Faculty Profiles - NOMA Kazuhiro

MISC - NOMA Kazuhiro

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成人横隔膜弛緩症に対し胸腔鏡下にてメッシュを用いて横隔膜形成し得た一例

神尾知宏, 白川靖博, 田辺俊介, 升田智也, 前田直見, 二宮卓之, 野間和広, 藤原俊義

日本臨床外科学会雑誌 78 ( 3 ) 2017

Fusionに留意した食道癌に対する胸腔鏡下上縦隔リンパ節郭清

白川靖博, 鳴坂徹, 前田直見, 二宮卓之, 田辺俊介, 野間和広, 西崎正彦, 香川俊輔, 藤原俊義

日本臨床外科学会雑誌 78 2017

腹臥位胸腔鏡下手術での合併症を起こさせない手術手技

野間和広, 白川靖博, 鳴坂徹, 前田直見, 二宮卓之, 田辺俊介, 藤原俊義

日本臨床外科学会雑誌 78 2017

食道癌術後早期にAeromonas hydrophilaによる壊死性軟部組織感染症を発症した1例

田辺俊介, 白川靖博, 金谷信彦, 前田直見, 二宮卓之, 櫻間数文, 野間和広, 藤原俊義

日本外科感染症学会雑誌 14 ( 5 ) 2017

胃上部早期胃癌に対する逆流防止弁形成食道残胃吻合(観音開き法)再建の定型化

西崎正彦, 黒田新士, 菊地覚次, 野間和広, 垣内慶彦, 田邊俊介, 香川俊輔, 白川靖博, 藤原俊義

日本消化器外科学会雑誌(Web) 50 ( Supplement1 ) 2017

胸腔鏡下食道癌手術における微細解剖に基づいた上縦隔リンパ節郭清

白川靖博, 河本慧, 松三雄騎, 前田直見, 二宮卓之, 田辺俊介, 野間和広, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会雑誌(Web) 50 ( Supplement1 ) 2017

食道胃接合部癌に対する術式の進化腹臥位併用完全鏡視下観音開き法再建の導入

野間和広, 白川靖博, 升田智也, 前田直見, 二宮卓之, 田辺俊介, 黒田新士, 西崎正彦, 香川俊輔, 藤原俊義

日本外科学会定期学術集会(Web) 117th 2017

POEM(Per-Oral Endoscopic Myotomy)を施行した食道アカラシアの1例

杉原雄策, 原田馨太, 加藤諒, 山内健司, 高嶋志保, 竹井大介, 井口俊博, 高原政宏, 川野誠司, 平岡佐規子, 田辺俊介, 野間和広, 白川靖博, 眞部紀明, 井上晴洋, 岡田裕之

岡山医学会雑誌 129 ( 2 ) 2017

Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer International journal

Seishi Nishitani, Kazuhiro Noma, Toshiaki Ohara, Yasuko Tomono, Shinichiro Watanabe, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

INTERNATIONAL JOURNAL OF ONCOLOGY 49 ( 4 ) 1351 - 1359 2016.10

Language：English Publisher：SPANDIDOS PUBL LTD

Esophageal carcinomas often have a poor prognosis due to early lymph node metastasis. Epithelial-mesenchymal transition (EMT) is strongly associated with the acquisition of cancer metastasis and invasion. However, there is no established treatment to eliminate the EMT of cancer cells. Iron is an essential element for both normal and cancer cells in humans. Recently, iron depletion has been discovered to suppress tumor growth. Therefore, we hypothesized that decreased iron conditions would regulate EMT phenotypes, as well as suppressing tumor growth. The human TE esophageal cancer cell lines and OE19 were used in our study. Decreased iron conditions were made using an iron-depletion diet in mice and the iron chelator deferasirox for cell studies. Migration and invasion abilities of cells were measured using migration, invasion, and sphere formation assays. Esophageal subcutaneous tumor growth was suppressed in decreased iron conditions. In vitro study showed that decreased iron conditions inhibited esophageal cancer cell proliferation as well as migration and invasion abilities, with downregulation of N-cadherin expression. Also, migration and invasion abilities were suppressed by inhibiting expression of N-cadherin. In conclusion, decreased iron conditions revealed a profound anticancer effect by the suppression of tumor growth and the inhibition of migration and invasion abilities via N-cadherin.

DOI： 10.3892/ijo.2016.3640

Web of Science

PubMed

researchmap

Iron depletion-induced downregulation of N-cadherin expression inhibits invasive malignant phenotypes in human esophageal cancer. International journal

Seishi Nishitani, Kazuhiro Noma, Toshiaki Ohara, Yasuko Tomono, Shinichiro Watanabe, Hiroshi Tazawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

International journal of oncology 49 ( 4 ) 1351 - 9 2016.10

Language：English Publisher：SPANDIDOS PUBL LTD

DOI： 10.3892/ijo.2016.3640

Web of Science

PubMed

researchmap

鉄代謝は癌幹細胞の新規治療ターゲットとなり得る Reviewed

大原利章, 二宮卓之, 桂佑貴, 賀島肇, 加藤卓也, 野間和広, 田澤大, 藤原俊義

日本癌学会総会記事 75回 E - 1109 2016.10

食道癌において癌関連繊維芽細胞が腫瘍転移に及ぼす影響の検証 Reviewed

賀島肇, 野間和広, 桂佑貴, 加藤卓也, 勝部亮一, 二宮卓之, 大原利章, 田澤大, 香川俊輔, 白川靖博, 藤原俊義

日本癌学会総会記事 75回 P - 3151 2016.10

炎症性微小環境によって誘導されるEMTの蛍光生細胞イメージングシステム Reviewed

家田偉史, 田澤大, 菊地覚次, 黒田新士, 大原利章, 野間和広, 岸本浩行, 永坂岳司, 西崎正彦, 香川俊輔, 今村健志, 藤原俊義

日本癌学会総会記事 75回 J - 3053 2016.10

癌関連線維芽細胞(CAFs)が及ぼす腫瘍免疫逃避の解明 CAFsと腫瘍浸潤リンパ球の検討 Reviewed

加藤卓也, 野間和広, 賀島肇, 桂佑貴, 二宮卓之, 大原利章, 田澤大, 香川俊輔, 白川靖博, 藤原俊義

日本癌学会総会記事 75回 E - 1068 2016.10

ウイルスによる遺伝子導入は抗原陰性胃癌に対する光線免疫療法を可能にする

香川俊輔, 石田道拡, 下山京子, 竹原清人, 野間和広, 田辺俊介, 白川靖博, 田澤大, 小林久隆, 藤原俊義

日本癌学会総会記事 75回 E - 2094 2016.10

Double-Flap Technique as an Antireflux Procedure in Esophagogastrostomy after Proximal Gastrectomy. International journal

Shinji Kuroda, Masahiko Nishizaki, Satoru Kikuchi, Kazuhiro Noma, Shunsuke Tanabe, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

Journal of the American College of Surgeons 223 ( 2 ) e7-e13 - E13 2016.8

Double-Flap Technique as an Antireflux Procedure in Esophagogastrostomy after Proximal Gastrectomy International journal

Shinji Kuroda, Masahiko Nishizaki, Satoru Kikuchi, Kazuhiro Noma, Shunsuke Tanabe, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 223 ( 2 ) E7 - E13 2016.8

A novel live imaging system for inflammation-induced epithelial-mesenchymal transition in colorectal cancers

Takeshi Ieda, Hiroshi Tazawa, Satoru Kikuchi, Shinji Kuroda, Toshiaki Ohara, Kazuhiro Noma, Hiroyuki Kishimoto, Takeshi Nagasaka, Masahiko Nishizaki, Shunsuke Kagawa, Toshiyoshi Fujiwara

CANCER RESEARCH 76 2016.7

Iron control is a novel therapeutic target of cancer stem cells

Toshiaki Ohara, Takayuki Ninomiya, Kazuhiro Noma, Hajime Kashima, Yuki Katsura, Takuya Kato, Yasuko Tomono, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

CANCER RESEARCH 76 2016.7

Prognostic correlation of tumor-infiltrating lymphocytes (TILs) and cancer associated fibroblasts (CAFs) in patients with human esophageal carcinoma

Takuya Kato, Kazuhiro Noma, Yuki Katsura, Hajime Kashima, Takayuki Ninomiya, Toshiaki Ohara, Hiroshi Tazawa, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

CANCER RESEARCH 76 2016.7

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