Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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Fontan術後の複数の難治性心房頻拍に対し,RhythmiaによるカテーテルアブレーションとTCPC conversionが奏効した1例

森本芳正, 西井伸洋, 水野智文, 浅田早央莉, 木村朋生, 宮本真和, 中川晃志, 渡邊敦之, 中村一文, 森田宏, 伊藤浩, 栄徳隆裕, 笠原真悟

日本不整脈心電学会カテーテルアブレーション委員会公開研究会プログラム・抄録集 2019 2019

薬物治療およびカテーテルアブレーションが無効のVT stormに対してCTガイド下胸部交感神経節ブロックが有効であった1例

宮本真和, 渡邊敦之, 浅田早央莉, 森本芳正, 中川晃志, 西井伸洋, 中村一文, 森田宏, 伊藤浩

心臓 51 2019

A Possible Biological Pacemaker Created by HCN4-overexpressing Human iPS Cell-derived Cardiomyocytes

中村一文, 斎藤幸弘, 吉田賢司, 中川晃志, 渡辺敦之, 西井伸洋, 森田宏, 伊藤浩

日本循環器学会学術集会(Web) 83rd 2019

心不全の併存症-病態・治療-弁膜症

中村一文, 中川晃志, 卜部力

日本臨床 77 2019

TCPC conversionが推奨されたAPC Fontan術後左室型単心室症の一例

田渕真基, 杜徳尚, 西井伸洋, 赤木禎治, 高谷陽一, 中川晃志, 赤木達, 吉田賢司, 谷山真規子, 渡邊敦之, 三好亨, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 113th 2018

Coral reef aorta一連の病変と考えられた移植腎動脈狭窄に対する血管内治療の1例

戸田洋伸, 大塚寛昭, 江尻健太郎, 内田治仁, 杜徳尚, 中川晃志, 渡邊敦之, 三好亨, 西井伸洋, 中村一文, 森田宏, 伊藤浩

脈管学(Web) 58 ( supplement ) 2018

血栓溶解療法とDOAC(direct oral anticoagulant)にて治療を行った腫瘍関連多発動静脈血栓症の一例

小倉聡一郎, 更科俊洋, 宮本真和, 中川晃志, 渡邊敦之, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本循環器学会中国地方会(Web) 112th 2018

クライオマッピングが治療効果指標ではなくリスク指標として有用であったHis束近傍起源心室性期外収縮の1例

宮本真和, 渡邊敦之, 佃早央莉, 森本芳正, 三好章仁, 中川晃志, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本不整脈心電学会カテーテルアブレーション委員会公開研究会プログラム・抄録集 2018 2018

極型Fallot四徴症に対してのRastelli術後遠隔期にVT/VFを認めた1例

横濱ふみ, 杜徳尚, 高谷陽一, 中川晃志, 赤木達, 吉田賢司, 谷山真規子, 渡邊敦之, 三好亨, 西井伸洋, 赤木禎治, 中村一文, 森田宏, 伊藤浩, 黒子洋介, 小谷恭弘, 笠原真悟

日本循環器学会中国地方会(Web) 113th 2018

心静止を呈した心臓抑制型神経調節性失神に対しペースメーカー移植術を行い失神を抑制し得た1例

卜部力, 森田宏, 伊藤浩, 赤木禎治, 中村一文, 三好亨, 吉田賢司, 杜徳尚, 三好章仁, 赤木達, 谷山真規子, 西井伸洋, 渡邊敦之, 中川晃志, 森本芳正, 戸田洋伸, 江尻健太郎, 吉田雅言, 大塚寛昭, 三木崇史

日本循環器学会中国地方会(Web) 113th 2018

当院における菌血症を伴う心臓植込み型デバイス感染に対するデバイス抜去術後の予後

森本芳正, 西井伸洋, 三好章仁, 佃早央莉, 宮本真和, 川田哲史, 中川晃志, 渡邊敦之, 中村一文, 森田宏, 衛藤弘城, 黒子洋介, 笠原真悟, 伊藤浩

日本循環器学会中国地方会(Web) 112th 2018

胸部交感神経節ブロックが有効であった,治療抵抗性心室頻拍の1例

宮本真和, 渡邊敦之, 森田宏, 佃早央莉, 森本芳正, 三好章仁, 川田哲史, 中川晃志, 西井伸洋, 中村一文, 松崎孝, 松井裕輔, 渡邊伸英, 田邊一明, 森松博史, 金澤右, 伊藤浩

日本循環器学会中国地方会(Web) 112th 2018

EnSite使用時に12誘導心電図に混入するノイズへの対応

竹中祐樹, 西山宏徳, 井口浩貴, 佃早央莉, 森本芳正, 宮本真和, 川田哲史, 中川晃志, 渡邊敦之, 西井伸洋, 中村一文, 森田宏, 伊藤浩

日本不整脈心電学会学術大会プログラム・抄録集(Web) 65th 2018

心房細動に伴う高度僧帽弁逆流・三尖弁逆流に対して両弁形成術を施行した1例

横濱ふみ, 中村一文, 高谷陽一, 杜徳尚, 中川晃志, 赤木達, 吉田賢司, 谷山真規子, 渡邊敦之, 三好亨, 西井伸洋, 赤木禎治, 森田宏, 伊藤浩, 衛藤弘樹, 末澤孝徳, 笠原真悟

日本循環器学会中国地方会(Web) 113th 2018

乳頭筋起源特発性心室頻拍stormの1例

渡邊敦之, 佃早央莉, 宮本真和, 森本芳正, 中川晃志, 三好章仁, 西井伸洋, 中村一文, 森田宏, 伊藤宏

日本不整脈心電学会カテーテルアブレーション委員会公開研究会プログラム・抄録集 2018 2018

Amplatzer Septal Occluderデバイスを穿刺し肺静脈隔離術を施行した心房中隔欠損症カテーテル閉鎖術後の1例

中川晃志, 森本芳正, 佃早央莉, 宮本真和, 高谷陽一, 渡邊敦之, 西井伸洋, 中村一文, 赤木禎治, 森田宏, 伊藤浩

日本不整脈心電学会カテーテルアブレーション委員会公開研究会プログラム・抄録集 2018 2018

Initial experience with the subcutaneous implantable cardioverter-defibrillator in a single Japanese center

Nobuhiro Nishii, Motomi Tachibana, Yoshimasa Morimoto, Satoshi Kawada, Akihito Miyoshi, Hiroyasu Sugiyama, Koji Nakagawa, Atsuyuki Watanabe, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Ito

Journal of Arrhythmia 33 ( 4 ) 338 - 341 2017.8

Language：English Publisher：Elsevier B.V.

Background The subcutaneous implantable cardioverter-defibrillator (S-ICD) is recognized as a viable alternative to the transvenous ICD. The safety and efficacy of this device has been demonstrated in Western countries, but studies with S-ICD implantation in Japanese patients have not been reported. Methods and results Twelve patients received an S-ICD implant in our institute between February and September 2016. All S-ICDs were successfully implanted without complications. One appropriate and one inappropriate therapy was identified. Conclusions S-ICD implantation appears to provide a viable alternative to transvenous ICD implantation for some Japanese patients. However, we should perform careful follow-up of patients to eliminate inappropriate therapy.

DOI： 10.1016/j.joa.2017.02.004

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Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice

Kazufumi Nakamura, Daiji Miura, Yukihiro Saito, Kei Yunoki, Yasushi Koyama, Minoru Satoh, Megumi Kondo, Kazuhiro Osawa, Omer F. Hatipoglu, Toru Miyoshi, Masashi Yoshida, Hiroshi Morita, Hiroshi Ito

PLOS ONE 12 ( 8 ) 159 - 166 2017.8

Language：English Publisher：PUBLIC LIBRARY SCIENCE

Background
The klotho gene was identified as an "aging-suppressor" gene that accelerates arterial calcification when disrupted. Serum and vascular klotho levels are reduced in patients with chronic kidney disease, and the reduced levels are associated with arterial calcification. Intake of eicosapentaenoic acid (EPA), an n-3 fatty acid, reduces the risk of fatal coronary artery disease. However, the effects of EPA on arterial calcification have not been fully elucidated. The aim of this study was to determine the effect of EPA on arterial calcification in klotho mutant mice.
Methods and results
Four-week-old klotho mutant mice and wild-type (WT) mice were given a diet containing 5% EPA (EPA food, klotho and WT: n = 12, each) or not containing EPA (control food, klotho and WT: n = 12, each) for 4 weeks. Calcium volume scores of thoracic and abdominal aortas assessed by computed tomography were significantly elevated in klotho mice after 4 weeks of control food, but they were not elevated in klotho mice after EPA food or in WT mice. Serum levels of EPA and resolvin E1, an active metabolite of EPA, in EPA food-fed mice were significantly increased compared to those in control food-fed mice. An oxidative stress PCR array followed by quantitative PCR revealed that NADPH oxidase-4 (NOX4), an enzyme that generates superoxide, gene expression was up-regulated in arterial smooth muscle cells (SMCs) of klotho mice. Activity of NOX was also significantly higher in SMCs of klotho mice than in those of WT mice. EPA decreased expression levels of the NOX4 gene and NOX activity. GPR120, a receptor of n-3 fatty acids, gene knockdown by siRNA canceled effects of EPA on NOX4 gene expression and NOX activity in arterial SMCs of klotho mice.
Conclusions
EPA prevents arterial calcification together with reduction of NOX gene expression and activity via GPR120 in klotho mutant mice.

DOI： 10.1371/journal.pone.0181009

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Early and frequent defibrillator discharge in patients with cardiac sarcoidosis compared with patients with idiopathic dilated cardiomyopathy

Yoichi Takaya, Kengo Kusano, Nobuhiro Nishii, Kazufumi Nakamura, Hiroshi Ito

INTERNATIONAL JOURNAL OF CARDIOLOGY 240 302 - 306 2017.8

Language：English Publisher：ELSEVIER IRELAND LTD

Background: Little is known about the suitability of implantable cardioverter defibrillator (ICD) implantation in patients with cardiac sarcoidosis (CS). We evaluated the efficacy of ICD implantation in patients with CS, including suspected CS, compared with those with idiopathic dilated cardiomyopathy (DCM).
Methods: A total of 102 consecutive patients with definite CS, suspected CS, or DCM who underwent ICD implantation were enrolled. The endpoint was the first documentation of appropriate ICD therapy for ventricular tachyarrhythmias. The follow-up started after ICD implantation.
Results: Appropriate ICD therapies occurred in 15 (56%) of 27 patients with definite CS, 17 (68%) of 25 with suspected CS, and 16 (32%) of 50 with DCM. The rate of appropriate ICD therapies was higher in patients with definite CS and those with suspected CS than in those with DCM (log-rank test, p= 0.010). After ICD implantation, five or more appropriate ICD therapies occurred in 5 (19%) patients with definite CS and 10 (40%) with suspected CS, but in only 1 (2%) with DCM. Cox proportional hazard analysis showed that CS, including suspected CS, was independently associated with appropriate ICD therapies. For primary prevention, the rate of appropriate ICD therapies was higher in patients with CS than in those with DCM(log-rank test, p= 0.034). More than half of patients with CS received appropriate ICD therapies.
Conclusions: Patients with CS receive appropriate ICD therapies for ventricular tachyarrhythmias at a higher rate, compared with those with DCM, suggesting that ICD implantation should be performed in patients with CS.

DOI： 10.1016/j.ijcard.2017.04.044

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Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid

Yukihiro Saito, Kazufumi Nakamura, Daiji Miura, Kei Yunoki, Toru Miyoshi, Masashi Yoshida, Norifumi Kawakita, Tomonari Kimura, Megumi Kondo, Toshihiro Sarashina, Satoshi Akagi, Atsuyuki Watanabe, Nobuhiro Nishii, Hiroshi Morita, Hiroshi Ito

NUTRIENTS 9 ( 8 ) 17574 - 17582 2017.8

Language：English Publisher：MDPI AG

Vascular medial calcification is often observed in patients with arteriosclerosis. It is also associated with systolic hypertension, wide pulse pressure, and fluctuation of blood pressure, which results in cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular calcification in previous animal experiments. We investigated the inhibitory effects of EPA on Wnt signaling, which is one of the important signaling pathways involved in vascular calcification. Intake of food containing 5% EPA resulted in upregulation of the mRNA expression of Klotho, an intrinsic inhibitor of Wnt signaling, in the kidneys of wild-type mice. Expression levels of beta-catenin, an intracellular signal transducer in the Wnt signaling pathway, were increased in the aortas of Klotho mutant (kl/kl) mice compared to the levels in the aortas of wild-type mice. Wnt3a or BIO, a GSK-3 inhibitor that activates beta-catenin signaling, upregulated mRNA levels of AXIN2 and LEF1, Wnt signaling marker genes, and RUNX2 and BMP4, early osteogenic genes, in human aorta smooth muscle cells. EPA suppressed the upregulation of AXIN2 and BMP4. The effect of EPA was cancelled by T0070907, a PPAR gamma inhibitor. The results suggested that EPA could suppress vascular calcification via the inhibition of Wnt signaling in osteogenic vascular smooth muscle cells via PPAR gamma activation.

DOI： 10.3390/nu9080858

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MISC - NAKAMURA Kazufumi