Faculty Profiles - NISHIDA Keiichiro

Papers - NISHIDA Keiichiro

Division display 261 - 280 of about 642 ／ All the affair displays >>

関節リウマチの滑膜細胞増殖におけるADAM12の役割とmiRNA-29bによる制御

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 大橋秀基, 木曽洋平, 沖田駿治, 松橋美波, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1740 - S1740 2019.9

腱骨接合部の恒常性におけるメカニカルストレスの影響

斎藤太一, 根津智史, 松橋美波, 吉田晶, 島村安則, 古松毅之, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1693 - S1693 2019.9

軟骨細胞によるIL-1β誘導性蛋白分解酵素発現に対する脂肪由来抽出液の影響とその機序

大橋秀基, 西田圭一郎, 佐伯正典, 那須義久, 中原龍一, 木曽洋平, 渡辺雅仁, 松橋美波, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1933 - S1933 2019.9

関節リウマチモデルマウスを用いたCD30阻害療法の検討

松橋美波, 西田圭一郎, 渡辺雅仁, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1850 - S1850 2019.9

RA 手のリハビリテーション

松山宜之, 中原龍一, 那須義久, 西田圭一郎

臨床リウマチ 31 ( 3 ) 259 - 265 2019.9

Tuberosity-overlapping Fixation of the Humeral Shaft in Humeral Head Replacement Surgery.

Takaaki Hiranaka, Keiichiro Nishida, Taizo Konishiike, Toshifumi Ozaki, Motohiko Mikasa

Acta medica Okayama 73 ( 4 ) 299 - 305 2019.8

Language：English Publishing type：Research paper (scientific journal)

The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable.

DOI： 10.18926/AMO/56931

PubMed

researchmap

リウマチ肘における手術適応、手術法と将来展望 Unlinked TEAの利点と限界

那須義久, 松橋美波, 渡辺雅仁, 木曽洋平, 中原龍一, 西田圭一郎, 尾崎敏文

関節の外科 46 ( 2 ) 51 - 51 2019.8

リウマチ肩関節外科の現状と将来展望解剖学的人工肩関節全置換術

西田圭一郎, 那須義久, 中原龍一, 尾崎敏文

関節の外科 46 ( 2 ) 40 - 40 2019.8

Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions. Reviewed International journal

Horita M, Nishida K, Hasei J, Furumatsu T, Sakurai M, Onodera Y, Fukuda K, Salter DM, Ozaki T

Calcified tissue international 105 ( 1 ) 97 - 106 2019.7

Language：English Publishing type：Research paper (scientific journal)

A disintegrin and metalloproteinase 12 (ADAM12) is known to be involved in chondrocyte proliferation and maturation; however, the mechanisms are not fully understood. In this study, expression and localization of ADAM12 during chondrocyte differentiation were examined in the mouse growth plate by immunohistochemistry. Adam12 expression during ATDC5 chondrogenic differentiation was examined by real-time PCR and compared with the expression pattern of type X collagen. The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system was used to generate Adam12-knockout (KO) ATDC5 cells. Adam12-KO and Adam12 overexpressing cells were used for analyses of ADAM12 expression with or without TGF-β1 stimulation. ADAM12 was identified predominantly in chondrocytes of the proliferative zone in mouse growth plates by immunohistochemistry. Adam12 was upregulated prior to Col10a1 during chondrogenic differentiation in wild-type ATDC5 cells. In Adam12-KO ATDC5 cells, following initiation of chondrogenic differentiation, we observed a reduction in Igf-1 expression along with an upregulation of hypertrophy-associated Runx2, Col10a1, and type X collagen protein expressions. In ATDC5 wild-type cells, stimulation with TGF-β1 upregulated the expressions of Adam12 and Igf-1 and downregulated the expression of Runx2. In contrast, in Adam12-KO ATDC5 cells, these TGF-β1-induced changes were suppressed. Adam12 overexpression resulted in an upregulation of Igf-1 and downregulation of Runx2 expression in ATDC5 cells. The findings suggest that ADAM12 has important role in the regulation of chondrocyte differentiation, potentially by regulation of TGF-β1-dependent signaling and that targeting of ADAM12 may have a role in management of abnormal chondrocyte differentiation.

DOI： 10.1007/s00223-019-00549-6

PubMed

researchmap

半月板からみた早期OAの予防と進行抑制

古松毅之, 西田圭一郎, 尾崎敏文

日本関節病学会誌 38 ( 2 ) 85 - 90 2019.7

慢性腰痛に対する「本音の」治療戦略慢性腰痛に対する集学的アプローチ

鉄永倫子, 西田圭一郎, 鉄永智紀, 井上真一郎, 太田晴之, 大倉和代, 宮本和子, 尾崎敏文

PAIN RESEARCH 34 ( 2 ) 120 - 120 2019.7

Prevalence of and Risk Factors for the Progression of Upper Cervical Lesions in Patients with Rheumatoid Arthritis.

Masahiro Horita, Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Sugimoto, Yoshihisa Nasu, Ryuichi Nakahara, Ryozo Harada, Toshifumi Ozaki

Acta medica Okayama 73 ( 3 ) 235 - 240 2019.6

Language：English Publishing type：Research paper (scientific journal)

We investigated the prevalence of and risk factors for the progression of upper cervical lesions (UCLs) in patients with rheumatoid arthritis (RA). A retrospective analysis of 49 patients with RA (4 males, 45 females) was conducted. The UCLs included atlanto-axial subluxation and vertical subluxation. We investigated the clinical factors including the Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) and the modified Health Assessment Questionnaire-Disability Index as well as radiographic changes between the baseline (at May 2010 to April 2013) and final follow-up. Forty patients (81.6%) were classified as the non-progressive group, and the other 9 patients (18.4%) comprised the progressive group. The progressive group's final CRP values, baseline or final MMP-3 levels, DAS28-CRP, and rate of pre-existing lesions at baseline were all significantly higher than those of the non-progressive group (p=0.017, p=0.043, p=0.002, p=0.008, p<0.001, and p=0.008 respectively). A multivariate logistic regression analysis demonstrated that DAS28-CRP at baseline was a risk factor for radiographic progression (p=0.018, odds ratio: 2.54, 95% confidence interval: 1.17-5.51). Our findings indicate that higher disease activity might influence the progression of UCLs in patients with RA.

DOI： 10.18926/AMO/56866

PubMed

researchmap

当院における人工肘関節置換術後の可動域訓練プログラム

松山宜之, 那須義久, 中原龍, 西田圭一郎, 尾崎敏文

運動器リハビリテーション 30 ( 2 ) 204 - 204 2019.6

慢性疼痛患者の集学的治療における活動能力の経時的変動と特徴に関する基礎的検討

太田晴之, 齋藤圭介, 鉄永倫子, 堅山佳美, 西田圭一郎, 千田益生, 尾崎敏文

運動器リハビリテーション 30 ( 2 ) 216 - 216 2019.6

Rasch分析を用いたRA患者における上肢機能評価の検討

原田遼三, 西田圭一郎, 那須義久, 中原龍一

運動器リハビリテーション 30 ( 2 ) 238 - 238 2019.6

ビスフォスフォネート製剤長期服用者に生じた尺骨非定型骨折の4例

沖田駿治, 斉藤太一, 松橋美波, 横尾賢, 望月雄介, 兼田大輔, 山本乃利男, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 36 ( 1 ) O23 - 6 2019.4

日本外傷データバンクからみる近年の日本における上肢切断に対する治療の傾向

斎藤太一, 沖田駿治, 松橋美波, 山川泰明, 湯本哲也, 島村安則, 西田圭一郎, 中尾篤典, 尾崎敏文

日本手外科学会雑誌 36 ( 1 ) O22 - 1 2019.4

関節リウマチに対する小指MP人工指関節置換術の治療成績

松橋美波, 那須義久, 木曽洋平, 斎藤太一, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 36 ( 1 ) O34 - 3 2019.4

その他の医原性免疫不全関連リンパ増殖性疾患

佐藤康晴, 祇園由佳, 西田圭一郎, 吉野正

病理と臨床 37 ( 4 ) 360 - 363 2019.4

サルコイドーシスの手指関節病変に対して外科的治療を行った2例

松橋美波, 那須義久, 中原龍一, 西田圭一郎

岡山医学会雑誌 131 ( 1 ) 61 - 61 2019.4

　 PREV - NEXT 　

< NISHIDA Keiichiro >

Papers - NISHIDA Keiichiro