研究者詳細 - 賴藤　貴志

論文 - 賴藤　貴志

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Characteristics of Abnormalities in Somatosensory Submodalities Observed in Residents Exposed to Methylmercury 査読

Takaoka S, Fujino T, Shigeoka SI, Yorifuji T

Toxics 11 ( 12 ) 1023 - 1023 2023年12月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Hundreds of thousands of people living along the Yatsushiro Sea coast have been exposed to methylmercury from the contaminated water of the Chisso factory in Minamata. The most common neurological disorder caused by methylmercury is somatosensory disturbance, but very few studies have been conducted in the world to determine its pathophysiology and origin, including the Japanese cases, which have produced numerous intoxicated individuals. We have already shown in previous studies the body part where the disorder occurs and that its cause is not peripheral nerve damage but damage to the parietal lobes of the cerebrum. We reanalyzed the results of subjective symptoms, neurological findings, and quantitative sensory measurements in 197 residents (63.2 ± 10.7 years old) from contaminated areas exposed to methylmercury from seafood and 130 residents (63.7 ± 9.3 years old) from control areas, the same subjects as in previous studies, to determine the characteristics of somatosensory disturbance in detail. The most commonly affected sensory modalities were superficial peripheral touch and pain in the extremities, followed by two-point discrimination and deep senses, and in the most severe cases, full-body sensory dysfunction and impairment of all sensory submodalities. The severity of sensory submodalities correlated with each other but not with peripheral nerve conduction test indices, further confirming the correctness of our assertion about the responsible foci of sensory disturbance. The health effects of chronic methylmercury toxicosis can be elucidated by a detailed examination of sensory deficits.

DOI： 10.3390/toxics11121023

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Obesity, overweight, and severe prognosis in COVID-19 patients in Japan. 査読

Kadowaki T, Matsumoto N, Matsuo R, Mitsuhashi T, Sasaki A, Takao S, Yorifuji T

J Infect Chemother. 29 ( 12 ) 1109 - 1113 2023年12月

Effect of stomach inflation during cardiopulmonary resuscitation on return of spontaneous circulation in out-of-hospital cardiac arrest patients: A retrospective observational study. 査読

Naito H, Hanafusa H, Hongo T, Yumoto T, Yorifuji T, Weissman A, Rittenberger JC, Guyette FX, Fujishima M, Maeyama H, Nakao A

Resuscitation. 109994 2023年12月

Fine Particulate Matter and Diabetes Prevalence in Okayama, Japan. 査読

Tani Y, Kashima S, Mitsuhashi T, Suzuki E, Takao S, Yorifuji T

Acta Med Okayama. 77 ( 6 ) 607 - 612 2023年12月

Review of a Series of Surveys on Adverse Reactions to the COVID-19 mRNA-1273 Vaccine at Okayama University. 査読

Matsumoto N, Higuchi C, Miyaji C, Mitsuhashi T, Hagiya H, Takao S, Yorifuji T

Acta medica Okayama 77 ( 6 ) 567 - 575 2023年12月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）

This paper presents the results of a series of surveys conducted from July 2021 to March 2023 to investigate the post-vaccination adverse reactions to the mRNA-1273 (Moderna) vaccine among faculty, staff, and students at Okayama University. These studies complement the official surveys conducted by the Ministry of Health, Labour and Welfare (MHLW) and provide a more representative picture of adverse reactions in the general population including large numbers of healthy young people. Pain, swelling, redness at the injection site, fever, headache, and malaise were the main adverse reactions reported. The proportion of adverse reactions was generally higher after the second vaccination and decreased with each additional vaccination. No statistically significant differences in the adverse reactions were found for males and females and those with/without a history of allergy, but a lower proportion of fever was observed in older participants and those with underlying medical conditions. We also evaluated the association between adverse reactions and antibody titers after the third vaccination and found no significant differences in antibody levels one month after vaccination. This series of studies highlights the importance of conducting surveys in diverse populations to provide a more representative picture of post-vaccination adverse reactions during a pandemic.

DOI： 10.18926/AMO/66148

PubMed

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Epidemiology and Reporting Characteristics of Systematic Reviews in Orthopedic Journals: A Meta-Epidemiological Study 査読

Yamamoto N, Taito S, Miura T, Ariie T, Tomita Y, Ogihara H, Shiratsuchi D, Yorifuji T, Tsujimoto Y

Journal of Clinical Medicine 12 ( 22 ) 7031 - 7031 2023年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Systematic reviews (SRs) with complete reporting or rigorous methods can lead to less biased recommendations and decisions. A comprehensive analysis of the epidemiological and reporting characteristics of SRs in orthopedics is lacking. We evaluated 360 SRs, including 165 and 195 published in orthopedic journals in 2012 and 2022. According to the established reporting guidelines, we examined these SRs for key epidemiological characteristics, including focus areas, type of meta-analysis (MA), and reporting characteristics. Most SRs (71%) were therapy-related, with a significant proportion originating from authors in the USA, UK, and China. Pairwise MA was performed on half of the SRs. The proportion of protocol registrations improved by 2022 but remained low (33%). Despite a formal declaration of adherence to the reporting guidelines (68%), they were often not used and reported enough. Only 10% of the studies used full search strategies, including trial registries. Publication bias assessments, subgroup analyses, and sensitivity analyses were not even planned. The risk of bias assessment improved in 2022; however, the certainty of the evidence remained largely unassessed (8%). The use and reporting of standard methods in orthopedic SRs have remained suboptimal. Thus, authors, peer reviewers, journal editors, and readers should criticize the results more.

DOI： 10.3390/jcm12227031

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Association between infant breastfeeding practices and timing of peak height velocity: A nationwide longitudinal survey in Japan. 査読

Higuchi Y, Matsumoto N, Fujiwara S, Ebuchi Y, Furujo M, Nakamura K, Kubo T, Yorifuji T

Pediatr Res. 94 ( 5 ) 1845 - 1854 2023年11月

Roles of Oxidative Injury and Nitric Oxide System Derangements in Kawasaki Disease Pathogenesis: A Systematic Review 査読

Tsuge M, Uda K, Eitoku T, Matsumoto N, Yorifuji T, Tsukahara H

Int J Mol Sci. 24 ( 20 ) 15450 - 15450 2023年10月

Effectiveness of the original COVID-19 vaccine in preventing COVID-19 exacerbations during the Omicron wave: A population-based study in Okayama, Japan. 査読

Matsumoto N, Mitsuhashi T, Matsuo R, Kadowaki T, Takao S, Yorifuji T

JMA J. 6 ( 4 ) 463 - 46 2023年10月

Participation in the Setouchi Triennale and the Health of Residents in Naoshima: A Cross-Sectional Study 査読

Habu H, Takao S, Miyaji C, Matsumoto N, Aoo K, Nishita Y, Tsuri M, Yorifuji T

Acta Med Okayama. 77 ( 5 ) 491 - 497 2023年10月

Does Participation in the Setouchi Triennale Foster Social Capital? : A Cross-Sectional Study 査読

Miyaji C, Takao S, Habu H, Matsumoto N, Aoo K, Nishita Y, Tsuri M, Yorifuji T

Acta Med Okayama. 77 ( 5 ) 443 - 449 2023年10月

Childcare and Child Development in Japan. 査読

Murata A, Matsumoto N, Miyaji C, Takao S, Yorifuji T

Acta Med Okayama. 77 ( 5 ) 479 - 490 2023年10月

Delivery room intubation and severe intraventricular hemorrhage in extremely preterm infants without low Apgar scores: A Japanese retrospective cohort study 査読

Kei Tamai, Naomi Matsumoto, Takashi Yorifuji, Akihito Takeuchi, Makoto Nakamura, Kazue Nakamura, Misao Kageyama

Scientific Reports 13 ( 1 ) 14990 - 14990 2023年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

The purpose of this study was to assess the associations between delivery room intubation (DRI) and severe intraventricular hemorrhage (IVH), as well as other neonatal outcomes, among extremely preterm infants without low Apgar scores using data from a large-scale neonatal registry data in Japan. We analyzed data for infants born at 24–27 gestational weeks between 2003 and 2019 in Japan using robust Poisson regression. Infants with low Apgar scores (≤ 1 at 1 min or ≤ 3 at 5 min) were excluded. The primary outcome was severe IVH. Secondary outcomes were other neonatal morbidities and mortality. The full cohort included 16,081 infants (intubation cohort, 13,367; no intubation cohort, 2714). The rate of DRI increased over time (78.6%, 2003–2008; 83.4%, 2009–2014; 87.8%, 2015–2019), while the rate of severe IVH decreased (7.1%, 2003–2008; 5.7%, 2009–2014; 5.3%, 2015–2019). Infants with DRI had a higher risk of severe IVH than those without DRI (6.8% vs. 2.3%; adjusted risk ratio, 1.86; 95% confidence interval, 1.33–2.58). The results did not change substantially when stratified by gestational age. Despite conflicting changes over time in DRI and severe IVH, DRI was associated with an increased risk of severe IVH among extremely preterm infants in Japan.

DOI： 10.1038/s41598-023-41010-x

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その他リンク： https://www.nature.com/articles/s41598-023-41010-x

Antibody Titers After a Third and Fourth SARS-CoV-2 Vaccine Dose in Bizen City, Japan 査読

Tomoka Kadowaki, Ayako Sasaki, Naomi Matsumoto, Toshiharu Mitsuhashi, Soshi Takao, Takashi Yorifuji

Journal of Epidemiology 33 ( 9 ) 484 - 486 2023年9月

Association between handwashing and gargling education for children and prevention of respiratory tract infections: a longitudinal Japanese children population-based study. 査読

Uraguchi K, Mitsuhashi T, Matsumoto N, Takao S, Makihara S, Ando M, Yorifuji T

Eur J Pediatr. 182 ( 9 ) 4037 - 4047 2023年9月

A population-based longitudinal study on glycated hemoglobin levels and new-onset chronic kidney disease among non-diabetic Japanese adults 査読

Yukari Okawa, Etsuji Suzuki, Toshiharu Mitsuhashi, Toshihide Tsuda, Takashi Yorifuji

Scientific Reports 13 ( 1 ) 13770 - 13770 2023年8月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Chronic kidney disease (CKD) is a major global public health problem. Recent studies reported that diabetes and prediabetes are risk factors for developing CKD; however, the exact glycated hemoglobin (HbA1c) cut-off value for prediabetes remains controversial. In this study, we aimed to examine the relationship between HbA1c levels and subsequent CKD development in greater detail than previous studies. Longitudinal data of annual checkups of 7176 Japanese non-diabetic people (male: 40.4%) from 1998 to 2022 was analyzed. HbA1c values were categorized into < 5.0%, 5.0–5.4%, 5.5–5.9%, and 6.0–6.4%. CKD was defined as an estimated glomerular filtration rate < 60 ml/min/1.73 m². The descriptive statistics at study entry showed that higher HbA1c values were associated with male, older, overweight or obese, hypertensive, or dyslipidemic people. During a mean follow-up of 7.75 person-years, 2374 participants (male: 40.0%) developed CKD. The Weibull accelerated failure time model was selected because the proportional hazards assumption was violated. The adjusted time ratios of developing CKD for HbA1c levels of 5.5–5.9% and 6.0–6.4% compared with 5.0–5.4% were 0.97 (95% confidence interval: 0.92–1.03) and 1.01 (95% confidence interval: 0.90–1.13), respectively. There was no association between HbA1c in the prediabetic range and subsequent CKD development.

DOI： 10.1038/s41598-023-40300-8

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その他リンク： https://www.nature.com/articles/s41598-023-40300-8

Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan 査読

Kataoka Takahiro, Habu Hiroshi, Tanaka Ayumi, Naoe Shota, Murakami Kaito, Fujimoto Yuki, Yukimine Ryohei, Takao Soshi, Mitsunobu Fumihiro, Yorifuji Takashi, Yamaoka Kiyonori

Acta Med Okayama. 77 ( 4 ) 387 - 394 2023年8月

Effect of 2-week postpartum check-ups on screening positive for postpartum depression: a population-based cohort study using instrumental variable estimation in Japan. 査読

Nakamura N, Mitsuhashi T, Nakashima Y, Matsumoto N, Yorifuji T

Fam Pract. cmad074 2023年7月

Longitudinal impact of the COVID-19 pandemic on the development of mental disorders in preadolescents and adolescents 査読

Matsumoto N, Kadowaki T, Takanaga S, Shigeyasu Y, Okada A, Yorifuji T

BMC Public Health 23 ( 1 ) 1308 - 1308 2023年7月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Background

School closures and social distancing may have affected mental health among preadolescent and adolescent children, who are in a social developmental stage. Rates of anxiety, depression, and stress have been reported to have increased during the COVID-19 pandemic among teenagers worldwide. However, most studies have measured children's mental health in cross-sectional studies or short-term comparisons before and after lockdowns and school closures, and few studies have tracked the long-term effects on mental health among children and adolescents, despite the pandemic lasting more than 2 years.

Methods

An interrupted time-series analysis was performed for longitudinal changes in the monthly number of new mental disorders (eating disorders, schizophrenia, mood disorders, and somatoform disorders). Using a nationwide multicenter electronic health records database in Japan, we analyzed data of patients aged 9 to 18 years from 45 facilities that provided complete data throughout the study period. The study period covered January 2017 to May 2021, defining a national school closure as an intervention event. We modeled the monthly new diagnoses of each mental disorder using a segmented Poisson regression model.

Results

The number of new diagnoses throughout the study period was 362 for eating disorders, 1104 for schizophrenia, 926 for mood disorders, and 1836 for somatoform disorders. The slope of the regression line in monthly number of new diagnoses increased in the post-pandemic period for all targeted mental disorders (change in slope for eating disorders 1.05, 95% confidence interval [CI] 1.00–1.11; schizophrenia 1.04, 95% CI 1.01–1.07; mood disorders 1.04, 95% CI 1.01–1.07; and somatoform disorders 1.04 95% CI 1.02–1.07). The number of new diagnoses for schizophrenia and mood disorders increased early after school closure; while eating disorders showed an increasing trend several months later. Somatoform disorders showed a decreasing trend followed by an increasing trend. Time trends by sex and age also differed for each mental disorder.

Conclusions

In the post-pandemic period, the number of new cases increased over time for eating disorders, schizophrenia, mood disorders, and somatoform disorders. The timing of increase and trends by sex and age differed for each mental disorder.

DOI： 10.1186/s12889-023-16228-z

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その他リンク： https://link.springer.com/article/10.1186/s12889-023-16228-z/fulltext.html

Efficacy of telerehabilitation for patients after hip fracture surgery: A systematic review and meta-analysis. 査読

Tsuge T, Yamamoto N, Taito S, Miura T, Shiratsuchi D, Yorifuji T

J Telemed Telecare. 1357633X231181632 2023年7月

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