研究者詳細 - 尾﨑　敏文

論文 - 尾﨑　敏文

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Neurofibromatosis type Iに合併した脊柱側彎症に対する後方固定術の治療成績

齋藤太一, 杉本佳久, 田中雅人, 三澤治夫, 高畑智宏, 尾崎敏文

中部日本整形外科災害外科学会雑誌 52 ( 秋季学会 ) 99 - 99 2009年9月

血管病変と診断され血管置換術が行われた滑膜肉腫の2例

藤原智洋, 国定俊之, 佐々木剛, 井谷智, 森本裕樹, 尾崎敏文

中部日本整形外科災害外科学会雑誌 52 ( 秋季学会 ) 214 - 214 2009年9月

末梢神経系腫瘍microRNA発現プロファイリングの検討

井谷智, 森本裕樹, 伊藤佐智夫, 大内田守, 吉田晶, 上甲良二, 米田泰史, 佐々木剛, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 83 ( 8 ) S1151 - S1151 2009年8月

感染パスツール処理骨に対する再建の経験

森定淳, 長谷川健二郎, 佐藤卓士, 渡邊敏之, 難波祐三郎, 木股敬裕, 尾崎敏文, 國定俊之

日本マイクロサージャリー学会会誌 22 ( 2 ) 136 - 136 2009年6月

血管柄付広背筋皮弁の有用であった左下腿腫瘍の1例

植村享裕, 妹尾貴矢, 目谷雅恵, 森定淳, 佐藤卓士, 渡邊敏之, 徳山英二郎, 杉山成史, 長谷川健二郎, 難波祐三郎, 木股敬裕, 尾崎敏文, 国定俊之, 森本裕樹

岡山医学会雑誌 121 ( 1 ) 62 - 62 2009年4月

治療後14年で肺転移をきたしたEwing肉腫の1例

米田泰史, 国定俊之, 田端雅弘, 二宮崇, 森本裕樹, 尾崎敏文

中部日本整形外科災害外科学会雑誌 52 ( 春季学会 ) 205 - 205 2009年3月

Safety of atlantoaxial fusion using laminar and transarticular screws combined with an atlas hook in a patient with unilateral vertebral artery occlusion (case report) 査読

Yoshihisa Sugimoto, Masato Tanaka, Kazuo Nakanishi, Haruo Misawa, Tomoyuki Takigawa, Yasuo Ito, Toshifumi Ozaki

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY 129 ( 1 ) 25 - 27 2009年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

A disadvantage of transarticular and C2 pedicle screws is vertebral artery (VA) injury as a result of screw misplacement. If unilateral occlusion of the VA is present, VA injury of the dominant side will cause fatal complications as a result of collateral flow insufficiency. Several authors have recently reported the usefulness of C2 laminar screws because of their safety on VA injury. We used transarticular and C2 laminar screws combined with the atlas hook in a patient with C1-2 instability and unilateral VA occlusion, in order to reduce the risk of further VA injury.
A 64-year-old woman with rheumatoid atlantoaxial subluxation complained of cervical myelopathy and neck pain. Preoperative MR angiography showed a left side VA occlusion.
The patient underwent atlantoaxial, posterior fusion using a transarticular screw on the side of the occlusion and a C2 laminar screw on the dominant side combined with a bilateral atlas hook. The transarticular screw was inserted using a navigation system and image intensifier, and the laminar screw was inserted free hand. Bone grafting from the iliac crest was performed.
Transarticular and C2 laminar screws fixation combined with the atlas hook in a patient with unilateral VA occlusion is a useful technique, in order to reduce the risk of further VA injury.

DOI： 10.1007/s00402-007-0510-9

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Posterior spinal fusion using a pedicle nail system with polymethylmethacrylate in a paraplegic patient after vertebral collapse caused by osteoporosis 査読

Yoshihisa Sugimoto, Masato Tanaka, Hitoshi Konishi, Tomoyuki Takigawa, Kazuo Nakanishi, Haruo Misawa, Yasuo Ito, Toshifumi Ozaki

Spine Journal 9 ( 1 ) -e8 2009年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background context: Because posterior decompression and fusion for vertebral collapse in an osteoporotic spine sometimes results in a pullout of the pedicle screw. Several authors reported that fixation of pedicle screws in severely osteoporotic bone could be improved by inserting polymethylmethacrylate (PMMA) into the hole before inserting the screw. However, pedicle screws were not designed to be used with PMMA. Purpose: To report a patient with vertebral collapse who were treated using a novel-concept, pedicle nail using with PMMA. Study design: Case report. Methods: The patient was a 74-year-old female who experienced back pain after some heavy lifting 3 months before. She was laid up for 2 months because of the back pain and weakness of her lower legs. Radiographs and magnetic resonance imaging showed vertebral collapse and neural severe compression from the posterior wall of vertebra T12. The pedicle nail consists of an outer sheath with evenly spaced holes and an internal, removable, threaded component. The outer sheath and the internal component were connected before insertion. The pedicle nail attaches to and is bound by the PMMA through the holes of the outer sheath. We performed a T11-L1 posterior fusion and laminectomy using the pedicle nail, and we used a hydroxyapatite block to perform a transpedicular vertebroplasty of T12. Results: Bone union was observed on a lateral radiograph without pedicle nail loosening. Conclusions: The authors speculate that posterior spinal fusion and vertebroplasty using the pedicle nail will be a reasonable choice for delayed paraplegia after osteoporotic vertebral fracture. © 2009 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.spinee.2007.10.036

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Cutting Tool Protects for Soft Tissues in Bone-Milling Machining. 査読

Naohiko Sugita, Taiga Nakano, Takayuki Osa, Yoshikazu Nakajima, Kazuo Fujiwara, Nobuhiro Abe, Toshifumi Ozaki, Masahiko Suzuki, Mamoru Mitsuishi

IJAT 3 ( 2 ) 185 - 192 2009年

Interference Free Tool Path Generation in Multi-Axis Milling Machine for Orthopedic Surgery. 査読

Taiga Nakano, Naohiko Sugita, Takeharu Kato, Kazuo Fujiwara, Nobuhiro Abe, Toshifumi Ozaki, Masahiko Suzuki, Mamoru Mitsuishi

IJAT 3 ( 5 ) 514 - 522 2009年

Tool path generation to protect soft tissue with multi-axis milling machine 査読

Nakano T, Sugita N, Nakajima Y, Kato T, Fujiwara K, Abe N, Ozaki T, Suzuki M, Mitsuishi M

Proceedings of the 5th International Conference on Leading Edge Manufacturing in 21st Century, LEM 2009 2009年

Dynamic controlled milling process for bone machining 査読

Sugita N, Nakano T, Nakajima Y, Fujiwara K, Abe N, Ozaki T, Suzuki M, Mitsuishi M

Journal of Materials Processing Technology 209 ( 17 ) 5777 - 5784 2009年

人工骨頭置換術後ステム折損の1例

皆川寛, 三谷茂, 遠藤裕介, 鉄永智紀, 尾崎敏文, 藤原一夫

中国・四国整形外科学会雑誌 21 ( 1 ) 83 - 88 2009年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

Cases of a fracture of the hydroxyapatite (HA)-coated stem in patients who underwent total hip arthroplasty have occasionally been reported. This article describes a case of stem fracture seen in a 61-year-old female patient more than 11 years after cementless bipolar head prostheses performed at this hospital. The patient had idiopathic avascular necrosis of the right femoral head, and at the age of 48, she underwent cementless bipolar head prosthesis using a titanium, HA-coated MCF stem (Kyocera Corporation, Kyoto, Japan). The stem was successfully implanted, and the postoperative clinical progress was uneventful. Eleven years and 10 months after operation, the patient had acute weakness of the right hip when she stood up, resulting in gait disturbance. Hip radiography revealed a fracture of the basal portion of the stem neck, and a revision hip arthroplasty was performed. Analysis showed that the fracture developed from the site of a rectangular notch serving as a gripper made at the stem neck. Therefore, the fracture might be caused by stress concentration at the rectangular part and the resultant metal fatigue. Implants with such design may be associated with breakage even a long time after bipolar head prostheseis.

DOI： 10.11360/jcsoa.21.83

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Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) 査読

Keisuke Horiuchi, Hideo Morioka, Kazumasa Nishimoto, Yoshihisa Suzuki, Michiro Susa, Robert Nakayama, Akira Kawai, Hiroshi Sonobe, Hironari Takaishi, Toshifumi Ozaki, Hiroo Yabe, Kazuo Umezawa, Yoshiaki Toyama

Cancer Letters 272 ( 2 ) 336 - 344 2008年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-κB (NF-κB) is constitutively activated in various cancer cells and has emerged as a potential therapeutic molecular target
however, the possible involvement of NF-κB in the pathology of sarcomas remains to be clarified. Herein we examined the effects of a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) on two synovial sarcoma-derived cell lines, HS-SY-II and SYO-1. The growth of both cell lines was completely inhibited by DHMEQ and apoptosis was induced at 10 μg/ml. Additionally, we found that DHMEQ showed additive effects when used in combination with other cytotoxic agents. These observations indicate that inhibition of NF-κB activity may serve as a potential therapeutic target for synovial sarcoma. © 2008 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.canlet.2008.07.021

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Isolation of a mRNA Preferentially Expressed in Synoviocytes from Rheumatoid Arthritis That is Identical with Lumican, which Encodes a Collagen Binding, Extracellular Matrix Protein 査読

Hiroki Mori, Keiichiro Nishida, Toshifumi Ozaki, Hajime Inoue, Tohru Nakanishi

JOURNAL OF HARD TISSUE BIOLOGY 17 ( 3 ) 125 - 130 2008年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JOURNAL HARD TISSUE BIOLOGY

Rheumatoid arthritis (RA) is a complex disease including autoimmune disorder and resulting in inflammation. It also shows progressive proliferation of synoviocytes, and these synoviocytes destroys articular structure. In order to understand the mechanism of this abnormal proliferation of RA-originated synoviocytes in molecular level, we analyzed the gene expression profiles by using DNA chips that contain more than 10,000 genes. Comparing the expression profiles of normal and RA-originated synoviocytes, we found several genes that are highly expressed in RA-originated synoviocytes than normal synoviocytes. Among these genes, we focused on one hypothetical protein, cDNA of which contains one reading frame in its DNA fragment, indicating that this fragment is a part of large mRNA structure. The expression of this gene in RA-originated synoviocytes is about three times higher than that in normal synoviocytes by DNA chip analysis. After cDNA cloning of this mRNA, we found that the gene is identical with lumican, which encodes a collagen binding, extracellular matrix protein. This mRNA was widely distributed in many tissues but its alternatively spliced forms are differently expressed in various tissues.

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CentPillar GB HA stemの短期成績

鉄永智紀, 三谷茂, 藤原一夫, 遠藤裕介, 皆川寛, 尾崎敏文

日本人工関節学会誌 38 522 - 523 2008年12月

下肢人工関節置換術後の静脈血栓症の予防に対するアリクストラ(Fondaparinux Sodium)の使用経験

皆川寛, 三谷茂, 阿部信寛, 遠藤裕介, 鉄永智紀, 藤原一夫, 尾崎敏文

日本人工関節学会誌 38 652 - 653 2008年12月

SAPHO syndrome associated spondylitis 査読

Tomoyuki Takigawa, Masato Tanaka, Kazuo Nakanishi, Haruo Misawa, Yoshihisa Sugimoto, Tomohiro Takahata, Hiroyuki Nakahara, Shinnosuke Nakahara, Toshifumi Ozaki

EUROPEAN SPINE JOURNAL 17 ( 10 ) 1391 - 1397 2008年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The concept of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome has been well clarified, after Chamot et al. suggested this peculiar disorder in 1987. The most commonly affected site in SAPHO syndrome is the anterior chest, followed by the spine. However, the clinical course and taxonomic concept of SAPHO spinal lesions are poorly understood. This study was performed to analyze: (1) the detailed clinical course of spinal lesions in SAPHO syndrome, and (2) the relationship between SAPHO syndrome with spinal lesions and seronegative spondyloarthropathy. Thirteen patients with spondylitis in SAPHO syndrome were analyzed. The features of spinal lesions were a chronic onset with a slight inflammatory reaction, and slowly progressing non-marginal syndesmophytes at multi spinal levels, besides the coexistence of specific skin lesions. SAPHO syndrome, especially spinal lesions related to palmoplantar pustulosis, can be recognized as a subtype of seronegative spondyloarthropathy.

DOI： 10.1007/s00586-008-0722-x

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SAPHO syndrome with rapidly progressing destructive spondylitis: two cases treated surgically 査読

Tomoyuki Takigawa, Masato Tanaka, Shinnosuke Nakahara, Yoshihisa Sugimoto, Toshifumi Ozaki

EUROPEAN SPINE JOURNAL 17 S331 - S337 2008年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The authors present two cases of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome with rapidly progressing destructive spondylitis treated surgically. The spinal lesions in SAPHO syndrome generally have a good prognosis and rarely cause the structural destruction or neurological deterioration. Case 1: a 63-year-old female had palmoplantar pustulosis for 2 years. At first, she only felt a pain in the nape with no inducing factor. Two months later, she had incomplete quadriplegia (ASIA scale C). Magnetic resonance imaging showed destruction of C4-C7, kyphotic deformity, and severe compression of the spinal cord. Decompression and reconstruction surgery using anterior and posterior approach improved her paralysis. Case 2: a 69-year-old female complained of persistent back pain. Magnetic resonance imaging revealed spondylitis of T7-T9. Although there were no typical skin lesions, we diagnosed SAPHO syndrome by hyperostosis of the stemocostoclavicular joint and sacral joint. Destruction with kyphotic deformity of the spine progressed gradually for 3 months. Curettage and reconstruction surgery using thoracic endoscope relieved her pain and prevented the destruction of the spine. The histopathology of the specimen obtained surgically showed non-specific inflammation in both cases. Spondylitis in SAPHO syndrome may cause severe destruction and kyphotic deformity followed by paralysis.

DOI： 10.1007/s00586-008-0663-4

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The expression of microRNA424 in rheumatoid arthritis

Yoshitaka, Teruhito, Nakasa, Tomoyuki, Inoue, Atsushi, Okubo, Atsuko, Takemoto, Fuko, Miyaki, Shigeru, Nishida, Keiichiro, Ochi, MitStio, Ozaki, Toshifumi, Sumida, Takayuki, Asahara, Hiroshi

ARTHRITIS AND RHEUMATISM 58 ( 9::Suppl. S ) 0 - 0 2008年9月

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