Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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188)Narrow QRSに対し心臓再同期療法を施行した2症例(第88回日本循環器学会中国・四国合同地方会)

西井伸洋, 草野研吾, 多田毅, 大田恵子, 村上正人, 平松茂樹, 渡辺敦之, 伴場主一, 永瀬聡, 中村一文, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1169 - 1169 2006.10

136)デスミン蓄積が原因と考えられた拡張型心筋症の一例(第88回日本循環器学会中国・四国合同地方会)

大郷恵子, 多田毅, 草野研吾, 酒井芳昭, 伴場主一, 西井伸洋, 渡辺敦之, 平松茂樹, 永瀬聡, 中村一文, 桜木悟, 由谷親夫, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1164 - 1164 2006.10

66)異常Purkinje線維の興奮が不整脈発生に関与したshort-coupled variant of torsades de pointesの一症例(第88回日本循環器学会中国・四国合同地方会)

伴場主一, 永瀬聡, 西井伸洋, 渡辺敦之, 村上正人, 多田毅, 大田恵子, 酒井芳昭, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1156 - 1156 2006.10

78)左上肺静脈局所起源発作性心房頻拍が心房細動の発生,維持に関係した一例(第88回日本循環器学会中国・四国合同地方会)

酒井芳昭, 伴場主一, 西井伸洋, 平松茂樹, 渡辺敦之, 村上正人, 永瀬聡, 桜木悟, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1157 - 1157 2006.10

142)肥大型心筋症患者の収縮不全における酸化ストレスによるDNA傷害の関与(第88回日本循環器学会中国・四国合同地方会)

木村英夫, 中村一文, 永瀬聡, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1165 - 1165 2006.10

4-hydroxy-2-nonenal induces calcium overload via NADPH oxidase-derived reactive oxygen species in isolated rat cardiac myocytes

Kazufumi Nakamura, Daiji Miura, Wakako Sumita, Makiko Taniyama, Satoshi Nagase, Satoru Sarkuragi, Kengo F. Kusano, Tohru Ohe, Hiromi Matsubara

CIRCULATION 114 ( 18 ) 207 - 207 2006.10

Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells

Ryuzea Miura, Kazufumi Nakamura, Daiji Miura, Aya Miura, Kenichi Hisamatsu, Masahito Kajiya, Satoshi Nagase, Hiroshi Morita, Kengo Fukushima Kusano, Tohru Ohe, Kazuhiko Ishihara

JOURNAL OF PHARMACOLOGICAL SCIENCES 101 ( 3 ) 256 - 259 2006.7

Language：English Publisher：JAPANESE PHARMACOLOGICAL SOC

We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. Specifically, 10 mu M of spironolactone significantly reduced cytokine production, compared to the same dose of alacepril or CV-11974. These findings indicate that spironolactone may contribute to ameliorate the prognosis of patients with cardiovascular diseases by reducing Ang II-induced inflammation, although further exploration including determining the mechanisms would be required.

DOI： 10.1254/jphs.SC0060049

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Low-dose isoproterenol for repetitive ventricular arrhythmia in patients with Brugada syndrome

A Watanabe, KF Kusano, H Morita, D Miura, W Sumida, S Hiramatsu, K Banba, N Nishii, S Nagase, K Nakamura, S Sakuragi, T Ohe

EUROPEAN HEART JOURNAL 27 ( 13 ) 1579 - 1583 2006.7

Language：English Publisher：OXFORD UNIV PRESS

Aims Arrhythmic storm or repetitive ventricular arrhythmia (VA) has been occasionally observed in Brugada syndrome (BS). A beta-adrenergic stimulator [isoproterenol (ISP)] has been reported to suppress this arrhythmic storm in sporadic cases. Accordingly, we investigated the antiarrhythmic effects of ISP infusion in consecutive BS patients with arrhythmic storm or repetitive VA.
Methods and results Seven BS patients with arrhythmic storm were studied. Intravenous ISP was administered as a bolus injection (1-2 mu g), followed by continuous infusion (0.15 mu g/min). Arrhythmic storm or repetitive VA was suppressed immediately after the bolus administration of ISP, which was followed by continuous infusion of low-dose ISP for 1-3 days. In all patients, ST-elevation decreased in right precordial leads. In six of the seven patients, VA subsided after the discontinuance of ISP. RR interval was shortened and ST-elevation in right precordial leads was decreased after ISP bolus injection. ST-elevation in right precordial leads remained decreased during continuous ISP infusion, whereas the RR interval returned to the control level.
Conclusion Continuous administration of low-dose ISP may be effective for the suppression of repetitive VA occurrence in patients with BS.

DOI： 10.1093/eurheartj/ehl060

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特発性肺動脈高血圧症に対するスタチンの効果

池田哲也, 中村一文, 小川愛子, 三浦大志, 永瀬聡, 桜木悟, 草野研吾, 大江透, 伊達洋至, 松原広己, 藤尾栄起

Circ J 70 ( Supplement 2 ) 1077 2006.4

246)自己免疫機序による慢性心筋炎が病因と考えられた左室機能不全の一例(第87回日本循環器学会中国・四国合同地方会)

大郷恵子, 多田毅, 三浦綾, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透, 由谷親夫

Circulation journal : official journal of the Japanese Circulation Society 70 1078 - 1078 2006.4

90) Brugada症候群におけるSCN5A遺伝子の変異と電気生理学的検査における検討(第87回日本循環器学会中国・四国合同地方会)

伴場主一, 草野研吾, 中村一文, 永瀬聡, 三浦大志, 平松茂樹, 西井伸洋, 渡辺敦之, 岩崎淳, 浦川茂美, 谷山真規子, 角田和歌子, 三浦綾, 桜木悟, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1061 - 1061 2006.4

92) Pilsicainide負荷時の高位肋間のみでBrugada型心電図を呈したSCN5A異常を有する1例(第87回日本循環器学会中国・四国合同地方会)

平松茂樹, 渡辺敦之, 西井伸洋, 伴場主一, 三浦大志, 永瀬聡, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1061 - 1061 2006.4

88)左室起源リエントリ性心室頻拍にて発見されたSCN5A遺伝子変異を認めるBrugada症候群の一例(第87回日本循環器学会中国・四国合同地方会)

酒井芳昭, 永瀬聡, 平松茂樹, 西井伸洋, 伴場主一, 渡辺敦之, 細木信吾, 三浦大志, 谷山真規子, 木村英夫, 岩崎淳, 浦川茂美, 角田和歌子, 三浦綾, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1060 - 1060 2006.4

59)β刺激薬負荷で誘発された冠攣縮性狭心症の一例(第87回日本循環器学会中国・四国合同地方会)

三宅智博, 和田匡史, 細木信吾, 永瀬聡, 中村一文, 桜木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1057 - 1057 2006.4

94)多種類の薬剤が心室性不整脈の抑制に有効であったAndersen症候群の2例(第87回日本循環器学会中国・四国合同地方会)

和田匡史, 永瀬聡, 細木信吾, 多田毅, 村上正人, 溝口博喜, 大郷恵子, 伴場主一, 酒井芳昭, 中村一文, 櫻木悟, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 70 1061 - 1061 2006.4

PJ-157 Changes of Late Potentials after Administration of Sodium Channel Blocker in Brugada Syndrome(ECG/Body surface potential mapping/Holter-6 () PJ27,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Watanabe Atsuyuki, Kusano Kengo, Hiramatsu Shigeki, Tada Takeshi, Murakami masato, Banba Kimikazu, Nishii Nobuhiro, Hosogi Shingo, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Sakuragi Satoru, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 70 528 - 528 2006.3

Brugada Syndrome(Morning Lecture 9 (ML9) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Kusano Kengo, Kusano Kengo F., Nagase Satoshi, Morita Hiroshi, Nishii Nobuhiro, Banba Kimikazu, Nakamura Kazufumi, Sakuragi Satoru, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 70 100 - 100 2006.3

PE-598 Detection of T Wave Abnormality in Brugada Syndrome : Usefulness of Vector Electrocardiograms and Body Surface Mapping(ECG/Body surface potential mapping/Holter-4 (A) PE60,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Hiramatsu Shigeki, Kusano Kengo, Murakami Masato, Tada Takeshi, Watanabe Atsuyuki, Banba Kimikazu, Nishii Nobuhiro, Hosogi Shingo, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Sakuragi Satoru, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 70 424 - 424 2006.3

肺動脈性肺高血圧症の診断・治療と経過の検討

小川愛子, 草野研吾, 松原広己, 宮地克維, 永瀬聡, 中村一文, 桜木悟, 伊達洋至, 大江透

日本内科学会雑誌 95 179 2006.2

冠動脈造影により診断できた若年発症心室細動の2症例．

伴場主一, 草野研吾, 永瀬聡, 平松茂樹, 宮地晃平, 木村英夫, 西井伸洋, 中村一文, 桜木悟, 大江透

心臓 38,3,105-111 2006

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