研究者詳細 - 尾﨑　敏文

MISC - 尾﨑　敏文

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麻痺のない脊椎の骨関連事象(SRE)に対するRTの治療成績

中田英二, 杉原進介, 尾崎敏文

日本整形外科学会雑誌 91 ( 6 ) S1261 - S1261 2017年6月

後腹膜脂肪肉腫の治療における問題点

杉原進介, 中田英二, 魚谷弘二, 尾崎敏文

日本整形外科学会雑誌 91 ( 6 ) S1276 - S1276 2017年6月

Sauve-Kapandji法術後掌屈可動域減少例の検討

竹下歩, 西田圭一郎, 島村安則, 那須義久, 尾崎敏文

日本手外科学会雑誌 34 ( 1 ) S415 - S415 2017年4月

大腿骨近位部病的骨折の治療成績

中田英二, 杉原進介, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 春季学会 ) 198 - 198 2017年4月

本邦のさまざまな医療機関における倫理委員会の現状と課題臨床研究が効率よく実施されるために

藤原智洋, 藤井政孝, 吉原久美子, 大野彩, 三橋利晴, 丸山貴之, 桑木健司, 伊東孝, 難波志穂子, 尾崎敏文, 樋之津史郎

日本整形外科学会雑誌 91 ( 2 ) S303 - S303 2017年3月

TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes

Joe Hasei, Takeshi Teramura, Toshiyuki Takehara, Yuta Onodera, Takuro Horii, Merissa Olmer, Izuho Hatada, Kanji Fukuda, Toshifumi Ozaki, Martin K. Lotz, Hiroshi Asahara

SCIENTIFIC REPORTS 7 42990 2017年2月

記述言語：英語出版者・発行元：NATURE PUBLISHING GROUP

The objective was to investigate the levels of TWIST1 in normal and OA cartilage and examine its role in regulating gene expression in chondrocytes. Human cartilage tissues and chondrocytes were obtained at autopsy from normal knee joints and from OA-affected joints at the time of total knee arthroplasty. TWIST1 expression was increased in human OA knee cartilage compared to normal knee cartilage. TWIST1 induced matrix metalloproteinase 3 (MMP3) expression without direct binding to MMP3 promoter and increased the 5-hydroxymethylcytosine (5hmC) level at the MMP3 promoter. The effect of TWIST1 on expression of TET family (TET1, 2 and 3) was measured in stable TWIST1 transfected TC28 cells, and TET1 expression was up-regulated. TWIST1 dependent upregulation of Mmp3 expression was suppressed in Tet triple KO fibroblast derived from mouse ES cells. Increased TWIST1 expression is a feature of OA-affected cartilage. We identified a novel mechanism of catabolic reaction where TWIST1 up-regulates MMP3 expression by enriching 5hmC levels at the MMP3 promoter via TET1 induction. These findings implicate TWIST1 as an important factor regulating OA related gene expression. Clarifying epigenetic mechanisms of 5hmC induced by TWIST1 is a critical molecule to understanding OA pathogenesis.

DOI： 10.1038/srep42990

Web of Science

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The epidemiology of developmental dysplasia of the hip in Japan: Findings from a nationwide multi-center survey

Tadashi Hattori, Yutaka Inaba, Sadafumi Ichinohe, Toshio Kitano, Daisuke Kobayashi, Takashi Saisu, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 22 ( 1 ) 121 - 126 2017年1月

記述言語：英語出版者・発行元：SPRINGER JAPAN KK

Background: It has been reported that the national incidence of developmental dysplasia of the hip (DDH) has decreased in Japan. This is because of prevention activities after birth since around 1970. However, cases of late-diagnosed DDH have still been noted in some children's hospitals. There has been no recent survey of DDH in Japan. The purpose of this study was to investigate the current epidemiology of DDH using a comprehensive nationwide survey.
Methods: A questionnaire was sent to orthopedic surgeons in 1987 facilities nationwide, who were asked to complete and return a survey card on each DDH patient treated between April 2011 and March 2013.
Results: A total of 783 (39%) facilities completed and returned the card. Of these, 79% reported no cases of DDH-related dislocation over the 2-year period, while the remaining facilities reported 1295 cases. The characteristics of children diagnosed with DDH-related dislocation were as follows: girls (89%), left side involvement (69%), bilateral involvement (4%), positive family history (27%), first-born (56%), and pelvic position at birth (15%). Seasonal variation showed an increase in DDH incidence among those born in the winter. Overall, 199 cases (15%) were diagnosed at >1 year of age, and these included 36 cases diagnosed very late, at >3 years of age. The majority of the 199 cases of late diagnosis had received earlier routine screening at <1 year of age.
Conclusion: The characteristics of the children diagnosed with DDH nationwide were similar to past data from local regions. However, many children were diagnosed late (>1 year of age), particularly in the more populous regions. The findings identify a need for improved early routine screening for DDH in Japan. (C) 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jos.2016.08.009

Web of Science

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ラット脊椎固定モデルにおけるrhBMP2添加リン酸化プルランフィルムの有用性の検討

宇川諒, 塩崎泰之, 村岡聡介, 池田吉弘, 内野崇彦, 小田孔明, 吉村将秀, 吉田晶, 瀧川朋亨, 三澤治夫, 尾崎敏文, 松川昭博

移植 52 ( 6 ) 582 - 582 2017年

半月板変性断裂におけるクラスター形成と細胞外器質構成成分の検討

児玉有弥, 古松毅之, 前原亜美, 釜付祐輔, 尾崎敏文

日本結合組織学会学術大会抄録集 49th 2017年

施設入所中の脳性麻痺児における健康関連QOL調査の試み

小田孔明, 堅山佳美, 赤澤啓史, 田中雅人, 千田益生, 尾崎敏文

Japanese Journal of Rehabilitation Medicine 54 ( Supplement ) 2017年

臓器移植とリハビリテーション

千田益生, 堅山佳美, 兼田大輔, 尾崎敏文

Japanese Journal of Rehabilitation Medicine 54 ( Supplement ) 2017年

椎間板線維輪の転写因子制御

中道亮, 浅原弘嗣, 尾崎敏文

日本骨代謝学会学術集会プログラム抄録集 35th 2017年

ラット脊椎固定モデルにおけるrhBMP2添加リン酸化プルランフィルムの有用性の検討

宇川諒, 塩崎泰之, 村岡聡介, 池田吉弘, 内野崇彦, 小田孔明, 吉村将秀, 吉田晶, 瀧川朋亨, 三澤治夫, 尾崎敏文, 松川昭博

整形外科バイオマテリアル研究会プログラム・抄録集 37th 2017年

Calcar femorale in patients with osteoarthritis of the hip secondary to developmental dysplasia

Tomonori Tetsunaga, Kazuo Fujiwara, Hirosuke Endo, Tomoko Tetsunaga, Naofumi Shiota, Toru Sato, Toshifumi Ozaki

CiOS Clinics in Orthopedic Surgery 9 ( 4 ) 413 - 419 2017年

記述言語：英語出版者・発行元：Korean Orthopaedic Association

Background: We investigated whether the calcar femorale, a cortical septum in the region of the lesser trochanter of the femur, correlates with results of femoral stem implantation in patients with osteoarthritis of the hip secondary to developmental dysplasia using computed tomography. Methods: This retrospective study included 277 hips (41 males and 236 females
age, 37 to 92 years) of patients who had presented to Okayama Medical Center with hip pain. Of these, a total of 219 hips (31 males and 188 females) had previously undergone total hip arthroplasty. According to the Crowe classification, 147 hips were classified as Crowe grade I, 72 hips as Crowe grade II– IV, and 58 hips as normal. Results: The calcar femorale was identified in 267 hips (96.4%). The calcar femorale was significantly shorter and more ante-verted in Crowe grade II–IV hips than in Crowe grade I or normal hips. Significant differences in the shape of the calcar femorale were found according to the severity of hip deformity. Three stem designs were analyzed: single-wedge (59 hips), double-wedge metaphyseal filling (147 hips), and modular (13 hips). Single-wedge stems were inserted more parallel to the calcar femorale rather than femoral neck anteversion, while other types of stems scraped the calcar femorale. Conclusions: The angle of the calcar femorale differs according to the severity of hip deformity, and the calcar femorale might thus serve as a more useful reference for stem insertion than femoral neck anteversion in total hip arthroplasty using a single-wedge stem.

DOI： 10.4055/cios.2017.9.4.413

Scopus

PubMed

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強直股に対する人工股関節全置換術の治療経験

鉄永智紀, 藤原一夫, 遠藤裕介, 藤井洋佑, 三宅孝昌, 山田和希, 塩田直史, 佐藤徹, 尾﨑敏文

日本人工関節学会誌 47 675 - 676 2017年

記述言語：日本語出版者・発行元：(一社)日本人工関節学会

強直股に対して THA(人工股関節全置換術)を行った11例12股(男性5股、女性7股、手術時平均年齢64歳)の術後成績について検討した。手術はCT basedナビゲーションシステム使用例が5例、非使用例が7例であった。術後平均観察期間35ヵ月の結果、手術に伴う合併症は異所性骨化が2例、ナビゲーションを使用しなかった1例で術中骨折、Hardingeで行った1例で中殿筋部の疼痛を認めた。隣接関節痛である腰痛や膝関節痛は術前に6例で認められていたが、最終調査時には5例で軽減していた。JOAスコアは術前平均46点から最終調査時平均79点へ改善していた。

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Fixation transtibiale des l?sions de la racine post?rieure du m?nisque m?dial. Un guide de vis?e sp?cifique am?liore le positionnement du tunnel tibial

T. Furumatsu, Y. Kodama, M. Fujii, T. Tanaka, T. Hino, Y. Kamatsuki, K. Yamada, S. Miyazawa, T. Ozaki

Revue de Chirurgie Orthopedique et Traumatologique, Revue de Chirurgie Orthopedique et Reparatrice de l'Appareil Moteur, Revue d'orthope?die et de chirurgie de l'appareil moteur 103 ( 3 ) 1 - 50 2017年

THA再置換術後に遅発性Bacteroides感染を生じた1例

三宅孝昌, 遠藤裕介, 鉄永智紀, 藤井洋佑, 山田和希, 尾﨑敏文

日本人工関節学会誌 47 735 - 736 2017年

大腿骨近位部病的骨折の治療成績

中田英二, 杉原進介, 尾﨑敏文

中部整災誌 60 ( 6 ) 1033 - 1034 2017年

麻痺の無い脊椎の骨関連事象( SRE )に対する RT の治療成績

中田英二, 杉原進介, 尾﨑敏文

整形外科と災害外科 66 ( 4 ) 921 - 925 2017年

記述言語：日本語出版者・発行元：西日本整形・災害外科学会

【目的】当院では，脊椎SREに保存的治療を行う場合，アルゴリズムを作成して安静度を決定し，廃用症候群予防のため早期離床させる取り組みを行っている．今回，麻痺の無い脊椎SREに対するRTの治療成績について報告する．【対象と方法】H24年7月よりH27年12月までに当院で治療を行った麻痺を認めない脊椎SRE 201例を対象とした．全例保存的治療（RT 188例）が行われた．このうち，再発を除く175例の脊椎不安定性（SINS），脊椎SRE部の体動時の疼痛（Numerical Rating Scale（NRS）），ADL（Barthel Index（BI）），QOL（EORTC-QLQ C30のglobal health status）の治療開始時と開始後1, 2, 3, 4, 6ヶ月の比較をWilcoxonの符号付順位和検定を用いて検討した．【結果】経時的にSINS，NRS，BI，C30の改善が認められた．再発例を除く症例では，経過中に固定術を要する不安定性や疼痛の増悪は認めなかった．【考察】麻痺を認めない症例は保存的治療で良好な成績が得られた．従って，根治的治療（TES）の適応がない場合，不安定性が著明でなければ，保存的治療が第一選択と考えられた．

DOI： 10.5035/nishiseisai.66.921

CiNii Article

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難治性慢性腰痛症例に対する集学的治療：痛みリエゾン外来

鉄永倫子, 西田圭一郎, 鉄永智紀, 尾﨑敏文

日本運動器疼痛学会誌 9 ( 2 ) 170 - 175 2017年

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