Faculty Profiles - NISHIDA Keiichiro

Papers - NISHIDA Keiichiro

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Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study. International journal

Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Haruo Misawa, Tomoyuki Takigawa, Kentaro Yamane, Hironori Tsuji, Yoshitaka Takei, Toshifumi Ozaki

Journal of orthopaedic surgery and research 15 ( 1 ) 191 - 191 2020.5

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Mirogabalin, which is approved for the treatment of peripheral neuropathic pain in Japan, is a ligand for the α2δ subunit of voltage-gated calcium channels. Both pregabalin and mirogabalin act as nonselective ligands at the α2δ-1 and α2δ-2 subunits. Mirogabalin has a unique binding profile and long duration of action. Pregabalin has been reported to produce intolerable adverse effects in some patients. This study investigated outcomes associated with mirogabalin administration in patients with peripheral neuropathic pain who ceased treatment with pregabalin. METHODS: We retrospectively assessed peripheral neuropathic pain using the neuropathic pain screening questionnaire (NeP score) in 187 patients (58 men, 129 women) who were treated with mirogabalin. All patients had switched from pregabalin to mirogabalin due to lack of efficacy or adverse events. Differences in the treatment course (i.e., numeric rating scale (NRS) scores) were compared using one-way analysis of variance with Bonferroni post hoc tests. RESULTS: The mean age of the patients was 72.3 years (range, 30-94 years), and the mean duration of disease was 37 months (range, 3-252 months). After treatment with mirogabalin for 1 week, NRS scores significantly decreased compared with baseline and continued to decrease over time. After 8 weeks, NRS scores improved by ≥ 30% from baseline in 113 patients (69.3%). Twenty-four patients (12.8%) stopped mirogabalin treatment due to adverse events. Somnolence (26.7%), dizziness (12.3%), edema (5.9%), and weight gain (0.5%) were noted as adverse events of mirogabalin. CONCLUSIONS: The results of this investigation indicate that mirogabalin is safe and effective for reducing peripheral neuropathic pain.

DOI： 10.1186/s13018-020-01709-3

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TEA後に許容される運動と実態調査

橋詰謙三, 西田圭一郎

整形・災害外科 63 ( 6 ) 817 - 824 2020.5

Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. Reviewed International journal

Takashi Ohtsuki, Omer F Hatipoglu, Keiichi Asano, Junko Inagaki, Keiichiro Nishida, Satoshi Hirohata

International journal of molecular sciences 21 ( 9 ) 2020.4

Language：English Publishing type：Research paper (scientific journal)

In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1β (IL-1β) stimulation in chondrocytic cells. We also observed that ERK activation and NF-κB nuclear translocation were involved in the induction of CEMIP by IL-1β. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1β-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.

DOI： 10.3390/ijms21093140

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関節リウマチによる高度拘縮肘に対するPROSNAP人工肘の使用経験

那須義久, 中原龍一, 松橋美波, 渡辺雅仁, 木曽洋平, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 32 ( 1 ) 184 - 184 2020.4

超音波ガイド下関節穿刺が診断治療に有用であった股関節偽痛風の2例

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 尾崎敏文, 原田遼三

中国・四国整形外科学会雑誌 32 ( 1 ) 1 - 7 2020.4

Language：Japanese Publisher：中国・四国整形外科学会

症例1は93歳女性で、右膝痛による体動困難を主訴とした。CT、超音波で右股関節包内前方に水腫と石灰化像を認め、超音波ガイド下に股関節穿刺吸引を施行した。関節液の検査結果は比重1.015、尿酸結晶(-)、CPPD結晶(+)、細胞数46325/μL(分画:Stab1%、Seg85%、Mono13%、Lymph1%)、糖77mg/dL、塗抹菌体(-)であり、股関節偽痛風と診断した。穿刺の際にキシロカインを投与し、症状が速やかに改善した。症例2は81歳女性で、誘因のない右股関節痛を主訴とした。CT、超音波で右股関節包内前方に水腫と石灰化像を認め、超音波ガイド下に股関節穿刺吸引を施行した。関節液の検査結果は比重1.020、尿酸結晶(-)、CPPD結晶(+)、細胞数20800/μL(分画:Stab0%、Seg82%、Mono13%、Lymph8%)、糖155mg/dL、塗抹菌体(-)であり、股関節偽痛風と診断した。穿刺の際にキシロカインを投与し、症状が速やかに改善した。以後、2例とも疼痛の再燃を認めなかった。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J02438&link_issn=&doc_id=20200602230001&doc_link_id=%2Fcm4ortho%2F2020%2F003201%2F001%2F0001-0007%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcm4ortho%2F2020%2F003201%2F001%2F0001-0007%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

橈骨遠位端骨折プレート橈骨遠位端骨折に対するDVRを使用した手術治療

島村安則, 斎藤太一, 西田圭一郎, 尾崎敏文, 近藤秀則, 森谷史郎, 今谷潤也

日本手外科学会雑誌 36 ( 6 ) 1068 - 1068 2020.4

舟状骨偽関節に対する低侵襲治療の術後成績

堀田佳史, 斎藤太一, 根津智史, 松橋美波, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 37 ( 1 ) O18 - 1 2020.4

外傷性母指ボタン穴変形に対し手術加療を行った2例

沖田駿治, 福田祥二, 門田康孝, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 37 ( 1 ) P48 - 2 2020.4

尺骨末端切除術(Darrach法)後に手指伸筋腱再断裂を生じた1例

那須義久, 大橋基秀, 木曽洋平, 沖田駿治, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

岡山医学会雑誌 132 ( 1 ) 48 - 48 2020.4

Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs? International journal

Hiromu Ito, Shigeyoshi Tsuji, Masanori Nakayama, Yuichi Mochida, Keiichiro Nishida, Hajime Ishikawa, Toshihisa Kojima, Takumi Matsumoto, Ayako Kubota, Takeshi Mochizuki, Koji Sakuraba, Isao Matsushita, Arata Nakajima, Ryota Hara, Akihisa Haraguchi, Tsukasa Matsubara, Katsuaki Kanbe, Natsuko Nakagawa, Masahide Hamaguchi, Shigeki Momohara

The Journal of Rheumatology 47 ( 4 ) 502 - 509 2020.4

Language：English Publishing type：Research paper (scientific journal) Publisher：The Journal of Rheumatology

<sec><title>Objective.</title>To investigate whether abatacept (ABA) causes more adverse events (AE) than conventional synthetic disease-modifying antirheumatic drugs (csDMARD) after orthopedic surgery in patients with rheumatoid arthritis (RA).

</sec><sec><title>Methods.</title>A retrospective multicenter nested case–control study was performed in 18 institutions. Patients receiving ABA (ABA group) were matched individually with patients receiving csDMARD and/or steroids (control group). Postoperative AE included surgical site infection, delayed wound healing, deep vein thrombosis or pulmonary embolism, flare, and death. The incidence rates of the AE in both groups were compared with the Mantel-Haenszel test. Risk factors for AE were analyzed by logistic regression model.

</sec><sec><title>Results.</title>A total of 3358 cases were collected. After inclusion and exclusion, 2651 patients were selected for matching, and 194 patients in 97 pairs were chosen for subsequent comparative analyses between the ABA and control groups. No between-group differences were detected in the incidence rates of each AE or in the incidence rates of total AE (control vs ABA: 15.5% vs 20.7% in total, 5.2% vs 3.1% in death).

</sec><sec><title>Conclusion.</title>Compared with csDMARD and/or steroids without ABA, adding ABA to the treatment does not appear to increase the incidence rates of postoperative AE in patients with RA undergoing orthopedic surgery. Large cohort studies should be performed to add evidence for the perioperative safety profile of ABA.

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DOI： 10.3899/jrheum.181100

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上肢の人工関節人工肘関節置換術の臨床成績

西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 94 ( 3 ) S528 - S528 2020.3

運動器慢性痛患者に対する就労支援のシステム構築を目指して

鉄永倫子, 鉄永智紀, 西田圭一郎, 松崎孝, 井上真一郎, 太田晴之, 尾崎敏文

日本整形外科学会雑誌 94 ( 2 ) S95 - S95 2020.3

慢性腰痛患者におけるデュロキセチン塩酸塩の効果は抑うつの有無により影響するか

鉄永倫子, 鉄永智紀, 三澤治夫, 瀧川朋亨, 山根健太郎, 西田圭一郎, 竹井義隆, 尾崎敏文

日本整形外科学会雑誌 94 ( 2 ) S297 - S297 2020.3

CD30をターゲットとした新規リウマチ治療の検討

松橋美波, 西田圭一郎, 渡辺雅仁, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 94 ( 2 ) S152 - S152 2020.3

人工知能を用いた超音波画像の同一画像自動検出

中原龍一, 西田圭一郎, 渡辺雅仁, 松橋美波, 木曽洋平, 那須義久, 尾崎敏文

日本整形外科学会雑誌 94 ( 3 ) S701 - S701 2020.3

骨・関節・カルシウム代謝疾患変形性関節症

宮澤慎一, 西田圭一郎, 西原茂樹, 神崎浩孝, 千堂年昭

薬局 2020年増刊病気とくすり2020 71 ( 4 ) 888 - 905 2020.3

Idiopathic Chondrolysis of the Hip Treated by Immunosuppressive Therapy and Arthroscopic Intervention.

Hirosuke Endo, Hirofumi Akazawa, Masato Yashiro, Kazuki Yamada, Tomoaki Sanki, Tomonori Tetsunaga, Keiichiro Nishida, Takayuki Furumatsu, Toshifumi Ozaki

Acta medica Okayama 74 ( 1 ) 77 - 81 2020.2

Language：English

Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.

DOI： 10.18926/AMO/57957

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関節リウマチに対する小指MP人工指関節置換術の治療成績

松橋美波, 西田圭一郎, 那須義久, 齋藤太一, 木曽洋平, 尾崎敏文

日本手外科学会雑誌 36 ( 5 ) 784 - 787 2020.2

Language：Japanese Publisher：(一社)日本手外科学会

関節リウマチの人工指関節置換術において小指は十分な可動域が得られにくいという問題点がある.著者らは,シリコンインプラント(SBi Silicone人工指関節:旧AVANTA人工指関節)による人工指関節置換術を行っており,2014年以降小指に対してはプレフレックスタイプを使用している.ストレートタイプ(S群)27例とプレフレックスタイプ(P群)21例に対し,術後1年時の握力,可動域,HAND20,DASHを調査し,比較検討した.術後1年時のMP関節の屈曲角度はS群50.1度,及びP群67.4度であり,可動域もS群33.5度,及びP群60.7度(P<0.01)であり有意に大きかった.他の検討項目では有意差を認めなかった.屈曲角度に影響する因子は様々であるが,プレフレックスタイプの選択により小指の屈曲は有意に増加し,可動域が増加した.(著者抄録)

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術前・術後ケアのための「既往症の知識」まとめシート関節リウマチ

西田圭一郎

月刊ナーシング 40 ( 3 ) 40 - 43 2020.2

Bone microarchitectural analysis using ultra-high-resolution CT in tiger vertebra and human tibia. International journal

Ryota Inai, Ryuichi Nakahara, Yusuke Morimitsu, Noriaki Akagi, Youhei Marukawa, Toshi Matsushita, Takashi Tanaka, Akihiro Tada, Takao Hiraki, Yoshihisa Nasu, Keiichiro Nishida, Toshifumi Ozaki, Susumu Kanazawa

European radiology experimental 4 ( 1 ) 4 - 4 2020.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: To reveal trends in bone microarchitectural parameters with increasing spatial resolution on ultra-high-resolution computed tomography (UHRCT) in vivo and to compare its performance with that of conventional-resolution CT (CRCT) and micro-CT ex vivo. METHODS: We retrospectively assessed 5 tiger vertebrae ex vivo and 16 human tibiae in vivo. Seven-pattern and four-pattern resolution imaging were performed on tiger vertebra using CRCT, UHRCT, and micro-CT, and on human tibiae using UHRCT. We measured six microarchitectural parameters: volumetric bone mineral density (vBMD), trabecular bone volume fraction (bone volume/total volume, BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), and connectivity density (ConnD). Comparisons between different imaging resolutions were performed using Tukey or Dunnett T3 test. RESULTS: The vBMD, BV/TV, Tb.N, and ConnD parameters showed an increasing trend, while Tb.Sp showed a decreasing trend both ex vivo and in vivo. Ex vivo, UHRCT at the two highest resolutions (1024- and 2048-matrix imaging with 0.25-mm slice thickness) and CRCT showed significant differences (p ≤ 0.047) in vBMD (51.4 mg/cm3 and 63.5 mg/cm3 versus 20.8 mg/cm3), BV/TV (26.5% and 29.5% versus 13.8 %), Tb.N (1.3 l/mm and 1.48 l/mm versus 0.47 l/mm), and ConnD (0.52 l/mm3 and 0.74 l/mm3 versus 0.02 l/mm3, respectively). In vivo, the 512- and 1024-matrix imaging with 0.25-mm slice thickness showed significant differences in Tb.N (0.38 l/mm versus 0.67 l/mm, respectively) and ConnD (0.06 l/mm3 versus 0.22 l/mm3, respectively). CONCLUSIONS: We observed characteristic trends in microarchitectural parameters and demonstrated the potential utility of applying UHRCT for microarchitectural analysis.

DOI： 10.1186/s41747-019-0135-0

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