Faculty Profiles - MORIZANE Yuki

Papers - MORIZANE Yuki

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ミュラー細胞の増殖、遊走における4型コラーゲンの役割

塩出雄亮, 森實祐基, 的場亮, 平野雅幸, 土居真一郎, 荒木亮一, 米澤朋子, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 168 - 168 2015.3

黄斑下血腫に対するt-PA網膜下注入+液空気置換併用硝子体手術前後の微小視野の検討

木村修平, 森實祐基, 細川海音, 塩出雄亮, 土居真一郎, 平野雅幸, 的場亮, 細木三佳, 藤原篤之, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 202 - 202 2015.3

AMPK活性化による網膜色素上皮細胞の上皮間葉転換の抑制

的場亮, 森實祐基, 塩出雄亮, 土居真一郎, 平野雅幸, 荒木亮一, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 179 - 179 2015.3

En face OCTイメージによる脈絡膜血管の検討

藤原篤之, 森實祐基, 木村修平, 塩出雄亮, 細川海音, 土居真一郎, 平野雅幸, 細木三佳, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 251 - 251 2015.3

早期老化誘導および急性酸化ストレスが網膜色素上皮細胞のMMP産生に及ぼす影響の比較

荒木亮一, 森實祐基, 塩出雄亮, 的場亮, 土居真一郎, 平野雅幸, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 332 - 332 2015.3

滲出型加齢黄斑変性に対するアフリベルセプトTreat and Extend法の1年成績

細川海音, 森實祐基, 木村修平, 塩出雄亮, 土居真一郎, 平野雅幸, 藤原篤之, 細木三佳, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 200 - 200 2015.3

【最先端の硝子体手術】内境界膜自家移植による難治性黄斑円孔の治療

森實祐基, 白神史雄

あたらしい眼科 32 ( 2 ) 189 - 195 2015.2

抗VEGF治療セミナー加齢黄斑変性に対するTreat and Extend法

細川海音, 森實祐基

あたらしい眼科 32 ( 1 ) 103 - 104 2015.1

POEMS syndrome in a 20-year-old patient diagnosed following a complaint of reduced visual acuity.

Shinichiro Doi, Shuhei Kimura, Yuki Morizane, Mika Hosogi, Mio Hosokawa, Yusuke Shiode, Tetsuhiro Kawata, Eisei Kondo, Fumio Shiraga

Acta medica Okayama 68 ( 6 ) 379 - 83 2014.12

Language：English Publishing type：Research paper (scientific journal)

We report a case of POEMS syndrome in a 20-year-old patient diagnosed after visiting an eye clinic with a chief complaint of reduced visual acuity. A male university student aged 20 years was referred to our department complaining of blurred vision in both eyes that had persisted for 1 month. He also noted headache, nausea, and paresthesia in the lower extremities around the same time. The visual acuity of his right and left eye was 20/40 and 20/20, respectively. Optic disc edema and serous retinal detachment were present. Brain magnetic resonance imaging showed no intracranial abnormalities, while elevated cerebrospinal fluid pressure, reduced nerve conduction velocity in both lower extremities, hepatosplenomegaly, M proteinemia, high blood VEGF levels, osteoblastic and osteolytic changes in the spine, and atypical plasma cells in bone lesions were noted. From the above findings, the patient was diagnosed with POEMS syndrome. He received high-dose dexamethasone, thalidomide, and radiotherapy on the sacral mass, followed by high-dose melphalan with autologous stem-cell support, and showed subsequent systemic and ophthalmologic improvement. Here, we report the youngest case ever of POEMS syndrome with ocular manifestation. If patients have optic disc edema in both eyes with no intracranial space-occupying lesion, POEMS syndrome should be considered in differential diagnosis, regardless of age.

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【黄斑疾患診療の進歩】最新の黄斑円孔手術内境界膜処理剥離除去から活用する時代へ

森實祐基

眼科 56 ( 12 ) 1415 - 1425 2014.11

【知識が広がる!業務に生かせる!めめ子とトライまるごと眼科クイズ230】(4章)眼科の疾患よく出会う後眼部の疾患(黄斑上膜、黄斑円孔、緑内障、Vogt-小柳-原田病、うっ血乳頭、網膜色素変性症、裂孔原性網膜剥離、網膜細動脈瘤、硝子体出血)

森實祐基

眼科ケア ( 2014夏季増刊 ) 177 - 184 2014.6

Autologous transplantation of the internal limiting membrane for refractory macular holes. International journal

Yuki Morizane, Fumio Shiraga, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Tetsuhiro Kawata, Mika Hosogi, Yukari Shirakata, Toshio Okanouchi

American journal of ophthalmology 157 ( 4 ) 861 - 869 2014.4

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To determine the effectiveness of autologous transplantation of the internal limiting membrane (ILM) for refractory macular holes. DESIGN: Prospective, interventional case series. PATIENT AND METHODS: Ten eyes of 10 consecutive patients who underwent autologous transplantation of the ILM for the treatment of refractory macular holes were studied. The primary diseases in these patients were large idiopathic macular holes that had existed for more than 1 year (4 eyes), a traumatic macular hole (1 eye), myopic foveoschisis (2 eyes), foveoschisis resulting from pit-macular syndrome (2 eyes), and proliferative diabetic retinopathy (1 eye). Apart from the 5 eyes with idiopathic or traumatic macular holes, macular holes developed in the other 5 eyes after initial vitrectomies with ILM removal. In all eyes, regular macular hole surgery failed to achieve closure. The main outcome measures used in this study were macular hole closure and best-corrected visual acuity (BCVA). RESULTS: Macular holes were closed successfully in 9 eyes (90%) after autologous transplantation of the ILM. The postoperative BCVAs were significantly better than the preoperative BCVAs (P = .007, paired t test). Postoperative BCVAs improved by more than 0.2 logarithm of the minimal angle of resolution units in 8 eyes (80%) and were unchanged in 2 eyes (20%). CONCLUSIONS: Although this is a pilot study, the results suggest that autologous transplantation of the ILM may contribute to improved anatomic and visual outcomes in the treatment of refractory macular holes and may warrant further investigation.

DOI： 10.1016/j.ajo.2013.12.028

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滲出型加齢黄斑変性治療後の地図状萎縮に対するウノプロストン0.15%点眼液の有効性

白神千恵子, 藤原篤之, 山下彩奈, 小野葵, 小林守, 真鍋紗季, 森田美沙子, 泉端佐枝子, 三崎佳奈, 馬場哲也, 森實祐基, 白神史雄

日本眼科学会雑誌 118 ( 臨増 ) 297 - 297 2014.3

Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration Reviewed

Y Murakami, H Matsumoto, M Roh, A Giani, K Kataoka, Y Morizane, M Kayama, A Thanos, S Nakatake, S Notomi, T Hisatomi, Y Ikeda, T Ishibashi, K M Connor, J W Miller, D G Vavvas

Cell Death & Differentiation 21 ( 2 ) 270 - 277 2014.2

EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. International journal

Kimio Takeuchi, Ryoji Yanai, Fumiaki Kumase, Yuki Morizane, Jun Suzuki, Maki Kayama, Katarzyna Brodowska, Mitsuru Nakazawa, Joan W Miller, Kip M Connor, Demetrios G Vavvas

PloS one 9 ( 3 ) e91849 2014

Language：English Publishing type：Research paper (scientific journal)

EGFL7 is a secreted angiogenic factor, which in contrast to the well-known secreted angiogenic molecules VEGF and FGF-2, is almost exclusively expressed by endothelial cells and may act in an autocrine fashion. Prior studies have shown EGFL7 to mediate its angiogenic effects by interfering with the Notch pathway and/or via the intronic miR126. Less is known about its effects on VEGF signaling. We wanted to investigate the role of epidermal growth factor-like domain 7 (EGFL7) in VEGF-driven angiogenesis using an ex vivo Matrigel-embedded mouse eye cup assay and siRNA mediated knockdown of EGFL7 by siRNA. Our results suggested that VEGF-induced vascular tube formation was significantly impaired after siRNA downregulation of EGFL7. In addition, knockdown of EGFL7 suppressed VEGF upregulation of phospho-Akt and phospho-Erk(1/2) in endothelial cells, but did not alter VEGFR phosphorylation and neuropilin-1 protein expression or miR126 expression. Thus, in conclusion, EGFL7 is required for VEGF upregulation of the Akt/Erk (1/2) pathway during angiogenesis, and may represent a new therapeutic target in diseases of pathological neovascularization.

DOI： 10.1371/journal.pone.0091849

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【抗VEGF薬をどう使う?】PDTとの併用療法

森實祐基, 白神史雄

臨床眼科 67 ( 12 ) 1850 - 1859 2013.11

眼球破裂による眼内凝血塊に対してt-PAを使用し硝子体手術を行った1例

塩出雄亮, 木村修平, 塚本真啓, 細木三佳, 森實祐基

眼科臨床紀要 6 ( 10 ) 840 - 841 2013.10

AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells. International journal

Kimio Takeuchi, Yuki Morizane, Cynthia Kamami-Levy, Jun Suzuki, Maki Kayama, Wenyi Cai, Joan W Miller, Demetrios G Vavvas

The Journal of biological chemistry 288 ( 28 ) 20581 - 91 2013.7

Language：English Publishing type：Research paper (scientific journal)

Caveolin-1 is the primary structural component of endothelial caveolae that is essential for transcellular trafficking of albumin and is also a critical scaffolding protein that regulates the activity of signaling molecules in caveolae. Phosphorylation of caveolin-1 plays a fundamental role in the mechanism of oxidant-induced vascular hyper permeability. However, the regulatory mechanism of caveolin-1 phosphorylation remains unclear. Here we identify a previously unexpected role for AMPK in inhibition of caveolin-1 phosphorylation under oxidative stress. A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside (AICAR), inhibited oxidative stress-induced phosphorylation of both caveolin-1 and c-Abl, which is the major kinase of caveolin-1, and endocytosis of albumin in human umbilical vein endothelial cell. These effects were abolished by treatment with two specific inhibitors of AICAR, dipyridamole, and 5-iodotubericidin. Consistently, knockdown of the catalytic AMPKα subunit by siRNA abolished the inhibitory effect of AICAR on oxidant-induced phosphorylation of both caveolin-1 and c-Abl. Pretreatment with specific c-Abl inhibitor, imatinib mesylate, and knock down of c-Abl significantly decreased the caveolin-1 phosphorylation after H2O2 exposure and abolished the inhibitory effect of AICAR on the caveolin-1 phosphorylation. Interestingly, knockdown of Prdx-1, an antioxidant enzyme associated with c-Abl, increased phosphorylation of both caveolin-1 and c-Abl and abolished the inhibitory effect of AICAR on the caveolin-1 phosphorylation. Furthermore, co-immunoprecipitation experiment showed that AICAR suppressed the oxidant-induced dissociation between c-Abl and Prdx1. Overall, our results suggest that activation of AMPK inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis, and this effect is mediated in part by stabilizing the interaction between c-Abl and Prdx-1.

DOI： 10.1074/jbc.M113.460832

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Modified vitreous surgery for symptomatic lamellar macular hole with epiretinal membrane containing macular pigment. International journal

Fumio Shiraga, Ippei Takasu, Kouki Fukuda, Tomoyoshi Fujita, Ayana Yamashita, Kazuyuki Hirooka, Yukari Shirakata, Yuki Morizane, Atsushi Fujiwara

Retina (Philadelphia, Pa.) 33 ( 6 ) 1263 - 9 2013.6

A new syringe adaptor for intravitreal injection of premature eye. International journal

Shuhei Kimura, Masahiro Tsukamoto, Yusuke Shiode, Mika Hosogi, Yuki Morizane

Retina (Philadelphia, Pa.) 33 ( 4 ) 889 - 90 2013.4

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Papers - MORIZANE Yuki