研究者詳細 - 尾﨑　敏文

論文 - 尾﨑　敏文

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"Gull Sign"を示す寛骨臼骨折の治療経験

藤原智洋, 野田知之, 中原龍一, 雑賀建多, 西山武, 島村安則, 尾崎敏文

骨折 32 ( Suppl. ) S87 - S87 2010年7月

Infant Hip Joint Diagnostic Support System Based on Clinical Manifestations in X-ray Images 査読

Mitsugi Honda, Seizaburo Arita, Shigeru Mitani, Yoshihiro Takeda, Toshifumi Ozaki, Keiji Inamura, Susumu Kanazawa

ACTA MEDICA OKAYAMA 64 ( 3 ) 189 - 196 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Plain X-ray radiography is frequently used for the diagnosis of developmental dislocation of the hip (DDH). The aim of this study was to construct a diagnostic support system for DDH based on clinical findings obtained from the X-ray images of 154 female infants with confirmed diagnoses made by orthopedists. The data for these subjects were divided into 2 groups. The Min-Max method of nonlinear analysis was applied to the data from Group 1 to construct the diagnostic support system based on the measurement of 4 items in X-ray images: the outward displacement rate, upward displacement rate, OE angle, and a angle. This system was then applied to the data from Group 2, and the results were compared between the 2 groups to verify the reliability of the system. We obtained good results that matched the confirmed diagnoses of orthopedists with an accuracy of 85.9%.

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当科における滑膜肉腫の治療成績

藤原智洋, 森本裕樹, 井谷智, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 84 ( 6 ) S998 - S998 2010年6月

Operative treatment for pincer type femoroacetabular impingement:a case report. 査読

Endo H, Noda T, Mitani S, Nakahara R, Tetsunaga T, Kunisada T, Ozaki T

Acta medica Okayama 64 ( 2 ) 149 - 154 2010年4月

The effect of service dogs on the improvement of health-related quality of life 査読

Mai Shintani, Masuo Senda, Tomoko Takayanagi, Yoshimi Katayama, Kazunari Furusawa, Tamami Okutani, Masaki Kataokani, Toshifumi Ozaki

Acta Medica Okayama 64 ( 2 ) 109 - 113 2010年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

To assess the effects of service dogs on health-related quality of life (HRQOL), we conducted a survey of 10 service dog owners using SF-36v2 (Medical Outcomes Study 36 Item Short-Form Health Survey Version 2.0) and compared it with a matched control group of people with physical disabilities who did not have service dogs but were eligible for one. The scores for mental health and role emotional of service dog owners were relatively high, and their mental component summary was higher than the general population norm. These results indicate that service dogs affect the mentality of their owners. The comparison with the control group indicated that service dogs alleviate the mental burden of daily activities, and subjectively improved the physical functioning of their owners. This study showed that service dogs have positive functional and mental effects on their disabled owners. © 2010 by Okayama University Medical School.

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化膿性膝関節炎後の膝蓋骨脱臼を伴った大腿骨変形に対する矯正術を行った1例

斎藤太一, 遠藤裕介, 三谷茂, 鉄永智紀, 尾崎敏文

岡山医学会雑誌 122 ( 1 ) 86 - 86 2010年4月

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 金澤智子, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 22 ( 1 ) 199 - 199 2010年4月

生物学的製剤使用下の手術治療について生物学的製剤の限界

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S228 - S228 2010年3月

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 野田知之, 西田圭一郎, 尾崎敏文

日本手の外科学会雑誌 27 ( 1 ) S138 - S138 2010年3月

生物学的製剤時代における手術の変遷画像診断と外科的治療画像からみた手術の適応とタイミングどの時期に手術が必要か

西田圭一郎, 橋詰謙三, 中原龍一, 門田康孝, 那須義久, 斎藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 54回・19回 219 - 219 2010年3月

関節リウマチに対する手術療法の進歩と今後関節リウマチに対する上肢手術の進歩と今後

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S231 - S231 2010年3月

Anterior cruciate ligament-derived cells have high chondrogenic potential 査読

Takayuki Furumatsu, Motomi Hachioji, Kenta Saiga, Naoki Takata, Yusuke Yokoyama, Toshifumi Ozaki

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 391 ( 1 ) 1142 - 1147 2010年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ACADEMIC PRESS INC ELSEVIER SCIENCE

Anterior cruciate ligament (ACL)-derived cells have a character different from medial collateral ligament (MCL)-derived cells. However, the critical difference between ACL and MCL is still unclear in their healing Potential and cellular response. The objective of this study was to investigate the mesenchymal differentiation property of each ligament-derived cell. Both ligament-derived cells differentiated into adipogenic, osteogenic, and chondrogenic lineages. In chondrogenesis, ACL-derived cells had the higher chondrogenic property than MCL-derived cells. The chondrogenic marker genes, Sox9 and alpha 1(II) collagen (Col2a1), were induced faster in ACL-derived pellets than in MCL-derived pellets. Sox9 expression preceded the increase of Col2a1 in both pellet-cultured cells. However, the expression level of Sox9 and a ligament/tendon transcription factor Scleraxis did not parallel the increase of Col2a1 expression along with chondrogenic induction. The present Study demonstrates that the balance between Sox9 and Scleraxis have an important role in the chondrogenic differentiation of ligament-derived cells. (C) 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2009.12.044

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Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription 査読

Takayuki Furumatsu, Chisa Shukunami, Michiyo Amemiya-Kudo, Hitoshi Shimano, Toshifumi Ozaki

International Journal of Biochemistry and Cell Biology 42 ( 1 ) 148 - 156 2010年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

During musculoskeletal development, Sry-type HMG box 9 (Sox9) has a crucial role in mesenchymal condensation and chondrogenesis. On the other hand, a tissue-specific basic helix-loop-helix (bHLH) transcription factor Scleraxis (Scx) regulates the differentiation of tendon and ligament progenitors. Whereas these two transcription factors cooperatively participate in the determination of cellular lineages, the precise interaction between Sox9 and Scx remains unclear. We have previously demonstrated that the Sox9-dependent transcription is synergistically activated by several Sox9-associating molecules, such as p300 and Smad3, on chromatin. In this study, we investigated the function of Scx in the Sox9-dependent transcription. The expression of α1(II) collagen (Col2a1) gene was stimulated by an appropriate transduction of Sox9 and Scx. Scx and its partner E47, which dimerizes with other bHLH proteins, cooperatively enhanced the Sox9-dependent transcription in luciferase reporter assays. Coactivator p300 synergistically increased the activity of Sox9-regulated reporter gene, which contains promoter and enhancer regions of Col2a1, in the presence of Scx and E47. Immunoprecipitation analyses revealed that Scx and E47 formed a transcriptional complex with Sox9 and p300. Scx/E47 heterodimer also associated with a conserved E-box sequence (CAGGTG) in the Col2a1 promoter on chromatin. These findings suggest that Scx and E47 might modulate the primary chondrogenesis by associating with the Sox9-related transcriptional complex, and by binding to the conserved E-box on Col2a1 promoter. © 2009 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.biocel.2009.10.003

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Bone Repair Using a Hybrid Scaffold of Self-Assembling Peptide PuraMatrix and Polyetheretherketone Cage in Rats 査読

Hiroyuki Nakahara, Haruo Misawa, Aid Yoshida, Takayuki Hayashi, Masato Tanaka, Takayuki Furumatsu, Noriaki Tanaka, Naoya Kobayashi, Toshifumi Ozaki

CELL TRANSPLANTATION 19 ( 6-7 ) 791 - 797 2010年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：COGNIZANT COMMUNICATION CORP

Self-assembling peptide scaffold (SAPS) is well known to have very good bone conduction properties. However, the intensity of SAPS is too weak to actually use it for a clinical bone regeneration. Therefore, we have produced a hybrid scaffold system that involves fabricating a cage from polyetheretherketone (PEEK) that has high intensity, filling the interior of this cage with SAPS, and then transplanted this hybrid scaffold to bone defects in rat femurs. After 28 days, soft X-ray radiographs and histological assessment revealed that good new bone formation was clearly observed in the defects transplanted the PEEK cage with SAPS, but not in the PEEK cage only. The PEEK cage maintained a form and osteoconduction ability of internal SAPS, and SAPS promoted bone formation inside the PEEK; therefore, each was in charge of intensity and bone regeneration separately. The present study suggests that hybrid scaffolds made from PEEK cages and SAPS can be useful tools for the regeneration of load-bearing bones, based on the idea that it should be possible to develop ideal bone filler materials by combining the strength of artificial bone with the bone regeneration and bone conduction properties of SAPS.

DOI： 10.3727/096368910X508906

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Interference free surgical tool-path generation in multi-axis bone milling robot 査読

Sugita N, Nakano T, Nakajima Y, Fujiwara K, Abe N, Ozaki T, Suzuki M, Mitsuishi M

2010 3rd IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2010 790 - 795 2010年

Optimal control of cutting feed rate in the robotic milling for total knee arthroplasty 査読

Inoue T, Sugita N, Mitsuishi M, Saito T, Nakajima Y, Yokoyama Y, Fujiwara K, Abe N, Ozaki T, Suzuki M, Kuramoto K, Nakashima Y, Tanimoto K

2010 3rd IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, BioRob 2010 215 - 220 2010年

仙骨骨巨細胞腫に対する動脈塞栓術 : 腫瘍の縮小を認めた1症例

佐々木剛, 森本裕樹, 尾﨑敏文, 国定俊之, 郷原英夫

中国・四国整形外科学会雑誌 22 ( 2 ) 267 - 272 2010年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

Giant cell tumor (GCT) of the sacrum is rare and difficult to treat, although several treatment modalities have been reported. Here we report a patient with sacral GCT who underwent selective intra-arterial embolization.<br>The patient, a 23-year-old woman, had been treated with curettage alone at a local hospital. However, 4 months after surgery, MRI showed recurrence of the tumor, and the patient was referred to our hospital for further treatment.<br>After discussion with her and her family, they accepted intra-arterial embolization of the tumor vessels. Embolization using a temporary embolic agent reduced the size of the tumor and the level of serum acid phosphatase (ACP). However, both the tumor size and the level of ACP increased a few months after the procedure. Therefore, embolization was performed using an embolic agent consisting of spherical particles. MRI showed a marked reduction of tumor size 1 month after the last embolization, and the level of serum ACP also fell to less than the standard value.<br>Embolization using a spherical-particulate embolic agent can be an effective treatment for sacral GCT.

DOI： 10.11360/jcsoa.22.267

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化膿性膝関節炎後の膝蓋骨脱臼を伴った大腿骨変形に対する矯正術を行った 1 例

斎藤太一, 三谷茂, 三宅由晃, 鉄永智紀, 尾﨑敏文, 遠藤裕介

中国・四国整形外科学会雑誌 22 ( 2 ) 343 - 348 2010年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

We report a case of valgus knee deformity with patellar dislocation caused by infantile septic arthritis. The patient, a boy, had a congenital heart malformation. He had developed infantile septic arthritis of the knee joint at 1 month of age, and the distal lateral epiphysis of the femur had been affected. At 6 years of age, valgus deformity appeared, and therefore we performed deformity correction and leg lengthening with an Ilizarov fixator. However, the deformity recurred and the patella became dislocated laterally 3 years after initial surgery. In a second operation, we performed osteotomy at two sites of the femur. Distally, we corrected the valgus deformity and reduced the patella by changing the rotation of the femur and overlapping the medial soft tissue. Proximally, we corrected the retroversion and performed lengthening on a gradual basis. In the left leg, the preoperative mLDFA was 110° and the postoperative mLDFA was improved to 90°. As the deformity will likely relapse because of the patientｾs age, we plan to achieve realignment again by corrective surgery.

DOI： 10.11360/jcsoa.22.343

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軸椎後方偽腫瘍 (Retro-odontoid pseudotumor) に対して後方固定を行った 1 例

塩崎泰之, 杉本佳久, 三澤治夫, 田中雅人, 尾﨑敏文

中国・四国整形外科学会雑誌 22 ( 2 ) 317 - 321 2010年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

Retro-odontoid pseudotumor is an inflammatory mass most frequently associated with rheumatoid arthritis and dialysis. Recently, some case reports of retro-odontoid pseudotumor without instability have been published. Here we describe a 63-year-old man who was admitted to our hospital with numbness of the left upper extremity and walking disturbance. MRI showed a large retro-odontoid pseudotumor and severe compression of the spinal cord at the C1 level. The patient underwent C1 laminectomy, posterior occipital-C2 fusion and tumor resection via a transdural approach. Postoperative MRI showed that the retro-odontoid pseudotumor had been partially removed, but this was enough to obtain sufficient decompression of the spinal cord. Neurological symptoms were markedly improved after surgery.

DOI： 10.11360/jcsoa.22.317

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ロッキングプレートによる下肢長管骨非感染性偽関節の治療成績

藤原智洋, 野田知之, 西山武, 中原龍一, 雑賀建多, 島村安則, 尾﨑敏文, 加原尚明, 宮澤慎一, 高城康師

中国・四国整形外科学会雑誌 22 ( 2 ) 355 - 361 2010年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

The development of the locking plate has allowed considerable progress in the treatment of fractures, but few studies have evaluated its usefulness for the treatment of aseptic non-union. We have treated 15 cases of aseptic non-union of long bones in the lower limb (femur : 5, tibia : 10, including 3 periprosthetic non-unions) using locking plates. The initial treatments were external fixation in 1 case, intramedullary nailing in 2, conventional plating in 5, locking plating in 4, and use of a cast only in 3. Nine cases were hypertrophic non-unions and 5 were atrophic non-unions. Union was achieved in all cases, although one case showed correction loss and 5 showed delayed union. These results were quite good, and allowed us to conclude that the locking plate is useful for the treatment of aseptic non-union of bones in the lower limb. Because the degree of bone defect and deformity differs in individual cases, detailed preoperative planning and choice of an appropriate operative technique are needed to achieve good results.

DOI： 10.11360/jcsoa.22.355

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