Faculty Profiles - NOMA Kazuhiro

MISC - NOMA Kazuhiro

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Differentiated gastric cancer cells have a potential to induce cancer-associated fibroblasts

Yuncheng Li, Hiroshi Tazawa, Nishizaki Masahiko, Yuuri Hashimoto, Naoto Hori, Ryoichi Katsube, Shinji Kuroda, Kazuhiro Noma, Shunsuke Kagawa, Toshiyoshi Fujiwara

CANCER RESEARCH 75 2015.8

食道癌患者における免疫栄養学的予後予測指数(PNI)と口腔内の状態との関連

山中玲子, 曽我賢彦, 水口真実, 横井彩, 前田直見, 田辺俊介, 野間和広, 白川博靖, 森田学, 飯田征二

日本食道学会学術集会プログラム・抄録集 69回 184 - 184 2015.7

当科における食道憩室手術症例の検討 Reviewed

賀島肇, 白川靖博, 前田直見, 田辺俊介, 大原利章, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 70回 ( Supplement1 ) P - 5 2015.7

その他鉄コントロールによるがん幹細胞に対する新規治療 Reviewed

二宮卓之, 大原利章, 浦野真一, 勝部亮一, 野間和広, 田澤大, 白川靖博, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 115回 OP - 7 2015.4

上部消化管超高齢者食道癌手術への取り組みと放射線併用ウイルス療法の可能性 Reviewed

田辺俊介, 白川靖博, 賀島肇, 国府島健, 前田直見, 大原利章, 黒田新士, 櫻間教文, 野間和広, 田澤大, 香川俊輔, 藤原俊義

日本外科学会定期学術集会抄録集 115回 OP - 2 2015.4

食道胃接合部癌の治療戦略内視鏡治療から集学的治療まで当科における食道胃接合部癌の治療経験

野間和広, 白川靖博, 加藤卓也, 竹原清人, 前田直見, 田辺俊介, 西崎正彦, 香川俊輔, 藤原俊義

日本胃癌学会総会記事 87回 180 - 180 2015.3

Prone-position thoracoscopic resection of posterior mediastinal lymph node metastasis from rectal cancer. International journal

Yasuhiro Shirakawa, Kazuhiro Noma, Takeshi Koujima, Naoaki Maeda, Shunsuke Tanabe, Toshiaki Ohara, Toshiyoshi Fujiwara

World journal of surgical oncology 13 ( 45 ) 45 - 45 2015.2

Language：English Publisher：BIOMED CENTRAL LTD

Mediastinal lymph node metastasis from colorectal cancer is rare, and barely any reports have described resection of this pathology. We report herein a successful thoracoscopic resection of mediastinal lymph node metastasis in a prone position. A 65-year-old man presented with posterior mediastinal lymph node metastasis after resection of the primary rectal cancer and metachronous hepatic metastasis. Metastatic lymph nodes were resected completely using thoracoscopic surgery in the prone position, which provided advantages of minimal invasiveness, good surgical field, and reduced ergonomic burden on the surgeon. Thoracoscopic resection in the prone position was thought to have the potential to become the standard procedure of posterior mediastinal tumors.

DOI： 10.1186/s12957-015-0466-0

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Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2-negative breast cancer cells. International journal

Kyoko Shimoyama, Shunsuke Kagawa, Michihiro Ishida, Shinichiro Watanabe, Kazuhiro Noma, Kiyoto Takehara, Hiroshi Tazawa, Yuuri Hashimoto, Shunsuke Tanabe, Junji Matsuoka, Hisataka Kobayashi, Toshiyoshi Fujiwara

Breast cancer research and treatment 149 ( 3 ) 597 - 605 2015.2

Language：English Publisher：SPRINGER

The prognosis of HER2-positive breast cancer has been improved by trastuzumab therapy, which features high specificity and limited side effects. However, trastuzumab-based therapy has shortcomings. Firstly, HER2-targeted therapy is only applicable to HER2-expressing tumors, which comprise only 20-25% of primary breast cancers. Secondly, many patients who initially respond to trastuzumab ultimately develop disease progression. To overcome these problems, we employed virus-mediated HER2 transduction and photoimmunotherapy (PIT) which involves trastuzumab conjugated with a photosensitizer, trastuzumab-IR700, and irradiation of near-infrared light. We hypothesized that the gene transduction technique together with PIT would expand the range of tumor entities suitable for trastuzumab-based therapy and improve its antitumor activity. The HER2-extracellular domain (ECD) was transduced by the adenoviral vector, Ad-HER2-ECD, and PIT with trastuzumab-IR700 was applied in the HER2-negative cancer cells. Ad-HER2-ECD can efficiently transduce HER2-ECD into HER2-negative human cancer cells. PIT with trastuzumab-IR700 induced direct cell membrane destruction of Ad-HER2-ECD-transduced HER2-negative cancer cells. Novel combination of viral transduction of a target antigen and an antibody-based PIT would expand and potentiate molecular-targeted therapy even for target-negative or attenuated cancer cells.

DOI： 10.1007/s10549-015-3265-y

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Cost-Utility Analysis of Cetuximab and Panitumumab in the Treatment of Unresectable, Progressive, and Recurrent Colorectal Cancer

NAGAO KANAKO, KOBAYASHI ASUKA, ZAMAMI YOSHITO, NAWA HIDEKI, SAGARA HIDENORI, NOMA KAZUHIRO, IGARASHI ATARU, MATSUNAGA HISASHI, SENDO TOSHIAKI, NAKURA HIRONORI

Prog Med 35 ( 2 ) 299 - 303 2015.2

Operative technique of antethoracic esophageal reconstruction with pedicled jejunal flap

Yasuhiro Shirakawa, Kazuhiro Noma, Takeshi Koujima, Naoaki Maeda, Shunsuke Tanabe, Toshiaki Ohara, Kazufumi Sakurama, Toshiyoshi Fujiwara

ESOPHAGUS 12 ( 1 ) 57 - 64 2015

Language：English Publisher：SPRINGER JAPAN KK

Esophageal reconstruction using intestine is often performed for esophageal cancer patients in cases where the stomach cannot be used. We have previously performed reconstruction using ileocolon with supercharge and drainage as our first choice in those cases. However, a less invasive, simpler, and safer reconstructive technique using jejunum without vascular anastomosis has recently become popular at our facility. This study describes the technique of esophageal reconstruction with jejunum, compares the surgical outcomes to those of standard reconstruction using ileocolon, and discusses the clinical significance of this new concept.Subjects comprised 53 patients (52 males, 1 female) who underwent esophageal reconstruction using jejunum between January 2008 and July 2013. Patient characteristics, technical details, and outcomes were compared with those of 51 subjects who had undergone esophageal reconstruction using ileocolon. When making the pedicled jejunal flap, the first jejunal vascular arcade was preserved, which in most cases allowed it to be pulled up to the cervical region by processing and transection up to the second jejunal vascular branch.The vascular anastomosis techniques were used in 80.4 % (41/51) of esophageal reconstructions using colon, compared with only 24.5 % (13/53) of reconstructions using jejunum. No difference in the frequency of postoperative adverse effects was seen between groups, but the frequency of diarrhea was significantly lower with reconstruction using jejunum.Esophageal reconstruction using jejunum with the blood vessel processing technique results in both simpler and safer pulling up. Thus the need to perform supercharge and superdrainage is reduced.

DOI： 10.1007/s10388-014-0455-3

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ERASと周術期チーム医療

白川靖博, 加藤卓也, 竹原清人, 前田直見, 田辺俊介, 櫻間教文, 野間和広, 足羽孝子, 佐藤健治, 森松博史, 藤原俊義

臨床雑誌外科 77 ( 2 ) 142 - 146 2015

癌関連線維芽細胞を標的とした新規食道癌治療法の開発

勝部亮一, 野間和広, 賀島肇, 加藤卓也, 二宮卓之, 大原利章, 田澤大, 白川靖博, 香川俊輔, 小林久隆, 藤原俊義

日本消化器癌発生学会総会プログラム・抄録集 26th 2015

Prone-Position Thoracoscopic Ligation of the Thoracic Duct for Chyle Leak Following Radical Neck Dissection in a Patient with a Right Aortic Arch.

Yasuhiro Shirakawa, Kazuhiro Noma, Toshiaki Ohara, Hajime Kashima, Naoaki Maeda, Shunsuke Tanabe, Shunsuke Kagawa, Toshiyoshi Fujiwara

Acta medica Okayama 69 ( 3 ) 173 - 6 2015

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edward's classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position.

DOI： 10.18926/AMO/53524

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鉄制御を用いた新しい癌の浸潤・転移抑制治療法の開発

大原利章, 大原利章, 二宮卓之, 野間和広, 賀島肇, 加藤卓也, 勝部亮一, 白川靖博, 藤原俊義

日本消化器癌発生学会総会プログラム・抄録集 26th 2015