Faculty Profiles - NAKAMURA Kazufumi

MISC - NAKAMURA Kazufumi

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SCN5A遺伝子変異を有するBrugada症候群の心電図および電気生理学的特徴－ピルジカイニド負荷試験を中心に－

伴場主一, 草野研吾, 中村一文, 永瀬聡, 渡邊敦之, 西井伸洋, 三浦大志, 森田宏, 櫻木悟, 大江透

Japanese Journal of Electrocardiology 26,4,S-4-97-S-4-101 2006

Elevated levels of oxidative DNA damage in serum and myocardium of patients with heart failure.

Kono Y, Nakamura K, Kimura H, Nishii N, Watanabe A, Banba K, Miura A, Nagase S, Sakuragi S, Kusano KF, Matsubara H, Ohe T

Circulation Journal 2006

特論致死的不整脈への対応．

村上正人, 中村一文, 大江透

日本臨床 64,5,985-989 2006

心機能低下例における不整脈の薬物療法－上流治療ならびに抗不整脈薬の効果－

中村一文, 岩崎淳

医学のあゆみ 218,14,1213-1216 2006

KCNJ2の遺伝子変異を認めるAndersen症候群 (LQT7) における心臓電気生理学的検討．

永瀬聡, 柚木佳, 三浦大志, 吉田賢司, 西井伸洋, 伴場主一, 中村一文, 斎藤博則, 草野研吾, 大江透

臨床心臓電気生理 29,257-264 2006

Carvedilol inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.

Fujio H, Nakamura K, Matsubara H, Kusano KF, Miyaji K, Nagase S, Ikeda T, Ogawa A, Ohta-Ogo K, Miura D, Miura A, Miyazaki M, Date H, Ohe T

J Cardiovasc Pharmacol 2006

特集/薬物によるQT延長の諸問題：遺伝子からICHまで 6. 後天性QT延長症候群の臨床的特徴．

草野研吾, 中村一文, 大江透

臨床薬理 37,4,227-230 2006

サイファーステント留置後, 再狭窄をきたした1症例(第86回日本循環器学会中国地方会)

吉川昌樹, 細木信吾, 武寛, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 907 - 907 2005.10

SCN5A遺伝子に異常を認めた Brugada 症候群-LQT3の2症例(第86回日本循環器学会中国地方会)

吉田賢司, 柚木佳, 三浦大志, 木村英夫, 平松茂樹, 渡辺敦之, 伴場主一, 西井伸洋, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透, 宮地晃平

Circulation journal : official journal of the Japanese Circulation Society 69 910 - 910 2005.10

巨大MACの一例(第86回日本循環器学会中国地方会)

杜徳尚, 村上正人, 谷口学, 丸尾健, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透, 宮地克維

Circulation journal : official journal of the Japanese Circulation Society 69 914 - 914 2005.10

原発性肺高血圧症 (PPH) と特発性血小板減少性紫斑病 (ITP) を合併した一例(第86回日本循環器学会中国地方会)

溝口博喜, 谷口学, 宮地克維, 藤尾栄起, 小川愛子, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 915 - 915 2005.10

T波の oversensing によるICD誤作動を繰り返した1例(第86回日本循環器学会中国地方会)

村上正人, 宮地剛, 角田和歌子, 西井伸洋, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 911 - 911 2005.10

心房細動に対して, 電気的 substarate ablation を行った2症例(第86回日本循環器学会中国地方会)

武寛, 西井伸洋, 永瀬聡, 草野研吾, 村上正人, 溝口博喜, 谷口学, 平松茂樹, 渡辺敦之, 伴場主一, 中村一文, 齋藤博則, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 910 - 910 2005.10

急性心筋炎後心室頻拍の乳児に対してアミオダロン持続静注が極めて有効であった1症例(第86回日本循環器学会中国地方会)

細木信吾, 永瀬聡, 中村一文, 齋藤博則, 草野研吾, 大江透

Circulation journal : official journal of the Japanese Circulation Society 69 911 - 911 2005.10

Equivalence of flow velocities through bilateral pulmonary vein anastomoses in bilateral living-donor lobar lung transplantation

K Miyaji, H Matsubara, K Nakamura, KF Kusano, K Goto, H Date, T Ohe

JOURNAL OF HEART AND LUNG TRANSPLANTATION 24 ( 7 ) 860 - 864 2005.7

Language：English Publisher：ELSEVIER SCIENCE INC

Background: Intraoperative transesophageal echocardiography (TEE) during lung transplantation is useful for monitoring cardiac condition and pulmonary vascular anastomoses to detect vascular complications, but the parameters for evaluation by TEE during lung transplantation have not been established.
Methods: We performed intraoperative TEE on 17 patients during living-donor lobar lung transplantation (LDLLT) and investigated the usefulness of measurement of peak flow velocities through bilateral pulmonary vein (PV) anastomoses and evaluation of the equivalence.
Results: The peak flow velocities through bilateral PV anastomoses were almost equivalent in 14 patients without complications and were not equivalent in 3 patients with complications such as vascular stenosis and peripheral atelectasis.
Conclusions: The flow velocities through the bilateral PV anastomoses are shown to be nearly equivalent during bilateral LDLLT, and the equivalence may be one factor for predicting the success of LDLLT.

DOI： 10.1016/j.healun.2004.05.021

Web of Science

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Therapeutic Effect of Beta-Stimulant on Patients with Brugada Syndrom(Arrhythmia, Pharmacological Therapy 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Watanabe Atsuyuki, Morita Hiroshi, Sumida Wakako, Banba Kimikazu, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 69 536 - 536 2005.3

The Use of Low Dose Quinidine Test to Differentiate between Symptomatic and Asymptomatic Patients with Brugada Syndrome (Arrhythmia, Diagnosis/Pathophysiology/EPS 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

Watanabe Atsuyuki, Morita Hiroshi, Sumida Wakako, Banba Kimikazu, Nishii Nobuhiro, Nagase Satoshi, Nakamura Kazufumi, Saitoh Hironori, Kusano Kengo, Ohe Toru

Circulation journal : official journal of the Japanese Circulation Society 69 290 - 290 2005.3

Relationship between oxidative stress and systolic dysfunction in patients with hypertrophic cardiomyopathy

K Nakamura, KF Kusano, H Matsubara, Y Nakamura, A Miura, N Nishii, K Banba, S Nagase, K Miyaji, H Morita, H Saito, T Emori, T Ohe

JOURNAL OF CARDIAC FAILURE 11 ( 2 ) 117 - 123 2005.3

Language：English Publisher：CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS

Background: Progression of hypertrophic cardiomyopathy (HCM) to left ventricular dilatation and systolic dysfunction sometimes occurs. However, the mechanism is not known. We examined whether oxidative stress was elevated in myocardia of HCM patients and whether the levels were correlated with left ventricular dilatation and systolic dysfunction.
Methods and Results: Endomyocardial biopsy samples obtained from the right ventricular side of the septum of 31 patients with HCM, and 10 control subjects were studied immunohistochemically for the expression of 4-hydroxy-2-nonenal (HNE)-modified protein, which is a major lipid peroxidation product. Expression of HNE-modified protein was found in all myocardial biopsy samples from patients with HCM. Expression was distinct in the cytosol of cardiomyocytes. The expression levels in patients with HCM were significantly increased compared with those in control subjects (P = .0005). The expression levels in patients with HCM were correlated with left ventricular end-diastolic diameter (r = 0.483, P = .0053) and end-systolic diameter (r = 0.500, P = .0037) determined by echocardiography. The expression levels were inversely con-elated with left ventricular ejection fraction determined by left ventriculography (r = -0.640, P = .0001).
Conclusion: Oxidative stress was elevated in myocardia of HCM patients and the levels were correlated with left ventricular dilatation and systolic dysfunction. Oxidative stress is involved in the pathogenesis of heart failure in patients with HCM.

DOI： 10.1016/j.cardfail.2004.05.005

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Risk of alveolar hemorrhage in patients with primary pulmonary hypertension -anticoagulation and epoprostenol therapy-

Ogawa A, Matsubara H, Fujio H, Miyaji K, Nakamura K, Morita H, Saito H, Kusano FK, Emori T, Date H, Ohe T

Circulation Journal 2005

Hepatocyte growth factor gene therapy reduces ventricular arrhythmia in animal models of myocardial ischemia.

Yumoto A, Kusano FK, Nakamura K, Hashimoto K, Aoki M, Morishita R, Kaneda Y, Ohe T

Acta Med. Okayama 2005

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