Faculty Profiles - NISHIDA Keiichiro

Papers - NISHIDA Keiichiro

Division display 341 - 360 of about 642 ／ All the affair displays >>

関節リウマチの手術4:上肢・その他関節リウマチの手術が患者のボディイメージに与える影響

小橋靖子, 西田圭一郎, 堀田昌宏, 那須義久, 橋詰謙三, 中原龍一, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 587 - 587 2018.3

関節リウマチの手術4:上肢・その他短母指伸筋腱の停止様式と母指ボタン穴変形との関連について

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 586 - 586 2018.3

術後早期に復職できたが機能回復には長期間を要したRA患者の一症例

松山宜之, 坂口和輝, 鍋倉由佳, 小川加苗, 藤岡晃, 岡佳純, 堅山佳美, 西田圭一郎, 千田益生

作業療法おかやま 27 54 - 54 2018.3

リウマチ性疾患の画像1:関節エコーRA 動画画像を教師画像とした深層学習を用いた関節リウマチ患者の超音波画像自動分類

中原龍一, 西田圭一郎, 木曽洋平, 沖田駿治, 大橋秀基, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 455 - 455 2018.3

リウマチ上肢のリハビリと手術〜真の寛解を目指して〜リウマチ上肢のリハビリと手術人工肘関節置換術で社会的・精神的寛解をえられるか

西田圭一郎, 那須義久, 小橋靖子, 橋詰謙三, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 231 - 231 2018.3

関節リウマチ患者のQOL向上を目指した薬物・手術のcombined therapy 疾患活動性からみた整形外科手術が患者Body Imageに与える影響

西田圭一郎, 小橋靖子, 堀田昌宏, 那須義久, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 220 - 220 2018.3

単純X線足荷重位正面像における外側趾MTP関節背側脱臼の重症度スコア

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1169 - S1169 2018.3

関節リウマチに対する手術加療の傾向初回手術例の患者背景

那須義久, 渡辺雅仁, 沖田駿治, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1041 - S1041 2018.3

関節リウマチ前足部手術における術式別のTUGおよびJSSF-RA scaleの検討

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 大橋秀基, 木曽洋平, 沖田駿治, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1028 - S1028 2018.3

関節リウマチ診療における超音波多関節評価・検査時間の短縮の研究

中原龍一, 西田圭一郎, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本整形外科学会雑誌 92 ( 2 ) S313 - S313 2018.3

短母指伸筋腱の停止様式が母指ボタン穴変形発症に与える影響

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 92 ( 2 ) S175 - S175 2018.3

アバタセプトは関節リウマチにおける周術期合併症を増やすか多施設コホート研究に基づく入れ子型ケースコントロール研究より

伊藤宣, 辻成佳, 中山政憲, 持田勇一, 西田圭一郎, 石川肇, 小嶋俊久, 松本卓巳, 窪田綾子, 望月猛, 桃原茂樹

日本整形外科学会雑誌 92 ( 3 ) S595 - S595 2018.3

関節リウマチの自己血輸血関節リウマチに対する整形外科手術施行時の術前Hb値と疾患活動性、使用薬剤との関係

那須義久, 西田圭一郎

自己血輸血 31 ( 学術総会 ) S32 - S32 2018.2

The clinical course of patients with rheumatoid arthritis who underwent orthopaedic surgeries under disease control by tofacitinib. Reviewed International journal

Nishida K, Harada R, Nasu Y, Takeshita A, Nakahara R, Matsumeda M, Ozaki T

Modern rheumatology 28 ( 6 ) 1 - 8 2018.1

Identification of specific protein markers of rheumatoid arthritis in synovial fluid and serum Reviewed

Keisuke Mihara, Sayuki Kohno, Shiho Hatanaka, Tsutomu Yamasaki, Kei-Ichiro Nishida, Tohru Nakanishi

Journal of Hard Tissue Biology 27 ( 1 ) 55 - 58 2018

Language：English Publishing type：Research paper (scientific journal) Publisher：Society of Hard Tissue Regenerative Biology

Rheumatoid arthritis (RA) is a common articular disease characterized by chronic inf lammation, hyperproliferation of synovial cells, and bone destruction. Recently, we showed that small interfering RNA targeting CD81 (siCD81) is therapeutically effective for RA. CD81 belongs to a family of cell-surface proteins (tetraspanins) known to be up-regulated in RA synoviocytes, and siCD81 decreases the expression of synoviolin and TNF-α at the cellular level. We also previously established a highly sensitive sandwich ELISA system using monoclonal antibodies (MAbs) against CD81 by immunization with the outer membrane region of CD81 (LEL), which was overexpressed as a recombinant protein. This assay can be used to detect CD81 in synovial fluids and serum. Here, we identified several specific marker proteins and peptides for diagnosis of RA, including CD81 by using a protein chip system, 2D-gels, and western blotting. These markers can be used for early diagnosis of RA and might contribute to further effective treatment.

DOI： 10.2485/jhtb.27.55

Scopus

researchmap

Mast Cells Exhibiting Strong Cytoplasmic Staining for IgE and High Affinity IgE Receptor are Increased in IgG4-Related Disease. Reviewed International journal

Kenji Nishida, Yuka Gion, Mai Takeuchi, Takehiro Tanaka, Tatsuki R Kataoka, Tadashi Yoshino, Yasuharu Sato

Scientific reports 8 ( 1 ) 4656 - 4656 2018

Language：English Publishing type：Research paper (scientific journal)

Immunoglobulin G4 (IgG4)-related disease is characterized by elevated serum IgG4 levels and increased numbers of IgG4-positive cells. However, its pathogenesis is not fully understood. We previously suggested that mast cells may play an important role in IgG4-related disease. In this study, we confirmed the characteristics of mast cells in IgG4-related lymphadenopathy by using immunohistochemistry and dual immunofluorescence. We analyzed 23 cases of IgG4-related lymphadenopathy and compared them with 23 cases of non-specific lymphoid hyperplasia. The majority of patients with IgG4-related lymphadenopathy had cervical lesions with involvement of other organs. Immunohistologically, mast cells with strong cytoplasmic staining for immunoglobulin E and high affinity immunoglobulin E receptor were significantly increased in IgG4-related lymphadenopathy as compared to those in non-specific lymphoid hyperplasia (mean: 3.83 ± 3.99 cells per high power field and 7.14 ± 8.21 cells per high power field, respectively; P = 0.007 and P = 0.011). In addition, dual immunofluorescence assay showed that immunoglobulin E and high affinity immunoglobulin E receptor staining exhibited a cytoplasmic granular pattern in IgG4-related lymphadenopathy, suggesting internalization of the antibodies and receptors. Our findings showed that mast cell activation might be involved in the pathogenesis of IgG4-related disease.

DOI： 10.1038/s41598-018-23043-9.

PubMed

researchmap

Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study

Kojima, T., Ishikawa, H., Tanaka, S., Haga, N., Nishida, K., Yukioka, M., Hashimoto, J., Miyahara, H., Niki, Y., Kimura, T., Oda, H., Asai, S., Funahashi, K., Kojima, M., Ishiguro, N.

International Journal of Rheumatic Diseases 21 ( 10 ) 2018

Mid-term results of alumina ceramic unlinked total elbow arthroplasty with cement fixation for patients with rheumatoid arthritis

Nishida, K., Hashizume, K., Nasu, Y., Ozawa, M., Fujiwara, K., Inoue, H., Ozaki, T.

Bone and Joint Journal 100B ( 8 ) 2018

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes Reviewed

Takahiro Machida, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Masahiro Horita, Ayumu Takeshita, Daisuke Kaneda, Aki Yoshida, Toshifumi Ozaki

INFLAMMATION RESEARCH 66 ( 11 ) 999 - 1009 2017.11

Language：English Publishing type：Research paper (scientific journal) Publisher：SPRINGER BASEL AG

To investigate whether janus kinase (JAK) inhibitor exhibits a chondro-protective effect against mechanical stress-induced expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) and matrix metalloproteinase (MMPs) in human chondrocytes.
Normal human articular chondrocytes were seeded onto stretch chambers and incubated with or without tofacitinib (1000 nM) for 12 h before mechanical stimulation or cytokine stimulation. Uni-axial cyclic tensile strain (CTS) (0.5 Hz, 10% elongation, 30 min) was applied and the gene expression levels of type II collagen alpha 1 chain (COL2A1), aggrecan (ACAN), ADAMTS4, ADAMTS5, MMP13, and runt-related transcription factor 2 (RUNX-2) were examined by real-time polymerase chain reaction. Nuclear translocation of RUNX-2 and nuclear factor-kappa B (NF-kappa B) was examined by immunocytochemistry, and phosphorylation of mitogen-activated protein kinase (MAPK) and signaling transducer and activator of transcription (STAT) 3 was examined by western blotting. The concentration of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha in the supernatant was examined by enzyme-linked immunosorbent assay.
COL2A1 and ACAN gene expression levels were decreased by CTS, but these catabolic effects were canceled by tofacitinib. Tofacitinib significantly down-regulated CTS-induced expression of ADAMTS4, ADAMTS5, MMP13, and RUNX2, and the release of IL-6 in supernatant by chondrocytes. Tofacitinib also reduced CTS-induced nuclear translocation of RUNX-2 and NF-kappa B, and phosphorylation of MAPK and STAT3.
Tofacitinib suppressed mechanical stress-induced expression of ADAMTS4, ADAMTS5, and MMP13 by human chondrocytes through inhibition of the JAK/STAT and MAPK cascades.

DOI： 10.1007/s00011-017-1083-x

Web of Science

researchmap

Integrating patients' perceptions into clinical practice guidelines for the management of rheumatoid arthritis in Japan. Reviewed International journal

Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern rheumatology 27 ( 6 ) 924 - 929 2017.11

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified. A focus group with five JRFA executive members was formed to verify the results of the questionnaire. RESULTS: A total of 1470 patients aged 20-79 years old returned the questionnaire. Analysis of the questionnaire data revealed that the topics selected by the CPG task force met the patients' needs. The focus group participants showed reluctance to use the term 'preference' because patients would not want to take any medications but would have to take them out of necessity. CONCLUSIONS: We confirmed that the new CPG successfully addressed clinical issues that were important to both rheumatologists and patients. Clinicians should understand patients' reluctance to take medications and explain the role of each medication well to increase adherence.

DOI： 10.1080/14397595.2016.1276511

PubMed

researchmap

　 PREV - NEXT 　

< NISHIDA Keiichiro >

Papers - NISHIDA Keiichiro