Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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41) 左心耳起源心房頻拍に対しnon-contact mapping法を用いてablationを行った一例(第91回日本循環器学会中国地方会)

宮地晃平, 永瀬聡, 村上正人, 多田毅, 平松茂樹, 西井伸洋, 中村一文, 森田宏, 岡岳文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 953 - 953 2008.4

54) 重複僧帽弁口を伴った孤立性左室緻密化障害にWPW症候群を合併した一例(第91回日本循環器学会中国地方会)

福家聡一郎, 中川晃志, 谷口学, 渡辺敦之, 永瀬聡, 中村一文, 森田宏, 岡岳文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 955 - 955 2008.4

60) 失神原因精査に携帯型イベントホルター心電図が有用であった発作性完全房室ブロックの1例(第91回日本循環器学会中国地方会)

山脇均, 福家聡一郎, 武田賢治, 岡岳文, 永瀬聡, 中村一文, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 955 - 955 2008.4

7) 入浴中にST上昇・VFを来たしたことが捉えられたBrugada症候群の一例(第91回日本循環器学会中国地方会)

野坂和正, 草野研吾, 田中正道, 福家聡一郎, 永瀬聡, 中村一文, 武田賢治, 岡岳文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 950 - 950 2008.4

85) 部分的肺静脈還流異常に原発性肺高血圧症を合併した一例(第91回日本循環器学会中国地方会)

森あい子, 草野研吾, 圓光賢希, 杉山洋樹, 永瀬聡, 中村一文, 森田宏, 岡岳文, 福康志, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 958 - 958 2008.4

44) 洞不全症候群を合併した無症候性ブルガダ心電図の一症例(第91回日本循環器学会中国地方会)

多田毅, 草野研吾, 永瀬聡, 西井伸洋, 宮地晃平, 平松茂樹, 村上正人, 中村一文, 森田宏, 岡岳文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 954 - 954 2008.4

61) 精巣摘出によりBrugada型心電図が消失した心筋ナトリウムチャネル遺伝子変異を有する一例(第91回日本循環器学会中国地方会)

森田宏, 草野研吾, 三浦大志, 永瀬聡, 中村一文, 大江透

Circulation journal : official journal of the Japanese Circulation Society 72 956 - 956 2008.4

OE-381 Clinical Features of and Effects of Angiotensin System Antagonists on Amiodarone-Induced Pulmonary Toxicity(Arrhythmia, therapy(04)(A),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Nikaido Akira, Kusano Kengo, Morita Hiroshi, Nakamura Kazufumi, Oka Takefumi, Nagase Satoshi, Nishii Nobuhiro, Fuke Soichiro, Enkoh Kenki, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 276 - 276 2008.3

OJ-008 Usefulness of the Hot-Bath Test in Brugada Sydrome(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Mori Aiko, Tanaka Masamichi, Kusano Kengo, Nosaka Kazumasa, Nakagawa Koji, Sugiyama Hiroki, Yamawaki Hitoshi, Onoue Go, Fuke Soichiro, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Takeda Kenji, Oka Takefumi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 289 - 290 2008.3

OJ-011 Characteristics and Diagnosis of Patients with Inherited Bidirectional Ventricular Tachycardia(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Sugiyama Hiroki, Morita Hiroshi, Takeda Kenji, Nagase Satoshi, Nakamura Kazufumi, Oka Takefumi, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 290 - 290 2008.3

OJ-007 Blunted QT Prolongation to Sudden R-R Prolongation in Brugada Syndrome Patients with Coved ST Elevation(Arrhythmia, diagnosis/ Pathophysiology/ EPS(03)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Tada Takeshi, Kusano Kengo, Nagase Satoshi, Nishii Nobuhiro, Hiramatsu Shigeki, Miyaji Kohei, Murakami Masato, Tanaka Masamichi, Nakagawa Koji, Miura Daiji, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 289 - 289 2008.3

OJ-056 Outcome After Implantable Cardioverter-Defibrillator in Brugada Syndrome(Arrhythmia, therapy(06)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Nishii Nobuhiro, Kusano Kengo, Miyaji Kohei, Hiramatsu Shigeki, Tada Takeshi, Murakami Masato, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru, Miura Daiji, Miura Aya

Circulation journal : official journal of the Japanese Circulation Society 72 301 - 301 2008.3

FRS-106 Fragmented QRS, a Marker of Intraventricular Conduction Abnormality and Predictor of Prognosis of Brugada Syndrome(New Horizon in Diagnosis and Pathophysiology of Arrhythmia(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Morita Hiroshi, Kusano Kengo, Miura Daiji, Nagase Satoshi, Nakamura Kazufumi, Oka Takefumi, Wu Jiashin, Zipes Douglas P, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 172 - 173 2008.3

6 Anti-KCNH2 Antibody-induced Long QT Syndrome : Novel Acquired Form of LQT Syndrome(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Nakamura Kazufumi, Katayama Yusuke, Morita Hiroshi, Kusano Kengo, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 20 - 20 2008.3

PJ-745 Clinical Usefulness of the Non-invasive Stroke Volume Measurement System, the Task Force[○!R] Monitor, in Patients with Pulmonary Hypertension(Pulmonary circulation(04)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Fuke Soichiro, Kusano Kengo, Mizoguchi Hiroki, Nagase Satoshi, Nakamura Kazufumi, Morita Hiroshi, Oka Takefumi, Ohe Tohru

Circulation journal : official journal of the Japanese Circulation Society 72 699 - 699 2008.3

Longer repolarization in the epicardium at the right ventricular outflow tract causes type 1 electrocardiogram in patients with Brugada syndrome

Satoshi Nagase, Kengo Fukushima Kusano, Hiroshi Morita, Nobuhiro Nishii, Kimikazu. Banba, Atsuyuki Watanabe, Shigeki Hiramatsu, Kazufumi Nakamura, Satoru Sakuragi, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51 ( 12 ) 1154 - 1161 2008.3

Language：English Publisher：ELSEVIER SCIENCE INC

Objectives We examined the relationship between repolarization abnormality and coved-type ST-segment elevation with terminal inverted T-wave (type 1 electrocardiogram [ECG]) in patients with Brugada syndrome (BrS).
Background Recent experimental studies have suggested that accentuation of the right ventricular action potential (AP) notch preferentially prolongs epicardial AP causing inversion of the T-wave.
Methods In 19 patients with BrS and 3 control subjects, activation-recovery intervals (ARIs) and repolarization times (RTs) in the epicardium and endocardium were directly examined with the use of local unipolar electrograms at the right ventricular outflow tract. Surface ECG, ARI, and RT were examined before and after administration of pilsicainide.
Results Type 1 ECG was observed in 10 of the 19 BrS patients before the administration of pilsicainide and in all of the 19 patients after the administration of pilsicainide. We found that ARI and RT in the epicardium were shorter than those in the endocardium in all 9 BrS patients without type 1 ECG under baseline conditions and in all control subjects regardless of pilsicainide administration. However, longer epicardial ARI than endocardial ARI was observed in 8 of the 10 BrS patients manifesting type 1 ECG under baseline conditions and in all of the BrS patients after the administration of pilsicainide. Also, epicardial RT was longer than endocardial RT in all patients manifesting type 1 ECG regardless of pilsicainide administration.
Conclusions Our data provide support for the hypothesis that the negative T-wave associated with type 1 BrS ECG is due to a preferential prolongation of the epicardial AP secondary to accentuation of the AP notch in the region of the right ventricular outflow tract.

DOI： 10.1016/j.jacc.2007.10.059

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Atrial fibrillation in patients with Brugada syndrome - Relationships of gene mutation, electrophysiology, and clinical backgrounds

Kengo F. Kusano, Makiko Tamyama, Kazufumi Nakamura, Daiji Miura, Kimikazu Banba, Satoshi Nagase, Hiroshi Morita, Nobuhlro Nishil, Atsuyuki Watanabe, Takeshi Tada, Masato Murakarm, Kohei Miyaji, Shigeki Hiramatsu, Koji Nakagawa, Masamichi Tanaka, Aya Miura, Hideo Kimura, Soichiro Fuke, Wakako Sumita, Satoru Sakuragi, Shigern Urakawa, Jun Iwasaki, Tohru Ohe

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 51 ( 12 ) 1169 - 1175 2008.3

Language：English Publisher：ELSEVIER SCIENCE INC

Objectives The goal of our work was to examine the relationships of atrial fibrillation (AF) with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS).
Background Atrial fibrillation is often observed in patients with BrS and indicates that electrical abnormality might exist in the atrium as well as in the ventricle. SCN5A, a gene encoding the cardiac sodium channel, has been reported to be causally related to BrS. However, little is known about the relationships of atrial arrhythmias with genetic, clinical, and electrophysiological backgrounds of BrS.
Methods Seventy-three BrS patients (49 +/- 12 years of age, men/women = 72/1) were studied. The existence of SCN5A mutation and clinical variables (syncopal episode, documented ventricular fibrillation [VF], and family history of sudden death) were compared with spontaneous AF episodes. Genetic and clinical variables were also compared with electrophysiologic (EP) parameters: atrial refractory period, interatrial conduction time (CT), repetitive atrial firing, and AF induction by atrial extra-stimulus testing.
Results Spontaneous AF occurred in 10 (13.7%) of the BrS patients and SCN5A mutation was detected in 15 patients. Spontaneous AF was associated with higher incidence of syncopal episodes (60.0% vs. 22.2%, p < 0.03) and documented VF (40.0% vs. 14.3%, p < 0.05). SCN5A mutation was associated with prolonged CT (p < 0.03) and AF induction (p < 0.05) in EP study, but not related to the spontaneous AF episode and other clinical variables. In patients with documented VF, higher incidence of spontaneous AF (30.8% vs. 10.0%, p < 0.05), AF induction (53.8% vs. 20.0%, p < 0.03), and prolonged CT was observed.
Conclusions Spontaneous AF and VF are closely linked clinically and electrophysiologically in BrS patients. Patients with spontaneous AF have more severe clinical backgrounds in BrS. SCN5A mutation is associated with electrical abnormality but not disease severity.

DOI： 10.1016/j.jacc.2007.10.060

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Clinical significance of macroscopic T-wave alternans after sodium channel blocker administration in patients with Brugada syndrome

Takeshi Tada, Kengo Fukushima Kusano, Satoshi Nagase, Kimikazu Banba, Daiji Miura, Nobuhiro Nishii, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Tohru Ohe

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY 19 ( 1 ) 56 - 61 2008.1

Language：English Publisher：BLACKWELL PUBLISHING

Clinical Significance of Macroscopic T-Wave Alternans. Introduction: Macroscopic T-wave alternans (TWA) is sometimes observed after sodium channel blocker administration in patients with Brugada syndrome (BS), but little is known about the association between occurrence of TWA and clinical characteristics in BS patients. We investigated the association between spontaneous ventricular fibrillation (VF) occurrence and TWA after pilsicainide, a sodium channel blocker administration in BS patients.
Methods and Results: We administered pilsicainide at a dose of 1 mg/kg to 77 BS patients (76 males and one female; mean age, 48.4 years) and examined the association between TWA after pilsicainide administration and clinical characteristics, including age, spontaneous VF, syncope, family history of sudden death, spontaneous coved ST elevation, late potentials (LP), induction of VF by programmed electrical stimulation, and SCN5A mutation. None of the patients had TWA before pilsicainide administration, but TWA became apparent in 17 (22.1%) of the patients after pilsicainide administration. Patients with TWA had a significantly higher incidence of spontaneous VF (52.9% vs 8.3%, P < 0.001) and syncope (58.8% vs 26.7%, P < 0.05) than did patients without TWA. Then, we focused on the association between spontaneous VF and clinical characteristics. Patients with spontaneous VF had a significantly higher incidence of TWA (64.3% vs 12.7%, P < 0.001) and LP positive (92.9% vs 56.5%, P < 0.01) than did patients without spontaneous VF. In multivariate analysis, TWA (P = 0.001) and LP (P = 0.047) appeared as the independent predictor for spontaneous VF.
Conclusion: TWA after pilsicainide administration is associated with a high risk of clinical VF in patients with BS.

DOI： 10.1111/j.1540-8167.2007.00967.x

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特集致死性不整脈をきたす疾患-診断と治療-特殊な機序によるQT延長症候群－HERGチャネルに対する自己抗体.

杉山洋樹, 中村一文, 大江透, 片山祐介

Heart View 12 ( 9 ) 1117 - 1121 2008

抗KCNH2抗体による自己免疫性QT延長症候群－後天性QT延長症候群の新しい発症機序－

中村一文, 片山祐介, 大江透

循環器専門医 16 ( 2 ) 231 - 236 2008

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MISC - NAKAMURA Kazufumi