研究者詳細 - 尾﨑　敏文

論文 - 尾﨑　敏文

分割表示 1,743 件中 1,241 - 1,260 件目／全件表示 >>

Erratum. Venous Thromboembolism after Total Hip Arthroplasty Diagnosed by Enhanced Computed Tomography:Comparison of Selective Thromboprophylaxis and No Thromboprophylaxis. 査読

Okada Y, Endo H, Tanaka T, Mitani S, Fujiwara K, Tetsunaga T, Kagawa Y, Fujii Y, Kunisada T, Ozaki T

Acta medica Okayama 69 ( 5 ) 325 - 325 2015年

microRNAs and Soft Tissue Sarcomas. 査読国際誌

Fujiwara T, Kunisada T, Takeda K, Ozaki T

Advances in experimental medicine and biology 889 179 - 199 2015年

Immunotherapy for Bone and Soft Tissue Sarcomas. 査読国際誌

Uehara T, Fujiwara T, Takeda K, Kunisada T, Ozaki T, Udono H

BioMed research international 2015 820813 - 820813 2015年

Venous thromboembolism after total hip arthroplasty diagnosed by enhanced computed tomography:comparison of selective thromboprophylaxis and no thromboprophylaxis. 査読

Okada Y, Endo H, Mitani S, Fujiwara K, Tetsunaga T, Kagawa Y, Fujii Y, Kunisada T, Ozaki T

Acta medica Okayama 69 ( 4 ) 205 - 212 2015年

Diagnostic value of Thallium-201 scintigraphy in differentiating malignant bone tumors from benign bone lesions. 査読

Inai R, Shinya T, Tada A, Sato S, Fujiwara T, Takeda K, Kunisada T, Yanai H, Ozaki T, Kanazawa S

Annals of nuclear medicine 29 ( 8 ) 674 - 681 2015年

Both a visual and a semiquantitative analysis for differentiating benign from malignant chondrogenic bone tumors using Tc-99m (V) DMSA scintigraphy: a prospective study. 査読国際誌

Shinya T, Sato S, Kunisada T, Inai R, Yanai H, Ozaki T, Kanazawa S

Nuclear medicine communications 36 ( 8 ) 802 - 807 2015年

Modification of the cell adhesion and hydrophilic characteristics of poly(ether-ether-ketone) by 172-nm Xenon excimer radiation 査読

Yukimasa Okada, Takayuki Furumatsu, Shinichi Miyazawa, Masataka Fujii, Hiroyuki Takahashi, Hiroomi Kimura, Toshifumi Ozaki, Nobuhiro Abe

BIO-MEDICAL MATERIALS AND ENGINEERING 25 ( 2 ) 169 - 175 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：IOS PRESS

BACKGROUND: Poly-ether-ether-ketone (PEEK) has biomechanical and chemical properties that are excellent for biomedical applications; however, PEEK adhesion to bone or chondral tissue proceeds slowly due to poor hydrophilicity and other surface characteristics.
OBJECTIVE: We investigated the structural change, hydrophilicity, and cytocompatibility of a PEEK surface after 172-nm xenon excimer UV-irradiation.
METHODS: The surface characteristics before and after irradiation were evaluated by contact angle and ATR-FTIR measurements. Mouse osteoblast-like cells (MC3T3-E1) were cultured on PEEK plates and collected after 6, 12 and 24 h for cell adhesion analysis by crystal violet staining (CVS) and scanning electron microscopy (SEM).
RESULTS: UV-irradiation improved PEEK surface hydrophilicity, as indicated by a significant drop in water contact angle (p < 0.05). Irradiated PEEK showed additional peaks around 3370 cm(-1) and 1720 cm(-1), highlighting the generation of hydroxyl and carbonyl groups. CVS and SEM revealed improved adhesion to the PEEK surface after UV-irradiation.
CONCLUSION: Our results suggest that 172-nm UV-irradiated PEEK may be used in biomedical applications that require good cell adhesion.

DOI： 10.3233/BME-151267

Web of Science

researchmap

The figure-of-nine leg position for anatomic anterior cruciate ligament reconstruction 査読

T. Furumatsu, M. Fujii, T. Tanaka, S. Miyazawa, T. Ozaki

Revue de Chirurgie Orthopedique et Traumatologique 101 ( 3 ) 249 2015年

記述言語：フランス語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier Masson SAS

Anatomic double-bundle anterior cruciate ligament (ACL) reconstruction can restore the function and kinematics of the knee in ACL-deficient patients. Several outside-in drilling systems for accurate femoral tunnel creations have been developed. However, the femoral tunnel creation at the lower position of the intercondylar notch can be difficult in an usual leg position with the knee flexed at 90° without varus stress. This technical note describes that the figure-of-nine leg position provides a better arthroscopic view to safely clean up the ACL femoral footprint located at the lower area of the lateral intercondylar wall. This position is useful to create the optimal femoral tunnels using the outside-in drilling technique, without damaging the lateral meniscus posterior root, lateral tibial eminence, and supplemental fibers that bridge the gap between the lateral meniscus and the ACL tibial insertion.

DOI： 10.1016/j.rcot.2014.12.013

Scopus

researchmap

Role of Rho Small GTPases in Meniscus Cells 査読

Tomoko Kanazawa, Takayuki Furumatsu, Emi Matsumoto-Ogawa, Ami Maehara, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC RESEARCH 32 ( 11 ) 1479 - 1486 2014年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

We previously reported that mechanical stretch regulates Sry-type HMG box (SOX) 9-dependent 1(II) collagen (COL2A1) expression in inner meniscus cells. This study examined the role of the small Rho guanosine 5' triphosphatase Rac1 and Rho-associated kinase (ROCK) in the regulation of stretch-induced SOX9 gene expression in cultured human inner meniscus cells. COL2A1 and SOX9 gene expression was assessed by real-time PCR after application of uni-axial cyclic tensile strain (CTS) in the presence or absence of ROCK and Rac1 inhibitors. The subcellular localization of SOX9 and the Rac1 effector cyclic AMP response element-binding protein (CREB), the phosphorylation state of SOX9, Rac1 activation, and the binding of CREB to the SOX9 promoter were assessed. CTS increased the expression of COL2A1 and SOX9, which was suppressed by inhibition of Rac1. ROCK inhibition enhanced COL2A1 and SOX9 gene expression in the absence of CTS. CTS stimulated the nuclear translocation and phosphorylation of SOX9, and increased Rac1 activation. CTS also increased the binding of CREB to the SOX9 promoter. The results suggest that mechanical stretch-dependent upregulation of SOX9 by CREB in inner meniscus cells depends on the antagonistic activities of ROCK and Rac1. (c) 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:1479-1486, 2014.

DOI： 10.1002/jor.22703

Web of Science

researchmap

乳がん骨転移における非定型大腿骨骨折の発生率の検討

中田英二, 杉原進介, 尾崎敏文

中部日本整形外科災害外科学会雑誌 57 ( 6 ) 1245 - 1246 2014年11月

記述言語：日本語出版者・発行元：(一社)中部日本整形外科災害外科学会

2004年11月〜2013年10月の間にビスフォスフォネート(BP)を24ヵ月以上静脈内投与した乳がん骨転移患者142名(全例女性、平均年齢69歳)を対象に、非定型型大腿骨骨折(AFF)の発生率について検討した。BP投与回数は24〜103回(中央値36回)、投与期間は16〜101ヵ月(中央値36ヵ月)であった。その結果、1)経過観察期間中に大腿骨病的骨折を11例に認められた。このうちAFFは2例で、1例は右側、他の1例は両側に発生していた。2)発生時のBP投与はそれぞれ41回と83回、投与期間は37・79ヵ月で、2例とも内固定術(髄内釘)が施行されたが、髄腔が硬化し髄内釘の挿入が困難なため骨折部を直視下に整復して挿入した。尚、術後合併症や遷延癒合は認められなかった。3)乳がん患者においてBPを2年以上使用した症例の非定型型大腿骨骨折の発生率は1.4%であるが、3年以上にわたり骨修飾薬を投与した症例中、大腿部痛が出現とともにX線像上で大腿骨外側部に骨皮質に肥厚を認めた場合は非定型型大腿骨骨折の可能性を考えるべきである。

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J00831&link_issn=&doc_id=20150123090015&doc_link_id=10.11359%2Fchubu.2014.1245&url=https%3A%2F%2Fdoi.org%2F10.11359%2Fchubu.2014.1245&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Spinal Metaplastic Meningioma with Osseous Differentiation in the Ventral Thoracic Spinal Canal 査読

Kentaro Yamane, Masato Tanaka, Yoshihisa Sugimoto, Kouichi Ichimura, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 68 ( 5 ) 313 - 316 2014年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Ossified meningioma is classified histologically as a phenotype of metaplastic meningioma, and it is extremely rare. There are only 12 cases involving ossified spinal meningiomas in the literature. We present the case of a 61-year-old female with a primary tumor within the ventral spinal canal at T12. Although we performed a total tumor excision using an ultrasonic bone aspirator, a temporary deterioration of motor evoked potentials (MEPs) was observed during curettage with a Kerrison rongeur. The neurologic findings worsened immediately after surgery. Histologically, the tumor was diagnosed as a metaplastic meningioma with osseous differentiation. In order to avoid spinal cord injury, great care must be taken when removing an ossified meningioma located on the ventral spinal cord.

Web of Science

researchmap

CBTスクリュー刺入部の3次元解析

瀧川朋亨, 田中雅人, 杉本佳久, 荒瀧慎也, 鉄永倫子, 尾崎敏文

Journal of Spine Research 5 ( 10 ) 1452 - 1455 2014年10月

記述言語：日本語出版者・発行元：(一社)日本脊椎脊髄病学会

本研究の目的はCBTスクリューの挿入可能な角度とスクリュー長、そのCT値を求めることである。64椎体の腰椎CTデータを用いて、4.5mm径の仮想スクリューが刺入可能な角度、スクリュー長およびスクリュー挿入部位のCT値を解析した。腰椎CBTスクリューは下位になるほどより尾外側方向で、より長いスクリューが刺入可能であった。CBTスクリュー挿入部位のCT値は椎弓根スクリューの約2倍であった。(著者抄録)

researchmap

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J05510&link_issn=&doc_id=20141104100020&doc_link_id=%2Ffg7spine%2F2014%2F000510%2F021%2F1452-1455%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffg7spine%2F2014%2F000510%2F021%2F1452-1455%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

藤原智洋, 国定俊之, 武田健, 尾崎敏文

関節外科 33 ( 10月増刊 ) 184 - 203 2014年10月

小児に生じた単発性骨嚢腫による大腿骨近位部病的骨折

杉生和久, 武田健, 藤原智洋, 国定俊之, 尾崎敏文

中国・四国整形外科学会雑誌 26 ( 3 ) 460 - 460 2014年10月

Dorsal defect of the patellaの1例

三宅孝昌, 藤原智洋, 武田健, 国定俊之, 尾崎敏文

中国・四国整形外科学会雑誌 26 ( 3 ) 460 - 460 2014年10月

Long-term follow-up of resection-replantation for sarcoma in the distal radius 査読

Eiji Nakada, Shinsuke Sugihara, Toshiyuki Kunisada, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 19 ( 5 ) 832 - 837 2014年9月

RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis 査読

Tomohiro Fujiwara, Ryou-u Takahashi, Nobuyoshi Kosaka, Yutaka Nezu, Akira Kawai, Toshifumi Ozaki, Takahiro Ochiya

MOLECULAR THERAPY-NUCLEIC ACIDS 3 e189 2014年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

Drug resistance and metastasis are lethal characteristics of tumors. We previously demonstrated that silencing of ribophorin II (RPN2), which is part of the N-oligosaccharyl transferase complex, efficiently induced apoptosis and reduced resistance to docetaxel in human breast cancer cells. Here, we report the clinical and functional correlations of RPN2 expression in osteosarcoma. Immunohistochemical evaluation of 35 osteosarcoma patient biopsies revealed that RPN2 was moderately to highly expressed in all specimens, and higher RPN2 mRNA expression was significantly correlated with poor prognosis. To investigate whether lethal phenotypes of osteosarcoma could be reduced by regulating the expression of RPN2, we conducted a study of RNAi-induced RPN2 knockdown in highly metastatic human osteosarcoma cells. The results indicated that RPN2 silencing reduced cell proliferation, sphere formation, cell invasion, and sensitized drug response in vitro. Mice bearing RPN2-silenced highly metastatic osteosarcoma xenografts showed reduced tumor growth and lung metastasis, and survived longer than mice bearing control tumor xenografts. Taken together, our data suggest that RPN2 silencing contributes to regulation of lethal osteosarcoma phenotypes and could be a novel target for RNAi-based therapeutics against osteosarcoma.

DOI： 10.1038/mtna.2014.35

Web of Science

PubMed

researchmap

切除縁評価法の問題点切除縁評価法の問題点悪性骨腫瘍

国定俊之, 武田健, 藤原智洋, 柳井広之, 尾崎敏文

日本整形外科学会雑誌 88 ( 9 ) 588 - 594 2014年9月

記述言語：日本語出版者・発行元：(公社)日本整形外科学会

2005年〜2011年に治療した初診時遠隔転移を認めない高悪性骨腫瘍52例を対象に、最近の症例について検討し、悪性骨腫瘍の切除縁評価法に関する疑問点・問題点について検討した。組織型は骨肉腫34例、軟骨肉腫12例、Ewing肉腫3例等であった。52例の切除縁評価は2cm wide margin以上45例、1cm wide margin 4例、marginal margin以下3例であった。1cm wide marginとなった4例は血管温存目的(2例)および術前化学療法効果著効例での関節温存目的(2例)であった。marginal margin以下となった3例は骨盤発生、脊椎発生、大腿骨巨大腫瘍で、広範囲切除縁確保が困難であった。再発は4例に認め、2cm wide margin以上1例、marginal margin以下3例であった。最初の問題点は反応層の定義で、反応層をもう少し詳細に分類する必要がある。2番目の問題点は術前画像での切除縁設定の基準を決めることで、全国で統一した安全な切除縁設定の基準を決める必要があると思われた。

researchmap

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01133&link_issn=&doc_id=20141006030026&doc_link_id=%2Ffj2ortho%2F2014%2Fs08809%2F005%2F0588-0594%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffj2ortho%2F2014%2Fs08809%2F005%2F0588-0594%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

仙骨発生骨巨細胞腫の治療成績

藤原智洋, 国定俊之, 武田健, 尾崎敏文

中部日本整形外科災害外科学会雑誌 57 ( 秋季学会 ) 248 - 248 2014年9月

Two-Directional Arthrographic Assessment for Treating Bilateral Development Dislocation of the Hips in Children after Walking Age 査読

Hirosuke Endo, Hirofumi Akazawa, Shigeru Mitani, Yoshiki Okada, Kentaro Yamane, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 68 ( 4 ) 201 - 206 2014年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We reviewed the treatment outcome in 14 hips of 7 patients who were diagnosed as having bilateral developmental dislocation of the hip (DDH) after walking age and could be followed up until they were at least 14 years of age. Based on the results of two-directional arthrography of the hip, closed reduction was performed in 2 hips, and open reduction was performed without osteotomy in 12 hips. The final radiographic evaluations were made according to the Kalamchi and MacEwen classification and Severin classification. The mean age at the initial visit was 1 year and 9 months (range, 1 year and 5 months to 3 years). The outcome was satisfactory for one hip in Group I and 2 hips in Group II according to the Kalamchi and MacEwen classification, and in 83% of the Severin Class I and II hips. Arthrography was useful for identifying asymmetry, demonstrating the usefulness of a treatment strategy based on arthrography of the hip.

Web of Science

researchmap

　前のページ - 次のページ　

<尾﨑 敏文>

論文 - 尾﨑 敏文

<尾﨑　敏文>

論文 - 尾﨑　敏文