Faculty Profiles - MORIZANE Yuki

Papers - MORIZANE Yuki

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23G・25G硝子体手術システム(Alcon社製)における術後低眼圧の比較

高畠隆, 森實祐基, 岡部泰史, 岡本和夫, 中山雅雄

眼科臨床紀要 1 ( 10 ) 1006 - 1006 2008.10

糖尿病および高血圧による網脈絡膜血管内皮のグリコカリクス障害と白血球の接着

熊瀬文明, 毛利聡, 森實祐基, 高須逸平, 大月洋, 大塚愛二

日本糖尿病眼学会誌 13 100 - 100 2008.9

虹彩の"動き"が瞳孔膜の消退を誘導する

森實祐基

日本眼科学会雑誌 111 ( 11 ) 872 - 880 2007.11

Language：Japanese Publisher：(公財)日本眼科学会

眼球の形成期における水晶体の表面は,瞳孔膜と呼ばれる血管網で覆われている.瞳孔膜は水晶体上皮細胞を栄養した後,光路を保つためアポトーシスにより消退する.しかし,瞳孔膜のアポトーシスを誘導する因子については十分解明されていない.私はラット眼において,瞳孔膜の消退時期に一致して虹彩の運動能(縮瞳・散瞳能)が成熟することに着目し,"虹彩の動き"が瞳孔膜のアポトーシスを誘導しているのではないかと考えた.まず,生体顕微鏡を用いて虹彩運動(縮瞳・散瞳)に伴う瞳孔膜の血流変化を可視化した.その結果,縮瞳時に瞳孔膜の血流が停止し,散瞳時に血流が再開することが明らかになった.次に,散瞳薬を点眼し虹彩運動を持続的に抑制すると,瞳孔膜血管内皮細胞のアポトーシスが対照群に比べて有意に抑制された.以上から,虹彩の動きが瞳孔膜に血流の変化(虚血・再灌流)を起こし,血管内皮細胞のアポトーシスを誘導すると結論した.(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2007&ichushi_jid=J01049&link_issn=&doc_id=20071113440004&doc_link_id=10019991048&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F10019991048&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

[Iris movement mediates pupillary membrane regression].

Yuki Morizane

Nippon Ganka Gakkai zasshi 111 ( 11 ) 872 - 80 2007.11

Language：Japanese Publishing type：Research paper (scientific journal)

In the course of mammalian lens development, a transient capillary meshwork called as the pupillary membrane (PM) forms. It is located in the pupil area to nourish the anterior surface of the lens, and then regresses to clear the optical path. Although the involvement of the apoptotic process has been reported in PM regression, the initiating factor remains unknown. We initially found that regression of the PM coincided with the development of iris motility, and that iris movement caused cessation and resumption of blood flow within the PM. Therefore, we investigated whether the development of the capacity of the iris to constrict and dilate can function as an essential signal that induces apoptosis in the PM. Continuous inhibition of iris movement with mydriatic agents suppressed apoptosis of the PM and resulted in the persistence of PM in rats. The distribution of apoptotic cells in the regressing PM was diffuse and showed no apparent localization. These results indicated that iris movement induced regression of the PM by changing the blood flow within it. This study suggests the importance of the physiological interactions between tissues-in this case, the iris and the PM-as a signal to advance vascular regression during organ development.

PubMed

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虹彩の動きはラット瞳孔膜の消退時期に血管のアポトーシスを誘導する(Iris movement mediates vascular apoptosis during rat pupillary membrane regression)

森實祐基

日本眼科学会雑誌 111 ( 臨増 ) 147 - 147 2007.3

発育期ラット水晶体におけるα-クリスタリン会合粒子形成と低温白内障消失への関与

中山雅雄, 毛利聡, 森實祐基, 宮坂武寛, 片野坂友紀, 大田昇, 井上勝晶, 大月洋, 成瀬恵治, 八木直人

日本眼科学会雑誌 111 ( 臨増 ) 255 - 255 2007.3

PDT後、再発を繰り返すAMDに伴うCNVの組織学的特徴

熊瀬文明, 高須逸平, 森實祐基, 高畠隆, 岡部泰史, 寺田佳子, 大月洋, 大塚愛二

日本眼科学会雑誌 111 ( 臨増 ) 265 - 265 2007.3

眼科医のための先端医療虹彩の"動き"が瞳孔膜の消退を誘導する虹彩のもうひとつの機能

森實祐基, 毛利聡

あたらしい眼科 23 ( 12 ) 1583 - 1586 2006.12

光線力学療法後のインドシアニングリーン蛍光眼底造影所見の検討

寺田佳子, 森實祐基, 岡本和夫, 細木三佳, 高須逸平

眼科臨床医報 100 ( 10 ) 812 - 812 2006.10

糖尿病網膜症の細胞表面プロテオグリカンの解析

熊瀬文明, 高須逸平, 森實祐基, 中山雅雄, 大月洋, 毛利聡, 大塚愛二

日本眼科学会雑誌 110 ( 臨増 ) 217 - 217 2006.3

Iris movement mediates vascular apoptosis during rat pupillary membrane regression. International journal

Yuki Morizane, Satoshi Mohri, Jun Kosaka, Shigenobu Toné, Takahiko Kiyooka, Takehiro Miyasaka, Juichiro Shimizu, Yasuo Ogasawara, Fumio Shiraga, Yohsuke Minatogawa, Junzo Sasaki, Hiroshi Ohtsuki, Fumihiko Kajiya

American journal of physiology. Regulatory, integrative and comparative physiology 290 ( 3 ) R819-25 2006.3

Language：English Publishing type：Research paper (scientific journal)

In the course of mammalian lens development, a transient capillary meshwork known as the pupillary membrane (PM) forms, which is located at the pupil area; the PM nourishes the anterior surface of the lens and then regresses to make the optical path clear. Although the involvement of apoptotic process has been reported in the PM regression, the initiating factor remains unknown. We initially found that regression of the PM coincided with the development of iris motility, and iris movement caused cessation and resumption of blood flow within the PM. Therefore, we investigated whether the development of the iris's ability to constrict and dilate functions as an essential signal that induces apoptosis in the PM. Continuous inhibition of iris movement with mydriatic agents from postnatal day 7 to day 12 suppressed apoptosis of the PM and migration of macrophage toward the PM, and resulted in the persistence of PM in rats. The distribution of apoptotic cells in the regressing PM was diffuse and showed no apparent localization. These results indicated that iris movement induced regression of the PM by changing the blood flow within it. This study suggests the importance of the physiological interactions between tissues-in this case, the iris and the PM-as a signal to advance vascular regression during organ development, and defines a novel function of the iris during ocular development in addition to the well-known function, that is, optimization of light transmission into the eye.

PubMed

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A new scleral depressor for premature infants. International journal

Yuki Morizane, Ippei Takasu, Satoshi Mohri, Hiroshi Ohtsuki

Retina (Philadelphia, Pa.) 25 ( 8 ) 1118 - 1118 2005.12

緑内障治療用房水排出インプラントの開発

宮坂武寛, 森實祐基, 山本健一郎, 毛利聡, 高須逸平, 清水壽一郎, 高島征助, 酒井清孝, 大月洋, 梶谷文彦

人工臓器 34 ( 2 ) S - 102 2005.11

虹彩による微小循環調節と血管アポトーシス

毛利聡, 森實祐基, 宮坂武寛, 清水壽一郎, 梶谷文彦

日本バイオレオロジー学会年会抄録集 28回 49 - 49 2005.6

冠微小循環の階層性血管調節機能におけるNOとEDHFの関与

山本岳玄, 廣田真規, 井内洋介, 梶谷昌史, 清岡崇彦, 森本太郎, 岩崎達雄, 森實祐基, 宮坂武寛, 毛利聡, 清水壽一郎, 梶谷文彦

日本生理学雑誌 67 ( 4 ) 165 - 165 2005.4

Autonomic response induces vascular apoptosis during lens development in the rat eye

Y Morizane, S Mohri, J Kosaka, S Tone, T Kiyooka, T Miyasaka, J Shimizu, Y Ogasawara, F Shiraga, Y Minatogawa, J Sasaki, H Ohtsuki, F Kajiya

FASEB JOURNAL 19 ( 5 ) A1672 - A1672 2005.3

正常発生における血管網のアポトーシスにも血流の生理的変化が関与する

森實祐基, 小阪淳, 毛利聡, 刀祢重信, 清岡崇彦, 宮坂武寛, 清水壽一郎, 小笠原康夫, 佐々木順造, 大月洋, 梶谷文彦

解剖学雑誌 80 ( Suppl. ) 137 - 137 2005.3

Direct observation of epicardial coronary capillary hemodynamics during reactive hyperemia and during adenosine administration by intravital video microscopy. International journal

Takahiko Kiyooka, Osamu Hiramatsu, Fumiyuki Shigeto, Hiroshi Nakamoto, Hiroyuki Tachibana, Toyotaka Yada, Yasuo Ogasawara, Masahito Kajiya, Taro Morimoto, Yuki Morizane, Satoshi Mohri, Juichiro Shimizu, Tohru Ohe, Fumihiko Kajiya

American journal of physiology. Heart and circulatory physiology 288 ( 3 ) H1437-43 2005.3

Language：English Publishing type：Research paper (scientific journal)

Using high-resolution intravital charge-coupled device video microscopy, we visualized the epicardial capillary network of the beating canine heart in vivo to elucidate its functional role under control conditions, during reactive hyperemia (RH), and during intracoronary adenosine administration. The pencil-lens video-microscope probe was placed over capillaries fed by the left anterior descending artery in atrioventricular-blocked hearts of open-chest, anesthetized dogs paced at 60-90 beats/min (n = 17). In individual capillaries under control conditions, red blood cell flow was predominant during systole or diastole, indicating that the watershed between diastolic arterial and systolic venous flows is located within the capillaries. Capillary flow increased during RH and reached a peak flow velocity (2.1 +/- 0.6 mm/s), twice as high as control (1.2 +/- 0.5 mm/s), with enhancement of intercapillary cross-connection flow and enlargement of diameter (by 17%). With adenosine, capillary flow velocity significantly increased (1.8 +/- 0.7 mm/s). However, the increase in volumetric capillary flow with adenosine estimated from red blood cell velocity and diameter was less than the increase in arterial flow, whereas that during RH was nearly equivalent to the increase in arterial flow. There was a time lag of approximately 1.5 s for refilling of capillaries during RH, indicating their function as capacitance vessels. In conclusion, the coronary capillary network functions as 1) the major watershed between diastolic-dominant arterial and systolic-dominant venous flows, 2) a capacitor, and 3) a significant local flow amplifier and homogenizer of blood supply during RH, but with adenosine the increase in capillary flow velocity was less than the increase in arterial flow.

PubMed

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ラットの冠状微小循環のin vivoにおける視覚化階層的血流制御(In Vivo Visualization of Coronary Microcirculation in Rats and Hierarchical Flow Control)

廣田真規, 井内洋介, 梶谷昌史, 清岡嵩彦, 森實祐基, 森本太郎, 岩崎達雄, 宮坂武寛, 毛利聡, 清水壽一郎, 梶谷文彦, 佐野俊二, 麻原仁子, 辻岡克彦

Circulation Journal 68 ( Suppl.III ) 938 - 938 2004.10

冠微小循環の可視化による高血圧および正常血圧ラットの年齢に応じた血管内皮由来弛緩因子の関与

井内洋介, 廣田真規, 清岡崇彦, 梶谷昌史, 森本太郎, 森實祐基, 岩崎達雄, 包金花, 宮坂武寛, 毛利聡, 清水壽一郎, 平松修, 小笠原康夫, 上甲剛, 梶谷文彦

生体医工学 42 ( 2 ) 147 - 147 2004.6

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