研究者詳細 - 尾﨑　敏文

論文 - 尾﨑　敏文

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Massive osteolysis in the pelvis - A case report

Tomoyuki Dan'ura, Toshifumi Ozaki, Shinsuke Sugihara, Kohji Taguchi, Hajime Inoue

Acta Orthopaedica Scandinavica 69 ( 2 ) 197 - 198 1998年

Treatment of Tumors of the Spine

Toshifumi Ozaki, Henry Halm, Ulrich Liljenqvist, Winfried Winkelmann

Hiroshima Journal of Medical Sciences 46 ( 4 ) 125 - 131 1997年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Thirty-one patients with spinal tumors underwent reconstructive surgery with our spinal instrumentation system (MPDS and MADS), with or without our new vertebral tumor prosthesis. The characteristics of the spinal tumors were analysed statistically and the treatment outcome was evaluated. There were 4 benign tumors, 6 malignant tumors, and 21 metastatic tumors. The malignant tumors involved the sacrum more frequently than the benign tumors (p=0.0098). Metastatic tumors involved the thoracic spine more frequently than benign or malignant tumors (p=0.0161). The average number of affected vertebrae was 1.2 in the benign tumors, 1.8 in the malignant tumors, and 2.4 in the metastatic tumors. The metastatic tumors had a tendency to involve the anterior or middle part of the spine more frequently than the benign or malignant tumors (statistically not significant). After surgery, neurological improvement was noted in 8 patients, nochange in 19 patients, and impairment due to resection of the nerve roots in sacral tumors in 4 patients.

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Preoperative Multidisciplinary Treatment with Hyperthermia for Soft Tissue Sarcoma 査読

Eiichi Makihata, Masahiro Kuroda, Akira Kawai, Toshifumi Ozaki, Shinsuke Sugihara, Hajime Inoue, Ikuo Joja, Junichi Asaumi, Shoji Kawasaki, Yoshio Hiraki

Acta Medica Okayama 51 ( 2 ) 93 - 99 1997年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times)
each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P &lt
0.05) in patients whose Time ≥ 42°C was of long duration. Postoperative complications were observed in six patients
among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.

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A Clinical Analysis of Malignant Schwannoma 査読

Toshiyuki Kunisada, Akira Kawai, Toshifumi Ozaki, Shinsuke Sugihara, Kohji Taguchi, Hajime Inoue

Acta Medica Okayama 51 ( 2 ) 87 - 92 1997年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

In this study, we reviewed the clinical features of 11 patients with malignant schwannoma who were treated in our institute. Five patients had coexistent von Recklinghausen's disease and one of them showed multifocal occurrence. Patients with the centrally located tumors had a poorer prognosis than those with the others. The overall 3-year survival rate was 36%
40% in patients with von Recklinghausen's disease and 33% in the others. At the time of the last follow-up, 9 patients had died of the tumor, one continued to be tumor free, and one was alive with tumor. Postoperative local recurrence developed in 5 patients (45%)
4 out of 6 patients (67%) who underwent a marginal excision and one out of 3 (33%) who underwent primary amputation. There was no local recurrence in patients after a wide excision with at least 3cm of normal tissue removed surrounding the tumor in all directions. Nine patients (82%) developed pulmonary metastasis. The effect of adjuvant chemotherapy was not clear in this study. The high risk of pulmonary metastasis in this disease indicates the necessity of more effective adjuvant chemotherapy.

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Magnetic resonance chemical shift imaging in bone and soft tissue tumours

T. Ozaki, S. Sugihara, M. Hamada, M. Akiyama, H. Inoue

International Orthopaedics 21 ( 1 ) 9 - 13 1997年

掲載種別：研究論文（学術雑誌）

A study was carried out in 14 patients to assess the location and differential diagnosis of bone and soft tissue tumours with a 0.5 Tesla scanner using water and fat images obtained by the three-point Dixon technique. We compared the magnetic resonance imaging findings obtained with this technique with conventional MRI, T1-T2-weighted images, and gadalinium-diethylenetriamine penta-acetic acid enhanced T1-weighted images. Localisation was better with the three-point Dixon technique than with conventional magnetic resonance imaging. Differentiation between the fat and water component around the tumour was possible. The gadalinium-diethylenetriamine penta-acetic acid enhanced water images were very sensitive to enhancement of the tissue. The three-point Dixon technique is useful when the tumour area is difficult to detect by conventional magnetic resonance imaging and information about its components is needed; these images can be made at the low magnet field.

DOI： 10.1007/s002640050109

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Cementation of primary aneurysmal bone cysts

Toshifumi Ozaki, Axel Hillmann, Norbert Lindner, Winfried Winkelmann

Clinical Orthopaedics and Related Research 337 240 - 248 1997年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media, LLC

The effects of polymethylmethacrylate (bone cement) on the local control of primary aneurysmal bone cysts excluding spinal lesions were analyzed. After intensive curettage of the lesions, 30 patients underwent a bone graft, and 35 patients had the defect packed with bone cement. After cementation (median time lapse, 4.5 months), 30 of 35 patients underwent a cancellous bone graft after removal of the packed bone cement. The followup period ranged between 24 and 161 months (median, 59.5 months). The local recurrence rate after curettage and cementation was 17% and after curettage and bone graft was 37%. The difference of the cumulative 10-year relapse free survival between patients of both groups was significant. The median time between surgery and local recurrence was 17 months (range, 2-90 months).

DOI： 10.1097/00003086-199704000-00026

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Chondrosarcoma of the pelvis

Toshifumi Ozaki, Axel Hillmann, Norbert Lindner, Sebastian Blasius, Winfried Winkelmann

Clinical Orthopaedics and Related Research 337 226 - 239 1997年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media, LLC

Thirty-one patients with chondrosarcoma of the pelvis were reviewed. The median followup period of the surviving patients was 66 months. Thirteen of 23 tumors after surgery with inadequate margins (57%) and 1 of 8 after surgery with adequate margins (13%) relapsed locally. Four of 10 patients had local recurrence, 2 of 2 patients had metastasis, and 4 of 4 patients who had local recurrence and metastasis died. A cumulative 10-year overall survival of patients with pelvic chondrosarcoma was 54%. Patients who had primary or high grade chondrosarcoma had a poor prognosis. Multivariate analysis (Cox proportional hazard model) showed that tumor type was the most important prognostic factor. Eight patients underwent hindquarter amputation, 6 patients had resection alone, and 17 patients had resection and reconstruction as follows: 3 interpubic arthrodeses, 2 iliosacral arthrodeses, 3 ischiofemoral arthrodeses, 8 hip prostheses 13 prostheses alone and 5 prostheses with allograft), and 1 hip transposition. Failure of reconstruction was attributed to infection in 5 patients, local recurrence of tumor in 5, and local recurrence and fracture of implant in 1 patient.

DOI： 10.1097/00003086-199704000-00025

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Dedifferentiated chondrosarcoma in Albright syndrome. A case report and review of the literature

Toshifumi Ozaki, Norbert Lindner, Sebastian Blasius

Journal of Bone and Joint Surgery - Series A 79 ( 10 ) 1545 - 1551 1997年

Salvage chemotherapy for recurrent Ewing's sarcomas

T. Ozaki, S. Sugihara, M. Hamada, Y. Nakagawa, H. Inoue

Neoplasma 42 ( 1 ) 39 - 42 1995年

掲載種別：研究論文（学術雑誌）

Metastatic disease tends to recur after remission of Ewing's sarcoma. The effectiveness of ifosfamide in patients with recurrent Ewing's sarcoma was reported in recent years. We administered IFOS combined with etoposide, pirarubicin, and cyclophosphamide to 4 Ewing's sarcoma patients with metastatic disease, and succeeded in inducing second remissions in all cases.

石濱琢央, 辻秀憲, 毛利隆広, 神原淳, 尾崎敏文

中国・四国整形外科学会雑誌 6 ( 2 ) 317 - 322 1994年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

Extraskeletal Ewing's sarcoma is a rare soft tissue tumor composed of small round cells. We report a case of extraskeletal Ewing's sarcoma in the left thigh. Chemotherapy, radiation therapy and hyperthermic therapy were performed preoperatively. On MRI taken after preoperative treatment, the tumor was decreased in size and was not enhanced by Gd-DTPA. These findings suggest that the tumor was necrosed by the preoperative treatments. MRI was very useful for showing the tumor area and for assessing the preoperative therapeutic effects.

DOI： 10.11360/jcsoa1989.6.317

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骨軟部腫瘍の化学療法における副作用対策

杉原進介, 尾崎敏文, 浜田全紀

中部日本整形外科災害外科学会雑誌 36 ( 6 ) 1631 - 1632 1993年11月

骨軟部腫瘍における化学シフトを利用したMRI Threepoint Dixon technique

尾崎敏文, 浜田全紀, 杉原進介

中部日本整形外科災害外科学会雑誌 36 ( 6 ) 1597 - 1598 1993年11月

Second malignant neoplasms after treatment for osteosarcoma: a report of three cases.

Ozaki Toshifumi, Sugihara Shinsuke, Inoue Hajime

Acta Medica Okayama 47 ( 2 ) 129 - 133 1993年4月

記述言語：英語出版者・発行元：Okayama University Medical School

We report second malignant neoplasms which developed between 7 and 19 years after treatment in 3 pediatric patients with osteosarcoma. Two patients had been treated with only surgery, and another patient had been treated with a combination of surgery with chemotherapy and radiation therapy for primary lesions. Pediatric patients with osteosarcoma, in particular, require careful long-term follow-up to monitor not only metastases but also development of second malignant neoplasms.

DOI： 10.18926/AMO/31575

中後貴江, 尾崎敏文, 杉原進介, 大塚和俊, 井上一

中国・四国整形外科学会雑誌 5 ( 2 ) 479 - 482 1993年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

Five cases of Paget's disease were anaylyzed clinically and histopathologically in this study. Plain X-rays revealed signs of a combined phase in all cases. Bone scintigraphy, performed in 3 cases, disclosed abnormal accumulation in the affected bone. A histopathological examinations, which was performed in all cases revealed a specific mosaic pattern for diagnosis of Paget's disease. However, a typical combined phase was observed in only one case. Two cases were treated by calcitonin and one case by calcitonin and EHDP. Although ALP rose again during long-term drug therapy or after discontinuation of drugs, pain could be controlled well by these drugs. Therefore, these drugs seem to provide an effective means for controlling pain associated with Paget's disease.

DOI： 10.11360/jcsoa1989.5.479

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Ewing's sarcoma: Evaluation of chemotherapy in 17 cases

T. Ozaki, H. Inoue, S. Sugihara, M. Hamada, Y. Nakagawa, K. Taguchi

Hiroshima Journal of Medical Sciences 42 ( 2 ) 89 - 96 1993年

Gadolinium-DTPA enhanced magnetic resonance imaging of bone and soft tissue sarcomas in comparison with pathological findings.

Ozaki Toshifumi, Inoue Hajime, Taguchi Kohji, Sugihara Shinsuke

Acta Medica Okayama 46 ( 6 ) 471 - 477 1992年12月

記述言語：英語出版者・発行元：Okayama University Medical School

We compared gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhanced T1-weighted images (T1-Gd) with the histopathological findings in 13 patients with bone or soft tissue sarcomas. Signal intensity of the viable tumor tissue was increased in T1-Gd in 92% of the patients. The necrotic or cystic areas in the tumor were not enhanced, rendering them distinctly. The degree of enhancement of the edematous area around the tumor was similar to or more marked than that of the tumor in 54% of the patients. Area showing inflammatory cells infiltration and edematous areas in the tumor tissue were also enhanced. Thus, the effect of preoperative chemotherapy in tumor tissues other than necrotic and cystic areas tended to be underestimated in T1-Gd. Its effect should be comprehensively evaluated based on not only T1-Gd but also T2-weighted images and findings of other imaging techniques.

DOI： 10.18926/AMO/32641

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骨軟部悪性腫瘍のsecond line chemotherapy

尾崎敏文, 杉原進介, 住居広士

中部日本整形外科災害外科学会雑誌 35 ( 5 ) 1479 - 1480 1992年9月

記述言語：日本語出版者・発行元：(一社)中部日本整形外科災害外科学会

骨軟部腫瘍の遠隔転移症例に対して,IFOSを中心とした化学療法を行った。1)多剤耐性が生じた症例(特にEwing肉腫)で,明らかな抗腫瘍効果が認められた。2)骨肉腫での有効率はEwing肉腫より低かった。3)IFOSをVP-16と使用すると,凡血球減少の如き厳重な副作用が問題となった。IFOS(+VP-16)は,メスナが市販されしだいEwing肉腫の第一選択で使用してよい薬剤である

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多発性悪性線維性組織球腫の1例

尾崎敏文, 杉原進介, 住居広士

骨転移: 病態・診断・治療 8 ( 1 ) 81 - 84 1992年9月

Clinical study of malignant tumors originating in the pelvic region.

Ozaki Toshifumi, Inoue Hajime, Sugihara Shinsuke

Acta Medica Okayama 46 ( 4 ) 265 - 271 1992年8月

記述言語：英語出版者・発行元：Okayama University Medical School

We evaluated the surgical problems encountered during treatment of 14 patients with malignant tumors originating in the pelvic region at our department. The tumor involved the iliac bone in 6 patients, the ischial bone in 2, the pubic bone in 2, and the gluteal region in 4. Invasion to the sacrum was observed in 7 patients. Twelve patients underwent surgical procedures consisting of intralesional resection in 6, marginal resection in 3, and wide margin resection in 3. Six of the 7 patients with sacral invasion developed local recurrence. Two patients with chondrosarcoma and one with parosteal osteosarcoma survived for 4 or more years, but the mean survival period in those with high grade malignant tumors was 11 months. These findings indicate the difficulties encountered in the treatment of malignant pelvic tumors.

DOI： 10.18926/AMO/32621

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骨肉腫肺転移の治療とその問題点

尾崎敏文, 杉原進介, 住居広士

中部日本整形外科災害外科学会雑誌 35 ( 3 ) 753 - 754 1992年5月

記述言語：日本語出版者・発行元：(一社)中部日本整形外科災害外科学会

37症例中肺癌転移は化学療法施行群で28例中19例(68%),未施行群では9例中7例(77%)であった.肺癌転移例は化学療法を施行して開胸術にて病巣切除可能なら,Kaplan-Miere法にて50%程度の生存率が得られた.ADM, MTX, CDDPのうち使用していない残りの化学療法が行われてきたが,近年IFOSの投与が行われている.組織学的には効果の認められるものがX線で効果が現われることが多い.また組織学的に著効を奏した例でも腫瘍細胞は残存するので開胸術は不可欠である.治療を中止した生命予後は非常に不良である

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