Faculty Profiles - MORIZANE Yuki

Papers - MORIZANE Yuki

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COMPARISON OF HALVING THE IRRADIATION TIME OR THE VERTEPORFIN DOSE IN PHOTODYNAMIC THERAPY FOR CHRONIC CENTRAL SEROUS CHORIORETINOPATHY. International journal

Yusuke Shiode, Yuki Morizane, Shuhei Kimura, Mio Hosokawa, Tetsuhiro Kawata, Shinichiro Doi, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

Retina (Philadelphia, Pa.) 35 ( 12 ) 2498 - 504 2015.12

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To compare the efficacy and safety of photodynamic therapy using reduced irradiation time or reduced verteporfin dose for chronic central serous chorioretinopathy. METHODS: Between April 2011 and December 2013, 45 eyes with chronic central serous chorioretinopathy (43 consecutive patients) were treated with photodynamic therapy, using either half the irradiation time (18 eyes) or half the verteporfin dose (27 eyes). Outcome measures at follow-up, over at least 3 months, were complete resolution of serous retinal detachment, best-corrected visual acuity, and central retinal thickness. RESULTS: After 3 months, serous retinal detachment had completely resolved in 88.8% of eyes in both treatment groups, which were therefore not significantly different. The logarithm of the minimal angle of resolution best-corrected visual acuity (Snellen equivalent) improved from 0.245 (20/35) to 0.130 (20/27) (P < 0.05, paired t-test) in the reduced time group and from 0.283 (20/38) to 0.138 (20/27) (P < 0.05) in the reduced verteporfin group. Final best-corrected visual acuities in the 2 groups were not significantly different. Central retinal thicknesses dropped from 337.0 μm to 146.6 μm (P < 0.05) in the reduced time group and from 343.5 μm to 166.9 μm (P < 0.05) in the reduced verteporfin group. No ocular or systemic side effects were observed. CONCLUSION: Reduced irradiation time and reduced verteporfin dose were equally effective and safe in photodynamic therapy for chronic central serous chorioretinopathy.

DOI： 10.1097/IAE.0000000000000621

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硝子体手術におけるOCT付き手術顕微鏡の有用性

藤原篤之, 森實祐基, 木村修平, 塩出雄亮, 細川海音, 河田哲宏, 土居真一郎, 細木三佳, 白神史雄

眼科臨床紀要 8 ( 11 ) 824 - 824 2015.11

レーベル遺伝性視神経症の新規発症者数に関する疫学調査

上田香織, 森實祐基, 白神史雄, 敷島敬悟, 石川均, 若倉雅登, 中村誠

神経眼科 32 ( 増補1 ) 63 - 63 2015.10

黄斑上膜術後の黄斑浮腫に対するトリアムシノロン後部テノン嚢下投与の効果

塩出雄亮, 木村修平, 森實祐基, 細川海音, 河田哲宏, 土居真一郎, 細木三佳, 藤原篤之, 井上康, 白神史雄

眼科臨床紀要 8 ( 10 ) 745 - 745 2015.10

初回手術で閉鎖が得られなかった陳旧性黄斑円孔に対する内境界膜移植

木村修平, 森實祐基, 細川海音, 塩出雄亮, 河田哲宏, 土居真一郎, 細木三佳, 藤原篤之, 井上康, 白神史雄

眼科臨床紀要 8 ( 10 ) 765 - 766 2015.10

網膜硝子体疾患と治療将来に向かっての展望新しい黄斑手術

森實祐基

眼科臨床紀要 8 ( 10 ) 741 - 741 2015.10

黄斑円孔の術後早期の回復過程

平野雅幸, 河田哲宏, 森實祐基, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 細木三佳, 藤原篤之, 白神史雄

眼科臨床紀要 8 ( 10 ) 744 - 744 2015.10

Inverted ILM flap technique術後の黄斑円孔の閉鎖過程

森實祐基, 河田哲宏, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 細木三佳, 藤原篤之, 井上康, 白神史雄

眼科臨床紀要 8 ( 10 ) 766 - 767 2015.10

Subretinal injection of recombinant tissue plasminogen activator for submacular hemorrhage associated with ruptured retinal arterial macroaneurysm. International journal

Makoto Inoue, Fumio Shiraga, Yukari Shirakata, Yuki Morizane, Shuhei Kimura, Akito Hirakata

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 253 ( 10 ) 1663 - 9 2015.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To evaluate the surgical outcomes of small-gauge vitrectomy with subretinal injection of recombinant tissue plasminogen activator (rt-PA) for a submacular hemorrhage caused by a ruptured retinal arterial macroaneurysm (RAM). METHODS: Non-comparative, consecutive case-series performed at two ophthalmological institutions. We examined 22 eyes of 22 patients with a submacular hemorrhage associated with a RAM but without a preretinal or sub-internal limiting membrane hemorrhage at the fovea. During 25-gauge vitrectomy, approximately 4000-8000 IU of rt-PA was injected subretinally, followed by the injection of air or 10 % sulfur hexafluoride as a tamponade. The patients maintained an upright position for 1 hour, then turned to a facedown position for 1 to 3 days. The best-corrected visual acuity (BCVA) and postoperative complications were evaluated. RESULTS: The average interval from the onset of symptoms to surgery was 8.4 ± 7.6 days, and the average size of the subretinal hemorrhage was 3.4 ± 1.0 disc diameters. The submacular hemorrhage was displaced from the foveal area in all eyes after 1 week. The mean baseline BCVA was 1.41 ± 0.41 logMAR units, and it improved to 0.91 ± 0.43 at 1 month and to 0.64 ± 0.45 at the final visit (P = 0.0001, P < 0.0001 respectively). A macular hole was detected intraoperatively in two eyes and postoperatively in two eyes, and both were closed by internal limiting membrane peeling or a second vitrectomy. CONCLUSIONS: Small-gauge vitrectomy with subretinal rt-PA injection and gas tamponade were effective in displacing a submacular hemorrhage associated with a RAM.

DOI： 10.1007/s00417-014-2861-6

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Planned foveal detachment technique for the resolution of diffuse diabetic macular edema.

Yuki Morizane, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Masayuki Hirano, Shinichiro Doi, Mika Hosogi, Atsushi Fujiwara, Yasushi Inoue, Fumio Shiraga

Japanese journal of ophthalmology 59 ( 5 ) 279 - 87 2015.9

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To evaluate the therapeutic efficacy of a novel surgical procedure for diffuse diabetic macular edema (DME), performed in conjunction with conventional vitrectomy. METHODS: This prospective, interventional case series involved 20 eyes of 18 consecutive DME patients with best-corrected visual acuities (BCVAs) between 0.301 and 1.221 logarithm of the minimal angle of resolution (logMAR) units and central retinal thicknesses (CRTs) greater than 275 μm. After vitrectomy, a small retinal detachment was made in the macula by injecting 50-100 μl balanced salt solution into the subretinal space using a 38-gauge needle. Before finishing the surgery, fluid-air exchange was performed. Patients were asked to remain in prone position for 1 day postoperatively. The main outcome measures were CRT and BCVA. RESULTS: The mean CRT of 554.6 ± 152.7 μm before surgery significantly decreased to 295.6 ± 92.5 μm (p < 0.0001) 1 week after surgery and to 185.8 ± 67.4 μm (p < 0.0001) at 6 months after surgery. The CRT was less than 250 μm in 18 eyes (90 %) at 6 months after surgery. The mean BCVA before surgery (0.706 ± 0.348) significantly improved at 6 months after surgery (0.431 ± 0.392, p < 0.0001). Postoperative BCVAs improved by more than 0.3 logMAR units in 13 eyes (65 %), remained unchanged in six eyes (30 %) and worsened in one eye (5 %). Macular edema recurred in three eyes (15 %) 2 months after surgery. CONCLUSIONS: This novel planned foveal detachment technique facilitated a rapid resolution of DME and contributed to improved visual acuity.

DOI： 10.1007/s10384-015-0390-4

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Successful displacement of a traumatic submacular hemorrhage in a 13-year-old boy treated by vitrectomy, subretinal injection of tissue plasminogen activator and intravitreal air tamponade: a case report. International journal

Shinichiro Doi, Shuhei Kimura, Yuki Morizane, Yusuke Shiode, Mio Hosokawa, Masayuki Hirano, Mika Hosogi, Atsushi Fujiwara, Kazuhisa Miyamoto, Fumio Shiraga

BMC ophthalmology 15 94 - 94 2015.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: The natural course of submacular hemorrhage resulting from traumatic choroidal rupture generally has a poor outcome unless treated. The intravitreal injection of gas only or gas with recombinant tissue plasminogen activator (rt-PA) has been reported to be effective, but has also been reported to induce severe complications such as retinal detachment and vitreous hemorrhage. Recently, we reported a safe and effective procedure for treating submacular hemorrhage due to polypoidal choroidal vasculopathy (PCV) with a low dose of rt-PA. Here we report the application of this procedure to a case of traumatic submacular hemorrhage in a 13-year-old boy, which achieved a good visual outcome. CASE PRESENTATION: A 13-year-old Japanese boy presented with a thick submacular hemorrhage in his left eye as a result of blunt trauma from being hit by a sinker. Best-corrected visual acuity (BCVA) was assessed as only able to perceive hand motions. We carried out a vitrectomy, subretinal injection of 4,000 IU rt-PA (6.9 μg) and air tamponade. The day after surgery, most of the submacular hemorrhage had moved to the inferior periphery. One month after the surgery, we observed cataract formation, thin remnants of the submacular hemorrhage and juxtafoveal choroidal rupture. We carried out cataract surgery and injected bevacizumab intravitreally to prevent the development of choroidal neovascularization. Two months after the second surgery, the submacular hemorrhage had totally disappeared and the patient had a BCVA of 20/40. CONCLUSION: Vitrectomy, subretinal injection of rt-PA, and intravitreal air tamponade may be a promising strategy for treating traumatic submacular hemorrhage in young patients.

DOI： 10.1186/s12886-015-0090-3

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Six-month results of intravitreal aflibercept injections for patients with polypoidal choroidal vasculopathy. International journal

Mio Hosokawa, Fumio Shiraga, Ayana Yamashita, Chieko Shiragami, Aoi Ono, Yukari Shirakata, Shuhei Kimura, Yusuke Shiode, Tetsuhiro Kawata, Mika Hosogi, Atsushi Fujiwara, Yuki Morizane

The British journal of ophthalmology 99 ( 8 ) 1087 - 91 2015.8

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: This study aims to evaluate the therapeutic effect of intravitreal aflibercept injection for polypoidal choroidal vasculopathy (PCV). METHODS: Eighteen eyes of 17 consecutive patients with PCV received three consecutive monthly intravitreal injections of aflibercept and one additional injection 2 months later (four injections totally). All patients underwent eye examinations, which included best-corrected visual acuity (BCVA), fluorescein angiography, indocyanine green angiography, and optical coherence tomography. The primary endpoint of the study was the regression of polypoidal lesions. The secondary endpoints were BCVA, central retinal thickness (CRT) and changes in retinal exudation. RESULTS: Six months after the first aflibercept injection, the polypoidal lesions were completely resolved in 14 eyes (77.7%) and partially resolved in 4 eyes (22.2%). Although branching choroidal vascular networks were still present in all eyes, retinal exudative changes had completely resolved in 17 eyes (94.4%), and the mean CRT decreased significantly from 407.2±100.1 µm to 229.1±57.2 µm (p<0.0001). BCVA (logarithm of the minimal angle of resolution, logMAR) improved significantly from 0.414±0.384 at baseline to 0.297±0.334 after 6 months (p=0.016). CONCLUSIONS: At 6 months, aflibercept monotherapy effectively reduced polyps, retinal exudation and CRT in patients with PCV.

DOI： 10.1136/bjophthalmol-2014-305275

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Case report: successful closure of a large macular hole secondary to uveitis using the inverted internal limiting membrane flap technique. International journal

Masayuki Hirano, Yuki Morizane, Tetsuhiro Kawata, Shuhei Kimura, Mio Hosokawa, Yusuke Shiode, Shinichiro Doi, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

BMC ophthalmology 15 83 - 83 2015.7

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Macular holes (MHs) are one of the complications of posterior uveitis that can significantly disturb vision. Conventional MH surgery (vitrectomy, internal limiting membrane (ILM) peeling, and gas tamponade) has been reported to show lower closure rates in patients with MHs secondary to uveitis than in patients with idiopathic MHs. Recently, the inverted ILM flap technique has been reported to be effective for treating refractory MHs. Here, we describe the application of this technique in a patient with a large MH secondary to uveitis, and its successful closure. CASE PRESENTATION: An 80-year-old woman presented with a chronic, large MH secondary to uveitis. The minimum aperture diameter of the MH was 569 μm and extensive post-inflammatory chorioretinal atrophy was present, which included the juxtafoveal region. Vitrectomy with the inverted ILM flap technique assisted by low molecular weight hyaluronic acid was performed. Three days after surgery, the MH was closed successfully, without excessive gliosis. CONCLUSION: The inverted ILM flap technique may be the preferred surgical procedure for the treatment of large MHs secondary to uveitis.

DOI： 10.1186/s12886-015-0072-5

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新しい黄斑円孔手術

森實祐基

臨床眼科 69 ( 7 ) 953 - 959 2015.7

Language：Japanese Publisher：(株)医学書院

近年の硝子体手術の進歩とともに,黄斑円孔の治癒率は向上し,現在では90%以上の症例が初回手術で治癒するようになった。しかし一方で,硝子体手術を行っても円孔が閉鎖しない,いわゆる難治性黄斑円孔の存在が明らかとなり,有効な治療法の登場が望まれてきた。近年,難治性黄斑円孔に対して,新しい術式が考案され,良好な手術成績が報告されている。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2015&ichushi_jid=J01537&link_issn=&doc_id=20150709070002&doc_link_id=10.11477%2Fmf.1410211396&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1410211396&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

眼科医の手引難治性黄斑円孔に対する内境界膜自家移植

森實祐基

日本の眼科 86 ( 6 ) 775 - 776 2015.6

Inverted internal limiting membrane flap technique術後の黄斑円孔の閉鎖過程

森實祐基, 河田哲宏, 木村修平, 細川海音, 塩出雄亮, 土居真一郎, 細木三佳, 藤原篤之, 井上康, 白神史雄

日本眼科学会雑誌 119 ( 4 ) 298 - 299 2015.4

Submacular hemorrhage in polypoidal choroidal vasculopathy treated by vitrectomy and subretinal tissue plasminogen activator. International journal

Shuhei Kimura, Yuki Morizane, Mio Hosokawa, Yusuke Shiode, Tetsuhiro Kawata, Shinichiro Doi, Ryo Matoba, Mika Hosogi, Atsushi Fujiwara, Yasushi Inoue, Fumio Shiraga

American journal of ophthalmology 159 ( 4 ) 683 - 9 2015.4

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To evaluate vitrectomy with subretinal tissue plasminogen activator (t-PA) injection, and air tamponade, followed by intravitreal anti-vascular endothelial growth factor (VEGF) therapy for submacular hemorrhage in polypoidal choroidal vasculopathy (PCV). DESIGN: Prospective, interventional case series. METHODS: setting: Two clinics. PATIENTS: Fifteen eyes of 15 consecutive patients (mean age 72 ± 7 years) with submacular hemorrhage attributable to PCV. INCLUSION CRITERIA: PCV diagnosis with unorganized submacular hemorrhage greater than 500 μm thick. EXCLUSION CRITERIA: Submacular hemorrhage attributable to macular diseases (eg, high myopia, typical age-related macular degeneration, retinal angiomatous proliferation, and angioid streaks). INTERVENTION: Vitrectomy with 4000 IU t-PA injected subretinally and fluid/air exchange. Patients remained facedown for 3 days after surgery. Anti-VEGF drugs were administered as exudative changes required. MAIN OUTCOME MEASURES: Submacular hemorrhage displacement from the macula and changes in best-corrected visual acuities (BCVAs). RESULTS: Mean time from onset to surgery was 9.5 ± 4.5 (range, 5-21) days. Mean follow-up period was 9.4 ± 3.1 (range, 6-17) months. Surgery successfully displaced submacular hemorrhages from the macula in all eyes. Mean BCVA at baseline (0.98 ± 0.44) had improved significantly both 1 month after surgery (0.41 ± 0.25, P < .01) and at final visits (0.23 ± 0.25, P < .001). In all eyes, exudative retinal changes relapsed after surgery but were completely resolved by anti-VEGF injections. No complications occurred in any patients. CONCLUSION: Treating submacular hemorrhage with vitrectomy and subretinal t-PA injection, followed by intravitreal anti-VEGF therapy, is a promising strategy for improving visual acuity in PCV patients warranting further investigation.

DOI： 10.1016/j.ajo.2014.12.020

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網膜静脈分枝閉塞症に対するラニビズマブ投与(Treat and Extend法)の1年治療成績

土居真一郎, 森實祐基, 木村修平, 細木三佳, 細川海音, 塩出雄亮, 平野雅幸, 藤原篤之, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 165 - 165 2015.3

【糖尿病網膜症2015年】びまん性糖尿病黄斑浮腫に対する硝子体手術の現状

森實祐基

あたらしい眼科 32 ( 3 ) 361 - 367 2015.3

網膜中心静脈閉塞症に対するラニビズマブ投与(Treat and Extend法)の1年治療成績

細木三佳, 森實祐基, 木村修平, 細川海音, 土居真一郎, 平野雅幸, 藤原篤之, 白神史雄

日本眼科学会雑誌 119 ( 臨増 ) 167 - 167 2015.3

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