研究者詳細 - 尾﨑　敏文

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MTXの有効性と安全性画像的にみたMTXの有効性と限界への対応

西田圭一郎, 橋詰謙三, 中原龍一, 斎藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 168 - 168 2012年3月

関節リウマチ手術の長期成績関節リウマチ手術の長期成績人工肘関節置換術 linked vs.unlinked

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 214 - 214 2012年3月

リウマチ性疾患の画像(1) 関節リウマチにおける大関節破壊の新たな画像評価基準(ARASHI status score)に関する検討

那須義久, 西田圭一郎, 高杉幸司, 山下美鈴, 棗田将光, 江澤香代, 江澤和彦, 金澤智子, 斉藤太一, 小澤正嗣, 中原龍一, 橋詰謙三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 292 - 292 2012年3月

リウマチ性疾患の画像(1) T2マッピング解析法複数シークエンス画像を用いた軟骨半自動抽出法

中原龍一, 西田圭一郎, 橋詰謙三, 小澤正嗣, 斉藤太一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 292 - 292 2012年3月

関節リウマチの手術下肢(1) 関節リウマチの足関節、中後足部変形に対する治療成績

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 393 - 393 2012年3月

関節リウマチの手術下肢(1) 関節リウマチ(RA)患者の外反母趾に対する切除関節形成術の治療成績

金澤智子, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 小澤正嗣, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 393 - 393 2012年3月

関節リウマチの手関節に対する部分固定術の術後成績

斎藤太一, 西田圭一郎, 橋詰謙三, 島村安則, 尾崎敏文

日本手外科学会雑誌 29 ( 1 ) S134 - S134 2012年3月

前方単独アプローチ(modified Stoppa+lateral window)による寛骨臼複合骨折の治療成績

野田知之, 島村安則, 中原龍一, 尾崎敏文, 木浪陽, 上田泰久, 戸田一潔, 高城康師, 小川健一, 依光正則

骨折 34 ( 1 ) 66 - 69 2012年2月

記述言語：日本語出版者・発行元：(一社)日本骨折治療学会

寛骨臼複合骨折に対してmodified Stoppa approachにlateral windowを併用した前方単独進入(以下、MS+LW)による整復固定術の治療成績につき検討した。対象は24例で、骨折型は両柱:19例、前柱+半横:3例、T型:2型であった。全例MS+LWにて進入したが3例にmiddle windowの追加が必要であった。Quadrilateral surfaceのbuttress plate固定を20骨折、lag screw固定を4骨折に施行した。平均術中出血量は1593mlで、平均手術時間は4時間24分であった。術後X線評価は平均step offは0.9mm、平均gapは1.4mmで、anatomical:14例、imperfect:9例、poor:1例であった。6ヵ月以上経過観察しえた症例のJOA hip scoreは平均88点であった。術中合併症は外腸骨静脈損傷1例、閉鎖動脈損傷1例であった。術後合併症は閉鎖神経不全麻痺:4例、外腸骨動脈血栓形成1例、坐骨神経麻痺:1例、関節内スクリュー誤挿入1例、術後再転移1例などであった。本アプローチの利用は前方単独進入では従来整復困難であった転位の大きい後柱成分の整復固定が直視下に施行可能で有用である。(著者抄録)

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下肢長管骨関節近傍骨折に対する一時的創外固定の有用性

野田知之, 島村安則, 西山武, 中原龍一, 雑賀建多, 斉藤太一, 金澤智子, 長谷井嬢, 尾崎敏文

日本創外固定・骨延長学会雑誌 23 207 - 207 2012年1月

当院における人工肘関節再置換術の術後成績

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本肘関節学会雑誌 19 ( 1 ) S24 - S24 2012年1月

A Portable Arthroscopic Diagnostic Probe to Measure the Viscoelasticity of Articular Cartilage. 査読

Naohiko Sugita, Toru Kizaki, Daisuke Kanno, Nobuhiro Abe, Yusuke Yokoyama, Toshifumi Ozaki, Mamoru Mitsuishi

JRM 24 ( 5 ) 782 - 790 2012年

Transplantation of Osteogenically Differentiated Mouse iPS Cells for Bone Repair 査読

Takahiro Hayashi, Haruo Misawa, Hiroyuki Nakahara, Hirofumi Noguchi, Aki Yoshida, Naoya Kobayashi, Masato Tanaka, Toshifumi Ozaki

CELL TRANSPLANTATION 21 ( 2-3 ) 591 - 600 2012年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：COGNIZANT COMMUNICATION CORP

Induced pluripotent stem (iPS) cells are a type of undifferentiated cell that can be obtained from differentiated cells and have the pluripotent potential to differentiate into the musculoskeletal system, the myocardium, vascular endothelial cells, neurons, and hepatocytes. We therefore cultured mouse iPS cells in a DMEM containing 15% FBS, 10(-7) M dexamethasone, 10 mM beta-glycerophosphate, and 50 mu g/ml ascorbic acid for 3 weeks, in order to induce bone differentiation, and studied the expression of the bone differentiation markers Runx2 and osteocalcin using RT-PCR in a time-dependent manner. Osteocalcin, a bone differentiation marker in bone formation, exhibited the highest expression in the third week. In addition, the deposition of calcium nodules was observed using Alizarin red S staining. iPS cells cultured for bone differentiation were transplanted into severe combined immunodeficiency (SCID) mice, and the osteogenic potential exhibited after 4 weeks was studied. When bone differentiation-induced iPS cells were transplanted into SCID mice, bone formation was confirmed in soft X-ray images and tissue specimens. However, teratoma formation was confirmed in 20% of the transplanted models. When mouse iPS cells were treated with irradiation of 2 Gray (Gy) prior to transplantation, teratoma formation was inhibited. When mouse iPS cells treated in a likewise manner were xenotransplanted into rats, bone formation was confirmed but teratoma formation was not observed. It is believed that irradiation before transplantation is an effective way to inhibit teratoma formation.

DOI： 10.3727/096368911X605529

Web of Science

PubMed

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右下腿軟部に発生した組織球性悪性腫瘍の一例

森本裕樹, 井谷智, 尾﨑敏文, 国定俊之

中国・四国整形外科学会雑誌 24 ( 1 ) 5 - 9 2012年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

Histiocytic sarcoma is a rare hematopoietic malignancy with a poor prognosis. We report a 31-year-old woman who developed histiocytic sarcoma in the lower extremity. An open biopsy was required because a definitive diagnosis could not be made on the basis of a core-needle biopsy specimen. The diagnosis of histiocytic sarcoma was established using immunohistochemistry. No metastatic lesion was detected by PET-CT, and wide resection based on the procedure for a malignant soft tissue tumor was performed without neo-adjuvant chemotherapy. However, adjuvant radiotherapy was performed because there are few reports of histiocytic sarcoma being treated using surgery alone. During 35 months of follow-up, neither local recurrence nor distant metastasis has been observed. Our experience suggests that if a solitary lesion of histiocytic sarcoma can be resected with a sufficient margin, chemotherapy may be unnecessary.

DOI： 10.11360/jcsoa.24.5

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関節唇の骨化を認めたFAIの1例

遠藤裕介, 原田遼三, 藤原一夫, 三宅由晃, 尾﨑敏文

中部日本整形外科災害外科学会雑誌 55 ( 2 ) 415 - 416 2012年

乾癬性関節炎による股関節変形に対しTHAを行った1例

山川泰明, 藤原一夫, 岡田芳樹, 遠藤裕介, 三宅由晃, 尾崎敏文

中部日本整形外科災害外科学会雑誌 55 ( 6 ) 1373 - 1374 2012年

四肢長管骨病的骨折に対する治療成績

中田英二, 杉原進介, 尾﨑敏文

中国・四国整形外科学会雑誌 24 ( 2 ) 259 - 263 2012年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

We evaluated the clinical results of treatment for bone metastases in the extremities associated with pathological fracture. Thirty-four patients (11 men and 23 women, mean age 62 years) were treated at our institution between August 2006 and July 2011. The site of the primary tumor was the kidney in 4 patients, lung in 5 patients, breast in 14 patients, and other sites in 11 patients. Pathological fractures were found in the humerus in 5 patients, femur in 23 patients, and tibia in 2 patients. Surgical treatment was performed in 28 cases. Pathological fracture of the femur was treated by resection and prosthetic replacement in 12 cases. The remaining fractures of the femur were stabilized using locking nails (n=6) or plates (n=5). Humeral lesions were stabilized using locking nails (n=3) or plates (n=2). Pathological fractures of the tibia were stabilized using plates (n=2). Postoperative performance status (PS) of the patients with pathological fractures recovered to that before the trauma in almost all patients. Postoperative complications occurred in 6 cases, including temporary palsy of the radial nerve in 2 patients, deep infection in 1 patient, plate breakage in 1 patient, and periprosthetic femoral fractures in 2 patients. The average survival after fracture was 10.5 months for patients who underwent surgery and 3.5 months for patients who were treated conservatively. These figures suggest that patient selection for treatment should be based on prognosis.

DOI： 10.11360/jcsoa.24.259

CiNii Article

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その他リンク： http://search.jamas.or.jp/link/ui/2013107549

外傷による足部骨髄炎の 5 例

岡田芳樹, 野田知之, 西山武, 中原龍一, 島村安則, 尾﨑敏文

中国・四国整形外科学会雑誌 24 ( 2 ) 209 - 214 2012年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

Osteomyelitis after trauma or surgery can be problematic, especially pedal osteomyelitis including calcaneal osteomyelitis. Here we report the results and problems associated with surgery for pedal osteomyelitis in five patients (four men and one woman). The mean age of the patients was 37 years (range 12-51 years). Four developed infection after surgery and one after contusion. Treatment involved thorough debridement of the infected area and filling of the dead space with artificial bone or cement beads incorporating a DDS (Drug Delivery System). Until the infection had subsided, we repeated this operation every 3 to 4 weeks. Finally, we performed a subtalar arthrodesis in one patient, a desis of the cuneiform bone in one, and auto-bone graft in three. The bacteria detected were MSSA in two patients, MRSA in three patients (including one case of MRSA combined with fungus). All of the infections subsided within a mean period of 9.6 months (range 5-21 months). The mean operation time was 3.2 hours (range 1-5 hours). We used mainly a DDS that released antibiotics from cement or artificial bone. There was no complication associated with this treatment. Since the calcaneus has poor vascularization and a large proportion of cancellous bone, pedal osteomyelitis, especially in the calcaneus, is challenging to treat. Filling the dead space using a DDS is effective for control of infection.

DOI： 10.11360/jcsoa.24.209

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その他リンク： http://search.jamas.or.jp/link/ui/2013107539

腰椎疾患に対するプレガバリン除痛効果の検討

鉄永倫子, 田中雅人, 杉本佳久, 三澤治夫, 瀧川朋亨, 塩崎泰之, 尾﨑修平, 馬﨑哲朗, 山根健太郎, 尾﨑敏文

中国・四国整形外科学会雑誌 24 ( 2 ) 325 - 329 2012年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

The anti-seizure drug, pregabalin, is used for treatment of neuropathic pain and degenerative lumbar disease. The objective of this study was to evaluate the effect of pregabalin (150-300 mg/day) in patients with chronic lower back/leg pain. We assessed 47 patients (17 men and 30 women) with an average age of 65 years (range 20 to 81 years), and an average disease duration of 87 months (range 3 to 480 months). All patients were assessed using a visual analogue scale (VAS, 0-100 mm), the Self-Rating Depression Scale (SDS, 20-80 points), and the Oswestry Disability Index (ODI, 0-100%). After 8 weeks, pregabalin improved lower back pain, leg pain, SDS and ODI significantly (P<0.01). Pain was improved significantly in the depression group as well as the normal group (P<0.01). Accepted sleepiness (51%), dizziness (19%), weight gain (16%) and rash (5%) were detected after medication. The use of the hypnotic agent was decreased in half of the cases after medication. Pregabalin is safe and effective for decreasing lower back pain and leg pain in patients with depression.

DOI： 10.11360/jcsoa.24.325

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その他リンク： http://search.jamas.or.jp/link/ui/2013107559

前額断剪断骨折線を示す大腿骨頚基部骨折の治療経験

山川泰明, 野田知之, 尾﨑敏文, 木浪陽, 遠藤裕介

中国・四国整形外科学会雑誌 24 ( 2 ) 295 - 299 2012年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

We describe our experience with atypical cases of basicervical fracture of the femur. The fracture line lay between the anterior aspect of the subcapital portion and the posterior aspect of the neck base, running through the neck with a shearing fracture line as viewed in the coronal plane. We treated ten cases : seven by hemiarthroplasty and three by osteosynthesis. Bone union was obtained within six months, and there was no implant failure or complication. For diagnosis of this fracture, careful radiological assessment is important, and for effective treatment the special characteristics of this fracture should be considered. Cases of this type present difficulty with reduction and acquisition of stable fixation because of the cortical defect of the calcar or shortness of the anterior portion of the proximal fragment.

DOI： 10.11360/jcsoa.24.295

CiNii Article

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その他リンク： http://search.jamas.or.jp/link/ui/2013107554

高悪性度腫瘍の脊椎転移に関する治療成績

馬﨑哲朗, 田中雅人, 杉本佳久, 瀧川朋亨, 鉄永倫子, 塩崎泰之, 尾﨑修平, 尾﨑敏文, 国定俊之, 三澤治夫, 片岡昌樹

中国・四国整形外科学会雑誌 24 ( 2 ) 273 - 277 2012年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

We report the outcome of patients with metastatic spine tumors showing high-grade malignancy using the Tokuhashi scoring system. A retrospectively compared 21 patients with such tumors (group H) and 29 patients with spinal metastases showing low-grade malignancy (group L). There were 18 men and 3 women in group H, and 16 men and 13 women in group L, and the average patient ages were 55 years and 65 years, respectively. All of the patients were scored with the Tokuhashi scoring system and evaluated for neurological symptoms with the ASIA Impairment Scale (AIS). Results : The rates of improvement in the AIS score and gait ability were almost the same in both groups. Among patients who we were able to follow postoperatively for 6 months or more, 7 in group H and 4 in group L died within 6 months. The mean survival period was 12 months in group H and 17 months in group L. Conclusions : The outcome after treatment in group H was almost the same as that in group L. This may have been due to progress in the treatment of malignancy. Further studies to determine the indications for surgery in such patients are warranted.

DOI： 10.11360/jcsoa.24.273

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その他リンク： http://search.jamas.or.jp/link/ui/2013107551

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