Faculty Profiles - NOMA Kazuhiro

MISC - NOMA Kazuhiro

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Outcome of Radiation Monotherapy for High-risk Patients with Stage I Esophageal Cancer

Yasuhiro Shirakawa, Kazuhiro Noma, Naoaki Maeda, Shunsuke Tanabe, Shinji Kuroda, Shunsuke Kagawa, Kuniaki Katsui, Norihisa Katayama, Susumu Kanazawa, Toshiyoshi Fujiwara

ACTA MEDICA OKAYAMA 71 ( 2 ) 127 - 133 2017.4

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified.

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外科研修の現状からみえた若手外科医の求めるもの大規模surveyより

菊地覚次, 野間和広, 山根正修, 岸本浩行, 黒田新士, 香川俊輔, 新井禎彦, 佐野俊二, 三好新一郎, 藤原俊義

日本外科学会定期学術集会抄録集 117回 SP - 3 2017.4

ePTFEを用いた新規カテーテル挿入補助デバイスの開発 Reviewed

大原利章, 櫻間教文, 平松聡, 野間和広, 白川靖博, 藤原俊義

日本外科学会定期学術集会抄録集 117回 SF - 7 2017.4

食道胃接合部癌に対する腹腔鏡下観音開き法食道残胃吻合(Laparoscopic esophagogastorostomy using double flap technique for esophago-gastric junction cancer)

西崎正彦, 黒田新士, 菊地覚次, 野間和広, 田邊俊介, 香川俊輔, 白川靖博, 藤原俊義

日本胃癌学会総会記事 89回 286 - 286 2017.3

胃粘膜下腫瘍に対するClosed-LECS手技の改良と定型化(Standardization and modification of Closed-LECS procedure for gastric submucosal tumor)

菊地覚次, 西崎正彦, 黒田新士, 伊藤雅典, 田邊俊介, 野間和広, 香川俊輔, 白川靖博, 岡田裕之, 藤原俊義

日本胃癌学会総会記事 89回 269 - 269 2017.3

Visualized Evaluation of Blood Flow to the Gastric Conduit and Complications in Esophageal Reconstruction. International journal

Kazuhiro Noma, Yasuhiro Shirakawa, Nobuhiko Kanaya, Tsuyoshi Okada, Naoaki Maeda, Takayuki Ninomiya, Shunsuke Tanabe, Kazufumi Sakurama, Toshiyoshi Fujiwara

Journal of the American College of Surgeons 226 ( 3 ) 858 - 867 2017

Language：English Publisher：ELSEVIER SCIENCE INC

BACKGROUND: Evaluation of the blood supply to gastric conduits is critically important to avoid complications after esophagectomy. We began visual evaluation of blood flow using indocyanine green (ICG) fluorescent imaging in July 2015, to reduce reconstructive complications. In this study, we aimed to statistically verify the efficacy of blood flow evaluation using our simplified ICG method. STUDY DESIGN: A total of 285 consecutive patients who underwent esophagectomy and gastric conduit reconstruction were reviewed and divided into 2 groups: before and after introduction of ICG evaluation. The entire cohort and 68 patient pairs after propensity score matching (PS-M) were evaluated for clinical outcomes and the effect of visualized evaluation on reducing the risk of complication. RESULTS: The leakage rate in the ICG group was significantly lower than in the non-ICG group for each severity grade, both in the entire cohort (285 subjects) and after PS-M; the rates of other major complications, including recurrent laryngeal nerve palsy and pneumonia, were not different. The duration of postoperative ICU stay was approximately 1 day shorter in the ICG group than in the non-ICG group in the entire cohort, and approximately 2 days shorter after PS-M. Visualized evaluation of blood flow with ICG methods significantly reduced the rate of anastomotic complications of all Clavien-Dindo (CD) grades. Odds ratios for ICG evaluation decreased with CD grade (0.3419 for CD ≥ 1; 0.241 for CD ≥ 2; and 0.2153 for CD ≥ 3). CONCLUSIONS: Objective evaluation of blood supply to the reconstructed conduit using ICG fluorescent imaging reduces the risk and degree of anastomotic complication.

DOI： 10.1016/j.jamcollsurg.2017.11.007

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気管気管支リンパ節郭清における左気管支動脈温存のための安全なアプローチ

白川靖博, 前田直見, 二宮卓之, 田辺俊介, 野間和広, 藤原俊義

手術 71 ( 4 ) 367 - 374 2017

胸部食道癌に対する頸部リンパ節郭清術

白川靖博, 野間和広, 田辺俊介, 藤原俊義

消化器外科 40 ( 5 ) 508 - 515 2017

癌関連線維芽細胞は食道癌のリンパ節転移を促進するか~臨床検体の解析と同所移植モデルを用いた検証~

賀島肇, 野間和広, 佐藤浩明, 桂佑貴, 加藤卓也, 大原利章, 田澤大, 白川靖博, 藤原俊義

日本がん転移学会学術集会・総会プログラム抄録集 26th 2017

有茎空腸による食道再建

白川靖博, 河本慧, 松三雄騎, 前田直見, 二宮卓之, 田辺俊介, 櫻間教文, 野間和広, 藤原俊義

臨床雑誌外科 79 ( 4 ) 355 - 359 2017

癌関連線維芽細胞はIL-6を分泌しリンパ球の遊走を制御することで腫瘍免疫抑制を誘導する

加藤卓也, 野間和広, 賀島肇, 桂佑貴, 佐藤浩明, 二宮卓之, 大原利章, 藤原俊義

日本がん転移学会学術集会・総会プログラム抄録集 26th 2017

40年経過した食道アカラシア術後の食道拡張・下部食道狭窄症に対して胸腔鏡下食道亜全摘が著効した1例

桂佑貴, 白川靖博, 田邊俊介, 前田直見, 野間和広, 藤原俊義

岡山医学会雑誌 129 ( 1 ) 41 - 44 2017

食道胃接合部癌に対する下部食道噴門側胃切除術-腹臥位胸腔鏡・腹腔鏡アプローチによる完全鏡視下手術-

野間和広, 白川靖博, 田辺俊介, 黒田新士, 西﨑正彦, 藤原俊義

手術 71 ( 5 ) 767 - 772 2017

WHAT ARE REAL NEEDS FOR YOUNG SURGEONS IN SURGICAL EDUCATION ? THE SURVEY OF CURRENT SURGICAL TRAINING

菊地覚次, 野間和広, 山根正修, 岸本浩行, 黒田新士, 香川俊輔, 新井禎彦, 佐野俊二, 三好新一郎, 藤原俊義

日本外科学会雑誌 = Journal of Japan Surgical Society 118 ( 5 ) 588 - 590 2017

超高齢者の進行食道癌に対し積極的に集学的治療を行い長期無再発生存中の1例

松三雄騎, 白川靖博, 田邊俊介, 河本慧, 前田直見, 二宮卓之, 野間和広, 西崎正彦, 香川俊輔, 藤原俊義

癌と化学療法 44 ( 12 ) 1784 - 1786 2017

岡山大学病院初期研修医に対する「共感性」スコアを使用した経時的調査について

小比賀美香子, 小比賀美香子, 片岡仁美, 三好智子, 小川弘子, 野間和広, 佐藤明香, 宇賀麻由, 大塚文男, 大塚文男

医学教育 48 ( Suppl. ) 2017

食道胃接合部癌125例から導かれる最適な術式根治性と術後QOLの併存を求めて

野間和広, 白川靖博, 河本慧, 松三雄騎, 前田直見, 二宮卓之, 田辺俊介, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会雑誌(Web) 50 ( Supplement1 ) 2017

進行食道癌に対するDCF療法を用いた集学的治療

田邊俊介, 白川靖博, 河本慧, 松三雄騎, 前田直見, 二宮卓之, 野間和広, 西崎正彦, 香川俊輔, 藤原俊義

日本消化器外科学会雑誌(Web) 50 ( Supplement1 ) 2017

胃管作製不能例に対する有茎空腸を用いた食道再建術

前田直見, 白川靖博, 河本慧, 松三雄騎, 二宮卓之, 田辺俊介, 野間和広, 櫻間教文, 藤原俊義

日本消化器外科学会雑誌(Web) 50 ( Supplement1 ) 2017

食道癌根治術後Oligometastasisに対する治療戦略

二宮卓之, 金谷信彦, 前田直見, 田辺俊介, 櫻間教文, 野間和広, 西崎正彦, 香川俊介, 白川靖博, 藤原俊義

日本消化器外科学会雑誌(Web) 50 ( Supplement1 ) 2017

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