Faculty Profiles - NOMA Kazuhiro

MISC - NOMA Kazuhiro

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腹腔鏡補助下胃切除術における術野展開の工夫

香川俊輔, 宇野太, 合地明, 小林直哉, 山辻知樹, 白川靖博, 永坂岳司, 野間和広, 藤原康宏, 田辺俊介, 近藤喜太, 猶本良夫, 藤原俊義

日本内視鏡外科学会雑誌 14 ( 7 ) 562 - 562 2009.12

糖質調整流動食MHN-01の食道癌術後高血糖抑制効果ランダム化クロスオーバー試験 Reviewed

山辻知樹, 猶本良夫, 田辺俊介, 藤原康宏, 野間和広, 大原利章, 元木崇之, 高岡宗徳, 白川靖博, 羽井佐実

日本消化器外科学会雑誌 42 ( 7 ) 1093 - 1093 2009.7

食道癌術後深部静脈血栓症の発症要因とリスク解析

山辻知樹, 猶本良夫, 田辺俊介, 藤原康宏, 野間和広, 櫻間一史, 白川靖博, 大原信哉, 羽井佐実, 田中紀章

日本食道学会学術集会プログラム・抄録集 63回 136 - 136 2009.6

PET導入後の再発食道癌の診断・治療局所治療のあり方とその成績

田辺俊介, 猶本良夫, 藤原康宏, 野間和広, 櫻間一史, 高岡宗徳, 白川靖博, 山辻知樹, 羽井佐実, 田中紀章

日本食道学会学術集会プログラム・抄録集 63回 137 - 137 2009.6

The Analysis of Head and Neck Cancers Coinciding with Thoracic Esophageal Cancer

Yasuhiro Shirakawa, Yoshio Naomoto, Shunsuke Tanabe, Yasuhiro Fujiwara, Kazuhiro Noma, Kazufumi Sakurama, Munenori Takaoka, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka

GASTROENTEROLOGY 136 ( 5 ) A459 - A459 2009.5

The upregulation of FAK contributes to tumor progression and a resistance to Imatinib in gastrointestinal stromal tumor

Xiaohong Bao, Nobuyuki Kamo, Huifang Hao, Kazufumi Sakurama, Kazuhiro Noma, Yasuhiro Shirakawa, Hitoshi Nagatsuka, Yasuko Tomono, Yasuhiro Fujiwara, Nobuyuki Watanabe, Seishi Nishitani, Toshiaki Ohara, Munenori Takaoka, Tomoki Yamatsuji, Junji Matsuoka, Seiichi Hirota, Shinji Hatakeyama, Osamu Omori, Zhigang Wang, Noriaki Tanaka, Yoshio Naomoto

CANCER RESEARCH 69 2009.5

Preferential Upregulation of Heparanase and Cyclooxygenase-2 in Barrett's Esophageal Adenocarcinoma and in Intestinal-Type Gastric Carcinoma

Shunsuke Tanabe, Yoshio Naomoto, Yasuhiro Shirakawa, Yasuhiro Fujiwara, Kazuhiro Noma, Kazufumi Sakurama, Munenori Takaoka, Takayuki Motoki, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka

GASTROENTEROLOGY 136 ( 5 ) A752 - A752 2009.5

Targeting mTOR by temsirolimus as a potential therapeutic alternate in esophageal cancer

Seishi Nishitani, Toshio Nishikawa, Toshiaki Ohara, Yasuko Tomono, Kazufumi Sakurama, Xiaohong Bao, Huifang Hao, Kazuhiro Noma, Takayuki Motoki, Yasuhiro Fujiwara, Shunsuke Tanabe, Munenori Takaoka, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, Noriaki Tanaka, Yoshio Naomoto

CANCER RESEARCH 69 2009.5

Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells. International journal

Kazufumi Sakurama, Yoshio Naomoto, Toshiaki Ohara, Nobuyuki Watanabe, Munenori Takaoka, Hitoshi Nagatsuka, Yasuko Tomono, Toru Tanida, Kazuhiro Noma, Shunsuke Tanabe, Yasuhiro Fujiwara, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Seiichi Hirota, Takahiro Taguchi, Noriaki Tanaka

Oncology reports 21 ( 2 ) 407 - 11 2009

Language：English Publisher：SPANDIDOS PUBL LTD

There is currently no suitable animal model of metastasis using cultured human gastrointestinal stromal tumor cells even though the molecular mechanisms of c-KIT-mediated progression and metastasis should be clarified. Ba/F3 murine lymphocyte cells transduced with mutant c-KIT have been utilized to analyze some molecular mechanisms related to a constitutively activated c-KIT signaling and to assess the efficacy of molecular-targeted inhibitors. Using this cellular system, we coincidentally discovered the development of axillary and inguinal lymph node swelling three weeks after subcutaneous injection of Ba/F3 cells with c-KIT mutation into nude mice. Mutation-specific PCR detected c-KIT mutation in the swollen lymph nodes but not in unmetastasized normal lymph nodes, indicating that the lymph nodes contain tumor cells which should come from a primary subcutaneous tumor. Microscopic observation revealed tumor cells infiltrating through lymphatic follicles with Ki-67-positive staining to distinguish them from lymphocytes. The significance of this model is helpful to understand the molecular mechanisms of c-KIT-mediated metastasis and is useful for assessments of molecular therapeutics and in vivo imaging.

DOI： 10.3892/or_00000237

Web of Science

PubMed

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医原性頸部食道穿孔に対する手術手技

猶本良夫, 田邊俊介, 藤原康宏, 野間和広, 高岡宗徳, 白川靖博, 山辻知樹, 田中紀章

外科治療 100 ( 3 ) 2009

A Case Report of FOLFOX Treatment for Primary Duodenal Carcinoma with Multiple Liver Metastases

藤原康宏, 猶本良夫, 田邊俊介, 櫻間一史, 野間和広, 西川敏雄, 元木崇之, 高岡宗徳, 白川靖博, 山辻知樹, 松岡順治, 田中紀章

癌と化学療法 36 ( 4 ) 655 - 7 2009

Language：Japanese

We report a case of a woman in her sixties having primary duodenal carcinoma with multiple liver metastases who was treated with oxaliplatin in combination with infusional 5-fluorouracil/Leucovorin(FOLFOX regimen). After completing 2 courses of the chemotherapy, computed tomography showed a partial response without any severe adverse events. Now at 8 months, the PR stage has been maintained. So far, no standard therapeutic strategy for metastatic duodenal carcinoma has been developed. However, we suggest a FOLFOX regimen can be highly effective as a safe approach for continuously maintaining the quality of life of patients with this rare type of cancer.

PubMed

J-GLOBAL

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胃機能温存手術の工夫

猶本良夫, 白川靖博, 田辺俊介, 藤原康宏, 野間和広, 山辻知樹

手術 63 ( 8 ) 2009

当科における食道ESDの工夫(外科医としての観点から)

白川靖博, 猶本良夫, 田辺俊介, 藤原康宏, 野間和広, 櫻間一史, 山辻知樹, 羽井佐実, 松岡順治, 田中紀章

Gastroenterological Endoscopy 51 ( Supplement 1 ) 2009

消化管間葉系腫瘍(GIST)におけるFAK発現の意義と新規分子標的としての可能性

高岡宗徳, 白川靖博, 鴨宣之, 鴨宣之, 桜間一史, 野間和広, 藤原康宏, 田邊俊介, 山辻知樹, 廣田誠一, 猶本良夫

日本消化器外科学会雑誌 42 ( 7 ) 2009

当院における内視鏡的胃瘻造設の現況

田辺俊介, 白川靖博, 近藤喜太, 藤原康宏, 野間和広, 宇野太, 永坂岳司, 香川俊輔, 山辻知樹, 小林直哉, 藤原俊義, 内藤稔, 猶本良夫

岡山医学会雑誌 121 ( 3 ) 2009

当科における反回神経リンパ節郭清手技と頸部郭清の簡略化の検討

猶本良夫, 田邊俊介, 藤原康宏, 野間和広, 櫻間一史, 高岡宗徳, 白川靖博, 山辻知樹, 羽井佐実, 松岡順治

日本臨床外科学会雑誌 70 2009

消化器外科手術アトラス胸部食道癌に対する胃機能温存食道切除・再建術

猶本良夫, 白川靖博, 田邉俊介, 藤原康宏, 野間和広, 高岡宗徳, 櫻間一史, 山辻知樹

消化器外科 32 ( 11 ) 2009

食道癌に対する空腸間置再建術における工夫

猶本良夫, 白川靖博, 田邊俊介, 藤原康宏, 野間和広, 櫻間一史, 高岡宗徳, 山辻知樹, 羽井佐実, 田中紀章

日本消化器外科学会雑誌 42 ( 7 ) 2009

FORFIRI療法が奏効した腹膜播種を伴った空腸癌の1例

櫻間一史, 平松聡, 田邊俊介, 藤原康宏, 野間和広, 高岡宗徳, 白川靖博, 山辻知樹, 猶本良夫

日本消化器外科学会雑誌 42 ( 7 ) 2009

若手消化器外科医の育成における現況とこれからの課題-若手の立場から-

田辺俊介, 猶本良夫, 藤原康宏, 野間和広, 櫻間一史, 白川靖博, 山辻知樹, 羽井佐実, 松岡順治

日本臨床外科学会雑誌 70 2009

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