Faculty Profiles - NOMA Kazuhiro

MISC - NOMA Kazuhiro

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Iron-controlled cancer therapy: A new concept for anti-angiogenic drug (bevacizumab and sorafenib)

T. Ohara, K. Noma, S. Urano, R. Katsube, T. Ninomiya, S. Tanabe, Y. Tomono, H. Tazawa, Y. Shirakawa, T. Fujiwara

EUROPEAN JOURNAL OF CANCER 49 S639 - S639 2013.9

除鉄を用いた新たな肝細胞癌治療 Reviewed

大原利章, 野間和広, 浦野真一, 前田直見, 二宮卓之, 田辺俊介, 友野靖子, 能祖一裕, 白川靖博, 貞森裕, 木村文昭, 藤原俊儀

日本癌治療学会誌 48 ( 3 ) 1949 - 1949 2013.9

透視を用いず位置確認が可能な内視鏡的バルーン拡張術の工夫 Reviewed

田辺俊介, 白川靖博, 前田直見, 勝部亮一, 大原利章, 櫻間教文, 野間和広, 藤原俊義

Gastroenterological Endoscopy 55 ( Suppl.2 ) 2890 - 2890 2013.9

胃が使用できない食道癌症例における空腸による食道再建術の工夫血管吻合は全例に必要か? Reviewed

渡邊伸一郎, 白川靖博, 勝部亮一, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 68回 ( Supplement1 ) RV - 5 2013.7

当科における腹臥位胸腔鏡下食道切除術定型化の工夫 Reviewed

青山克幸, 白川靖博, 勝部亮一, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 68回 ( Supplement1 ) O - 6 2013.7

除鉄効果を利用した新たな消化器癌治療 Reviewed

大原利章, 白川靖博, 浦野真一, 前田直見, 勝部亮一, 渡辺伸一郎, 田辺俊介, 野間和広, 櫻間教文, 藤原俊儀

日本消化器外科学会総会 68回 ( Supplement1 ) P - 8 2013.7

当科における低侵襲再建術の試み用手補助的腹腔鏡下胃管作製の60例の検討 Reviewed

前田直見, 白川靖博, 勝部亮一, 大原利章, 田辺俊介, 野間和広, 櫻間教文, 藤原俊義

日本消化器外科学会総会 68回 ( Supplement1 ) RV - 3 2013.7

食道胃接合部癌の外科治療戦略当科における食道胃接合部癌の治療経験下縦隔リンパ節転移症例の検討 Reviewed

野間和広, 白川靖博, 前田直見, 勝部亮一, 大原利章, 田辺俊介, 櫻間教文, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会総会 68回 ( Supplement1 ) PD - 5 2013.7

胸部食道癌のよりよい周術期管理を目指して PERIOと鏡視下手術の融合 Reviewed

白川靖博, 勝部亮一, 前田直見, 大原利章, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

日本消化器外科学会総会 68回 ( Supplement1 ) O - 1 2013.7

岡山大学病院卒後臨床研修センターにおける専属事務スタッフの取り組み

渡辺文恵, 小比賀美香子, 野間和広, 三好智子, 片岡仁美, 尾崎敏文, 大塚文男

医学教育 44 ( Suppl. ) 197 - 197 2013.7

岡山大学病院初期臨床研修における「たすきがけプログラム」アンケート結果より

小比賀美香子, 片岡仁美, 渡辺文恵, 野間和広, 三好智子, 尾崎敏文, 大塚文男

医学教育 44 ( Suppl. ) 196 - 196 2013.7

A novel synergistic effect of iron depletion on antiangiogenic cancer therapy. International journal

Toshiaki Ohara, Kazuhiro Noma, Shinichi Urano, Shinichiro Watanabe, Seishi Nishitani, Yasuko Tomono, Fumiaki Kimura, Shunsuke Kagawa, Yasuhiro Shirakawa, Toshiyoshi Fujiwara

International journal of cancer 132 ( 11 ) 2705 - 13 2013.6

Language：English Publisher：WILEY-BLACKWELL

Iron is an essential element for both normal and cancer cells in humans. Treatment to reduce iron levels has been shown to suppress tumor growth in vivo. However, iron depletion monotherapy by iron decreased treatment has not been thought to be superior to ordinary chemotherapy and is not part of the standard therapeutic strategy for the treatment of cancer. Iron depletion is also known to reduce serum hemoglobin and oxygen supply to the tissue, which indicates that iron depletion may induce angiogenesis. Therefore, we hypothesized that iron depletion with antiangiogenic therapy can have a novel therapeutic effect in the treatment of cancer. Human nonsmall cell carcinoma cell lines A549 and H1299 were used in our study. An iron-deficient diet and an iron chelator were used to simulate an iron-depleted condition. The antitumor effects of iron depletion and antiangiogenic therapy were determined on A549 xenograft mice. The iron-depleted condition produced by an iron-deficient diet suppressed tumor growth. Tumor tissue from the iron-deficient diet group showed that cancer cell proliferation was suppressed and hypoxia was induced. Microvessel density of this group was increased which suggested that the iron-depleted condition induced angiogenesis. Bevacizumab administration had a synergetic effect on inhibiting the tumor growth on Day 39. An iron-depleted condition inhibited cancer cell proliferation and reciprocally induced angiogenesis. Bevacizumab synergistically enhanced the iron-depleted antitumor effect. Treatment to deplete iron levels combined with anti-angiogenic therapy could induce a novel therapeutic effect in the treatment of cancer.

DOI： 10.1002/ijc.27943

Web of Science

PubMed

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食道がん手術患者の集中治療体験とその後の心理状態(第一報) Reviewed

伊藤真理, 足羽孝子, 岩谷美貴子, 前田直見, 勝部亮一, 大原利章, 田辺俊介, 野間和広, 白川靖博, 藤原俊義

日本食道学会学術集会プログラム・抄録集 67回 223 - 223 2013.6