Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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Brugada症候群の不整脈の予知．

森田宏, 永瀬聡, 原岡佳代, 藤尾栄起, 久松研一, 森田志保, 垣下幹夫, 中村一文, 草野研吾, 江森哲郎, 松原広己, 大江透

心電図 23,159-167 2003

Direct evidence for increased hydroxy1 radicals in angiotensin Ⅱ-induced cardiac hypertrophy through angiotensin Ⅱ type 1a receptor.

Kakishita M, Nakamura K, Asanuma M, Morita H, Saito H, Kusano K, Nakamura Y, Emori T, Matsubara H, Sugaya T, Ogawa N, Ohe T

Journal of Cardiovascular Pharmacology 2003

Ventricular arrhythmia induced by sodium channel blocker in patients with brugada syndrome.

Morita H, Morita TS, Nagase S, Banba K, Nishii N, Tani Y, Watanabe A, Nakamura K, Kusano FK, Emori T, Matsubara H, Hina K, Kita T, Ohe T

JACC 2003

Tissue factor expression in atrial endothelia associated with nonvalvular atrial fibrillation: possible involvement in intracardiac thrombogenesis

Y Nakamura, K Nakamura, K Fukushima-Kusano, K Ohta, H Matsubara, T Hamuro, C Yutani, T Ohe

THROMBOSIS RESEARCH 111 ( 3 ) 137 - 142 2003

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Introduction: Tissue factor plays a key role in the extrinsic coagulation pathway and is induced by inflammatory cytokines. Atrial myocarditis has been detected recently in some patients with lone atrial fibrillation. Virchow's triad of low blood flow, hypercoagulability, and endothelial dysfunction, enhances thrombus formation. The present study was designed to elucidate the role of endothelial dysfunction in thrombogenesis associated with nonvalvular atrial fibrillation. Material and methods: We investigated tissue factor expression in the endothelia of left atrial appendages obtained from seven patients with nonvalvular atrial fibrillation and cardiogenic thromboembolism. Tissues were divided into 7-13 sections and compared with control specimens from four patients who died of noncardiac events. Expression of tissue factor, von Willebrand factor and tissue factor pathway inhibitor was evaluated by immunohistochemistry. Results: Histopathologically, inflammatory cells infiltrated the endocardium and all seven patients showed features of persistent myocarditis. Activated T cells [15.3 +/- 9.4 cells/high power field (HPF, mean +/- S.D.) vs. control 2.2 +/- 4.4/HPF (P = 0.0294)] and a few macrophages [5.1 +/- 8.4 cells/HPF vs. control 2.4 +/- 3.5 cells/HPF (P = NS)] infiltrated the endocardium. Tissue factor was overexpressed in the endothelia particularly in tissues containing inflammatory cells and denuded matrix of the endocardium, compared with the control group. Von Willebrand factor, but not tissue factor pathway inhibitor, was also overexpressed in these tissues. Conclusion: Tissue factor expression induced by local inflammation is involved in the pathogenesis of thrombosis in patients with nonvalvular atrial fibrillation. (C) 2003 Elsevier Ltd. All rights reserved.

DOI： 10.1016/S0049-3848(03)00405-5

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Brugada症候群の診断とリスク評価．

森田宏, 永瀬聡, 西井伸洋, 伴場主一, 渡辺敦之, 谷義則, 中村一文, 森田志保, 草野研吾, 江森哲郎, 松原広己, 大江透

Japanese Journal of Electrocardiology 2003

Gene-specific response of dynamic ventricular repolarization to sympathetic stimulation in LQT1, LQT2 and LQT3 forms of congenital long QT syndrome

T Noda, H Takaki, T Kurita, K Suyama, N Nagaya, A Taguchi, N Aihara, S Kamakura, K Sunagawa, K Nakamura, T Ohe, M Horie, C Napolitano, JA Towbin, SG Priori, W Shimizu

EUROPEAN HEART JOURNAL 23 ( 12 ) 975 - 983 2002.6

Language：English Publisher：W B SAUNDERS CO LTD

Aims Differences in the sensitivity of the genotype of the congenital long QT syndrome to sympathetic stimulation have been suggested. This study compared the influence of sympathetic stimulation on continuous corrected QT (QTc) intervals between LQT1, LQT2 and LQT3 forms of the congenital long QT syndrome.
Methods and Results We recorded a 12-lead electrocardiogram continuously before and after bolus injection (0.1 mug. kg(-1)) of epinephrine followed by continuous infusion (0.1 mug. kg(-1) min(-1)) in 12 LQT1, 10 LQT2, 6 LQT3, and 13 control patients. The QT intervals and previous RR intervals of all beats were measured semi-automatically, and the QTc intervals of all beats were calculated by Bazett's method. The dynamic response of the RR interval to epinephrine was no different between the four groups. The QTc was prolonged remarkably (477 +/- 42 to 631 +/- 59 ms; P<0.0005, % delta prolongation = + 32%) as the RR was maximally decreased (at peak of epinephrine), and remained prolonged at steady state conditions of epinephrine (556 +/- 56 ms; P<0.0005 vs baseline, + 17%) in LQT1 patients. Epinephrine also prolonged the QTc dramatically (502 +/- 23 to 620 +/- 39 ms, P<0.0005, +24%) at peak of epinephrine in LQT2 patients, but this shortened to baseline levels at steady state (531 25 ms; P=ns vs baseline, +6%). The QTc was Much less prolonged at peak of epinephrine in LQT3 (478 +/- 44 to 532 +/- 41 ms; P<0.05, +11%) and controls (394 +/- 21 to 456 +/- 18 ms; P<0.0005, + 16%) than in LQT1 and LQT2 patients, and shortened to the baseline levels (LQT3; 466 +/- 49 ms, -3%, controls; 397 +/- 16 ms, +1%; P=ns vs baseline) at steady state.
Conclusion Our data suggest that the dynamic response of ventricular repolarization to sympathetic stimulation differs between LQT1, LQT2 and LQT3 syndromes, and may explain why the trigger of cardiac events differs between the genotypes.
(C) 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.

DOI： 10.1053/euhj.2001.3079

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4)若年者の冠動脈病変の原因として弾性線維性仮性黄色腫(PXE)が考えられた1例(日本循環器学会第79回中国四国地方会)

垣下幹夫, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 66 961 - 961 2002.4

128)高熱と心膜炎で発症した成人発症型スティル病の一例(日本循環器学会第79回中国四国地方会)

三浦龍志, 佐藤克政, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Circulation journal : official journal of the Japanese Circulation Society 66 975 - 975 2002.4

Persistent Adenovirus Myocarditis : Is It Degeneration or Inflammation?

Ohta Keiko, Nakamura Kazufumi, Kusano Kengo, Nagase Satoshi, Kakishita Mikio, Morita Hiroshi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru, Nakamura Yoichi

Circulation journal : official journal of the Japanese Circulation Society 66 840 - 840 2002.3

Characteristics of action potential duration (APD) restitution in Angiotensin II type 1a receptor knockout (AT1a KO) mice

Kakishita Mikio, Hashimoto Katsushi, Nakamura Kazufumi, Morita Hiroshi, Kusano Kengo, Emori Tetsurou, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 66 688 - 688 2002.3

Usefullness of 16-lead signal average electrocardiogram to differentiate between Brugada syndrome and asymptomatic Brugada

Hisamatsu Kenichi, Kusano Kengo, Morita Hiroshi, Takenaka Shiho, Nagase Satoshi, Nakamura Kazufumi, Emori Tetsuro, Matsubara Hiromi, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 66 684 - 684 2002.3

The Ventricular Activation Pattern of the Body Surface Mapping during Polymorphic Ventricular Tachycardia in Patients with the Brugada Syndrome

Morita Hiroshi, Nagase Satoshi, Hisamatsu Kenichi, Kobayashi Makoto, Nakamura Kazufumi, Kusano Kengo, Emori Tetsuro, Matsubara Hiromi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 66 452 - 452 2002.3

Atrial fibrillation and atrial vulnerability in patients with brugada syndrome.

Morita H, Fukushima KK, Nagase S, Fujimoto Y, Hisamatsu K, Fujio H, Haraoka K, Kobayashi M, Takenaka MS, Nakamura K, Emori T, Matsubara H, Hina K, Kita T, Fukatani M, Ohe T

JACC 2002

Anti-inflammatory effects of long-lasting locally-delivered human recombinant tissue factor pathway inhibitor after balloon angioplasty.

Nakamura Y, Nakamura K, Ohta K, Matsubara H, Yutani C, Hamuro T, Kato H, Ohe T

Basic Res Cardiol 2002

Altered nano/micro-order mechanical property of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension.

Nakamura K, Hashimoto K, Ohta K, Kakishita M, Fujio H, Motita H, Fukushima KK, Emori T, Matsubara H, Ohe T, Date H, Shimizu N, Kataoka N, Mochizuki S, Hashimoto K, Shimizu J, Kajiya F

Curculation 2002

原発性肺高血圧症における右室心筋内微小血管の組織学的検討

大田恵子, 中村陽一, 草野研吾, 永瀬聡, 宮地克維, 中村一文, 森田宏, 江森哲郎, 松原広己, 大江透

Therapeutic Research 23,2,34-37 2002

心不全を合併した致死性不整脈の治療

中村一文, 永瀬聡, 大江透

循環器科 52,4,309-315 2002

Differential effects of beta-blockade on dispersion of repolarization in the absence and presence of sympathetic stimulation between the LQT1 and LQT2 forms of congenital long QT syndrome.

Shimizu W, Tanabe Y, Aiba T, Inagaki M, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Sunagawa K, Nakamura K, Ohe T, Towbin JA, Priori SG, Kamakura S

JACC 2002

Carvedilol decreases elevated oxidative stress in human failing myocardium.

Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S, Yamamoto M, Miyaji K, Saito H, Morita H, Emori T, Matsubara H, Toyokuni S, Ohe T

Circulation 2002

Epicardial electrogram of the right ventricular outflow tract in patients with the brugada syndrome.

Nagase S, Fukushima KK, Morita H, Fujimoto Y, Kakishita M, Nakamura K, Emori T, Matsubara H, Ohe T

JACC 2002

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