研究者詳細 - 賴藤　貴志

Asian dust and daily emergency ambulance calls among elderly people in Japan 査読

Saori Kashima, Takashi Yorifuji, Etsuji Suzuki

Journal of Occupational and Environmental Medicine 56 ( 12 ) 1277 - 1283 2014年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lippincott Williams and Wilkins

Objective: To evaluate the direct health effects of Asian dust on ambulance calls and its role as an effect modifier on the effects of anthropogenic air pollution in Japan.
Methods: The subjects were 51,945 elderly residents who visited hospital emergency departments from 2006 to 2010. We evaluated the impact of Asian dust by time-series analyses and the excess risk from suspended particulate matter (SPM) stratified by Asian-dust exposure.
Results: Asian dust was associated with daily ambulance calls due to allcause, cardiovascular, and respiratory disease independently of SPM, for example, the relative risk per interquartile increase in Asian dust (3-day lag) was 1.021 (1.002 to 1.039) for cardiovascular disease. Furthermore, Asian dust modified the effects of SPM on cardiovascular and respiratory diseases.
Conclusions: Asian dust had adverse effects and modified the effect of SPM.

DOI： 10.1097/JOM.0000000000000334

Hourly differences in air pollution and risk of respiratory disease in the elderly: a time-stratified case-crossover study 査読

Takashi Yorifuji, Etsuji Suzuki, Saori Kashima

Environmental Health 13 ( 1 ) 67 2014年12月

Outdoor air pollution and out-of-hospital cardiac arrest in Okayama, Japan 査読

Takashi Yorifuji, Etsuji Suzuki, Saori Kashima

Journal of Occupational and Environmental Medicine 56 ( 10 ) 1019 - 1023 2014年10月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lippincott Williams and Wilkins

Objectives: We evaluated the association between short-term exposure to outdoor air pollution and out-of-hospital cardiac arrest in Japan.
Conclusions: Short-term exposure to outdoor air pollution was associated with increased risk of cardiac arrest.
Methods: We studied 558 residents of Okayama, Japan, who visited hospital emergency departments between January 2006 and December 2010 for out-of-hospital cardiac arrest using a time-stratified case-crossover design. We calculated city-representative average concentrations of different air pollutants and examined the association between air pollution and cardiac arrest.
Results: Exposure to air pollution was associated with an elevated risk of cardiac arrest
for example, odds ratios was 1.17 (95% confidence interval, 1.02 to 1.33) per interquartile-range increase in suspended particulate matter concentrations in the previous 48 to 72 hours. We also observed different susceptibilities to suspended particulate matter and ozone exposures by age category.

DOI： 10.1097/JOM.0000000000000274

Breastfeeding and behavioral development: a nationwide longitudinal survey in Japan. 査読

Yorifuji T, Kubo T, Yamakawa M, Kato T, Inoue S, Tokinobu A, Doi H

J Pediatr. 164 ( 5 ) 1019 - 1025 2014年5月

Correspondence to the Editor Re Maternal exposure to high levels of dioxins in relation to birth weight in women affected by Yusho disease 査読

Takashi Yorifuji, Saori Kashima, Eiji Yamamoto

ENVIRONMENT INTERNATIONAL 64 69 - 70 2014年3月

Minamata 査読

T. Yorifuji, T. Tsuda

Encyclopedia of Toxicology: Third Edition 340 - 344 2014年1月

担当区分：筆頭著者記述言語：英語掲載種別：論文集(書籍)内論文出版者・発行元：Elsevier

The history of Minamata disease is presented in chronological order (from the first outbreak to the current situation). The history of the disease provides us with invaluable lessons for future public health strategies. First, prompt countermeasures should be taken when a cause is identified and should not be postponed until an etiologic agent is identified. Second, lack of investigation obscures the features as well as the expansion of the disease and unnecessarily confuses the situation. Third, the womb is the environment. Finally, social circumstances can induce disease.

DOI： 10.1016/B978-0-12-386454-3.00038-5

Industrial distributions of severe occupational injuries among workers in Thailand. 査読国際誌

Michiyo Yamakawa, Pornchai Sithisarankul, Takashi Yorifuji, Sarunya Hengpraprom, Narin Hiransuthikul, Hiroyuki Doi, Soshi Takao

Journal of occupational health 55 ( 5 ) 415 - 21 2014年

記述言語：英語

BACKGROUND: In industrializing countries, occupational safety and health have been affected by globalization. However, a lack of reliable data prevents evaluation of this situation. Therefore, we examined industrial distributions and risks of severe occupational injuries among workers in Thailand, which is one of the few industrializing countries that compiles nationwide data. METHODS: Data on workers who made claims for occupational injuries from 2007 to 2009 were extracted from the Workmen's Compensation Fund records in Thailand. Among 501,334 claimants, we evaluated the industrial distributions of severe occupational injuries (i.e., permanent disability and death). We then examined the associations between industry and those injuries, using proportionate ratios (PRs) between each industrial category and the overall distribution of occupational injuries. RESULTS: The number of workers in manufacturing making claims for severe occupational injuries was the largest among all industrial categories (319,114/501,334 injuries), although the total number of occupational injuries recently declined. Additionally, workers in manufacturing experienced severe occupational injuries more often compared with the overall distribution of occupational injuries. The PRs (95% confidence interval) for manufacturing were 1.17 (1.14-1.20) in men and 1.33 (1.27-1.38) in women. After adjusting for individual characteristics, the results did not substantially change. CONCLUSIONS: Manufacturing seems to have the largest burden of occupational injuries in industrializing countries like Thailand.

DOI： 10.1539/joh.13-0085-fs

Cardiovascular emergency hospital visits and hourly changes in air pollution 査読

Takashi Yorifuji, Etsuji Suzuki, Saori Kashima

Stroke 45 ( 5 ) 1264 - 1268 2014年

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Lippincott Williams and Wilkins

BACKGROUND AND PURPOSE-: Few studies have examined the effect of hourly changes in air pollution on cardiovascular disease morbidity. We evaluated the associations between hourly changes in air pollution and the risks of several types of cardiovascular disease. METHODS-: We used a time-stratified case-crossover design. Study participants were 10 949 residents of the city of Okayama, Japan, aged ?65 years who were taken to hospital emergency rooms between January 2006 and December 2010 for onset of cardiovascular disease. We calculated city representative hourly average concentrations of air pollutants from several monitoring stations and examined the associations between air pollution exposure before the case event, focusing mainly on suspended particulate matter, and disease onset. RESULTS-: Suspended particulate matter exposure 0 to &lt
6 hours before the case events was associated with risks of onset of cardiovascular and cerebrovascular disease
odds ratios after 1 interquartile range increase in suspended particulate matter exposure were 1.04 (95% confidence interval, 1.01-1.06) for cardiovascular disease and 1.04 (95% confidence interval, 1.00-1.08) for cerebrovascular disease. We observed an elevated risk of hemorrhagic as well as ischemic stroke, but the risk was slightly higher for hemorrhagic stroke, and this elevation was persistent. Women tended to have higher effect estimates. CONCLUSIONS-: This study provides further evidence that particulate matter exposure increases the risks of onset of cardiovascular and cerebrovascular disease (including hemorrhagic stroke) shortly after exposure. © 2014 American Heart Association, Inc.

DOI： 10.1161/STROKEAHA.114.005227

Outdoor particulate matter exposure and lung cancer: A systematic review and meta-analysis 査読

Ghassan B. Hamra, Neela Guha, Aaron Cohen, Francine Laden, Ole Raaschou-Nielsen, Jonathan M. Samet, Paolo Vineis, Francesco Forastiere, Paulo Saldiva, Takashi Yorifuji, Dana Loomis

Environmental Health Perspectives 122 ( 9 ) 906 - 911 2014年

記述言語：英語出版者・発行元：Public Health Services, US Dept of Health and Human Services

Background: Particulate matter (PM) in outdoor air pollution was recently designated a Group I carcinogen by the International Agency for Research on Cancer (IARC). This determination was based on the evidence regarding the relationship of PM2.5 and PM10 to lung cancer risk
however, the IARC evaluation did not include a quantitative summary of the evidence. Objective: Our goal was to provide a systematic review and quantitative summary of the evidence regarding the relationship between PM and lung cancer. Methods: We conducted meta-analyses of studies examining the relationship of exposure to PM2.5 and PM10 with lung cancer incidence and mortality. In total, 18 studies met our inclusion criteria and provided the information necessary to estimate the change in lung cancer risk per 10-μg/m3 increase in exposure to PM. We used random-effects analyses to allow between-study variability to contribute to meta-estimates. Results: The meta-relative risk for lung cancer associated with PM2.5 was 1.09 (95% CI: 1.04, 1.14). The meta-relative risk of lung cancer associated with PM10 was similar, but less precise: 1.08 (95% CI: 1.00, 1.17). Estimates were robust to restriction to studies that considered potential confounders, as well as subanalyses by exposure assessment method. Analyses by smoking status showed that lung cancer risk associated with PM2.5 was greatest for former smokers [1.44 (95% CI: 1.04, 1.22)], followed by never-smokers [1.18 (95% CI: 1.00, 1.39)], and then current smokers [1.06 (95% CI: 0.97, 1.15)]. In addition, meta-estimates for adenocarcinoma associated with PM2.5 and PM10 were 1.40 (95% CI: 1.07, 1.83) and 1.29 (95% CI: 1.02, 1.63), respectively. Conclusion: The results of these analyses, and the decision of the IARC Working Group to classify PM and outdoor air pollution as carcinogenic (Group 1), further justify efforts to reduce exposures to air pollutants that can arise from many sources.

DOI： 10.1289/ehp.1408092

Social Cohesion and Mortality: A Survival Analysis of Older Adults in Japan 査読

Sachiko Inoue, Takashi Yorifuji, Soshi Takao, Hiroyuki Doi, Ichiro Kawachi

AMERICAN JOURNAL OF PUBLIC HEALTH 103 ( 12 ) E60 - E66 2013年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER PUBLIC HEALTH ASSOC INC

Objectives. We examined the association between social cohesion and mortality in a sample of older adults in Japan.
Methods. Data were derived from a cohort study of elderly individuals (65-84 years) in Shizuoka Prefecture; 14 001 participants were enrolled at baseline (1999) and followed up in 2002, 2006, and 2009. Among the 11 092 participants for whom we had complete data, 1427 had died during follow-up. We examined the association between social cohesion (assessed at both the community and individual levels) and subsequent mortality after control for baseline and time-varying covariates. We used clustered proportional hazard regression models to estimate hazard ratios (HRs) and confidence intervals (CIs).
Results. After control for individual characteristics, individual perceptions of community cohesion were associated with a reduced risk of all-cause mortality (HR = 0.78; 95% CI = 0.73, 0.84) as well as mortality from cardiovascular disease (HR = 0.75; 95% CI = 0.67, 0.84), pulmonary disease (HR = 0.66; 95% CI = 0.58, 0.75), and all other causes (HR = 0.76; 95% CI = 0.66, 0.89). However, no statistically significant relationship was found between community cohesion and mortality risk.
Conclusions. Among the elderly in Japan, more positive individual perceptions of community cohesion are associated with reduced risks of all-cause and cause-specific mortality.

DOI： 10.2105/AJPH.2013.301311

The carcinogenicity of outdoor air pollution.

Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H, Straif K, International Agency for, Research on Cancer Monograph Working, Group IARC

Lancet Oncol. 14 ( 13 ) 1262 - 1263 2013年12月

Associations of Preterm Births with Child Health and Development: Japanese Population-Based Study 査読

Tsuguhiko Kato, Takashi Yorifuji, Sachiko Inoue, Michiyo Yamakawa, Hiroyuki Doi, Ichiro Kawachi

JOURNAL OF PEDIATRICS 163 ( 6 ) 1578 - U98 2013年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MOSBY-ELSEVIER

Objective To examine associations between the duration of gestation and health and development outcomes at 2.5 years and 5.5 years using a Japanese population-based longitudinal survey (n = 47 015).
Study design Hospitalization was used as an indicator of physical health, and responses to questions about age-appropriate behaviors were used as an indicator of behavioral development. We conducted logistic regression analyses controlling for a set of neonatal and family factors. We also estimated population-attributable fractions.
Results We observed a steady increase toward shorter duration of gestation in the risk of hospitalizations at age 2.5 years and 5.5 years and developmental delays at 2.5 years (P-linear (trend) <.001 for all outcomes). We found associations only between extremely preterm birth and delayed behavioral development at age 5.5 years.
Conclusion There is a linear relationship between shorter duration of gestation and increased risk of later health and developmental problems. In line with Rose's "population paradox," the population-attributable risks for these problems are greater for moderately preterm infants compared with extremely preterm infants.

DOI： 10.1016/j.jpeds.2013.07.004

Who is at Risk of Inadequate Weight Gain During Pregnancy? Analysis by Occupational Status Among 15,020 Deliveries in a Regional Hospital in Japan 査読

Sachiko Inoue, Hiroo Naruse, Takashi Yorifuji, Takeshi Murakoshi, Hiroyuki Doi, Ichiro Kawachi

MATERNAL AND CHILD HEALTH JOURNAL 17 ( 10 ) 1888 - 1897 2013年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER/PLENUM PUBLISHERS

A lower bodyweight may be associated with adverse birth outcomes, such as low birth weight and being small for a given gestational age. In Japan, the rate of low birth weight has been increasing over the last two decades, such that both low pre-pregnancy weight and inadequate weight gain during pregnancy are viewed as critical issues in terms of the reproductive health of Japanese women. The aim of our study was to evaluate the relationship between socioeconomic status (SES) and inadequate weight gain during pregnancy. A cross-sectional, hospital-based study using data from a large hospital in Hamamatsu city, Japan, from 1997 to 2010 was conducted. Among a total of 21,855 deliveries, 15,020 participants were analyzed. Odds ratios and confidence intervals were estimated using a logistic regression model. We defined maternal occupational status as follows: home-maker married to a salaried-spouse, home-maker married to a self-employed spouse, home-maker married to a professional, all other home-makers, office worker, professional, and all other occupations. In the high SES groups (home-makers married to self-employed spouse and professional spouse, as well as office workers and professional workers), we found an association with inadequate weight gain during pregnancy, especially among underweight women. There was no association between SES and inadequate weight gain among normal-weight and overweight women. Japanese women from higher socioeconomic backgrounds appear to be at greater risk for inadequate weight gain. This result may contribute to enhancing prenatal education on pregnancy-related weight gain in Japan.

DOI： 10.1007/s10995-012-1213-6

Response to Fukuda et al.

R. Catalano, T. Yorifuji, I. Kawachi

American Journal of Human Biolog 25 ( 6 ) 860 - 860 2013年11月

Inhibitory Function and Working Memory in Attention Deficit/Hyperactivity Disorder and Pervasive Developmental Disorders: Does a Continuous Cognitive Gradient Explain ADHD and PDD Traits? 査読

Akihito Takeuchi, Tatsuya Ogino, Kaoru Hanafusa, Teruko Morooka, Makio Oka, Takashi Yorifuji, Yoko Ohtsuka

ACTA MEDICA OKAYAMA 67 ( 5 ) 293 - 303 2013年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

To clarify the relationship between attention deficit/hyperactivity disorder (AD/HD) and pervasive developmental disorders (PDD), we investigated the common features and differences of these disorders in neuropsychological profiles. The subjects were 4 groups of Japanese boys aged 6 to 15 years, categorized by diagnosis: AD/HD (n = 20), PDD with comorbid AD/HD (PDD+ : n = 16), PDD without comorbid AD/HD (PDD-: n = 8), and typically developing (n = 60). We evaluated executive function (EF) through verbal and visuospatial memory tasks, the Go/NoGo task, and the color-word matching Stroop task. We performed a categorical analysis to estimate the effects of the 3 disorders on EF and a dimensional analysis to estimate the effects of symptom scales on EF. We found that the AD/HD and PDD+ subjects had negative effects on verbal working memory and infra-individual response variability. The severity of these impairments was positively correlated with the inattentiveness score. The subjects with a PDD+ or PDD- diagnosis had poorer scores on interference control; the severity of this impairment was correlated with the PDD symptom score. Impairments in visuospatial working memory were detected in the AD/HD and PDD- groups but not in the PDD+ group. Impairments in inhibition of the pre-potent response were noted in all 3 categories. AD/HD and PDD share neuropsychological features, though each disorder has a specific impairment pattern. Our findings partially support the idea that AD/HD and PDD are on a spectrum.

Breastfeeding and obesity among schoolchildren: a nationwide longitudinal survey in Japan 査読国際誌

Yamakawa M, Yorifuji T, Inoue S, Kato T, Doi T

JAMA Pediatr 167 ( 10 ) 919 - 25 2013年10月

Regional impact of exposure to a polychlorinated biphenyl and polychlorinated dibenzofuran mixture from contaminated rice oil on stillbirth rate and secondary sex ratio 査読

Takashi Yorifuji, Saori Kashima, Akiko Tokinobu, Tsuguhiko Kato, Toshihide Tsuda

ENVIRONMENT INTERNATIONAL 59 12 - 15 2013年9月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Yusho disease, a polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF) mixed poisoning caused by contaminated rice oil, occurred in Japan in 1968. The evidence on reproductive outcome is limited. We therefore evaluated the regional impact of the exposure to the PCB and PCDF mixture on stillbirth rate and secondary sex ratio among the residents in two severely affected areas. We selected the regionally-affected towns of Tamanoura (n = 4390 in 1970) and Naru (n = 6569) in Nagasaki Prefecture, Japan, for study. We obtained data on stillbirths (spontaneous/artificial) and live-born births (total/male/female) from 1958 to 1994. For a decade and a half after the exposure, an increase in the rate of spontaneous stillbirths coincided with a decrease in the male sex ratio. Compared with the years 1958-1967, the ratios for spontaneous stillbirth rates were 2.16 (95% confidence interval: 1.58 to 2.97) for 1968-1977 and 1.80(95% confidence interval: 1.25 to 2.60) for 1978-1987. The sex ratio (male proportion) was 0.483 (95% confidence interval: 0.457 to 0.508) in the first 10 years after exposure. Exposure to a mixture of PCBs and PCDFs affected stillbirth and sex ratio for a decade and a half after the exposure. (C) 2013 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.envint.2013.05.002