浩三

Circulation journal : official journal of the Japanese Circulation Society 68 946 - 946 2004.10

Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: Roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action

M Takeda, F Otsuka, K Nakamura, K Inagaki, J Suzuki, D Miura, H Fujio, H Matsubara, H Date, T Ohe, H Makino

ENDOCRINOLOGY 145 ( 9 ) 4344 - 4354 2004.9

Language：English Publisher：ENDOCRINE SOC

The functional involvement of bone morphogenetic protein (BMP) system in primary pulmonary hypertension (PPH) remains unclear. Here we demonstrate a crucial role of the BMP type 113 receptor, activin receptor-like kinase (ALK)-6 for pulmonary arterial smooth muscle cell (pphPASMC) mitosis isolated from a sporadic PPH patient bearing no mutations in BMPR2 gene. A striking increase in the levels of ALK-6 mRNA was revealed in pphPASMC compared with control PASMCs, in which ALK-6 transcripts were hardly detectable. BMP-2 and -7 stimulated the mitosis of pphPASMCs, which was opposite to their suppressive effects on the mitosis of the control PASMCs. BMP-4 and -6 and activin inhibited pphPASMC mitosis, whereas these did not affect control PASMCs. The presence of BMP signaling machinery in pphPASMCs was elucidated based on the analysis on Id-1 transcription and Smad-reporter genes. Overexpression of a dominant-negative ALK-6 construct revealed that ALK-6 plays a key role in the mitosis as well as intracellular BMP signaling of pphPASMCs. Gene silencing of ALK-6 using small interfering RNA also reduced DNA synthesis as well as Id-1 transcription in pphPASMCs regardless of BMP-2 stimulation. Although Id-1 response was not stimulated by BMP-2 in control PASMCs, the gene delivery of wild-type ALK-6 caused significant increase in the Id-1 transcripts in response to BMP-2. Additionally, inhibitors of ERK and p38 MAPK pathways suppressed pphPASMC mitosis induced by BMP-2, implying that the mitotic action is in part MAPK dependent. Thus, the BMP system is strongly involved in pphPASMC mitosis through ALK-6, which possibly leads to activation of Smad and MAPK, resulting in the progression of vascular remodeling of pulmonary arteries in PPH.

DOI： 10.1210/en.2004-0234

Diagnostic value of epinephrine test for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome

W Shimizu, T Noda, H Takaki, N Nagaya, K Satomi, T Kurita, K Suyama, N Aihara, K Sunagawa, S Echigo, Y Miyamoto, Y Yoshimasa, K Nakamura, T Ohe, JA Towbin, SG Priori, S Kamakura

HEART RHYTHM 1 ( 3 ) 276 - 283 2004.9

Language：English Publisher：ELSEVIER SCIENCE INC

OBJECTIVES The aim of this study was to test the hypothesis that epinephrine test may have diagnostic value for genotyping LQT1, LQT2, and LQT3 forms of congenital long QT syndrome (LQTS).
BACKGROUND A differential response of dynamic QT interval to epinephrine infusion between LQT1, LQT2, and LQT3 syndromes has been reported, indicating the potential diagnostic value of the epinephrine test for genotyping the three forms.
METHODS The responses of 12-lead ECG parameters to epinephrine were retrospectively examined in 15 LQT1, 10 LQT2, 8 LQT3, and 10 healthy volunteers to select the best ECG criteria for separating the four groups. The epinephrine test then was prospectively conducted in 42 probands clinically affected with LQTS, their 67 family members, and 10 new volunteers. The best criteria were applied in a blinded fashion to prospectively separate a different group of 31 LQT1, 23 LQT2, 6 LQT3, and 30 Control patients (10 genotype-negative LQT1, 10 genotype-negative LQT2 family members, and 10 volunteers).
RESULTS The sensitivity (penetrance) by ECG diagnostic criteria was lower in LQT1 (68%) than in LQT2 (83%) or LQT3 (83%) before epinephrine and was improved with steady-state epinephrine in LQT1 (87%) and LQT2 (91%) but not in LQT3 (83%), without the expense of specificity (100%). The sensitivity and specificity to differentiate LQT1 from LQT2 were 97% and 96%, those from LQT3 were 97% and 100%, and those from Control were 97% and 100%, respectively, when Delta mean corrected Q-Tend greater than or equal to35ms at steady state was used. The sensitivity and specificity to differentiate LQT2 from LQT3 or Control were 100% and 100%, respectively, when Delta mean corrected Q-Tend greater than or equal to80ms at peak was used.
CONCLUSIONS Epinephrine infusion is a powerful test to predict the genotype of LQT1, LQT2, and LQT3 syndromes as well as to improve the clinical diagnosis of genotype-positive patients, especially those with LQT1 syndrome.

DOI： 10.1016/j.hrthm.2004.04.021

Differences between flow profiles of pulmonary vein anastomoses affected by peripheral atelectasis in cadaveric and bilateral living-donor lobar lung transplantations

K Miyaji, H Matsubara, K Nakamura, T Maruo, H Morita, H Saito, KF Kusano, T Emori, K Goto, H Date, T Ohe

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 17 ( 9 ) 1003 - 1004 2004.9

Language：English Publisher：MOSBY, INC

We report two cases of peripheral atelectasis during cadaveric and living-donor lobar lung transplantation, which had different effects on the flow profile of pulmonary vein (PV) anastomoses. In the patient who underwent living-donor lobar lung transplantation, we detected the increase in the velocity of blood flow through the left PV anastomosis by intraoperative transesophageal echocardiography. Then peripheral atelectasis occurred in the transplanted left lung lobe. On the other hand, in the patient who underwent cadaveric bilateral lung transplantation, peripheral atelectasis occurred, but no changes in velocities of blood flow through PV anastomoses were detected by intraoperative transesophageal echocardiography. This difference may have been caused by the difference in sizes of pulmonary beds of transplanted grafts. These findings indicate the necessity of careful monitoring of PV anastomoses, especially in cases of living-donor lobar lung transplantation.

DOI： 10.1016/j.echo.2004.04.034

Effect of a kink in unilateral pulmonary artery anastomosis on velocities of blood flow through bilateral pulmonary vein anastomose's in living-donor lobar lung transplantation

K Miyaji, K Nakamura, T Maruo, H Morita, H Saito, T Emori, K Goto, H Date, T Ohe

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 17 ( 9 ) 998 - 999 2004.9

Language：English Publisher：MOSBY, INC

Intraoperative transesophageal echocardiography is generally performed to detect vascular complications during lung transplantation. We report a case with a kink in pulmonary artery (PA) anastomosis suggested by an abnormal flow profile of pulmonary vein (PV) anastomoses during living-donor lobar lung transplantation. During the transplantation, velocity of blood flow through the right PV anastomosis showed abnormal elevation. Then, the patient's PA pressure elevated abnormally and a kink in the left PA anastomosis was found. Careful monitoring of PV anastomoses; may enable detection of not only an abnormality of PV anastomoses but also that of PA anastomoses, especially in living-donor lobar lung transplantation.

DOI： 10.1016/j.echo.2004.04.014

Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in the LQT1 form of congenital long QT syndrome - Multicenter study in Japan

W Shimizu, M Horie, S Ohno, K Takenaka, M Yamaguchi, M Shimizu, T Washizuka, Y Aizawa, K Nakamura, T Ohe, T Aiba, Y Miyamoto, Y Yoshimasa, JA Towbin, SG Priori, S Kamakura

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 44 ( 1 ) 117 - 125 2004.7

Language：English Publisher：ELSEVIER SCIENCE INC

OBJECTIVES We sought to compare the arrhythmic risk and sensitivity to sympathetic stimulation of mutations located in transmembrane regions and C-terminal regions of the KCNQ1 channel in the LQT1 form of congenital long QT syndrome (LQTS).
BACKGROUND The LQT1 syndrome is frequently manifested with variable expressivity and incomplete penetrance and is much more sensitive to sympathetic stimulation than the other forms.
METHODS Sixty-six LQT1 patients (27 families) with a total of 19 transmembrane mutations and 29 patients (10 families) with 8 C-terminal mutations were enrolled from five Japanese institutes.
RESULTS Patients with transmembrane mutations were more frequently affected based on electrocardiographic (ECG) diagnostic criteria (82% vs. 24%, p < 0.0001) and had more frequent LQTS-related cardiac events (all cardiac events: 55% vs. 21%, p = 0.002; syncope: 55% vs. 21%, p = 0.002; aborted cardiac arrest or unexpected sudden cardiac death: 15% vs. 0%, p = 0.03) than those with C-terminal mutations. Patients with transmembrane mutations had a greater risk of first cardiac events occurring at an earlier age, with a hazard ratio of 3.4 (p = 0.006) and with an 8% increase in risk per 10-ms increase in corrected Q-Tend. The baseline ECG parameters, including Q-Tend, Q-Tpeak, and Tpeak-end intervals, were significantly greater in patients with transmembrane mutations than in those with C-terminal mutations (p < 0.005). Moreover, the corrected Q-Tend and Tpeak-end were more prominently increased with exercise in patients with transmembrane mutations (p < 0.005).
CONCLUSIONS In this multicenter Japanese population, LQT1 patients with transmembrane mutations are at higher risk of congenital LQTS-related cardiac events and have greater sensitivity to sympathetic stimulation, as compared with patients with C-terminal mutations. (C) 2004 by the American College of Cardiology Foundation.

DOI： 10.1016/j.jacc.2004.03.043

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia

K Ueda, K Nakamura, T Hayashi, N Inagaki, M Takahashi, T Arimura, H Morita, Y Higashiuesato, Y Hirano, M Yasunami, S Takishita, A Yamashina, T Ohe, M Sunamori, M Hiraoka, A Kimura

JOURNAL OF BIOLOGICAL CHEMISTRY 279 ( 26 ) 27194 - 27198 2004.6

Language：English Publisher：AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Hyperpolarization-activated cyclic nucleotide-gated channel 4 gene HCN4 is a pacemaker channel that plays a key role in automaticity of sinus node in the heart, and an HCN4 mutation was reported in a patient with sinus node dysfunction. Expression of HCN4 in the heart is, however, not confined to the sinus node cells but is found in other tissues, including cells of the conduction system. On the other hand, mutations in another cardiac ion channel gene, SCN5A, also cause sinus node dysfunction as well as other cardiac arrhythmias, including long QT syndrome, Brugada syndrome, idiopathic ventricular fibrillation, and progressive cardiac conduction disturbance. These observations imply that HCN4 abnormalities may be involved in the pathogenesis of various arrhythmias, similar to the SCN5A mutations. In this study, we analyzed patients suffering from sinus node dysfunction, progressive cardiac conduction disease, and idiopathic ventricular fibrillation for mutations in HCN4. A missense mutation, D553N, was found in a patient with sinus node dysfunction who showed recurrent syncope, QT prolongation in electrocardiogram, and polymorphic ventricular tachycardia, torsade de pointes. In vitro functional study of the D553N mutation showed a reduced membranous expression associated with decreased If currents because of a trafficking defect of the HCN4 channel in a dominant-negative manner. These data suggest that the loss of function of HCN4 is associated with sinus nodal dysfunction and that a consequence of pacemaker channel abnormality might underlie clinical features of QT prolongation and polymorphic ventricular tachycardia developed under certain conditions.

DOI： 10.1074/jbc.M311953200

Sarcomere-length dependence of lattice volume and radial mass transfer of myosin cross-bridges in rat papillary muscle

N Yagi, H Okuyama, H Toyota, J Araki, J Shimizu, G Iribe, K Nakamura, S Mohri, K Tsujioka, H Suga, F Kajiya

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 448 ( 2 ) 153 - 160 2004.5

Language：English Publisher：SPRINGER-VERLAG

We examined the sarcomere length-dependence of the spacing of the hexagonal lattice of the myofilaments and the mass transfer of myosin cross-bridges during contraction of right ventricular papillary muscle of the rat. The lattice spacing and mass transfer were measured by using X-ray diffraction, and the sarcomere length was monitored by laser diffraction at the same time. Although the lattice spacing and the sarcomere length were inversely related, their relationship was not exactly isovolumic. The cell volume decreased by about 15% when the sarcomere length was shortened from 2.3 mum to 1.8 mum. Twitch tension increased with sarcomere length (the Frank-Starling law). At the peak tension, the ratio of the intensity of the (1,0) equatorial reflection to that of the (1,1) reflection was smaller when the tension was greater, showing that the larger tension at a longer sarcomere length accompanies a larger amount of mass transfer of cross-bridges from the thick to the thin filament. The result suggests that the Frank-Starling law is due to an increase in the number of myosin heads attached to actin, not in the average force produced by each head.

DOI： 10.1007/s00424-004-1243-z

121) プロスプロスタグランディンI2による薬剤性間質性肺炎を来した原発性肺高血圧症の一例(第83回日本循環器学会中国・四国合同地方会)

木村英夫, 宮地晃平, 河野康之, 伴場圭一, 藤尾栄起, 宮地克維, 中村一文, 森田宏, 齋藤博則, 江森哲郎, 大江透, 松原広己

Circulation journal : official journal of the Japanese Circulation Society 68 836 - 836 2004.4

129) 冠動脈炎による急性心筋梗塞を発症した若年女性の一症例(第83回日本循環器学会中国・四国合同地方会)

伴場圭一, 木村英夫, 永瀬聡, 中村一文, 森田宏, 齋藤博則, 江森哲郎, 大江透

Circulation journal : official journal of the Japanese Circulation Society 68 837 - 837 2004.4

130) 心室細動にて発症し救命しえた冠動脈瘤病変を有した一症例(第83回日本循環器学会中国・四国合同地方会)

伴場主一, 木村英夫, 永瀬聡, 中村一文, 森田宏, 齋藤博則, 江森哲郎, 大江透

Circulation journal : official journal of the Japanese Circulation Society 68 837 - 837 2004.4

OE-297 Elevated Levels of 8-Hydroxy-2-Deoxyguanosine in Serum and Myocardium of Patients with Dilated Cardiomyopathy(Cardiomyopathy, Clinical 6 (M) : OE37)(Oral Presentation (English))

Nakamura Kazufumi, Kusano Kengo, Miura Aya, Nishii Nobuhiro, Miyaji Katsumasa, Nagase Satoshi, Morita Hiroshi, Saitoh Hironori, Emori Tetsuro, Nakamura Yoichi, Murakami Takashi, Matsubara Hiromi

Circulation journal : official journal of the Japanese Circulation Society 68 212 - 213 2004.3

PJ-016 Effect of Sodium Channel Blocker on Electrophysiologic : Characteristics in Patients with the Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A) : PJ3)(Poster Session (Japanese))

Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Emori Tetsuro, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 68 483 - 483 2004.3

PJ-007 Longitudinal and Transverse Activation Pattern in Human Coronary Sinus(Arrhythmia, Diagnosis/Pathophysiology/EPS 4 (A): PJ2)(Poster Session (Japanese))

Nagase Satoshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Morita Hiroshi, Saitoh Hironori, Kusano Kengo, Emori Tetsuro, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 68 481 - 481 2004.3

PE-030 Reproducibility of Induction of Ventricular Fibrillation by Programmed Electrical Stimulation in Patients with Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 6 (A) : PE5)(Poster Session (English))

Watanabe Atsuyuki, Morita Hiroshi, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Emori Tetsuro, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 68 369 - 369 2004.3

OE-340 Body Surface Activation during Polymorphic Ventricular Tachycardia and Ventricular Fibrillation in Patients with Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 11 (A) : OE43)(Oral Presentation (English))

Morita Hiroshi, Kusano Kengo, Nagase Satoshi, Nakamura Kazufumi, Saito Hironori, Emori Tetsuro, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 68 222 - 223 2004.3

β遮断薬による心不全・不整脈治療の基礎と臨床カルベジロールを中心として β遮断薬と酸化ストレス

中村一文, 垣下幹夫, 草野研吾, 三浦綾, 久松研一, 永瀬聡, 森田宏, 斉藤博則, 江森哲郎, 浅沼幹人, 小川紀雄, 宮崎正博, 中村陽一, 松原広己, 伏見和郎, 豊國伸哉, 大江透

心電図 24 ( 1 ) 15 - 21 2004.1

Language：Japanese Publisher：(一社)日本不整脈心電学会

拡張型心筋症患者と正常心機能者の心内膜生検組織において,過酸化脂質の代謝産物である4-Hydroxy-2-nonenal(HNE)修飾蛋白質を免疫染色にて検出した.拡張型心筋症患者全例の心筋においてHNE修飾蛋白質が増加していた.その増加は心筋の細胞質に多かった.更にカルベジロール投与を行った後再び調べたところ,心機能の改善と共に,HNE修飾蛋白質が有意に低下していた.以上の検討より,活性酸素による酸化ストレスの発生が不全心筋において増強しており,カルベジロールによるその抑制が心不全治療のターゲットの1つになりうることが示唆された

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00681&link_issn=&doc_id=20040205230003&doc_link_id=%2Fdn4eleca%2F2004%2F002401%2F004%2F0015-0021%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdn4eleca%2F2004%2F002401%2F004%2F0015-0021%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Sinus node function in patients with brugada-type ECG.

Morita H, Kusano FK, Nagase S, Miyaji K, Hiramatsu S, Banba K, Nishii N, Watanabe A, Kakishita M, Morita TS, Nakamura K, Saito H, Emori T, Ohe T

Circulation Journal 2004

PGI2持続静注療法中の抗凝固療法について

小川愛子, 松原広己, 藤尾栄起, 宮地克維, 渡辺敦之, 永瀬聡, 中村一文, 森田宏, 斎藤博則, 江森哲郎, 伊達洋至, 清水信義, 大江透

Progress in Medicine 24,1,310-313 2004

β遮断薬による心不全・不整脈治療の基礎と臨床ーカルベジロールを中心としてー3.β遮断薬と酸化ストレス

中村一文, 垣下幹夫, 草野研吾, 三浦綾, 久松研一, 永瀬聡, 森田宏, 斎藤博則, 江森哲郎, 浅沼幹人, 小川紀雄, 宮崎正博, 中村陽一, 松原広己, 伏見和郎, 豊國伸哉, 大江透

Japanese Journal of Electrocardiology 24,1,15-21 2004

高齢にて発症したQT延長症候群の1例 -同一家系内で異なる発症様式を示したLQT1の1家系ｰ

三浦大志, 中村一文, 久松研一, 森田宏, 森田志保, 永瀬聡, 斎藤博則, 草野研吾, 江森哲郎, 大江透, 大内田守, 清水憲二, 西内崇将, 幡芳樹, 水尾浩三, 大杉保

Therapeutic Research 25,11,2137-2141 2004

心不全における酸化ストレスの関与-基礎的ならびに臨床的検討

中村一文, 草野研吾, 垣下幹夫, 三浦綾, 久松研一, 西井伸洋, 伴場主一, 渡辺敦之, 藤尾栄起, 宮地克維, 永瀬聡, 森田宏, 斎藤博則, 江森哲郎, 浅沼幹人, 宮崎正博, 中村陽一, 松原広己, 大江透

岡山医学会雑誌 116,9-16 2004

Failure of disopyramide to improve right ventricular outflow tract obstruction after living-donor lobar transplantation.

Miyaji K, Matsubara H, Kajiya M, Tani Y, Nakamura K, Morita H, Emori T, Date H, Ohe T

Circulation Journal 2004

PGI2持続静注療法を施行した肺高血圧症35例の検討

小川愛子, 松原広己, 藤尾栄起, 宮地克維, 永瀬聡, 中村一文, 森田宏, 斎藤博則, 江森哲郎, 伊達洋至, 清水信義, 大江透

Therapeutic Research 25,10,29-30 2004

著明なT wave alternans現象を示したLQT1の一家系

森田宏, 中村一文, 大田恵子, 森田志保, 三浦大志, 斎藤博則, 草野研吾, 江森哲郎, 大江透, 幡芳樹, 水尾浩三

心臓 36,3,136-141 2004

特集不整脈死を防ぐ不整脈死の基質を識る心不全

中村一文

Heart View 8,1,45-49 2004

特発性心室細動と考えられた2症例－Short coupled variant of torsades de pointesとの比較検討－

渡辺敦之, 森田宏, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 斎藤博則, 草野研吾, 江森哲郎, 大江透

Japanese Journal of Electrocardiology 24,4,S4-61-S4-67 2004

Evaluation of the usefulness of recording the ECG in the 3rd intercostal space and prevalence of brugada-type ECG in accordance with recently established electrocardiographic criteria.

Hisamatsu K, Morita H, Kusano FK, Takenaka S, Nagase S, Nakamura K, Emori T, Ohe T

Circulation Journal 2004

Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.

Yamanari H, Nakamura K, Kakishita M, Ohe T

Clin. Cardiol 2004

Usefulness of body surface mapping to differentiate patients with brugada syndrome from patients with asymptomatic brugada syndrome.

Hisamatsu K, Kusano FK, Morita H, Takenaka S, Nagase S, Nakamura K, Emori T, Matsubara H, Ohe T

Acta Med. Okayama 2004

Epoprostenol therapy decreases elevated circulating levels of monocyte chemoattractant protein-1 in patients with primary pulmonary hypertension.

Hashimoto K, Nakamura K, Fujio H, Miyaji K, Morita H, Kusano K, Date H, Shimizu N, Emori T, Matsubara H, Ohe T

Circulation Journal 2004

X-ray diffraction from a left ventricular wall of rat heart.

Yagi N, Shimizu J, Mohri S, Araki J, Nakamura K, Okuyama H, Toyota H, Morimoto T, Morizane Y, Kurusu M, Miura T, Hashimoto K, Tsujioka K, Suga H, Kajiya F

Biopysical Journal 2004

2-O-alpha-D-glucopyranosyl-L-ascorbic acid(AA2G)のコラーゲン合成作用によるES細胞からの高率な心筋分化

久松研一, 中村一文, 草野研吾, 三浦龍志, 江森哲郎, 大江透, 梶谷文彦

Circulation Journal 68 ( Supplement 3 ) 2004

著明なT wave alteransを認めた先天性QT延長症候群の3症例(第82回日本循環器学会中国地方会)

渡辺敦之, 森田宏, 竹内一文, 大田恵子, 西井伸洋, 池田哲也, 永瀬聡, 中村一文, 松原広己, 江森哲郎, 大江透

Circulation journal : official journal of the Japanese Circulation Society 67 998 - 998 2003.10

194)心室性不整脈を合併した心線維腫の一例

西井伸洋, 藤尾栄起, 小林誠, 永瀬聡, 垣下幹夫, 中村一文, 森田宏, 江森哲朗, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 67 866 - 866 2003.4

73)Brugada症候群における上室性不整脈の合併

森田宏, 永瀬聡, 中村一文, 江森哲朗, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 67 853 - 853 2003.4

77)冠静脈洞内で通電することによってアフレーションが成功したWPW症候群の一症例

伴場主一, 大河啓介, 永瀬聡, 垣下幹夫, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 67 853 - 853 2003.4

92)完全型心内膜床欠損症の一成人例

渡邊敦之, 河合勇介, 宮地克雄, 大塚ふよう, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透, 佐野俊二

Circulation journal : official journal of the Japanese Circulation Society 67 855 - 855 2003.4

87)Short-Coupled Variant of Torsades de Pointesの二例

三浦龍志, 永瀬聡, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 67 854 - 854 2003.4

Localization of Depolarization Abnormality in Patient with Brugada : Using Body Surface Signal Averaged ECG

Hisamatsu Kenichi, Kusano Kengo, Morita Hiroshi, Takenaka Shiho, Nagase Satoshi, Nakamura Kazufumi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 67 530 - 530 2003.3

Long-Term Clinical Course of Non-lschemic Cardiomyopathy Patients with Ventricular Tachycardia

Nishii Nobuhiro, Emori Tetsuro, Nagase Satoshi, Morita Hiroshi, Nakamura Kazufumi, Matsubara Hiromi, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 67 518 - 518 2003.3

Left Ventricular Conduction Abnormality in Brugada Syndrome

Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Kobayashi Makoto, Nakamura Kazufumi, Kakishita Mikio, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 67 577 - 577 2003.3

Risk Stratification and Therapeutic Management of Patients with Right Bundle Branch Block and ST-Segment Elevation

Emori Tetsuro, Morita Hiroshi, Takenaka-Morita Shiho, Nagase Satoshi, Nakamura Kazufumi, Kusano Kengo, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 67 71 - 71 2003.3

Clinical Characteristics of Asymptomatic Patients with the Brugada Syndrome

Morita Hiroshi, Morita Shiho, Ohta Keiko, Nagase Satoshi, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 67 311 - 311 2003.3

PGI2持続静注療法を施行した肺高血圧症27症例の検討．

小川愛子, 藤尾栄起, 宮地克維, 永瀬聡, 大田恵子, 中村一文, 森田宏, 斎藤博則, 江森哲郎, 大江透, 松原広己, 伊達洋至, 清水信義

Therapeutic Research 24,9,51-53 2003

Pulmonary Capillary Hemangiomatosisの2症例．

西井伸洋, 松原広己, 小川愛子, 大田恵子, 藤尾栄起, 宮地克維, 中村一文, 森田宏, 江森哲郎, 大江透, 青江基, 伊達洋至

Therapeutic Research 24,9,39-40 2003

右室自由壁脂肪浸潤を認め、不整脈源性右室異形成との鑑別を要したカテコラミン誘発性多形成心室頻拍の1例．

森田宏, 原岡佳代, 大田恵子, 中村陽一, 森田志保, 中村一文, 江森哲郎, 松原広己, 中谷陽子, 林一彦, 赤木忠厚, 大江透

心臓 35,3,45-49 2003

LQT/Brugada症候群での遺伝子解析の意義．

中村一文, 三浦大志, 森田宏, 大江透

Cardiac Practice 14,4,27-33 2003

Site-specific arrhythmogenesis in patients with brugada syndrome.

Morita H, Kusano FK, Nagase S, Morita TS, Nishii N, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

Journal of Cardiovasuclar Electrophysiology 2003

Risk stratification for asymptomatic patients with brugada syndrome --prediction of induction of ventricular fibrillation by noninvasive methods--

Morita H, Morita TS, Kusano FK, Kobayashi M, Nagase S, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

Circulation Journal 2003

Epinephrine unmasks latent mutation carriers with LQT1 form congenital long-QT syndrome.

Shimizu W, Noda T, Takaki H, Kurita T, Nagaya N, Satomi K, Suyama K, Aihara N, Kamakura S, Sunagawa K, Echigo S, Nakamura K, Ohe T

JACC 2003

Local Drug DeliveryとしてのTissue Factor Pathway Inhibitorの可能性．

中村陽一, 中村一文, 大田恵子, 草野研吾, 松原広己, 羽室強, 植田初江, 由谷親夫, 加藤久雄, 大江透

Japanese Journal of Interventional Cardiology 2003

Brugada症候群の不整脈の予知．

森田宏, 永瀬聡, 原岡佳代, 藤尾栄起, 久松研一, 森田志保, 垣下幹夫, 中村一文, 草野研吾, 江森哲郎, 松原広己, 大江透

心電図 23,159-167 2003

Direct evidence for increased hydroxy1 radicals in angiotensin Ⅱ-induced cardiac hypertrophy through angiotensin Ⅱ type 1a receptor.

Kakishita M, Nakamura K, Asanuma M, Morita H, Saito H, Kusano K, Nakamura Y, Emori T, Matsubara H, Sugaya T, Ogawa N, Ohe T

Journal of Cardiovascular Pharmacology 2003

Ventricular arrhythmia induced by sodium channel blocker in patients with brugada syndrome.

Morita H, Morita TS, Nagase S, Banba K, Nishii N, Tani Y, Watanabe A, Nakamura K, Kusano FK, Emori T, Matsubara H, Hina K, Kita T, Ohe T

JACC 2003

Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis

Y Nakamura, K Nakamura, K Fukushima-Kusano, K Ohta, H Matsubara, T Hamuro, C Yutani, T Ohe

THROMBOSIS RESEARCH 111 ( 3 ) 137 - 142 2003

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Introduction: Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus formation. The present study was designed to elucidate the role of endothelial dysfunction in thrombogenesis associated with nonvalvular atrial fibrillation. Material and methods: We investigated tissue factor expression in the endothelia of left atrial appendages obtained from seven patients with nonvalvular atrial fibrillation and cardiogenic thromboembolism. Tissues were divided into 7-13 sections and compared with control specimens from four patients who died of noncardiac events. Expression of tissue factor, von Willebrand factor and tissue factor pathway inhibitor was evaluated by immunohistochemistry. Results: Histopathologically, inflammatory cells infiltrated the endocardium and all seven patients showed features of persistent myocarditis. Activated T cells [15.3 +/- 9.4 cells/high power field (HPF, mean +/- S.D.) vs. control 2.2 +/- 4.4/HPF (P = 0.0294)] and a few macrophages [5.1 +/- 8.4 cells/HPF vs. control 2.4 +/- 3.5 cells/HPF (P = NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. Von Willebrand factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. Conclusion: Tissue factor expression induced by local inflammation is involved in the pathogenesis of thrombosis in patients with nonvalvular atrial fibrillation. (C) 2003 Elsevier Ltd. All rights reserved.

DOI： 10.1016/S0049-3848(03)00405-5

Brugada症候群の診断とリスク評価．

森田宏, 永瀬聡, 西井伸洋, 伴場主一, 渡辺敦之, 谷義則, 中村一文, 森田志保, 草野研吾, 江森哲郎, 松原広己, 大江透

Japanese Journal of Electrocardiology 2003

Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

T Noda, H Takaki, T Kurita, K Suyama, N Nagaya, A Taguchi, N Aihara, S Kamakura, K Sunagawa, K Nakamura, T Ohe, M Horie, C Napolitano, JA Towbin, SG Priori, W Shimizu

EUROPEAN HEART JOURNAL 23 ( 12 ) 975 - 983 2002.6

Language：English Publisher：W B SAUNDERS CO LTD

Aims Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome.
Methods and Results We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0.1 mug. kg(-1)) of epinephrine followed by continuous infusion (0.1 mug. kg(-1) min(-1)) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477 +/- 42 to 631 +/- 59 ms; P<0.0005, % delta prolongation = + 32%) as the RR was maximally decreased (at peak of epinephrine), and remained prolonged at steady state conditions of epinephrine (556 +/- 56 ms; P<0.0005 vs baseline, + 17%) in LQT1 patients. Epinephrine also prolonged the QTc dramatically (502 +/- 23 to 620 +/- 39 ms, P<0.0005, +24%) at peak of epinephrine in LQT2 patients, but this shortened to baseline levels at steady state (531 25 ms; P=ns vs baseline, +6%). The QTc was Much less prolonged at peak of epinephrine in LQT3 (478 +/- 44 to 532 +/- 41 ms; P<0.05, +11%) and controls (394 +/- 21 to 456 +/- 18 ms; P<0.0005, + 16%) than in LQT1 and LQT2 patients, and shortened to the baseline levels (LQT3; 466 +/- 49 ms, -3%, controls; 397 +/- 16 ms, +1%; P=ns vs baseline) at steady state.
Conclusion Our data suggest that the dynamic response of ventricular repolarization to sympathetic stimulation differs between LQT1, LQT2 and LQT3 syndromes, and may explain why the trigger of cardiac events differs between the genotypes.
(C) 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.

DOI： 10.1053/euhj.2001.3079

4)若年者の冠動脈病変の原因として弾性線維性仮性黄色腫(PXE)が考えられた1例(日本循環器学会第79回中国四国地方会)

垣下幹夫, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 66 961 - 961 2002.4

128)高熱と心膜炎で発症した成人発症型スティル病の一例(日本循環器学会第79回中国四国地方会)

三浦龍志, 佐藤克政, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 66 975 - 975 2002.4

Persistent Adenovirus Myocarditis : Is It Degeneration or Inflammation?

Ohta Keiko, Nakamura Kazufumi, Kusano Kengo, Nagase Satoshi, Kakishita Mikio, Morita Hiroshi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru, Nakamura Yoichi

Circulation journal : official journal of the Japanese Circulation Society 66 840 - 840 2002.3

Characteristics of action potential duration (APD) restitution in Angiotensin II type 1a receptor knockout (AT1a KO) mice

Kakishita Mikio, Hashimoto Katsushi, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo, Emori Tetsurou, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 66 688 - 688 2002.3

Usefullness of 16-lead signal average electrocardiogram to differentiate between Brugada syndrome and asymptomatic Brugada

Hisamatsu Kenichi, Kusano Kengo, Morita Hiroshi, Takenaka Shiho, Nagase Satoshi, Nakamura Kazufumi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 66 684 - 684 2002.3

The Ventricular Activation Pattern of the Body Surface Mapping during Polymorphic Ventricular Tachycardia in Patients with the Brugada Syndrome

Morita Hiroshi, Nagase Satoshi, Hisamatsu Kenichi, Kobayashi Makoto, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 66 452 - 452 2002.3

Atrial fibrillation and atrial vulnerability in patients with brugada syndrome.

Morita H, Fukushima KK, Nagase S, Fujimoto Y, Hisamatsu K, Fujio H, Haraoka K, Kobayashi M, Takenaka MS, Nakamura K, Emori T, Matsubara H, Hina K, Kita T, Fukatani M, Ohe T

JACC 2002

Anti-inflammatory effects of long-lasting locally-delivered human recombinant tissue factor pathway inhibitor after balloon angioplasty.

Nakamura Y, Nakamura K, Ohta K, Matsubara H, Yutani C, Hamuro T, Kato H, Ohe T

Basic Res Cardiol 2002

Altered nano/micro-order mechanical property of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension.

Nakamura K, Hashimoto K, Ohta K, Kakishita M, Fujio H, Motita H, Fukushima KK, Emori T, Matsubara H, Ohe T, Date H, Shimizu N, Kataoka N, Mochizuki S, Hashimoto K, Shimizu J, Kajiya F

Curculation 2002

原発性肺高血圧症における右室心筋内微小血管の組織学的検討

大田恵子, 中村陽一, 草野研吾, 永瀬聡, 宮地克維, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Therapeutic Research 23,2,34-37 2002

心不全を合併した致死性不整脈の治療

中村一文, 永瀬聡, 大江透

循環器科 52,4,309-315 2002

Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome.

Shimizu W, Tanabe Y, Aiba T, Inagaki M, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Sunagawa K, Nakamura K, Ohe T, Towbin JA, Priori SG, Kamakura S

JACC 2002

Carvedilol decreases elevated oxidative stress in human failing myocardium.

Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, Ohe T

Circulation 2002

Epicardial electrogram of the right ventricular outflow tract in patients with the brugada syndrome.

Nagase S, Fukushima KK, Morita H, Fujimoto Y, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

JACC 2002

The ventricular arrhythmia induced by Pilsicainide in patients with the Brugada syndrome

OGAWA A, Morita Hiroshi, Nagase Satoshi, Hisamatsu Kenichi, Yamamoto Mika, Ootsuka Fuyo, Morita Shiho, Kakishita Mikio, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

Circulation J 66 298 - 298 2002

57) 末端肥大症に合併した僧帽弁閉鎖不全症の2症例(日本循環器学会第78回中国地方会)

岩崎淳, 森田宏, 宮地克雄, 原岡佳代, 中村一文, 草野研吾, 江森哲郎, 松原広己, 大江透

Japanese circulation journal 65 802 - 802 2001.10

80) 心電図上, 著明なQT延長並びにT波の交代現象を示した原発性副甲状腺機能低下症の1例(日本循環器学会第78回中国地方会)

藤尾栄起, 草野研吾, 岩崎淳, 原岡佳代, 谷義則, 小林誠, 池田哲也, 永瀬聡, 宮地克雄, 山本美香, 橋本克史, 中村一文, 垣下幹夫, 斎藤博則, 森田宏, 松原広巳, 江森哲郎, 大江透, 徳永常登

Japanese circulation journal 65 805 - 805 2001.10

43) Brugada症候群における心房受攻性異常(日本循環器学会第78回中国地方会)

森田宏, 草野研吾, 永瀬聡, 中村一文, 久松研一, 小林誠, 山本美香, 竹中志保, 江森哲郎, 松原広己, 大江透

Japanese circulation journal 65 801 - 801 2001.10

55) 1年間でデルタ波の出現と自然消退によりA型WPW症候群からC型WPW症候群への心電図変化を示した肥大型心筋症の一例(日本循環器学会第78回中国地方会)

小林誠, 森田宏, 谷義則, 原岡佳代, 岩崎淳, 藤尾栄紀, 池田哲也, 片山祐介, 永瀬聡, 宮地克雄, 山本美香, 垣下幹夫, 中村一文, 斉藤博則, 草野研吾, 江森哲郎, 松原広己, 大江透, 中濱一

Japanese circulation journal 65 802 - 802 2001.10

115) 器質的異常を伴いBrugada型心電図を呈した一症例

竹中志保, 草野研吾, 久松研一, 永瀬聡, 大田恵子, 中村一文, 森田宏, 松原広己, 江森哲郎, 大江透

Japanese circulation journal 65 673 - 673 2001.4

101) 自律神経障害により発作性上室性頻拍から心室細動を来したWPW症候群の一例

湯本晃久, 草野研吾, 永瀬聡, 竹中志保, 中村一文, 森田宏, 江森哲朗, 松原広己, 大江透, 松原奎一

Japanese circulation journal 65 671 - 671 2001.4

113) 先天性QT延長症候群患者のNaチャネル遮断薬に対する反応

森田宏, 草野研吾, 永瀬聡, 中村一文, 大田恵子, 小林誠, 山本美香, 竹中志保, 江森哲郎, 松原広己, 大江透

Japanese circulation journal 65 672 - 672 2001.4

68) 心房粗動での体表面電位図の有効性

森田宏, 草野研吾, 垣下幹夫, 中村一文, 藤本良久, 山本美香, 竹中志保, 久松研一, 宮地維克, 松原広己, 山成洋, 大江透

Japanese circulation journal 64 939 - 939 2000.10

92) 拡張型心筋症患者の心筋組織からのアデノウイルスの検出

中村一文, 草野研吾, 中村陽一, 松原広己, 山成洋, 森田宏, 藤本良久, 大江透, 山田雅夫

Japanese circulation journal 64 942 - 942 2000.10

116) Antidromic型房室回帰性頻拍の一例

永瀬聡, 草野研吾, 中村一文, 大江透, 佐藤博彦

Japanese circulation journal 64 822 - 822 2000.4

P412 拡張型心筋症におけるカルベジロールの再分極過程への影響

竹中志保, 山成洋, 中村一文, 森田宏, 草野研吾, 松原広己, 大江透

Japanese circulation journal 64 562 - 562 2000.3

P261 QT延長症候群におけるT wave alternans心電図の特徴

森田宏, 草野(福島) 研吾, 垣下幹夫, 中村一文, 藤本良久, 山本美香, 永瀬聡

Japanese circulation journal 64 524 - 524 2000.3

P090 拡張型心筋症におけるMCP-1の心筋発現と心機能との相関

中村一文, 草野研吾, 中村陽一, 垣下幹夫, 藤本良久, 森田宏, 松原広己, 山成洋, 大江透

Japanese circulation journal 64 481 - 481 2000.3

P899 rasファルネシル化阻害剤, Manumycin Aによる血管平滑筋細胞の増殖および遊走抑制効果

河内裕輔, 中村一文, 森田宏, 草野研吾, 松原広己, 山成洋, 大江透, 難波正義

Japanese circulation journal 64 684 - 684 2000.3

0870 ACE阻害薬投与高血圧症例の内皮機能におけるシクロオキシゲナーゼ依存性因子の関与

山成洋, 中村一文, 垣下幹夫, 森田宏, 草野研吾, 松原広己, 大江透

Japanese circulation journal 64 404 - 404 2000.3

0455 QT延長症候群におけるT wave alternansの特徴

森田宏, 草野(福島) 研吾, 垣下幹夫, 中村一文, 藤本良久, 山本美香, 竹中志保, 松原広己, 山成洋, 大江透

Japanese circulation journal 64 299 - 299 2000.3

Evaluation of atherosclerosis in hemodialysis patients: Significance of monocyte chemoattractant protein-1 for carotid arterial sclerosis.:Significance of monocyte chemoattractant protein-1 for carotid arterial sclerosis

Kusano Kengo Fukushima, Nakamura Kazufumi, Nakamura Yoichi, Ohe Tohru, Kusano Hitoshi, Kusano Isao

Journal of Japanese Society for Dialysis Therapy 33 ( 9 ) 1245 - 1249 2000

Language：Japanese Publisher：The Japanese Society for Dialysis Therapy

Recently, monocyte infiltration into the vessel wall mediated by monocyte chemoattractant protein-1 (MCP-1) is a key initial step in the process of atherosclerosis. We investigated factors that affect atherosclerosis in chronic hemodialysis patients and examined the effect of MCP-1 on atherosclerosis. Ultrasonic carotid arteriography was performed to evaluate the degree of atherosclerosis. To exclude the influence of the cause of the disease, patients with diabetic nephropathy and hypertensive nephrosclrosis were excluded. A total of 52 patients (29 men and 23 women; age, 56±10 years; mean duration of hemodialysis, 10.1±7.4 years) were entered in this study. The degree of arterial sclerosis was evaluated by the degree of intimal-medial thickness (IMT) in the carotid arteries. Age, duration of hemodialysis, left ventricular hypertrophy (LVH), smoking, lipid profiles, lipoprotein (a), uric acid, fibrinogen, homocystein, and MCP-1 were investigated as possible factors affecting atherosclerosis. They were compared with the mean value of IMT. A 12-lead ECG was used to evaluate three degrees of LVH: normal range, only high voltage, and high voltage with ST change. Age, LVH, smoking and MCP-1 were found to be significantly correlated with the mean value of IMT. However, the correlation of other variables was insignificant. Multiple linear regression analysis revealed age, LVH, MCP-1 and apolioprotein A-1 to be the independent factors affecting the mean value of IMT. These findings suggest that MCP-1 is sensitive marker for atherosclerosis in patients with chronic hemodialysis.

DOI： 10.4009/jsdt.33.1245

CiNii Article

Sympathetic Stimulation Produces a Greater Increase in Both Transmural and Spatial Dispersion of Repolarization in LQT1 Than LQT2 Forms of Congenital Long QT Syndrome.

Tanabe Y, Inagaki M, Kurita T, Nagaya N, Taguchi A, Suyama K, Aihara N, Kamakura S, Sunagawa K, Nakamura K, Ohe T

JACC 2000

Hepatitis C virus infection in a patient with dermatomyositis and left ventricular dysfunction

K. Nakamura, A. Matsumori, K. F. Kusano, K. Banba, M. Taniyama, Y. Nakamura, H. Morita, H. Matsubara, H. Yamanari, T. Ohe

Japanese Circulation Journal 64 ( 8 ) 617 - 618 2000

Language：English Publisher：Japanese Circulation Society

Hepatitis C virus (HCV) infection is frequently associated with autoimmune disease. We present here a case of dermatomyositis manifested as heart failure in which HCV was detected from an endomyocardial biopsy sample. HCV infection may have contributed to the left ventricular dysfunction in this patient with dermatomyositis.

DOI： 10.1253/jcj.64.617

Effects of Low-Dose Aspirin on Endothelial Function in Hypertensive Patients.

Monobe H, Yamanari H, Nakamura K, Ohe T

Clin. Cardiol 2000

Involvement of Ca2+ in antiarrhythmic effect of ischemic preconditioning in isolated rat heart

Kui Hong, Kengo Fukushima Kusano, Hiroshi Morita, Yoshihisa Fujimoto, Kazufumi Nakamura, Hiroshi Yamanari, Tohru Ohe

Japanese Journal of Physiology 50 ( 2 ) 207 - 213 2000

Language：English Publisher：The Physiological Society of Japan

We investigated the relationship between the effects of ischemic preconditioning (IPC) and Ca2+ preconditioning (CPC) on reperfusion-induced arrhythmias. In the control group (noPC), Langendorff-perfused rat hearts were subjected to 5-min zero-flow global ischemia (I) followed by 15-min reperfusion (I/R). In ischemic preconditioning groups (IPC), the hearts were subjected to three cycles of 3-min global ischemia and 5-min reperfusion. In the CPC group, the hearts were exposed to three cycles of 3-min perfusion of higher Ca2+ (2.3 mmol/l Ca2+) followed by 5-min perfusion of normal 1.3 mmol/l Ca2+, and the hearts were then subjected to I/R. Verapamil was administered in several hearts of the IPC group (VR+IPC). Ventricular arrhythmias upon reperfusion were less frequently seen in the IPC and CPC groups than in the noPC and VR+IPC groups. IPC and CPC could attenuate conduction delay and enhance shortening of the monophasic action potential duration during ischemia. The ventricular fibrillation threshold measured at 1-min reperfusion was significantly higher in the IPC and CPC groups than in the noPC and VR+IPC groups. Verapamil completely abolished the salutary effects of IPC. These results demonstrate that Ca2+ plays an important role in the antiarrhythmic effect of IPC during reperfusion.

DOI： 10.2170/jjphysiol.50.207

Hepatitis C virus infection in a patient with dermatomyositis and left ventricular dysfunction

K. Nakamura, A. Matsumori, K. F. Kusano, K. Banba, M. Taniyama, Y. Nakamura, H. Morita, H. Matsubara, H. Yamanari, T. Ohe

Japanese Circulation Journal 64 ( 8 ) 617 - 618 2000

Language：English Publisher：Japanese Circulation Society

DOI： 10.1253/jcj.64.617

Relatively Benign Clinical Course in Asymptomatic Patients with Brugada-Type Electrocardiogram Without Family History of Sudden Death.

Takenaka S, Fukushima K K, Hisamatsu K, Nagase S, Nakamura K, Morita H, Matsubara H, Emori T, Ohe T

Journal of Cardiovascular Electrophysiology 2000

Lone AFにおける心房心筋炎の関与．

草野研吾, 中村陽一, 中村一文, 垣下幹夫, 永瀬聡, 斉藤博則, 松原広己, 山成洋, 大江透, 磯村寛樹, 山田雅夫

Therapeutic Research 22,3,29-32 2000

Involvement of Ca2+ in antiarrhythmic effect of ischemic preconditioning in isolated rat heart

Kui Hong, Kengo Fukushima Kusano, Hiroshi Morita, Yoshihisa Fujimoto, Kazufumi Nakamura, Hiroshi Yamanari, Tohru Ohe

Japanese Journal of Physiology 50 ( 2 ) 207 - 213 2000

Language：English Publisher：The Physiological Society of Japan

DOI： 10.2170/jjphysiol.50.207

Manumycin A, inhibitor of ras farnesyltransferase, inhibits proliferation and migration of rat vascular smooth muscle cells

Hirosuke Kouchi, Kazufumi Nakamura, Kazuo Fushimi, Masakiyo Sakaguchi, Masahiro Miyazaki, Tohru Ohe, Masayoshi Namba

Biochemical and Biophysical Research Communications 264 ( 3 ) 915 - 920 1999.11

Language：English Publisher：Academic Press Inc.

Restenosis after angioplasty is thought to be caused by proliferation and migration of vascular smooth muscle cells (VSMCs), and it is a most serious problem in medical treatment. A low dose (50 ng/ml) of manumycin A, an inhibitor of p21(ras) (ras) farnesylation, significantly inhibited proliferation of rat VSMCs stimulated by the platelet-derived growth factor (PDGF). The mitoinhibitory effect of manumycin A was dose- and time-dependent but was independent of cell density. Western blot analysis showed that manumycin A reduced the amount of functional ras localized at the cytoplasmic membrane and inhibited the phosphorylation of p42/44 mitogen-activated protein kinase (MAPK). Manumycin A also inhibited VSMC migration and disorganized α actin fibers, as shown by immnofluorecence staining. These results indicate that the interruption of the ras/MAPK signal transduction pathway and the disorganization of α actin fibers are the main cause of manumycin A inhibition of VSMC proliferation and migration induced by PDGF.

DOI： 10.1006/bbrc.1999.1546

Manumycin A, inhibitor of ras farnesyltransferase, inhibits proliferation and migration of rat vascular smooth muscle cells

Hirosuke Kouchi, Kazufumi Nakamura, Kazuo Fushimi, Masakiyo Sakaguchi, Masahiro Miyazaki, Tohru Ohe, Masayoshi Namba

Biochemical and Biophysical Research Communications 264 ( 3 ) 915 - 920 1999.11

Language：English Publisher：Academic Press Inc.

DOI： 10.1006/bbrc.1999.1546

24) 右室流出路起源特発性心室頻拍におけるQRS波形からみた起源の推定

森田宏, 福島研吾, 中村一文, 藤本義久, 垣下幹夫, 山成洋, 大江透

Japanese circulation journal 63 ( 3 ) 914 - 914 1999.10

83) Atriofascicular connectionのMahaim束の一例

中村一文, 福島研吾, 伴場主一, 垣下幹夫, 森田宏, 山成洋, 大江透

Japanese circulation journal 63 ( 3 ) 921 - 921 1999.10

APICAL HYPERTROPHY ASSOCIATED WITH RAPID T-WAVE INVERSION ON THE ELECTROCARDIOGRAM

H YAMANARI, D SAITO, K MIKIO, K NAKAMURA, T NANBA

HEART AND VESSELS 10 ( 4 ) 221 - 224 1995

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：SPRINGER VERLAG

A 53-year-old man who had no chest pain and no family history of heart disease demonstrated a rapid T wave change on an electrocardiogram, from a positive T wave to a giant negative T wave, within 1 year. Echocardiography showed no left ventricular hypertrophy before or after the T wave change. Cine-magnetic resonance imaging revealed focal apical hypertrophy after the appearance of the giant negative T wave. Although T wave inversions sometimes develop within a short period in patients with hypertrophic cardiomyopathy, they are rare in a patient without hypertension or chest pain.

DOI： 10.1007/BF01744991

APICAL HYPERTROPHY ASSOCIATED WITH RAPID T-WAVE INVERSION ON THE ELECTROCARDIOGRAM

H YAMANARI, D SAITO, K MIKIO, K NAKAMURA, T NANBA

HEART AND VESSELS 10 ( 4 ) 221 - 224 1995

Language：English Publishing type：Article, review, commentary, editorial, etc. (scientific journal) Publisher：SPRINGER VERLAG

DOI： 10.1007/BF01744991