Faculty Profiles - NOMA Kazuhiro

MISC - NOMA Kazuhiro

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食道領域cadaver surgical trainingの取り組みについて

白川靖博, 前田直見, 田辺俊介, 野間和広, 藤原俊義

日本胸部外科学会定期学術集会(Web) 72nd 2019

切除不能食道癌に対し化学放射線療法(CRT)を行いConversion Surgeryを行った11例の検討

小林照貴, 白川靖博, 梅田将志, 橋本将志, 前田直見, 田辺俊介, 野間和広, 楳田祐三, 藤原俊義

日本消化器外科学会雑誌(Web) 52 ( Supplement1 ) 2019

食道癌患者に対する腫瘍融解ウイルスの内視鏡的投与の実際~病棟実施にむけた他部署連携~

矢野朋美, 采女典子, 森隆弘, 笠原由美子, 石川貴子, 田辺俊介, 黒田新二, 野間和広, 田澤大, 香川俊輔, 白川靖博, 藤原俊義

日本消化器内視鏡技師学会プログラム・講演抄録 83rd 2019

肝移植患者の移植後二次発癌

松田達雄, 楳田祐三, 吉田一博, 吉田龍一, 野間和広, 信岡大輔, 田辺俊介, 杭瀬崇, 前田直見, 安井和也, 白川靖博, 八木孝仁, 藤原俊義

日本外科学会定期学術集会(Web) 119th 2019

ゼロ価鉄ナノ粒子を用いた油性溶媒中PCBの脱塩素分解技術の開発

野間淳一, 高木和広, 栢岡理

廃棄物資源循環学会研究発表会講演集(Web) 30th 2019

Dual-targeting Photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in tumor microenvironment

Hiroaki Sato, Kazuhiro Noma, Toru Narusaka, Satoshi Komoto, Toshiaki Ohara, Hiroshi Tazawa, Toshiyoshi Fujiwara

CANCER SCIENCE 109 371 - 371 2018.12

Visualization of epithelial-mesenchymal transition in inflammatory microenvironment-colorectal cancer crosstalk

Hiroshi Tazawa, Takeshi Ieda, Shuya Yano, Kunitoshi Shigeyasu, Shinji Kuroda, Toshiaki Ohara, Kazuhiro Noma, Hiroyuki Kishimoto, Masahiko Nishizaki, Shunsuke Kagawa, Takashi Saitou, Takeshi Imamura, Toshiyoshi Fujiwara

CANCER SCIENCE 109 669 - 669 2018.12

Stemness control by iron chelator is a novel strategy for cancer treatment

Toshiaki Ohara, Yuki Katsura, Kazuhiro Noma, Toru Narusaka, Hiroaki Sato, Satoshi Komoto, Takuya Kato, Hiroshi Tazawa, Shunsuke Kagawa, Toshiyoshi Fujiwara

CANCER SCIENCE 109 1309 - 1309 2018.12

Near-infrared photoimmunotherapy using anti-GD2 antibody-photosensitizer conjugate for neuroblastoma

Hiroshi Nouso, Hiroshi Tazawa, Terutaka Tanimoto, Morimochi Tani, Takanori Oyama, Hiroaki Sato, Kazuhiro Noma, Shunsuke Kagawa, Hisataka Kobayashi, Takuo Noda, Toshiyoshi Fujiwara

CANCER SCIENCE 109 1140 - 1140 2018.12

Novel virotherapy for scirrhous gastric cancer with peritoneal metastasis

Wataru Ishikawa, Satoru Kikuchi, Hiroshi Tazawa, Shinji Kuroda, Kazuhiro Noma, Hiroyuki Kishimoto, Masahiko Nishizaki, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara

CANCER SCIENCE 109 761 - 761 2018.12

Cancer-associated fibroblasts affect the intra-tumoral infiltration of CD8+and FoxP3+T cells via IL-6

Takuya Kato, Kazuhiro Noma, Hiroaki Sato, Satoshi Komoto, Toshiaki Ohara, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

CANCER SCIENCE 109 1120 - 1120 2018.12

Oncolytic virotherapy for inhibition of epithelial- mesenchymal transition in esophageal cancer

Tomoya Masuda, Hiroshi Tazawa, Takeshi Ieda, Yuuri Hashimoto, Shunsuke Tanabe, Kazuhiro Noma, Yasuo Urata, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

CANCER SCIENCE 109 868 - 868 2018.12

Cancer-Associated Fibroblasts Affect Intratumoral CD8(+) and FoxP3(+) T Cells Via IL6 in the Tumor Microenvironment Reviewed International journal

Kato Takuya, Noma Kazuhiro, Ohara Toshiaki, Kashima Hajime, Katsura Yuki, Sato Hiroaki, Komoto Satoshi, Katsube Ryoichi, Ninomiya Takayuki, Tazawa Hiroshi, Shirakawa Yasuhiro, Fujiwara Toshiyoshi

CLINICAL CANCER RESEARCH 24 ( 19 ) 4820 - 4833 2018.10

Language：English Publisher：AMER ASSOC CANCER RESEARCH

Purpose: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a central role in tumor progression. We investigated whether CAFs can regulate tumor-infiltrating lymphocytes (TILs) and their role in tumor immunosuppression.Experimental Design: A total of 140 cases of esophageal cancer were analyzed for CAFs and CD8+ or forkhead box protein 3 (FoxP3+) TILs by IHC. We analyzed cytokines using murine or human fibroblasts and cancer cells. Murine-derived fibroblasts and cancer cells were also inoculated into BALB/c or BALB/c-nu/nu mice and the tumors treated with recombinant IL6 or anti-IL6 antibody.Results: CD8+ TILs and CAFs were negatively correlated in intratumoral tissues (P < 0.001), whereas FoxP3+ TILs were positively correlated (P < 0.001) in esophageal cancers. Cocultured Colon26 cancer cells and fibroblasts resulted in accelerated tumor growth in BALB/c mice, along with decreased CD8+ and increased FoxP3+ TILs, compared with cancer cells alone. In vitro, IL6 was highly secreted in both murine and human cancer cell/fibroblast cocultures. IL6 significantly increased Colon26 tumor growth in immune-competent BALB/c (P < 0.001) with fewer CD8+ TILs than untreated tumors (P < 0.001), whereas no difference in BALB/c-nu/nu mice. In contrast, FoxP3+ TILs increased in IL6-treated tumors (P < 0.001). IL6 antibody blockade of tumors cocultured with fibroblasts resulted not only in regression of tumor growth but also in the accumulation of CD8+ TILs in intratumoral tissues.Conclusions: CAFs regulate immunosuppressive TIL populations in the TME via IL6. IL6 blockade, or targeting CAFs, may improve preexisting tumor immunity and enhance the efficacy of conventional immunotherapies. Clin Cancer Res; 24(19); 4820-33. ©2018 AACR.

DOI： 10.1158/1078-0432.CCR-18-0205

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癌関連線維芽細胞が放出するIL-6が腫瘍内に浸潤するCD8+ならびにFoxP3+T細胞に影響を与える(Cancer-associated fibroblasts affect the intra-tumoral infiltration of CD8+ and FoxP3+ T cells via IL-6)

加藤卓也, 野間和広, 佐藤浩明, 河本慧, 大原利章, 田澤大, 白川靖博, 藤原俊義

日本癌学会総会記事 77回 1860 - 1860 2018.9

消化管がん治療の新展開食道癌におけるがん細胞及びがん関連線維芽細胞に対するDual-targeting Photoimmunotherapy(Developments in gastrointestinal cancer treatments Dual-targeting Photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in tumor microenvironment) Reviewed

佐藤浩明, 野間和広, 鳴坂徹, 河本慧, 大原利章, 田澤大, 藤原俊義

日本癌学会総会記事 77回 96 - 96 2018.9

炎症性微小環境-大腸がんクロストークにおけるEMTイメージング(Visualization of epithelial-mesenchymal transition in inflammatory microenvironment-colorectal cancer crosstalk) Reviewed

田澤大, 家田偉史, 矢野修也, 重安邦俊, 黒田新士, 大原利章, 野間和広, 岸本浩行, 西崎正彦, 香川俊輔, 斎藤卓, 今村健志, 藤原俊義

日本癌学会総会記事 77回 1204 - 1204 2018.9

鉄キレート剤の幹細胞性制御による新規癌治療法(Stemness control by iron chelator is a novel strategy for cancer treatment) Reviewed

大原利章, 桂佑貴, 野間和広, 鳴坂徹, 佐藤浩明, 河本慧, 加藤卓也, 田澤大, 香川俊輔, 藤原俊義

日本癌学会総会記事 77回 2318 - 2318 2018.9

腹膜播種を伴うスキルス胃癌に対する斬新なウイルス療法(Novel virotherapy for scirrhous gastric cancer with peritoneal metastasis)

石川亘, 菊地覚次, 田澤大, 黒田新士, 野間和広, 岸本浩行, 西崎正彦, 浦田泰生, 香川俊輔, 藤原俊義

日本癌学会総会記事 77回 952 - 952 2018.9

神経芽腫に対する抗GD2抗体-光感受性物質結合体を用いた光線免疫療法(Near-infrared photoimmunotherapy using anti-GD2 antibody-photosensitizer conjugate for neuroblastoma)

納所洋, 田澤大, 谷本光隆, 谷守通, 尾山貴徳, 佐藤浩明, 野間和広, 香川俊輔, 小林久隆, 野田卓男, 藤原俊義

日本癌学会総会記事 77回 1948 - 1948 2018.9

Clinical characteristics and management of gastric tube cancer after esophagectomy Reviewed

Yasuhiro Shirakawa, Kazuhiro Noma, Naoaki Maeda, Takayuki Ninomiya, Shunsuke Tanabe, Satoru Kikuchi, Shinji Kuroda, Masahiko Nishizaki, Shunsuke Kagawa, Yoshiro Kawahara, Hiroyuki Okada, Toshiyoshi Fujiwara

Esophagus 15 ( 3 ) 180 - 189 2018.7

Language：English Publisher：Springer Tokyo

Background: Gastric cancer is the second most common malignancy, overlapping with thoracic esophageal cancer (TEC). Among them, metachronous gastric tube cancers after TEC surgery have been increasing. The aims of this study were to examine the clinicopathological factors and treatment outcomes of gastric tube cancer (GTC) after TEC surgery. Methods: Thirty-three GTCs in 30 cases after TEC treated between 1997 and 2016 were investigated retrospectively. Results: Most cases were males. The median interval from TEC surgery to GTC occurrence was 57 (6.5–107.5) months. Almost 2/3 lesions occurred in the lower third of the gastric tube (21/33)
29 lesions (in 26 cases) were superficial cancers, and 4 lesions were advanced cancers. Twenty-two lesions of superficial cancer were differentiated type, and the remaining seven lesions were undifferentiated type. Treatment for superficial cancer had previously been performed with partial gastric tube resection (10 lesions), and the number of cases undergoing endoscopic submucosal dissection (ESD) had increased recently (19 lesions). Most cases with superficial cancer survived without relapse. Four lesions of advanced cancer were found after a relatively long interval following TEC surgery. Most lesions of advanced cancer were scirrhous, undifferentiated type, and they died due to GTC. Conclusion: GTCs may occur late in the postoperative course following TEC surgery. If they are discovered at an early stage, these lesions can be cured with ESD. Long-term periodic endoscopic examinations after TEC surgery are important.

DOI： 10.1007/s10388-018-0611-2

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