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Description of a surgical technique of medial meniscus root repair: a fixation technique with two simple stiches under an expected initial tension. 査読国際誌

Okazaki Y, Furumatsu T, Kodama Y, Kamatsuki Y, Masuda S, Ozaki T

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 29 ( 3 ) 705 - 709 2019年4月

A randomized phase III trial of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group Study JCOG1610. 査読

Urakawa H, Mizusawa J, Tanaka K, Eba J, Hiraga H, Kawai A, Nishida Y, Hosaka M, Iwamoto Y, Fukuda H, Ozaki T

Japanese journal of clinical oncology 49 ( 4 ) 379 - 382 2019年4月

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects. 査読国際誌

Takenori Uehara, Shingo Eikawa, Mikako Nishida, Yuki Kunisada, Aki Yoshida, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Heiichiro Udono

International immunology 31 ( 4 ) 187 - 198 2019年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

CD11b+ myeloid subpopulations, including myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), play crucial roles in the suppression of T-cell-mediated anti-tumor immunity. Regulation of these cell types is a primary goal for achieving efficient cancer immunotherapy. We found that metformin (Met) induces CD11b+-cell-mediated growth inhibition of a K7M2neo osteosarcoma independent of T cells, as growth inhibition of K7M2neo was still observed in wild-type (WT) mice depleted of T cells by antibodies and in SCID; this contrasted with the effect of Met on Meth A fibrosarcoma, which was entirely T-cell-dependent. Moreover, the inhibitory effect seen in SCID was abrogated by anti-CD11b antibody injection. PMN-MDSCs were significantly reduced in both spleens and tumors following Met treatment. In TAMs, production of IL-12 and TNF-α, but not IL-10, became apparent, and elevation of MHC class II with reduction of CD206 was observed, indicating a shift from an M2- to M1-like phenotype via Met administration. Metabolically, Met treatment decreased basal respiration and the oxygen consumption rate (OCR)/extracellular acidification rate (ECAR) ratio of CD11b+ cells in tumors, but not in the spleen. In addition, decreased reactive oxygen species (ROS) production and proton leakage in MDSCs and TAMs were consistently observed in tumors. Uptake of both 2-deoxy-2-d-glucose (2-NBDG) and BODIPY® decreased in MDSCs, but only BODIPY® incorporation was decreased in TAMs. Overall, our results suggest that Met redirects the metabolism of CD11b+ cells to lower oxidative phosphorylation (OXPHOS) while elevating glycolysis, thereby pushing the microenvironment to a state that inhibits the growth of certain tumors.

DOI： 10.1093/intimm/dxy079

PubMed

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Comparison of the postoperative analgesic efficacies of intravenous acetaminophen and fascia iliaca compartment block inhip fracture surgery: A randomised controlled trial. 査読国際誌

Yamamoto N, Sakura S, Noda T, Nishiyama A, Dan'ura T, Matsui Y, Ozaki T

Injury 50 ( 10 ) 1689 - 1693 2019年3月

Predicting acetabular growth in developmental dysplasia of the hip following open reduction after walking age. 査読

Miyake T, Tetsunaga T, Endo H, Yamada K, Sanki T, Fujiwara K, Nakata E, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 2 ) 326 - 331 2019年3月

Early response assessment of re-ossification after palliative conventional radiotherapy for vertebral bone metastases. 査読

Nakata E, Sugihara S, Kataoka M, Yamashita N, Furumatsu T, Takigawa T, Tetsunaga T, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 2 ) 332 - 336 2019年3月

Mini-open excision of osteoid osteoma using intraoperative O-arm/Stealth navigation. 査読

Fujiwara T, Kunisada T, Takeda K, Hasei J, Nakata E, Mochizuki Y, Kiyono M, Yoshida A, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 24 ( 2 ) 337 - 341 2019年3月

Time-Dependent Increase in Medial Meniscus Extrusion after Medial Meniscus Posterior Root Tear Analyzed by Using Magnetic Resonance Imaging. 査読国際誌

Okazaki Y, Furumatsu T, Shimamura Y, Saiga K, Ohashi H, Uchino T, Kamatsuki Y, Okazaki Y, Ozaki T

Knee surgery & related research 31 ( 2 ) 120 - 125 2019年3月

Pullout repair using modified Mason-Allen suture induces better meniscal healing and superior clinical outcomes: A comparison between two surgical methods. 査読国際誌

Furumatsu T, Okazaki Y, Kodama Y, Okazaki Y, Masuda S, Kamatsuki Y, Takihira S, Hiranaka T, Yamawaki T, Ozaki T

The Knee 26 ( 3 ) 653 - 659 2019年3月

Injury patterns of medial meniscus posterior root tears. 査読国際誌

Furumatsu T, Okazaki Y, Okazaki Y, Hino T, Kamatsuki Y, Masuda S, Miyazawa S, Nakata E, Hasei J, Kunisada T, Ozaki T

Orthopaedics & traumatology, surgery & research : OTSR 105 ( 1 ) 107 - 111 2019年2月

Is immunohistochemical staining for β-catenin the definitive pathological diagnostic tool for desmoid-type fibromatosis? A multi-institutional study. 査読国際誌

Koike H, Nishida Y, Kohno K, Shimoyama Y, Motoi T, Hamada S, Kawai A, Ogose A, Ozaki T, Kunisada T, Matsumoto Y, Matsunobu T, Ae K, Gokita T, Sakai T, Shimizu K, Ishiguro N

Human pathology 84 155 - 163 2019年2月

New TNM classification (AJCC eighth edition) of bone and soft tissue sarcomas: JCOG Bone and Soft Tissue Tumor Study Group. 査読国際誌

Tanaka K, Ozaki T

Japanese journal of clinical oncology 49 ( 2 ) 103 - 107 2019年2月

Meniscal repair concurrent with anterior cruciate ligament reconstruction restores posterior shift of the medial meniscus in the knee-flexed position. 査読国際誌

Okazaki Y, Furumatsu T, Miyazawa S, Kodama Y, Kamatsuki Y, Hino T, Masuda S, Ozaki T

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 27 ( 2 ) 361 - 368 2019年2月

Transtibial pullout repair of medial meniscus posterior root tear restores physiological rotation of the tibia in the knee-flexed position. 査読国際誌

Okazaki Y, Furumatsu T, Kodama Y, Hino T, Kamatsuki Y, Okazaki Y, Masuda S, Miyazawa S, Endo H, Tetsunaga T, Yamada K, Ozaki T

Orthopaedics & traumatology, surgery & research : OTSR 105 ( 1 ) 113 - 117 2019年2月

Sub-deltoid approach for removal of large lipoma around the proximal humerus: A report of three cases. 査読

Hasei J, Kunisada T, Nakata E, Ozaki T

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 26 ( 6 ) 1147 - 1151 2019年2月

Changes in acetabular component alignment due to screw fixation in patients with hip dysplasia. 査読国際誌

Tetsunaga T, Fujiwara K, Endo H, Tetsunaga T, Miyake T, Yamada K, Sanki T, Ozaki T

Hip international : the journal of clinical and experimental research on hip pathology and therapy 29 ( 5 ) 1120700019828708 - 542 2019年2月

Minimally Invasive Percutaneous Spinopelvic Fixation for Unstable Pelvic Ring Fracture Performed With the Patient in a Lateral Position. 査読国際誌

Tsuji H, Takigawa T, Misawa H, Shiozaki Y, Yamakawa Y, Noda T, Ozaki T

Clinical spine surgery 32 ( 5 ) 191 - 197 2019年2月

The morphology of the femur in elderly Japanese females: Analysis using 3D-CT. 査読

Maehara T, Kiyono M, Noda T, Sato R, Kadota H, Hori T, Koga Y, Hidaka Y, Joko R, Muraoka S, Ozaki T

Journal of orthopaedic surgery (Hong Kong) 27 ( 1 ) 2309499018816488 2019年1月

Avulsion fracture of the ischial tuberosity treated with the suture bridge technique: a case report. 査読国際誌

Tetsunaga T, Endo H, Tetsunaga T, Yamada K, Furumatsu T, Ozaki T

BMC musculoskeletal disorders 20 ( 1 ) 9 - 9 2019年1月

Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan 査読

Nishida Y, Kawai A, Toguchida J, Ogose A, Ae K, Kunisada T, Matsumoto Y, Matsunobu T, Takahashi K, Nishida K, Ozaki T

International Journal of Clinical Oncology 24 ( 11 ) 1498 - 1505 2019年

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