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論文 - 尾﨑　敏文

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大腿骨骨幹部開放骨折の治療成績

市川千夏, 山川泰明, 根津智史, 斉藤太一, 野田知之, 尾崎敏文

中国・四国整形外科学会雑誌 30 ( 3 ) 346 - 346 2018年10月

An evaluation of anesthetic fade in motor evoked potential monitoring in spinal deformity surgeries. 査読国際誌

Ugawa R, Takigawa T, Shimomiya H, Ohnishi T, Kurokawa Y, Oda Y, Shiozaki Y, Misawa H, Tanaka M, Ozaki T

Journal of orthopaedic surgery and research 13 ( 1 ) 227 - 227 2018年9月

Carbon ion radiotherapy for unresectable localized axial soft tissue sarcoma 査読

Reiko Imai, Tadashi Kamada, Nobuhito Araki, Satoshi Abe, Yukihide Iwamoto, Toshifumi Ozaki, Hirokazu Chuman, Hiroaki Hiraga, Toru Hiruma, Noriaki Kameda, Chihiro Kanehira, Mitsunori Kaya, Rikuo Machinami, Akihiko Matsumine, Seiichi Matsumoto, Hideo Morioka, Yoshihiro Nishida, Kazuhisa Takahashi, Masazumi Tsuneyoshi, Takehiko Yamaguchi, Tsukasa Yonemoto

Cancer Medicine 7 4308 - 4314 2018年9月

© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. Carbon ion radiotherapy is known for its high-precision dose distribution and high biological effectiveness. We evaluated the results of carbon ion radiotherapy in 128 patients with unresectable localized axial soft tissue sarcoma at a single institution. The patients’ median age was 54 years, and the median follow-up period was 49.4 (range 6.4-146.4) months. The median tumor volume was 356 cm3. The 5-year local control, overall survival, and disease-free survival rates were 65%, 46%, and 39%, respectively. In the univariate analysis, tumor volume, local control, and incidences of metastases were significantly related to overall survival. In the multivariate analysis, tumor volume and local control were significantly related to overall survival. We did not find any factors related to local control. Five patients required surgical intervention because of adverse events in the bones. Carbon ion radiotherapy may be a treatment option for unresectable axial soft tissue sarcoma.

DOI： 10.1002/cam4.1679

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当科における股関節鏡の合併症

三喜知明, 遠藤裕介, 山田和希, 鉄永智紀, 河村涌志, 尾崎敏文

中部日本整形外科災害外科学会雑誌 61 ( 秋季学会 ) 112 - 112 2018年9月

関節リウマチによる高度手関節破壊に対して人工手関節置換術を施行した2例

那須義久, 中原龍一, 西田圭一郎, 尾崎敏文

中部日本整形外科災害外科学会雑誌 61 ( 秋季学会 ) 249 - 249 2018年9月

治療に難渋した壊死性筋膜炎の1例

松橋美波, 齋藤太一, 山川泰明, 野田知之, 尾崎敏文

中部日本整形外科災害外科学会雑誌 61 ( 秋季学会 ) 135 - 135 2018年9月

Prospective comparison of various radiological response criteria and pathological response to preoperative chemotherapy and survival in operable high-grade soft tissue sarcomas in the Japan Clinical Oncology Group study JCOG0304. 査読国際誌

Kazuhiro Tanaka, Gakuto Ogawa, Junki Mizusawa, Norifumi Naka, Akira Kawai, Mitsuru Takahashi, Toru Hiruma, Yoshihiro Matsumoto, Hiroyuki Tsuchiya, Robert Nakayama, Hiroshi Hatano, Makoto Emori, Masami Hosaka, Yukihiro Yoshida, Junya Toguchida, Satoshi Abe, Kunihiro Asanuma, Ryohei Yokoyama, Hiroaki Hiraga, Tsukasa Yonemoto, Takeshi Morii, Seiichi Matsumoto, Akihito Nagano, Hideki Yoshikawa, Haruhiko Fukuda, Toshifumi Ozaki, Yukihide Iwamoto

World journal of surgical oncology 16 ( 1 ) 162 - 162 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Soft tissue sarcomas (STS) are rare malignant tumors. The efficacy of preoperative chemotherapy for STS is evaluated using various tumor size-based radiological response criteria. However, it is still unclear which set of criteria would show the best association with pathological response and survival of the patients with STS. METHODS: We compared radiological responses to preoperative chemotherapy for operable STS by the Response Evaluation Criteria in Solid Tumors (RECIST), modified RECIST, World Health Organization criteria, Japanese Orthopaedic Association criteria, and modified Choi criteria and analyzed the association with pathological response and survival using the data from the Japan Clinical Oncology Group (JCOG) study JCOG0304, a phase II clinical trial evaluating the efficacy of perioperative chemotherapy for STS in the extremities. RESULTS: Seventy eligible patients in JCOG0304 were analyzed. The results demonstrated that none of the size-based radiological response criteria showed significant association with pathological response to preoperative chemotherapy for STS. The difference between overall survival of the patients assessed as partial response and stable disease/progressive disease by RECIST was not significant (hazard ratio 1.37, p = 0.63), and calculated C-index was 0.50. All other response criteria also could not exhibit significant association between radiological responses and survival. CONCLUSION: In the present study, none of the radiological response criteria analyzed demonstrated association of response to preoperative chemotherapy with pathological response or survival of the patients with operable STS. Further prospective investigation is required to develop criteria to evaluate not only tumor shrinkage but biological effects of preoperative chemotherapy for the patients with localized STS. TRIAL REGISTRATION: UMIN Clinical Trials Registry C000000096. Registered 30 August, 2005 (retrospectively registered).

DOI： 10.1186/s12957-018-1462-y

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Mid-term results of alumina ceramic unlinked total elbow arthroplasty with cement fixation for patients with rheumatoid arthritis

K. Nishida, K. Hashizume, Y. Nasu, M. Ozawa, K. Fujiwara, H. Inoue, T. Ozaki

Bone and Joint Journal 100B ( 8 ) 1066 - 1073 2018年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：British Editorial Society of Bone and Joint Surgery

Aims The aim of this study was to report the mid-term clinical outcome of cemented unlinked J-alumina ceramic elbow (JACE) arthroplasties when used in patients with rheumatoid arthritis (RA). Patients and Methods We retrospectively reviewed 87 elbows, in 75 patients with RA, which was replaced using a cemented JACE total elbow arthroplasty (TEA) between August 2003 and December 2012, with a follow-up of 96%. There were 72 women and three men, with a mean age of 62 years (35 to 79). The mean follow-up was nine years (2 to 14). The clinical condition of each elbow before and after surgery was assessed using the Mayo Elbow Performance Index (MEPI, 0 to 100 points). Radiographic loosening was defined as a progressive radiolucent line of &gt
1 mm that was completely circumferential around the prosthesis. Results The mean MEPI scores significantly improved from 40 (10 to 75) points preoperatively to 95 (30 to 100) points at final follow-up (p &lt
0.0001). Complications were noted in ten elbows (ten patients
11%). Two had an intraoperative humeral fracture which was treated by fixation and united. One had a postoperative fracture of the olecranon which united with conservative treatment and one had a radial neuropathy which resolved. Further surgery was required for one with a dislocation, three with an ulnar neuropathy and one with a postoperative humeral fracture. Revision with removal of the components was performed in one elbow due to deep infection. There was no radiographic evidence of loosening around the components.With any revision surgery or revision with implant removal as the endpoint, the rates of survival up to 14 years were 93% (95% confidence interval (CI), 83.9 to 96.6) and 99% (95% CI 91.9 to 99.8), respectively, as determined by Kaplan-Meier analysis. Conclusion With the appropriate indications, the mid-term clinical performance of the cemented JACE TEA is reliable and comparable to other established TEAs in the management of the elbow in patients with RA.

DOI： 10.1302/0301-620X.100B8.BJJ-2017-1451.R1

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Venous Thromboembolism in Patients with Acute Thoracolumbar Spinal Cord Injury. 査読

Morita T, Sugimoto Y, Takigawa T, Misawa H, Ito Y, Ozaki T

Acta medica Okayama 72 ( 4 ) 375 - 378 2018年8月

Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. 査読国際誌

Urakawa H, Yonemoto T, Matsumoto S, Takagi T, Asanuma K, Watanuki M, Takemoto A, Naka N, Matsumoto Y, Kawai A, Kunisada T, Kubo T, Emori M, Hiraga H, Hatano H, Tsukushi S, Nishida Y, Akisue T, Morii T, Takahashi M, Nagano A, Yoshikawa H, Sato K, Kawano M, Hiraoka K, Tanaka K, Iwamoto Y, Ozaki T

World journal of surgical oncology 16 ( 1 ) 160 - 160 2018年8月

A Multidisciplinary Approach to the Management of Chronic Pain through a Self-managed Behavioral Exercise Program : A Pilot Study in Japan. 査読

Nishie H, Tetsunaga T, Kanzaki H, Oda K, Inoue S, Ryuo Y, Ota H, Miyawaki T, Arakawa K, Tetsunaga T, Kitamura Y, Sendo T, Morimatsu H, Ozaki T, Nishida K

Acta medica Okayama 72 ( 4 ) 343 - 350 2018年8月

股関節鏡手術に際し電気凝固メスの破損を生じた2例

遠藤裕介, 山田和希, 三喜知明, 三宅孝昌, 尾崎敏文

Hip Joint 44 ( 2 ) 725 - 729 2018年8月

記述言語：日本語出版者・発行元：日本股関節学会

症例1は初診時46歳女性で、特に誘因なく左股関節痛が出現し、49歳時に手術加療を希望された。X線上CE角0°と形成不全股であり、左寛骨臼回転骨切り術(RAO)前に股関節鏡を施行し関節唇断裂に対して電気凝固メス(VAPR)でシュリンケージを施行した。その後、スロットカニューラからVAPRを出す際に先端を回転させ破損した。関節内には破損片は認められず、関節内洗浄後にイメージで確認したところ外側ポータルの関節外に破損片が認められた。イメージ下にコッヘルでつかんで除去できており、器具が破損したが摘出できた旨を説明し、予定通り4週後に左RAOを施行した。症例2は初診時39歳女性で、特に誘因なく両股関節痛が出現し、40歳時に右RAOを施行、左側も41歳時に手術を希望された。骨切り術前に股関節鏡を施行し関節唇断裂に対してVAPRでシュリンケージを施行したが、ポータルの入れ替え時に助手がVAPRを入れる際に完全に先端がカニューラ先から出る前に回転させ破損した。関節内には破損片は認められたが深部へと落ち込み、器具が到達できない部位へ移動した。2週後の再入院時のX線像で破損片の関節内の移動を認め、RAO手術時に一部関節包を切開し破片を回収した。予定とおり左RAOを施行し、摘出した破損片は2.5mmのサイズで破損部に合致し術後X線像からも完全に除去できたと考えられた。

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高度の緩みを有する人工肘関節周囲骨折に対して骨接合術を施行した1例

沖田駿治, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

岡山医学会雑誌 130 ( 2 ) 99 - 99 2018年8月