研究者詳細 - 賴藤　貴志

論文 - 賴藤　貴志

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Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit. 査読

Atsuyoshi Iida, Hiromichi Naito, Takashi Yorifuji, Yoshito Zamami, Akane Yamada, Tadashi Koga, Toru Imai, Toshiaki Sendo, Atsunori Nakao, Shingo Ichiba

Acta medica Okayama 73 ( 2 ) 101 - 107 2019年4月

記述言語：英語

Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.

DOI： 10.18926/AMO/56645

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Population-based longitudinal study showed that children born small for gestational age faced a higher risk of hospitalisation during early childhood. 査読

Yoshimoto J, Yorifuji T, Washio Y, Okamura T, Watanabe H, Doi H, Tsukahara H

Acta paediatrica (Oslo, Norway : 1992) 108 ( 3 ) 473 - 478 2019年3月

Early childhood exposure to maternal smoking and Kawasaki Disease: A longitudinal survey in Japan. 査読

Yorifuji T, Tsukahara H, Doi H

The Science of the total environment 655 141 - 146 2019年3月

Associations of gestational age with child health and neurodevelopment among twins: A nationwide Japanese population-based study. 査読国際誌

Kei Tamai, Takashi Yorifuji, Akihito Takeuchi, Makoto Nakamura, Yosuke Washio, Hirokazu Tsukahara, Hiroyuki Doi, Misao Kageyama

Early human development 128 41 - 47 2019年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The prevalence of multiple births has recently increased. However, the association between gestational age and long-term morbidity among twins remains unclear. AIMS: To examine the association of gestational age with child health and neurological development in early childhood among twins. STUDY DESIGN: Population-based longitudinal study. SUBJECTS: We included 947 children from 479 pairs of twins with information on gestational age. OUTCOME MEASURES: Hospitalization was used as an indicator of physical health, and responses to questions about age-appropriate behaviors were used as an indicator of neurobehavioral development. We conducted binomial log-linear regression analyses, controlling for both child and maternal variables in the model. We accounted for correlations within the pairs with generalized estimating equations. RESULTS: The early term group (i.e., 37 to 38 weeks of gestation) had a lower risk of poor child health and unfavorable neurodevelopment compared with the full term group (≥39 weeks of gestation) and preterm group (<37 weeks of gestation). Compared with the early term group, the adjusted risk ratios for hospitalization for all causes during the period from 7 to 18 months of age was 2.2 (95% confidence interval: 1.3-3.8) for very preterm children (<32 weeks of gestation), 1.1 (0.8-1.6) for moderately and late preterm children (32 to 36 weeks of gestation), and 1.8 (1.0-3.2) for full term children. CONCLUSION: We observed a U-shaped association of gestational age with child health and neurodevelopment. The early term group had the lowest risk of poor outcomes among twins.

DOI： 10.1016/j.earlhumdev.2018.11.005

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Acute exposure to sulfur dioxide and mortality: Historical data from Yokkaichi, Japan. 査読

Yorifuji T, Kashima S, Suryadhi MAH, Abudureyimu K

Archives of environmental & occupational health 74 ( 5 ) 271 - 278 2019年

Long-stay pediatric patients in Japanese intensive care units: their significant presence and a newly developed, simple predictive score. 査読

Knaup E, Nosaka N, Yorifuji T, Tsukahara K, Naito H, Tsukahara H, Nakao A, JaRPAC Study Group

Journal of intensive care 7 38 2019年

Mortality in trauma patients admitted during, before, and after national academic emergency medicine and trauma surgery meeting dates in Japan. 査読

Yumoto T, Naito H, Ihoriya H, Yorifuji T, Nakao A

PloS one 14 ( 1 ) e0207049 2019年

Association of early daycare attendance with allergic disorders in children: a longitudinal national survey in Japan. 査読

Tokinobu A, Yorifuji T, Yamakawa M, Tsuda T, Doi H

Archives of environmental & occupational health 75 ( 1 ) 18 - 26 2018年12月

Air quality management policy and reduced mortality rates in Seoul Metropolitan Area: A quasi-experimental study 査読

Changwoo Han, Youn-Hee Lim, Takashi Yorifuji, Yun-Chul Hong

Environment International 121 600 - 609 2018年12月

Life Satisfaction, Interpersonal Relationships, and Learning Influence Withdrawal from School: A Study among Junior High School Students in Japan 査読

Sachiko Inoue, Tsuguhiko Kato, Takashi Yorifuji

International Journal of Environmental Research and Public Health 15 ( 10 ) 2309 - 2309 2018年10月

担当区分：最終著者掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

School absenteeism, particularly among junior high school students, has increased annually in Japan. This study demonstrates the relationship between subjective adjustment to school life and students’ absenteeism. Data were collected from 17,378 junior high school students in Japan. A longitudinal design was used for the study. Teachers were asked to distribute the Adaptation Scale for School Environments on Six Spheres (ASSESS) questionnaire to junior high school students and ask the students to fill out the questionnaire at the beginning of the 2014 academic year in April 2014, and the relationship between their subjective adjustment and absenteeism as measured by the total number of absent days during the 2014 academic year was evaluated by logistic regression and a survival analysis model. Low life satisfaction was associated with absences. The corresponding odds ratio (OR) was higher for seventh graders (OR 3.29, confidence interval (CI): 2.41–4.48, hazard ratio (HR) 5.57, CI: 3.51–8.84) than for students in other grades. Interpersonal relationships were significantly related to absenteeism for seventh and eighth graders in the group with scores less than 39 points. Lower adjustment to learning seemed to be related to absenteeism for seventh and eighth graders. For effective interventions, a well-designed study that uses detailed information regarding life-related covariates is necessary.

DOI： 10.3390/ijerph15102309

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Intelligence test at preschool-age predicts reading difficulty among school-aged very low birth weight infants in Japan. 査読国際誌

Akihito Takeuchi, Tatsuya Ogino, Tatsuya Koeda, Makio Oka, Takashi Yorifuji, Toshimitsu Takayanagi, Kazuo Sato, Noriko Sugino, Motoki Bonno, Makoto Nakamura, Misao Kageyama

Brain & development 40 ( 9 ) 735 - 742 2018年10月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: To elucidate whether the results of an intelligence test at preschool age are predictive of reading difficulty (RD) at school age among very low birth weight infants (VLBWI). METHODS: Subjects were 48 Japanese children whose birth weight was <1500 g and who regularly visited a follow-up clinic. All subjects completed the Wechsler Intelligence Scale for Children-III (WISC-III) during the last grade of kindergarten, and four reading tasks during the second to fourth grade of elementary school. All participants had a full-scale intelligence quotient score of 85 or higher. Subjects with a standard deviation reading time score greater than 2.0 in two or more tasks were considered to have RD. We evaluated the associations between each WISC-III score and RD using logistic regression analyses. Furthermore, we performed receiver operating characteristic (ROC) analysis to determine a cutoff WISC-III score predictive of RD. RESULTS: In the mutually-adjusted model, the adjusted odds ratio per 1 score increase of freedom from distractibility (FD) was 0.832 (95% confidence interval: 0.720-0.962). In the ROC analysis, an FD score of <95.5 was chosen as the cutoff value for predicting RD (sensitivity, 0.77; specificity, 0.74). CONCLUSION: The present study indicated that a lower FD score at preschool age, which was associated with deficits in verbal working memory and attention, is a risk factor for RD at school age among Japanese VLBWI. Further investigation is desired to clarify the cognitive deficits underlying RD in Japanese-speaking preterm children, and to establish appropriate interventions for these children.

DOI： 10.1016/j.braindev.2018.05.002

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Disease and injury trends among evacuees in a shelter located at the epicenter of the 2016 Kumamoto earthquakes, Japan 査読

Takashi Yorifuji, Takushi Sato, Toru Yoneda, Yoshiomi Kishida, Sumie Yamamoto, Taro Sakai, Hiroshi Sashiyama, Shuko Takahashi, Hayato Orui, Daisuke Kato, Taro Hasegawa, Yoshihiro Suzuki, Maki Okamoto, Hideki Hayashi, Shigeru Suganami

Archives of Environmental & Occupational Health 73 ( 5 ) 284 - 291 2018年9月

Accelerated functional losses in ageing congenital Minamata disease patients 査読

Takashi Yorifuji, Shigeru Takaoka, Philippe Grandjean

Neurotoxicology and Teratology 69 49 - 53 2018年9月

Epidemiology of Pediatric Acute Encephalitis/Encephalopathy in Japan. 査読

Goto S, Nosaka N, Yorifuji T, Wada T, Fujii Y, Yashiro M, Washio Y, Hasegawa K, Tsukahara H, Morishima T

Acta medica Okayama 72 ( 4 ) 351 - 357 2018年8月

National data showed that delayed sleep in six-year-old children was associated with excessive use of electronic devices at 12 years 査読

Tsuguhiko Kato, Takashi Yorifuji, Michiyo Yamakawa, Sachiko Inoue

Acta Paediatrica 107 ( 8 ) 1439 - 1448 2018年8月

Comparison of land use regression models for NO2 based on routine and campaign monitoring data from an urban area of Japan 査読

Saori Kashima, Takashi Yorifuji, Norie Sawada, Tomoki Nakaya, Akira Eboshida

Science of The Total Environment 631-632 1029 - 1037 2018年8月

Survey of the Extent of the Persisting Effects of Methylmercury Pollution on the Inhabitants around the Shiranui Sea, Japan 査読

Shigeru Takaoka, Tadashi Fujino, Yoshinobu Kawakami, Shin-ichi Shigeoka, Takashi Yorifuji

Toxics 6 ( 3 ) 39 - 39 2018年7月

担当区分：最終著者掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

In 1956 methylmercury poisoning, known as Minamata disease, was discovered among the inhabitants around the Shiranui Sea, Kyushu, Japan. Although about five hundred thousand people living in the area had supposedly been exposed to methylmercury, administrative agencies and research institutes had not performed any subsequent large scale, continuous health examination, so the actual extent of the negative health effects was not clearly documented. In 2009, we performed health surveys in order to examine residents in the polluted area and to research the extent of the polluted area and period of pollution. We analyzed data collected on 973 people (age = 62.3 ± 11.7) who had lived in the polluted area and had eaten the fish there and a control group, consisting of 142 persons (age = 62.0 ± 10.5), most of whom had not lived in the polluted area. Symptoms and neurological signs were statistically more prevalent in the four groups than in the control group and were more prevalent and severe in those who had eaten most fish. The patterns of positive findings of symptoms and neurological findings in the four groups were similar. Our data indicates that Minamata disease had spread outside of the central area and could still be observed recently, almost 50 years after the Chisso Company’s factory had halted the dumping of mercury polluted waste water back in 1968.

DOI： 10.3390/toxics6030039

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Self-rated School Adjustment and Absenteeism: An Epidemiological Study 査読

Sachiko Inoue, Tsuguhiko Kato, Takashi Yorifuji

Health Behavior and Policy Review 5 ( 3 ) 59 - 66 2018年5月

Birth order and paediatric allergic disease: A nationwide longitudinal survey 査読

T. Kikkawa, T. Yorifuji, Y. Fujii, M. Yashiro, A. Okada, M. Ikeda, H. Doi, H. Tsukahara

Clinical & Experimental Allergy 48 ( 5 ) 577 - 585 2018年5月

Maternal smoking as a risk factor for childhood intussusception 査読

Yasuo Nakahara, Takashi Yorifuji, Toshihide Kubo, Hiroyuki Doi

Archives of Environmental & Occupational Health 73 ( 2 ) 96 - 101 2018年3月

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