MISC - 尾﨑　敏文

軟部腫瘍におけるダイナミックMRIの有用性

杉原 進介, 川井 章, 尾崎 敏文, 井上 一, 佐藤 徹

中部日本整形外科災害外科学会雑誌   38 ( 2 )   369 - 370   1995年3月

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記述言語：日本語  

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Polyostotic lesions compatible with osteofibrous dysplasia - A case report

T. Ozaki, M. Hamada, K. Taguchi, Y. Nakatsuka, S. Sugihara, H. Inoue

Archives of Orthopaedic and Trauma Surgery   113 ( 1 )   46 - 48   1993年12月

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掲載種別：速報，短報，研究ノート等（学術雑誌）  

An 18-month-old girl with lesions in the cortex of the bilateral tibiae and ulnae and right fibula is reported. The lesion in the right tibia disappeared after curettage and xenogeneic bone grafting, and the other lesions disappeared spontaneously by the age of 12 years. All lesions involved the bone cortex. The right tibial lesion exhibited the histopathological features of "zonal architecture" and a osteoblast rim formation around the trabeculae. We consider that osteofibrous dysplasia can involve systemically any long bone. © 1993 Springer-Verlag.

DOI： 10.1007/BF00440594

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Adjuvant Chemotherapy for Patients with Soft Tissue Sarcoma

Ozaki Toshifumi, Sugihara Shinsuke, Hamada Masanori, Nakagawa Yukou, Inoue Hajime

Hiroshima Journal of Medical Sciences   42 ( 3 )   109 - 115   1993年9月

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記述言語：英語   出版者・発行元：Hiroshima University Medical Press  

Forty patients with soft tissue sarcoma (Enneking's stage I and II) were treated in our department between 1965 and 1992. We administered VACA regimen (composed of vincristine, actinomycin-D, cyclophosphamide, and doxorubicin) to 14 of 40 patients. Among 40 patients, the 5-year survival rate was 56% in 14 patients with chemotherapy and 39% in 26 without chemotherapy (p<0.02). In 32 patients of Stage II, the 5-year survival rate was 40% in 11 patients with chemotherapy and 31 % without chemotherapy (p<0.05). The improvement of the survival rate was due to delay in the development of lung metastases (chemotherapy group: 21.2 months after first visit, non-chemotherapy group: 9.4 months) and prolongation of the survival period after metastases (chemotherapy group: 26 months, non-chemotherapy group: 7.4 months).

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ヒト骨・軟部腫瘍における優性および劣性癌遺伝子の変異に関する研究

尾崎 敏文

岡山医学会雑誌   101 ( 5 )   589 - 602   1989年6月

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記述言語：日本語   出版者・発行元：岡山医学会  

Osteosarcoma is a malignant bone tumor which usually occurs in the metaphysis of long bones in adolescents or young adults, but the mechanism of disease occurrence is unknown. To examine alterations in the dominant oncogenes in the osteosarcoma and other bone and soft tissue tumors, DNA extracted from 12 bone tumors, 12 soft part tumors and 2 cells lines was hybridized with c-oncogene (c-myc, c-sis, c-raf-1, c-fos, K-ras2, c-erbB, c-fms, c-fos). DNA extracted from the same samples was examined with Rb cDNA (p0.9R, p3.8R) probes, the retinoblastoma gene (Rb gene) localized at 13q14, to analize whether a recessive mutation is a target in osteosarcoma, and other bone and soft tissue tumors. Amplification of c-myc was observed in 3 cases from 7 osteosarcomas and abnormalities in structure of the Rb gene were found in 4 from 7 osteosarcomas, 2 from 4 MFH, and 1 from 2 Ewing's sarcomas. Both amplification of the c-myc and abnormalities of the Rb gene were observed in 3 osteosarcoma cases. The results indicated that both the Rb gene and c-myc oncogene may be involved in the initiation of osteosarcoma.

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その他リンク： http://search.jamas.or.jp/link/ui/1991067104