Faculty Profiles - MORIZANE Yuki

Papers - MORIZANE Yuki

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Two-year Results of Intravitreal Ranibizumab Injections Using a Treat-and-extend Regimen for Macular Edema due to Branch Retinal Vein Occlusion.

Mika Hosogi, Yusuke Shiode, Yuki Morizane, Shuhei Kimura, Mio Hosokawa, Shinichiro Doi, Shinji Toshima, Kosuke Takahashi, Atsushi Fujiwara, Fumio Shiraga

Acta medica Okayama 73 ( 6 ) 517 - 522 2019.12

Language：English Publishing type：Research paper (scientific journal)

We investigated the effectiveness of a treat-and-extend regimen (TAE) of intravitreal ranibizumab injections for macular edema (ME) due to branch retinal vein occlusion (BRVO). We retrospectively examined 2-year results of 32 eyes of 32 patients who underwent TAE to treat ME due to BRVO. The patients whose treatment interval extended to ≥ 12 weeks were switched to a pro re nata regimen (PRN). For the patients whose treatment interval was <12 weeks, TAE was continued. At 2 years, 10 eyes had required no additional injections after the initial treatment period [recurrence(-) group], whereas the other 22 eyes required additional treatment [recurrence(+) group]. Among the recurrence(+) patients, 11 eyes (34.4% of total) were eventually switched from TAE to PRN; the other 11 eyes (34.4%) continued TAE for 2 years. Visual acuity and central retinal thickness were significantly improved in both the recurrence(+) and (-) groups, and there was no significant betweengroup difference in visual acuity at 2 years. Univariate analyses revealed significant differences in visual acuity (p=0.004), age (p=0.014), and vessel occlusion site (p=0.018) between these groups. Our results suggest that TAE may be effective for BRVO patients with lower visual acuity, older age, and occlusion of a major vein.

DOI： 10.18926/AMO/57716

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【中途失明の可能性のある疾患Q&A】中途失明の可能性のある疾患とその検査/治療網膜硝子体黄斑円孔の進行様式と治療について教えてください

木村修平, 森實祐基

あたらしい眼科 36 ( 臨増 ) 141 - 144 2019.11

Results of lamellar macular hole-associated epiretinal proliferation embedding technique for the treatment of degenerative lamellar macular hole. International journal

Kosuke Takahashi, Yuki Morizane, Shuhei Kimura, Yusuke Shiode, Shinichiro Doi, Toshio Okanouchi, Ippei Takasu, Yasushi Inoue, Fumio Shiraga

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 257 ( 10 ) 2147 - 2154 2019.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To investigate the outcomes of embedding lamellar hole-associated epiretinal proliferation (LHEP) into retinal cleavage for the surgical treatment of degenerative lamellar macular hole (LMH). METHODS: We retrospectively reviewed the medical records of 34 consecutive eyes of degenerative LMH patients who underwent vitrectomy with LHEP embedding and who were followed up for at least 12 months. Best-corrected visual acuity (BCVA), central retinal thickness (CRT), and macular structure preoperatively and at the final follow-up were compared. RESULTS: The mean (±SD) follow-up period was 30.0 ± 17.7 months. Twelve patients (35.3%) were men, and the mean age was 69.6 ± 10.1 years. Twenty-three eyes (67.6%) underwent simultaneous cataract surgery. BCVA was significantly improved at the final visit, from 0.31 ± 0.25 logarithm of the minimum angle of resolution units to 0.10 ± 0.25 (P < 0.01). This improvement in mean BCVA at the final postoperative visit occurred regardless of whether the eyes underwent simultaneous cataract surgery, from 0.30 ± 0.26 preoperatively to 0.04 ± 0.16 (P < 0.01) in the "with cataract surgery" group and from 0.32 ± 0.26 preoperatively to 0.21 ± 0.35 (P < 0.05) in the "without cataract surgery" group. CRT was also significantly improved at the final visit, from 123.2 ± 42.6 μm preoperatively to 191.2 ± 42.6 μm (P < 0.01). External limiting membrane and ellipsoid zone defects were detected in 17 (50.0%) and 15 (44.1%) eyes, respectively, but these were resolved in 10 (58.8%) and 7 (46.7%) eyes, respectively, at the final visit. No intraoperative or postoperative complications were observed. CONCLUSIONS: Embedding LHEP may be an effective and safe procedure to treat degenerative LMH.

DOI： 10.1007/s00417-019-04425-9

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Twist Knot: A New Sliding Noose in Adjustable Suture Strabismus Surgery.

Kiyo Shibata, Ichiro Hamasaki, Takehiro Shimizu, Reika Kono, Hiroshi Ohtsuki, Yuki Morizane, Fumio Shiraga

Acta medica Okayama 73 ( 5 ) 463 - 468 2019.10

Language：English

To permit noose movement without fraying the sutures following strabismus surgery, we designed a new sliding noose, the "twist knot" and investigated its advantages and disadvantages. We measured the tensile strength required to move the twist knot in a tightly tied state (134±19 gf) and in a loosened state (21±7 gf), and that required to move the conventional sliding noose in a tightly tied state (48±14 gf), and used the Kruskal-Wallis test to compare them. A significant difference was observed among the three tensile strengths (p<0.001). The twist knot technique allowed easy sliding without the multifilament braided suture becoming frayed and a knot to be firmly fixed without slipping. However, if the 2 strings of the pole sutures exit from the sclera at 2 widely separated positions, the sliding noose may become slack. Therefore, the distance between the pole sutures should be small. The simple twist knot technique was found to be an effective approach following adjustable surgery of strabismus.

DOI： 10.18926/AMO/57378

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Planned Foveal Detachment Technique for the Resolution of Diabetic Macular Edema Resistant to Anti-Vascular Endothelial Growth Factor Therapy. International journal

Shinji Toshima, Yuki Morizane, Shuhei Kimura, Fumio Shiraga

Retina (Philadelphia, Pa.) 39 Suppl 1 S162-S168 2019.10

黄斑上膜における網膜皺襞と網膜層構造との関係

神崎勇希, 平野雅幸, 森實祐基, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 戸島慎二, 高橋耕介, 藤原篤之, 細木三佳, 白神史雄

眼科臨床紀要 12 ( 10 ) 781 - 781 2019.10

Outcomes of vitrectomy combined with subretinal tissue plasminogen activator injection for submacular hemorrhage associated with polypoidal choroidal vasculopathy.

Shuhei Kimura, Yuki Morizane, Mio Morizane Hosokawa, Yusuke Shiode, Shinichiro Doi, Mika Hosogi, Atsushi Fujiwara, Toshio Okanouchi, Yasushi Inoue, Fumio Shiraga

Japanese journal of ophthalmology 63 ( 5 ) 382 - 388 2019.9

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To examine the outcomes of vitrectomy with subretinal tissue plasminogen activator (tPA) injection and postoperative intravitreal antivascular endothelial growth factor (VEGF) injection for submacular hemorrhage (SMH) associated with polypoidal choroidal vasculopathy (PCV). STUDY DESIGN: Retrospective, consecutive case series. METHODS: Patients who underwent vitrectomy for SMH associated with PCV and who were followed up for at least 12 months were included. Surgery consisted of vitrectomy with subretinal tPA and air tamponade. Postoperative intravitreal anti-VEGF was administered pro re nata. The following were examined: best-corrected visual acuity (BCVA) at baseline, at 1 month, and at the final visit; the percentage of patients requiring anti-VEGF postoperatively; and the number of injections administered. RESULTS: This study included 23 eyes of 23 patients (21 men, 2 women) with a mean age of 72.5 ± 9.0 years. The mean duration from disease onset to surgery was 9.0 ± 6.6 days. The mean maximum SMH size was 5.8 ± 4.8 disc diameters. The mean follow-up period was 33 ± 14 months. The BCVA was significantly improved when compared with baseline 1 month after surgery and at the final visit. Postoperative anti-VEGF was required for 91% of the eyes. In eyes that underwent anti-VEGF therapy until the final visit, the mean injection number was 4.1/year. CONCLUSIONS: Vitrectomy with subretinal tPA and air tamponade improved visual acuity in patients with SMH associated with PCV. Postoperative intravitreal anti-VEGF injection maintained the improved BCVA throughout a mean period of 33 months.

DOI： 10.1007/s10384-019-00679-2

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Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye. International journal

Mutsuko Kato, Keita Sato, Munenori Habuta, Hirofumi Fujita, Tetsuya Bando, Yuki Morizane, Fumio Shiraga, Satoru Miyaishi, Hideyo Ohuchi

Biochemistry and biophysics reports 19 100665 - 100665 2019.9

Language：English Publishing type：Research paper (scientific journal)

Recent studies show that exposure to ultraviolet (UV) light suppresses ocular elongation, which causes myopia development. However, the specific mechanisms of this process have not been elucidated. A UV-sensor, Opsin 5 (Opn5) mRNA was shown to be present in extraretinal tissues. To test the possibility that UV-signals mediated by Opn5 would have a direct effect on the outer connective tissues of the eye, we first examined the expression patterns of a mammalian type Opn5 (Opn5m) in the late-embryonic chicken eye. Quantitative PCR showed Opn5m mRNA expression in the cornea and sclera. The anti-Opn5m antibody stained a small subset of cells in the corneal stroma and fibrous sclera. We next assessed the effect of UV-A (375 nm) irradiation on the chicken fibroblast cell line DF-1 overexpressing chicken Opn5m. UV-A irradiation for 30 min significantly increased the expression of Early growth response 1 (Egr1), known as an immediate early responsive gene, and of Matrix metalloproteinase 2 (Mmp2) in the presence of retinal chromophore 11-cis-retinal. In contrast, expression of Transforming growth factor beta 2 and Tissue inhibitor of metalloproteinase 2 was not significantly altered. These results indicate that UV-A absorption by Opn5m can upregulate the expression levels of Egr1 and Mmp2 in non-neuronal, fibroblasts. Taken together with the presence of Opn5m in the cornea and sclera, it is suggested that UV-A signaling mediated by Opn5 in the extraretinal ocular tissues could influence directly the outer connective tissues of the chicken late-embryonic eye.

DOI： 10.1016/j.bbrep.2019.100665

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Internal Limiting Membrane Transposition for Persistent Macular Holes Using Double Layers of Viscoelastic. International journal

Mohamed Kamel Soliman, Alexander J Lingley, Yuki Morizane, Raman Tuli

Ophthalmic surgery, lasers & imaging retina 50 ( 6 ) 401 - 403 2019.6

Language：English Publishing type：Research paper (scientific journal)

Internal limiting membrane (ILM) grafting provides a useful option for repair of large and refractory macular holes that fail to close following prior ILM removal. However, current ILM graft techniques are associated with several challenges that may result in failure, most notably the difficulty in maintaining the graft in situ. In this video, the authors describe their modified technique for ILM grafting using a double layer of viscoelastic for stabilization in situ during the procedure. Four of five eyes managed with this technique demonstrated type 1 closure, and all eyes demonstrated improvement in visual acuity.

DOI： 10.3928/23258160-20190605-11

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Lights-out Surgery for Strabismus Using a Heads-Up 3D Vision System.

Ichiro Hamasaki, Kiyo Shibata, Takehiro Shimizu, Reika Kono, Yuki Morizane, Fumio Shiraga

Acta medica Okayama 73 ( 3 ) 229 - 233 2019.6

Language：English Publishing type：Research paper (scientific journal)

During strabismus surgery using illumination from a light source, patients complain of photophobia. The NGENUITYⓇ (Alcon) system is equipped with a high-dynamic-range (HDR) camera. A 4K display viewed by wearing circularly polarized glasses provides clear three-dimensional images of the operative field. A light source is usually required for surgeries of the anterior segment (including strabismic surgery), but the digital processing function of the NGENUITYⓇ system allows image display in relatively dark regions even without a light source. We devised a novel 'lights-out' surgery that does not use a microscope's light source, and we examined the usefulness of this technique in 2 cases of strabismic surgery. We performed strabismus surgery using the NGENUITYⓇ system in two patients between January and June 2018. The HDR function was used, and the aperture was opened to the maximum while the gain was adjusted. Surgery was conducted without using the microscope's light source. We report the 2 cases' results and evaluate the novel method. The surgeries were performed without problem even though the microscope's light source was not used. The patients' photophobia was alleviated. Lights-out surgery is a potentially useful modality for strabismus surgery.

DOI： 10.18926/AMO/56865

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Impact of Cataract Surgery on Filtering Bleb Morphology Identified Via Swept-source 3-dimensional Anterior Segment Optical Coherence Tomography. International journal

Akiko Narita, Yuki Morizane, Tomoe Miyake, Kae Sugihara, Tomoko Ishikawa, Jiro Seguchi, Fumio Shiraga

Journal of glaucoma 28 ( 5 ) 433 - 439 2019.5

Language：English Publishing type：Research paper (scientific journal)

PRéCIS:: Analysis of filtering bleb morphology using swept-source 3-dimensional anterior segment optical coherence tomography (3D AS-OCT) indicates that phacoemulsification can negatively impact the morphology of preexisting filtering blebs. PURPOSE: To identify the cross-sectional morphologic changes in successful filtering blebs after phacoemulsification using swept-source 3D AS-OCT. MATERIALS AND METHODS: In total, 30 phakic eyes of 29 patients with successful filtering blebs after primary trabeculectomy were included in this retrospective cohort study. Success was defined as intraocular pressure (IOP)≤15 mm Hg and a>20% reduction in IOP without glaucoma medication or additional glaucoma surgery after trabeculectomy. The subjects were classified into 2 groups according to whether they had undergone phacoemulsification or not after trabeculectomy: a phaco group and a control group. Filtering blebs were examined using swept-source 3D AS-OCT and evaluated for quantitative parameters, including maximum bleb height, maximum bleb wall thickness, and the ratio of the hyporeflective space of the bleb wall. RESULTS: Sixteen eyes were assigned to the phaco group and 14 eyes to the control group. The eyes in the control group showed no significant differences in IOP or in any of the 3D AS-OCT parameters at any of the follow-up timepoints. In the phaco group, the mean IOP increased significantly after phacoemulsification (P=0.003). Furthermore, the eyes in the phaco group showed a significant decrease in maximum bleb height (P=0.030), maximum bleb wall thickness (P=0.006), and the ratio of the hyporeflective space of the bleb wall (P=0.011) between prephacoemulsification and 1-year postphacoemulsification. CONCLUSION: Phacoemulsification can have a negative impact on filtering bleb morphology, which may lead to an IOP increase.

DOI： 10.1097/IJG.0000000000001204

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分層黄斑円孔と黄斑偽円孔のあたらしい捉え方 En face画像を用いた網膜牽引の評価と分類

平野雅幸, 森實祐基

眼科 61 ( 4 ) 387 - 395 2019.4

Language：Japanese Publisher：金原出版(株)

光干渉断層計(OCT)の解像度の向上とともに、黄斑偽円孔(MPH)と似た形態を示す分層黄斑円孔(LMH)との鑑別が難しくなった。現在のLMHとMPHの分類上の問題点を解説したうえで、筆者らが報告したOCTのen face画像を用いたLMHとMPHの新しい分類、さらに分類に基づいた治療法について述べた。牽引型LMHとMPHは、黄斑上膜による網膜牽引が病態に関与し、その強さと方向の均一性によって分類することができると考えられた。

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J00293&link_issn=&doc_id=20190426130010&doc_link_id=10.18888%2Fga.0000001129&url=https%3A%2F%2Fdoi.org%2F10.18888%2Fga.0000001129&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

黄斑疾患に対する硝子体手術最近の話題

森實祐基

眼科臨床紀要 12 ( 4 ) 348 - 348 2019.4

黄斑上膜の手術前後における網膜血管移動距離と網膜皺襞深度との関係

神崎勇希, 土居真一郎, 森實祐基, 木村修平, 細川海音, 塩出雄亮, 戸島慎二, 高橋耕介, 藤原篤之, 高須逸平, 白神史雄

日本眼科学会雑誌 123 ( 臨増 ) 206 - 206 2019.3

Surgical retinaの最先端黄斑手術に及ぼすSwept Source OCTの影響(Cutting edge In surgical retina Impact of Swept Source OCT on Macular Surgery)

森實祐基

日本眼科学会雑誌 123 ( 臨増 ) 73 - 73 2019.3

Plication法を用いた短縮術と筋切除術を施行した外斜視の術後1年成績と戻りの比較

柴田貴世, 濱崎一郎, 清水壯洋, 河野玲華, 森澤伸, 古瀬尚, 長谷部聡, 大月洋, 森實祐基, 白神史雄

日本眼科学会雑誌 123 ( 臨増 ) 233 - 233 2019.3

前眼部OCTを用いたPlication法での短縮術の外眼筋の術後評価

清水壯洋, 濱崎一郎, 柴田貴世, 河野玲華, 藤原篤之, 森實祐基, 白神史雄

日本眼科学会雑誌 123 ( 臨増 ) 233 - 233 2019.3

滲出型加齢黄斑変性に対するアフリベルセプトtreat and extend法の4年成績

細川海音, 森實祐基, 木村修平, 塩出雄亮, 土居真一郎, 戸島慎二, 高橋耕介, 藤原篤之, 細木三佳, 白神史雄

日本眼科学会雑誌 123 ( 臨増 ) 161 - 161 2019.3

The Impact of Prefilled Syringes on Endophthalmitis Following Intravitreal Injection of Ranibizumab. International journal

Philip P Storey, Zujaja Tauqeer, Yoshihiro Yonekawa, Bozho Todorich, Jeremy D Wolfe, Sumit P Shah, Ankoor R Shah, Takashi Koto, Ashkan M Abbey, Yuki Morizane, Priya Sharma, Edward H Wood, Mio Morizane-Hosokawa, Pooja Pendri, Maitri Pancholy, Shawn Harkey, Karen W Jeng-Miller, Anthony Obeid, Durga S Borkar, Eric Chen, Patrick Williams, Annabelle A Okada, Makoto Inoue, Fumio Shiraga, Akito Hirakata, Chirag P Shah, Jonathan Prenner, Sunir Garg

American journal of ophthalmology 199 200 - 208 2019.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To compare the rates of infectious endophthalmitis following intravitreal injection of ranibizumab using prefilled syringes vs conventional preparation. DESIGN: Multicenter retrospective cohort study. METHODS: All eyes receiving intravitreal injection of 0.5 mg ranibizumab for retinal vascular diseases at 10 retina practices across the United States (2016 to 2017) and Japan (2009 to 2017) were included. The total numbers of eyes and injections were determined from billing codes. Endophthalmitis cases were determined from billing records and evaluated with chart review. Primary outcome was the rate of postinjection acute endophthalmitis. Secondary outcomes were visual acuity and microbial spectrum. RESULTS: A total of 243 754 intravitreal 0.5 mg ranibizumab injections (165 347 conventional and 78 407 prefilled) were administered to 43 132 unique patients during the study period. In the conventional ranibizumab group, a total of 43 cases of suspected endophthalmitis occurred (0.026%; 1 in 3845 injections) and 22 cases of culture-positive endophthalmitis occurred (0.013%; 1 in 7516 injections). In the prefilled ranibizumab group, 12 cases of suspected endophthalmitis occurred (0.015%; 1 in 6534 injections) and 2 cases of culture-positive endophthalmitis occurred (0.0026%; 1 in 39 204 injections). Prefilled syringes were associated with a trend toward decreased risk of suspected endophthalmitis (odds ratio 0.59; 95% confidence interval 0.31-1.12; P = .10) and a statistically significant decreased risk of culture-positive endophthalmitis (odds ratio 0.19; 95% confidence interval 0.045-0.82; P = .025). Average logMAR vision loss at final follow-up was significantly worse for eyes that developed endophthalmitis from the conventional ranibizumab preparation compared to the prefilled syringe group (4.45 lines lost from baseline acuity vs 0.38 lines lost; P = .0062). Oral-associated flora was found in 27.3% (6/22) of conventional ranibizumab culture-positive endophthalmitis cases (3 cases of Streptococcus viridans, 3 cases of Enterococcus faecalis) compared to 0 cases in the prefilled ranibizumab group. CONCLUSION: In a large, multicenter, retrospective study the use of prefilled syringes during intravitreal injection of ranibizumab was associated with a reduced rate of culture-positive endophthalmitis, including from oral flora, as well as with improved visual acuity outcomes.

DOI： 10.1016/j.ajo.2018.11.023

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Magnetic resonance imaging findings of age-related distance esotropia in Japanese patients with high myopia. International journal

Reika Kono, Hiroshi Ohtsuki, Fumiko Kishimoto, Ichiro Hamasaki, Yuki Morizane, Fumio Shiraga

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 257 ( 3 ) 657 - 662 2019.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: This study aimed to investigate the characteristics of the extraocular muscles and the orbital connective tissue pulleys in Japanese patients with age-related distance esotropia (ARDE) and high myopia using magnetic resonance imaging (MRI). METHODS: This was a retrospective case-series study. High-resolution coronal MRI scans of 12 orbits were obtained in 6 patients with ARDE and high myopia (age range: 51-69 years). We analyzed the images to determine the positions of the rectus muscle pulleys relative to the center of the globe, the integrity of the lateral rectus-superior rectus muscle (LR-SR) band, and the LR angle (the angle between the major axis of the LR and the vertical plane). RESULTS: The distance esotropia ranged from 4 to 25∆, and 3 cases exhibited vertical deviations. The mean (±standard deviation (SD)) axial length was 28.5 (± 1.6) mm. The mean positions of the medial rectus muscle pulley and LR pulley were 1.3 mm inferior and 1.4 mm inferior, respectively, to those seen in the normal control group in our previous study (P = 0.002 and P = 0.05, respectively). All 12 orbits had abnormal elongated LR-SR bands, and 8 orbits (67%) displayed ruptured LR-SR bands. The LR angle (mean±SD; 18.8° ± 8.5°) increased significantly with the inferior displacement of the LR pulley (R2 = 0.77, P = 0.0002). CONCLUSIONS: Inferior displacement of the LR pulley and abnormal LR-SR bands were seen in Japanese ARDE patients with high myopia, as was found in ARDE patients without high myopia. The LR angle might be useful for judging the degree of LR pulley displacement.

DOI： 10.1007/s00417-019-04250-0

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