Faculty Profiles - MORIZANE Yuki

Papers - MORIZANE Yuki

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En-face画像を用いた前眼部OCTでの健常者の外眼筋の形状解析

濱崎一郎, 柴田貴世, 清水壯洋, 河野玲華, 藤原篤之, 森實祐基, 白神史雄

日本眼科学会雑誌 123 ( 臨増 ) 301 - 301 2019.3

強膜内陥術後に残存する網膜下液のEn face画像による検討

塩出雄亮, 森實祐基, 木村修平, 細川海音, 土居真一郎, 戸島慎二, 高橋耕介, 細木三佳, 藤原篤之, 白神史雄

日本眼科学会雑誌 123 ( 臨増 ) 260 - 260 2019.3

Congenital Multiple Ocular Motor Nerve Palsy Complicated by Splitting of the Lateral Rectus Muscle.

Reika Kono, Takehiro Shimizu, Hiroshi Ohtsuki, Ichiro Hamasaki, Kiyo Shibata, Fumiko Kishimoto, Yuki Morizane, Fumio Shiraga

Acta medica Okayama 73 ( 1 ) 67 - 70 2019.2

Language：English Publishing type：Research paper (scientific journal)

We report a case of congenital multiple ocular motor nerve palsy combined with splitting of the lateral rectus muscle (LR). A 59-year-old Japanese female was investigated for worsening esotropia after corrective surgery. She presented with left hypertropia (35Δ) and esotropia (45-50Δ). Orbital magnetic resonance imaging (MRI) showed reduced belly sizes in the superior rectus, inferior rectus, and superior oblique muscles and splitting of the LR, extending from the origin to the belly, in the left eye. Splitting of the LR belly was detected on MRI in a case of congenital multiple ocular motor nerve palsy.

DOI： 10.18926/AMO/56460

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分層黄斑円孔と黄斑偽円孔 En face画像を用いた網膜牽引の評価と分類

平野雅幸, 森實祐基

眼科手術 32 ( 1 ) 65 - 70 2019.1

Language：Japanese Publisher：(公社)日本眼科手術学会

分層黄斑円孔(LMH)もしくは黄斑偽円孔(MPH)と診断された60例63眼を対象として、波長掃引型光干渉断層計を用いてEn face画像を撮影した。En face画像を用いて、網膜(黄斑)上膜(ERM)の有無、網膜皺襞の有無、網膜分層の有無を評価し、この結果に基づいて対象を分類した。その結果、対象は網膜皺襞の有無と網膜分層の有無によって三つのグループに分類された。網膜皺襞と網膜分層をともに認めたグループ(グループA)は、その97%がBスキャン画像に基づく分類における牽引型LMHであった。網膜皺襞を認めたが網膜分層を認めなかったグループ(グループB)は全例がMPHであった。網膜皺襞を認めなかったが、網膜分層を認めたグループ(グループC)はその81%が変性型LMHであった。グループCの視力は、グループAおよびBよりも有意に不良であった。網膜皺襞の深度と黄斑の網膜開口部の真円度を定量評価した結果、グループAはグループBよりも網膜にかかる牽引力が大きく、また牽引の方向に偏りがあることが推察された。以上の結果から、LMHとMPHの病態における網膜牽引の関与が明らかになった。今後、多数例の検討を行い、病態に基づいた診断基準を策定する必要がある。(著者抄録)

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Incidence and causes of visual impairment in Japan: the first nation-wide complete enumeration survey of newly certified visually impaired individuals.

Yuki Morizane, Noriko Morimoto, Atsushi Fujiwara, Ryo Kawasaki, Hidetoshi Yamashita, Yuichiro Ogura, Fumio Shiraga

Japanese journal of ophthalmology 63 ( 1 ) 26 - 33 2019.1

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To investigate the visual impairment certification status in Japan. STUDY DESIGN: Observational cross-sectional study. METHODS: We asked all welfare offices throughout Japan to submit data concerning age, sex, causative diseases, and visual impairment grades for newly certified visually impaired individuals aged ≥ 18 years in the fiscal year of 2015. The certification was based on criteria of the Act on Welfare of Physically Disabled Persons. RESULTS: In total, data were collected for 12,505 newly certified visually impaired individuals. The most common age group for these individuals was 80-89 years (29.6%), followed by 70-79 (26.3%) and 60-69 (17.3%) years. The most common causative disease was glaucoma (28.6%), followed by retinitis pigmentosa (14.0%), diabetic retinopathy (12.8%), and macular degeneration (8.0%). Glaucoma was the most common causative disease in both sexes (30.2% in men and 27.0% in women). The most common impairment grade was grade 2 (31.8%), followed by grades 5 (24.3%) and grade 1 (16.1%). The number of visually impaired individuals with underlying glaucoma had increased in comparison with the number in the most recent surveys (from fiscal years 2007 to 2009), whereas the number of individuals with underlying diabetic retinopathy and macular degeneration had decreased. CONCLUSION: To our knowledge, this is the first nation-wide complete enumeration survey of newly certified visually impaired individuals in Japan. These findings may contribute to administrative activities concerning medical welfare as well as educational activities for preventing visual impairment.

DOI： 10.1007/s10384-018-0623-4

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Four-year follow-up of an elderly Japanese patient with distance Esotropia using magnetic resonance imaging

Reika Kono, Hiroshi Ohtsuki, Ichiro Hamasaki, Jiro Seguchi, Yuki Morizane, Fumio Shiraga

Neuro-Ophthalmology Japan 36 ( 3 ) 349 - 356 2019

Language：English Publishing type：Research paper (scientific journal) Publisher：Neuro-Ophthalmology Society of Japan

This report describes a case involving a Japanese patient with distance esotropia, who was followed-up for 4 years using magnetic resonance imaging (MRI). A 68-year-old woman with high myopia exhibited esotropia of 10 prism diopters (Δ) and right hypotropia of 5Δ
her axial lengths were 31.0 mm oculus dextrus (OD) and 30.7 mm oculus sinister (OS). Bilateral enlarged lateral rectus (LR)-superior rectus (SR) bands and posterior staphylomata were observed on orbital MRI. At the 4-year follow-up, her ocular deviation had deteriorated to esotropia of 18 Δ and right hypotropia of 8Δ
however, her axial lengths had scarcely changed (31.0 mm OD
30.8 mm OS). The enlargement and rupturing of the bilateral LR-SR bands had worsened. Progressive enlargement and rupturing of the LR-SR bands, which are presumably related to aging and possibly linked to progressive connective tissue degeneration, may increase ocular deviation.

DOI： 10.11476/shinkeiganka.36.349

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森實祐基

月刊糖尿病 10 ( 9 ) 14 - 21 2018.12

光線力学的療法が奏功した15歳男児の網膜血管腫の1例

難波倫江, 塩出雄亮, 藤原美幸, 森實祐基, 木村修平, 細川海音, 平野雅幸, 土居真一郎, 戸島慎二, 高橋耕介, 松前洋, 藤原篤之, 白神史雄

眼科臨床紀要 11 ( 11 ) 835 - 835 2018.11

Successful resolution of coats disease by photodynamic therapy: a case report. International journal

Michie Namba, Yusuke Shiode, Yuki Morizane, Shuhei Kimura, Mio Hosokawa, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

BMC ophthalmology 18 ( 1 ) 264 - 264 2018.10

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Coats disease is a retinal disease characterized by exudative retinal detachment due to abnormal retinal blood vessels. Coats disease is generally treated using laser photocoagulation and cryotherapy to ablate the abnormal retinal blood vessels. However, if abnormal blood vessels are present near the posterior pole of the eye and there is a severe exudative change there, it is difficult to perform these standard treatments. We describe a case of Coats disease with severe exudative retinal change and retinal vascular abnormality near the posterior pole for which we performed photodynamic therapy and successfully suppressed the disease and improved vision. CASE PRESENTATION: A 15-year-old Japanese boy presented to hospital with a chief complaint of decreased vision in his right eye. At the initial examination, corrected visual acuity of the right eye was 20/100. On the right fundus, exudative retinal detachment with subretinal haemorrhage was observed from the upper intermediate periphery to the posterior pole. Abnormal telangiectatic vessels and microaneurysms were found at the nasal peripheral retina. From these findings, we diagnosed the case as Coats disease. We conducted photodynamic therapy for the right eye. At 10 months after treatment, both the subretinal haemorrhage and the exudative retinal detachment had disappeared completely. Further, the retinal structure of the macula had recovered, and right vision had improved to 20/20. CONCLUSION: Photodynamic therapy may be an effective and safe treatment for Coats disease in cases that present with abnormal retinal vessels close to the posterior pole of the eye.

DOI： 10.1186/s12886-018-0930-z

PubMed

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PCVによる黄斑下血腫に対するt-PA網膜下注入併用硝子体手術の長期成績

木村修平, 森實祐基, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 高橋耕介, 松前洋, 細木三佳, 藤原篤之, 岡野内俊雄, 白神史雄

眼科臨床紀要 11 ( 10 ) 780 - 780 2018.10

【7年前の常識は現在の非常識!-眼科診療の最新標準】網膜・硝子体疾患手術手技黄斑円孔手術

森實祐基

臨床眼科 72 ( 11 ) 256 - 261 2018.10

光線力学的療法後に漿液性網膜剥離が再発した中心性漿液性脈絡網膜症の検討

松前洋, 塩出雄亮, 中澤理沙, 森實祐基, 木村修平, 細川海音, 平野雅幸, 土居真一郎, 戸島慎二, 高橋耕介, 細木三佳, 藤原篤之, 白神史雄

眼科臨床紀要 11 ( 10 ) 776 - 776 2018.10

Differences in the Stability and Amount of Postoperative Exodrift with Age after Unilateral Lateral Rectus Muscle Recession and Medial Rectus Muscle Resection of Intermittent Exotropia.

Ichiro Hamasaki, Kiyo Shibata, Takehiro Shimizu, Shin Morisawa, Shinji Toshima, Manabu Miyata, Takashi Furuse, Satoshi Hasebe, Hiroshi Ohtsuki, Yuki Morizane, Fumio Shiraga

Acta medica Okayama 72 ( 5 ) 487 - 492 2018.10

Language：English Publishing type：Research paper (scientific journal)

We investigated variances in the stability and amount of postoperative exodrift among age groups of intermittent exotropia (XPT) patients who underwent unilateral lateral rectus muscle recession and medial rectus muscle resection. We analyzed the cases of 110 consecutive patients who underwent the surgery in 2004-2011, dividing the patients into groups by their age at surgery: <10, 10-19, and ≥20 years. We performed a regression analysis (dependent variable: postoperative exodrift (°); independent variable: number of days post-surgery) using the formula of curve lines. When the tangent line slope was = 0.01 (°/days) for each group, we defined the numbers of days until alignment became stable as the 'stable days.' We evaluated the between-group differences in the amount of exodrift calculated for the stable days. The coefficients and coefficients of determination for the fitting curves were: <10 year group: f(x)=12.2 (1-e-0.0183x) (r2=0.588, p<0.05); 10-19 year group: f(x)=10.0 (1-e-0.0178x) (r2=0.453, p<0.05); ≥20 year group: f(x)=3.40 (1-e-0.0382x) (r2=0.217, p<0.05). There were 389 , 388, and 153 stable days, and the estimated postoperative exodrift with long-term follow-up was 11.5±3.7°, 9.3±4.4°, and 4.1±3.6° for the < 10 year, 10-19 year, and ≥ 20 year groups, respectively (≥20 year vs. other 2 groups, p<0.05). Longer periods and more postoperative exodrift were associated with younger age at surgery. The postoperative evaluation was approx. ≥ 1 year post-surgery in patients aged < 20. These findings may contribute to evaluating XPT's success rate and prognoses.

DOI： 10.18926/AMO/56246

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Embedding of lamellar hole-associated epiretinal proliferation combined with internal limiting membrane inversion for the treatment of lamellar macular hole: a case report. International journal

Yusuke Shiode, Yuki Morizane, Kosuke Takahashi, Shuhei Kimura, Mio Hosokawa, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

BMC ophthalmology 18 ( 1 ) 257 - 257 2018.9

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: We recently reported that lamellar macular hole (LMH) with lamellar hole-associated epiretinal proliferation (LHEP) can be effectively treated by embedding the LHEP into the retinal cleavage to improve foveal contour and visual acuity. Here, we report a case of LMH with LHEP for which we performed embedding of the LHEP combined with internal limiting membrane (ILM) inversion. We then evaluated the effects of this surgery on macular morphology and visual functions. CASE PRESENTATION: A 62-year-old man presented with visual disturbance (20/29) and metamorphopsia in his right eye. B-scan optical coherence tomography (OCT) imaging revealed the presence of both partial-thickness defect of the macula with degenerative retinal cleavage and LHEP at the surface of the retina. En face OCT imaging showed the absence of retinal fold. We performed phacoemulsification with intraocular lens implantation, vitrectomy, embedding of LHEP into the retinal cleavage, and ILM inversion. Three months after the surgery, both foveal contour and visual acuity (20/20) were improved and metamorphopsia was reduced. CONCLUSION: Embedding of the LHEP combined with ILM inversion may be an effective treatment for LMH with LHEP.

DOI： 10.1186/s12886-018-0926-8

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Impact of Polyp Regression on 2-year Outcomes of Intravitreal Aflibercept Injections: A Treat-and-Extend Regimen for Polypoidal Choroidal Vasculopathy.

Mio Morizane-Hosokawa, Yuki Morizane, Shuhei Kimura, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Shinji Toshima, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

Acta medica Okayama 72 ( 4 ) 379 - 385 2018.8

Language：English Publishing type：Research paper (scientific journal)

We conducted intravitreal aflibercept injections (IVAs) for 37 Japanese patients (28 males, 9 females, mean age 73.4 years) with polypoidal choroidal vasculopathy (PCV), with a treat-and-extend regimen (TER). We evaluated the impact of polyp regression after a loading dose (2-mg IVA 1×/month for 3 months) on the patients' 2-year treatment outcomes. Thirty-seven eyes were treated with IVA by a TER for 2 years. We divided the patients into 2 groups based on their polyp status after the loading dose: polyp regression (PR+) (n=19) and no polyp regression (PR-) (n=18). We compared the groups' best-corrected visual acuity (BCVA), central retinal thickness (CRT), recurrence rate, total number of injections, and final treatment interval. Both the BCVA and CRT were significantly improved by the treatment in both groups, with no between-group difference in the amount of change (p=0.769). In the polyp regression (+) group, recurrence was significantly less common (p=0.03), the mean total number of injections was significantly lower (p=0.013), and the mean treatment interval was significantly longer (0.042). Regarding the 2-year outcomes for PCV, the eyes with post-loading-dose polyp regression demonstrated less frequent recurrence and required fewer numbers of injections compared to the eyes without polyp regression.

DOI： 10.18926/AMO/56175

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Col4a3ノックアウトマウスにおける網膜の表現型解析

米澤朋子, 松前洋, 神崎勇希, Chuyuan Lou, 前場崇宏, 森實祐基, 美名口順, Miner Jeffrey, 大橋俊孝

日本結合組織学会学術大会プログラム・抄録集 50回 106 - 106 2018.6

Characteristics of early filtering blebs that predict successful trabeculectomy identified via three-dimensional anterior segment optical coherence tomography. International journal

Akiko Narita, Yuki Morizane, Tomoe Miyake, Jiro Seguchi, Tetsuya Baba, Fumio Shiraga

The British journal of ophthalmology 102 ( 6 ) 796 - 801 2018.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND/AIMS: To identify the cross-sectional characteristics of filtering blebs at 2 weeks post-trabeculectomy associated with intraocular pressure (IOP) control at 1 year post-trabeculectomy. METHODS: Ninety-nine eyes of 94 patients who had undergone primary trabeculectomy were included in this retrospective consecutive case series study. Surgical success was defined as an IOP ≤15 mm Hg and a >20% reduction in IOP without glaucoma medication or additional glaucoma surgeries at 1 year post-trabeculectomy. Subjects were classified into two groups according to whether surgery was successful or unsuccessful. Blebs were examined using swept-source three-dimensional anterior segment optical coherence tomography and evaluated for quantitative parameters, including maximum height, maximum wall thickness and ratio of hyporeflective space of the wall, as well as qualitative parameters, including multiple parallel hyporeflective layers within the wall (striping phenomenon), decreased visibility of the sclera underlying the bleb (shading phenomenon) and cyst-like structures of the wall. RESULTS: Seventy-seven eyes (77.8%) were assigned to the successful group and 22 (22.2%) to the unsuccessful group. Univariate analysis showed significant differences between the groups regarding maximum bleb height (p=0.044), maximum bleb wall thickness (p=0.017) and the striping phenomenon of the bleb wall (p=0.007). Multivariate logistic regression analysis confirmed that the striping phenomenon at 2 weeks post-trabeculectomy was significantly associated with success at 1 year post-trabeculectomy (OR 3.405; 95% CI 1.059 to 10.947; p=0.040). CONCLUSION: Taller blebs with thicker walls that showed the striping phenomenon at 2 weeks post-trabeculectomy appeared to predict good IOP control at 1 year post-trabeculectomy.

DOI： 10.1136/bjophthalmol-2017-310707

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Assessment of Lamellar Macular Hole and Macular Pseudohole With a Combination of En Face and Radial B-scan Optical Coherence Tomography Imaging. International journal

Masayuki Hirano, Yuki Morizane, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Mika Hosogi, Atsushi Fujiwara, Ippei Takasu, Toshio Okanouchi, Masaya Kawabata, Fumio Shiraga

American journal of ophthalmology 188 29 - 40 2018.4

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To investigate lamellar macular hole (LMH) and macular pseudohole (MPH) using a combination of en face and radial B-scan OCT. DESIGN: Retrospective observational case series. METHODS: Setting: Institutional study. PATIENT POPULATION: En face and radial B-scan OCT images of 63 eyes of 60 patients diagnosed with LMH or MPH based on an international classification were reviewed. OBSERVATION PROCEDURES: Cases were classified using en face images based on the presence/absence of epiretinal membrane (ERM), retinal folds, parafoveal epicenter of contractile ERM (PEC-ERM), and retinal cleavage. We compared the en face imaging-based classification system with the international classification system using radial B-scan images. We quantitatively evaluated visual function and macular morphology. MAIN OUTCOME MEASURES: Characterization of multimodal OCT-based subtypes of LMH and MPH. RESULTS: All cases showed ERM and were classified into 4 groups. In the first group, which lacked retinal folds and showed significantly lower visual acuity than the other groups, 81% of eyes had degenerative LMH. In the second group, which lacked PEC-ERM and retinal cleavage and showed significantly lower retinal fold depth, all eyes had MPH. The third group, in which 95% of eyes had symmetric tractional LMH, included eyes with retinal cleavage but without PEC-ERM, and this group showed higher circularity of the foveal aperture and cleavage area than the group with both these features, in which all eyes had asymmetric tractional LMH. CONCLUSIONS: Multimodal OCT enables classification of LMH and MPH based on pathologic conditions. Retinal traction in particular may be useful for determining treatment methods.

DOI： 10.1016/j.ajo.2018.01.016

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手術に踏み切るタイミングと手術のコツ網膜下出血

森實祐基

日本眼科学会雑誌 122 ( 臨増 ) 114 - 114 2018.3

細胞外基質が細胞遊走に及ぼす影響の評価を目的とした細胞遊走アッセイ

塩出雄亮, 森實祐基, 平野雅幸, 土居真一郎, 戸島慎二, 荒木亮一, 高橋耕介, 松前洋, 神崎勇希, 細木三佳, 米澤朋子, 白神史雄

日本眼科学会雑誌 122 ( 臨増 ) 226 - 226 2018.3

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