Faculty Profiles - NISHIDA Keiichiro

Papers - NISHIDA Keiichiro

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Safety and effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: Up to 3-year results from a postmarketing surveillance study

Hideto Kameda, Keiichiro Nishida, Toshihiro Nanki, Akira Watanabe, Yukiya Oshima, Shigeki Momohara

Modern Rheumatology 34 ( 6 ) 1103 - 1114 2024.3

Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

ABSTRACT

Objectives

To report up to 3-year safety and effectiveness of certolizumab pegol (CZP) in Japanese patients with rheumatoid arthritis from a postmarketing surveillance study.

Methods

Patients enrolled previously completed 24 weeks of CZP in the 24-week postmarketing surveillance study. Adverse drug reactions (ADRs) were recorded for patients who received ≥1 CZP dose. Effectiveness outcomes were 28-joint Disease Activity Score with erythrocyte sedimentation rate and European Alliance of Associations for Rheumatology response. Week 24–156 safety and Week 0–52 effectiveness data are reported here.

Results

A total of 781 patients were enrolled, with 735 and 376 patients evaluated for safety and effectiveness, respectively. Within the safety set, 17.8% (131/735) of patients reported ADRs; 9.4% (69/735) reported serious ADRs. Among patients with history of respiratory, thoracic, and mediastinal disorders, 38.4% (28/73) reported ADRs. The most frequent ADRs were infections and infestations (11.8%; 87/735); skin and subcutaneous tissue disorders (1.9%; 14/735); respiratory, thoracic, and mediastinal disorders (1.6%; 12/735). Mean 28-joint Disease Activity Score with erythrocyte sedimentation rate reduced from 4.6 (Week 0) to 2.8 (Week 52). At Week 52, 51.8% (161/311) of patients achieved European Alliance of Associations for Rheumatology Good response.

Conclusions

The long-term safety and effectiveness of CZP in the real-world setting in Japan were consistent with previously reported data; no new safety signals were identified.

DOI： 10.1093/mr/roae019

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Other Link： https://academic.oup.com/mr/article-pdf/34/6/1103/60153600/roae019.pdf

リウマチ性疾患の手術(休薬・合併症・その他) 関節リウマチの整形外科手術において,周術期の休薬は非休薬に比べて術後合併症を増やすか

伊藤宣, 石川肇, 辻成佳, 中山政憲, 西田圭一郎, 望月猛, 蛯名耕介, 小嶋俊久, 松本卓巳, 窪田綾子, 中島新, 金子敦史, 松下功, 原良太, 櫻庭康司, 赤崎幸穂, 松原司, 持田勇一, 神戸克明, 桃原茂樹

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 645 - 645 2024.3

非転位型の橈骨遠位端骨折において骨折部位,Lister結節形状は長母指伸筋腱断裂に影響する

斎藤太一, 近藤秀則, 古谷友希, 中道亮, 島村安則, 西田圭一郎, 今谷潤也, 尾崎敏文

日本整形外科学会雑誌 98 ( 3 ) S781 - S781 2024.3

人工膝関節置換術後の関節リウマチ患者における生物学的製剤・JAK阻害剤使用とD-dimer値の関係

志水紀之, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 846 - 846 2024.3

自動統計のための日本語大規模言語モデルを用いたカルテサマリーからの情報抽出

中原龍一, 西田圭一郎, 那須義久, 原田遼三, 浪花崇一, 志水紀之, 市川千夏, 高橋康, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 714 - 714 2024.3

リウマチ性疾患の手術(上肢) 関節リウマチに対するMCP人工関節置換術と手関節・手指伸筋腱同時手術症例の検討

市川千夏, 西田圭一郎, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 532 - 532 2024.3

リウマチ性疾患の手術(上肢) AVANTAとINTEGRAを用いたMCP人工指関節置換術の術後短期成績の比較

浪花崇一, 市川千夏, 志水紀之, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 532 - 532 2024.3

Consensus statement on the management of late-onset rheumatoid arthritis

Masayo Kojima, Takahiko Sugihara, Yutaka Kawahito, Toshihisa Kojima, Yuko Kaneko, Hajime Ishikawa, Asami Abe, Kazuo Matsui, Shintaro Hirata, Mitsumasa Kishimoto, Eiichi Tanaka, Akio Morinobu, Motomu Hashimoto, Isao Matsushita, Toshihiko Hidaka, Toshihiro Matsui, Keiichiro Nishida, Shuji Asai, Hiromu Ito, Ryozo Harada, Masayoshi Harigai

Modern Rheumatology 34 ( 6 ) 1095 - 1102 2024.2

Publishing type：Research paper (scientific journal) Publisher：Oxford University Press (OUP)

ABSTRACT

Objectives

Late-onset rheumatoid arthritis (LORA), which has been increasing in recent years, lacks evidence for initial treatment. Japanese rheumatology experts recognized this gap and addressed it by developing consensus statements on the first clinical application of LORA.

Methods

These statements were created following an introductory discussion about treatment fundamentals, which included a review of existing literature and cohort data. The steering committee created a draft, which was refined using a modified Delphi method that involved panel members reaching a consensus. The panel made decisions based on input from geriatric experts, clinical epidemiologists, guideline developers, patient groups, and the LORA Research Subcommittee of the Japan College of Rheumatology.

Results

The consensus identified four established facts, three basic approaches, and six expert opinions for managing LORA. Methotrexate was recommended as the primary treatment, with molecular-targeted agents being considered if treatment goals cannot be achieved. An emphasis was placed on assessing the lives of older patients due to challenges in risk management and methotrexate accessibility caused by comorbidities or cognitive decline.

Conclusions

The experts substantiated and refined 13 statements for the initial treatment of LORA. To validate these claims, the next is to conduct a registry study focusing on new LORA cases.

DOI： 10.1093/mr/roae011

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Other Link： https://academic.oup.com/mr/article-pdf/34/6/1095/60153479/roae011.pdf

High Fracture Rate of AVANTA Silicone Implant Following Arthroplasty of the Thumb MCP Joint of Rheumatoid Arthritis Patients with Boutonniere Deformities. Reviewed

Daisuke Kaneda, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Ryozo Harada, Yoshifumi Hotta, Shuichi Naniwa, Toshifumi Ozaki

Acta medica Okayama 78 ( 1 ) 71 - 78 2024.2

Language：English Publishing type：Research paper (scientific journal)

We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute.

DOI： 10.18926/AMO/66673

PubMed

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Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes Reviewed

Yoshifumi Hotta, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Shuichi Naniwa, Noriyuki Shimizu, Chinatsu Ichikawa, Deting Lin, Tomohiro Fujiwara, Toshifumi Ozaki

International Journal of Molecular Sciences 2024.1

Intra-Articular Corrective Osteotomy for Distal Radial Intra-Articular Malunion Using Patient-Matched Instruments: A Prospective, Multicenter, Open-Label, Single-Arm Trial. Reviewed International journal

Kunihiro Oka, Satoshi Miyamura, Ryoya Shiode, Hiroyuki Tanaka, Norimasa Iwasaki, Daisuke Kawamura, Kazuki Sato, Takuji Iwamoto, Michiro Yamamoto, Keiichiro Nishida, Yasunori Shimamura, Tomomi Yamada, Seiji Okada, Tsuyoshi Murase

JB & JS open access 9 ( 3 ) e24 2024

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Corrective osteotomy for intra-articular malunion is a challenging procedure. However, recent advancements, including patient-matched instruments created on the basis of preoperative computer simulation, enable accurate intra-articular correction. We hypothesized that intra-articular corrective osteotomy using patient-matched instruments for the treatment of distal radial intra-articular malunion would reduce intra-articular deformity and restore wrist function at 12 months of follow-up. METHODS: This prospective study included 12 patients with distal radial intra-articular malunion who underwent intra-articular corrective osteotomy external to the joint using patient-matched instruments. The primary end point was the maximum step-off on the articular surface of the distal radius, measured with use of computed tomography (CT), with an expected postoperative value of ≤1.5 mm. The secondary end points included the gap of the articular surface; range of motion; grip strength; pain evaluated using a visual analog scale (VAS); patient satisfaction; Disabilities of the Arm, Shoulder and Hand (DASH) score; and Patient-Rated Wrist Evaluation (PRWE) score. A mean postoperative step-off of ≤1.5 mm for the primary end point was assessed with use of the 1-sample t test. The secondary end points were assessed with use of the Dunnett multiple comparison test. RESULTS: The average step-off significantly improved from 3.75 ± 1.04 mm preoperatively to 0.51 ± 0.40 mm at the 52-week postoperative follow-up and was maintained within 1.5 mm. The average wrist and forearm range of motion, VAS score, grip strength, DASH score, and PRWE score significantly improved. Eleven patients were either very satisfied or satisfied with their outcomes. CONCLUSIONS: The use of patient-matched instruments could contribute to improving postoperative outcomes of intra-articular corrective osteotomy procedures involving the distal radius. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

DOI： 10.2106/JBJS.OA.24.00026

PubMed

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A preliminary survey of rheumatologists on the management of late-onset rheumatoid arthritis in Japan

Satoshi Takanashi, Yuko Kaneko, Yutaka Kawahito, Takashi Kida, Takahiko Sugihara, Toshihisa Kojima, Ryozo Harada, Michinori Ishitoku, Shintaro Hirata, Motomu Hashimoto, Toshihiko Hidaka, Asami Abe, Hajime Ishikawa, Hiromu Ito, Mitsumasa Kishimoto, Kazuo Matsui, Toshihiro Matsui, Isao Matsushita, Akira Onishi, Akio Morinobu, Keiichiro Nishida, Shuji Asai, Eiichi Tanaka, Masayoshi Harigai, Masayo Kojima

Internal Medicine 2024

最適な治療を目指した周術期管理 JAK阻害剤

西田圭一郎, 市川千夏, 那須義久, 中原龍一, 原田遼三, 浪花崇一, 志水紀之, 林徳てい, 大塚憲昭

関節の外科 51 ( 2 ) 40 - 40 2024

関節リウマチ患者における人工関節置換術のリスクファクターの検討

志水紀之, 大塚憲昭, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

関節の外科 51 ( 2 ) 70 - 70 2024

Unlinked TEAを第一選択とする治療戦略

那須義久, 西田圭一郎, 中原龍一, 大塚憲昭, 市川千夏, 志水紀之, 浪花崇一, 尾崎敏文

関節の外科 51 ( 2 ) 51 - 51 2024

前方及び後方アプローチを併用した尺骨鉤状突起および肘頭骨折を伴う肘関節脱臼開放骨折の1例

古谷友希, 齋藤太一, 中道亮, 島村安則, 西田圭一郎, 尾崎敏文

日本肘関節学会雑誌 31 ( 1 ) S84 - S84 2024

The Effectiveness of Rehabilitation after Open Surgical Release for Trigger Finger: A Prospective, Randomized, Controlled Study Reviewed

Taichi Saito, Ryo Nakamichi, Ryuichi Nakahara, Keiichiro Nishida, Toshifumi Ozaki

Journal of Clinical Medicine 12 ( 22 ) 7187 - 7187 2023.11

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Background: It is not clear whether rehabilitation after surgery for trigger finger is effective. The aim of this study was to reveal its effectiveness for trigger finger. Methods: This study was a randomized, controlled trial that included patients who underwent operations for trigger fingers. The patients in the rehabilitation group had postoperative occupational therapy (OT) for 3 months, while the patients in the control group were not referred for rehabilitation but received advice for a range of motion exercises. We evaluated the severity of trigger finger, Disability of Arm-Shoulder-Hand (DASH) score, pain-visual analogue scale (VAS), grip strength, whether they gained a full range of motion (ROM), and complications before and after surgery. Results: Finally, 29 and 28 patients were included in the control and rehabilitation groups, respectively. At final follow-up, the DASH score, grip strength, and ROM were significantly improved in the rehabilitation group compared to that preoperatively. At final follow-up, pain was significantly improved in both groups from that preoperatively. There were no significant differences in the results, including the DASH score, grip strength, ROM and pain-VAS between the control and rehabilitation groups at the final follow-up. Subgroup analysis showed that there is a significant difference in the DASH score of patients doing housework or light work and those with a duration of symptoms >12 months between the control and rehabilitation groups at the final follow-up.

DOI： 10.3390/jcm12227187

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ChatGTP と paper mills

西田圭一郎

整形外科 74 ( 11 ) 1168 - 1168 2023.11

変形性関節症の画像診断，バイオマーカーのトピックス

西田圭一郎

関節外科 42 ( 10 ) 16 - 22 2023.10

関節リウマチ患者の整形外科手術における手術部位感染，創傷治癒遅延の治療と生物学的製剤使用の関係

浪花崇一, 那須義久, 西田圭一郎

別冊整形外科 1 ( 84 ) 149-153 2023.10

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