Faculty Profiles - NOMA Kazuhiro

外科指導者養成のための講習会の意義と効果

山根正修, 万代康弘, 野間和広, 伊野英男, 藤原俊義, 佐野俊二, 三好新一郎

日本外科学会定期学術集会抄録集 116回 OP - 101 2016.4

鉄コントロールによる新規がん幹細胞治療 Reviewed

二宮卓之, 大原利章, 加藤卓也, 賀島肇, 野間和広, 田澤大, 田辺俊介, 香川俊輔, 白川靖博, 藤原俊義

日本外科学会定期学術集会抄録集 116回 PS - 8 2016.4

Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer. International journal

Michihiro Ishida, Shunsuke Kagawa, Kyoko Shimoyama, Kiyoto Takehara, Kazuhiro Noma, Shunsuke Tanabe, Yasuhiro Shirakawa, Hiroshi Tazawa, Hisataka Kobayashi, Toshiyoshi Fujiwara

Molecular cancer therapeutics 15 ( 3 ) 402 - 11 2016.3

Language：English Publisher：AMER ASSOC CANCER RESEARCH

Peritoneal dissemination is the most frequent metastasis in gastric cancer and is associated with poor prognosis. The lack of particular target antigens in gastric cancer other than HER2 has hampered the development of treatments for peritoneal dissemination of gastric cancer. Wehypothesized that HER2-extracellular domain (HER2-ECD) gene transduction combined with trastuzumab-based photoimmunotherapy (PIT) might provide excellent and selective antitumor effects for peritoneal dissemination of gastric cancer. In vitro, adenovirus/HER2-ECD (Ad/HER2-ECD) efficiently transduced HER2-ECD into HER2-negative gastric cancer cells. Trastuzumab-IR700 (Tra-IR700)-mediated PIT induced selective cell death of HER2-ECD-transduced tumor cells. Ad/HER2-ECD also induced homogenous expression of HER2 in heterogeneous gastric cancer cells, resulting in uniform sensitivity of the cells to Tra-IR700-mediated PIT. Anti-HER2 PIT integrated with adenoviral HER2-ECD gene transfer was applied in mice bearing peritoneal dissemination of HER2-negative gastric cancer. Intraperitoneal administration of Ad/HER2-ECD and Tra-IR700 with PIT inhibited peritoneal metastasis and prolonged the survival of mice bearing MKN45. Furthermore, minimal side effects allowed the integrated therapy to be used repeatedly, providing better control of peritoneal dissemination. In conclusion, the novel therapy of molecular-targeted PIT integrated with gene transfer technology is a promising approach for the treatment of peritoneal dissemination in gastric cancer. (C) 2016 AACR.

DOI： 10.1158/1535-7163.MCT-15-0644

Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer International journal

Michihiro Ishida, Shunsuke Kagawa, Kyoko Shimoyama, Kiyoto Takehara, Kazuhiro Noma, Shunsuke Tanabe, Yasuhiro Shirakawa, Hiroshi Tazawa, Hisataka Kobayashi, Toshiyoshi Fujiwara

MOLECULAR CANCER THERAPEUTICS 15 ( 3 ) 402 - 411 2016.3

Language：English Publisher：AMER ASSOC CANCER RESEARCH

DOI： 10.1158/1535-7163.MCT-15-0644

腹腔鏡下・ロボット支援下噴門側胃切除後「観音開き法」再建(Esophagogastrostomy with double flap technique after laparoscopic and robotic proximal gastrectomy)

西崎正彦, 黒田新士, 菊地覚次, 渡邉めぐみ, 野間和広, 香川俊輔, 白川靖博, 藤原俊義

日本胃癌学会総会記事 88回 272 - 272 2016.3

Surgeons have knowledge gaps in the safe use of energy devices: a multicenter cross-sectional study International journal

Yusuke Watanabe, Yo Kurashima, Amin Madani, Liane S. Feldman, Minoru Ishida, Akihiko Oshita, Takeshi Naitoh, Kazuhiro Noma, Keigo Yasumasa, Hiroshi Nagata, Fumitaka Nakamura, Koichi Ono, Yoshinori Suzuki, Nobuhisa Matsuhashi, Toshiaki Shichinohe, Satoshi Hirano

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES 30 ( 2 ) 588 - 592 2016.2

Language：English Publisher：SPRINGER

Despite the widespread use of surgical energy devices and the potential for rare but serious complications, pilot data from North America suggest that surgeons and surgical trainees have knowledge gaps in their safe use. The purpose of this study was to determine baseline knowledge of general surgeons and surgical trainees regarding the safe use of electrosurgery (ES) across varying levels of experience in Japan.
Participants completed a 35-item multiple-choice question examination, testing critical knowledge of ES. The examination was developed according to the objectives and blueprints of SAGES' Fundamental Use of Surgical Energy (TM) curriculum. Sections of the examination included: "principles of ES," "ES-related adverse events," "monopolar and bipolar devices," and "pediatric considerations and interference with implantable devices." Scores were compared between PGY > 5 and PGY 1-5 participants.
A total of 145 general surgeons and surgical trainees of all years after medical school (PGY 1-5: 57, PGY > 5: 88) from ten academic and five community hospitals completed the assessment (mean age 35; 91 % male). The mean score in the entire cohort was 58 +/- A 12 % (range 23-83 %), with significantly higher scores in the PGY > 5 group compared to the PGY 1-5 group (60 +/- A 11 vs. 53 +/- A 12 %, p < 0.01). Among all participants, 92 % were not familiar with best practices when using ES on patients with a pacemaker; 44 % believe that ES uses thermal energy from cautery; 19 % did not know how to manage an operating room fire; 16 % thought that a dispersive electrode should be cut to fit a child; and 27 % believe that insulation failure in minimally invasive surgical instruments is mostly visible under careful inspection.
General surgeons and trainees at all levels have knowledge gaps in the safe and effective use of energy devices, regardless of years of experience. There is a need for educational curricula to help address these gaps and contribute to safer surgery.

DOI： 10.1007/s00464-015-4243-5

Surgeons have knowledge gaps in the safe use of energy devices: a multicenter cross-sectional study. International journal

Yusuke Watanabe, Yo Kurashima, Amin Madani, Liane S Feldman, Minoru Ishida, Akihiko Oshita, Takeshi Naitoh, Kazuhiro Noma, Keigo Yasumasa, Hiroshi Nagata, Fumitaka Nakamura, Koichi Ono, Yoshinori Suzuki, Nobuhisa Matsuhashi, Toshiaki Shichinohe, Satoshi Hirano

Surgical endoscopy 30 ( 2 ) 588 - 592 2016.2

Language：English Publisher：SPRINGER

DOI： 10.1007/s00464-015-4243-5

Iron depletion enhances the effect of sorafenib in hepatocarcinoma

CANCER BIOLOGY & THERAPY 17 ( 6 ) 648 - 656 2016

Language：English Publisher：TAYLOR & FRANCIS INC

DOI： 10.1080/15384047.2016.1177677