Faculty Profiles - MORIZANE Yuki

Papers - MORIZANE Yuki

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黄斑前膜および黄斑円孔に対する25Gと27G小切開硝子体手術の手術時間の比較

熊瀬文明, 森實祐基, 木村修平, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 細木三佳, 藤原篤之, 白神史雄

眼科臨床紀要 9 ( 10 ) 846 - 847 2016.10

抗VEGF療法に抵抗する糖尿病黄斑浮腫に対する網膜下眼内灌流液注入

森實祐基, 平野雅幸, 戸島慎二, 木村修平, 熊瀬文明, 細川海音, 塩出雄亮, 土居真一郎, 細木三佳, 藤原篤之, 井上康, 白神史雄

眼科臨床紀要 9 ( 10 ) 852 - 853 2016.10

網膜静脈分枝閉塞症へのラニビズマブ投与(treat and extend法)1年の再発に関わる因子

細木三佳, 森實祐基, 木村修平, 熊瀬文明, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 藤原篤之, 白神史雄

眼科臨床紀要 9 ( 10 ) 835 - 835 2016.10

ポリープ状脈絡膜血管症に対するアフリベルセプトの治療効果に関連する因子の検討

細川海音, 森實祐基, 木村修平, 熊瀬文明, 塩出雄亮, 土居真一郎, 平野雅幸, 藤原篤之, 戸島慎二, 細木三佳, 白神史雄

眼科臨床紀要 9 ( 10 ) 838 - 838 2016.10

ポリープ状脈絡膜血管症におけるアフリベルセプト投与後の地図状萎縮

藤原篤之, 森實祐基, 細川海音, 細木三佳, 木村修平, 熊瀬文明, 塩出雄亮, 土居真一郎, 平野雅幸, 戸島慎二, 白神史雄

眼科臨床紀要 9 ( 10 ) 838 - 838 2016.10

Factors Affecting Choroidal Vascular Density in Normal Eyes: Quantification Using En Face Swept-Source Optical Coherence Tomography. International journal

Atsushi Fujiwara, Yuki Morizane, Mio Hosokawa, Shuhei Kimura, Fumiaki Kumase, Yusuke Shiode, Shinichiro Doi, Masayuki Hirano, Shinji Toshima, Mika Hosogi, Fumio Shiraga

American journal of ophthalmology 170 1 - 9 2016.10

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To quantify the vascular density of the choroid of normal eyes and to identify the influencing factors using en face images obtained with swept-source optical coherence tomography (SS OCT). DESIGN: Prospective cross-sectional study. METHODS: One hundred and sixty-three eyes of 163 healthy volunteers (83 female; mean age 42.2 ± 22.6 years) with a corrected visual acuity of ≥1.0 were investigated. En face SS OCT images of the choroid were used for quantitative assessment of the vascular density in the large choroid vessel layer. Relationships between vascular density of the choroid and age, sex, refractive error (RE), axial length (AL), and subfoveal choroidal thickness (SCT) were also investigated. RESULTS: There was a significant negative relationship between vascular density of the choroid and subject age (P < .001). Analysis according to age showed a significant correlation in the group aged >30 years (P < .001), but not in the group aged ≤30 years (P = .225). SCT had a significant positive relationship with vascular density of the choroid (P < .001). However, a significant correlation was not observed between sex, RE, or AL and vascular density of the choroid (P = .981, P = .292, and P = .216, respectively). Multivariable regression analysis with vascular density of the choroid as the dependent variable and age, sex, RE, AL, and SCT as independent variables showed that age and SCT are important determinants of vascular density of the choroid (P < .001). CONCLUSION: Age and SCT affect vascular density of the choroid.

DOI： 10.1016/j.ajo.2016.07.006

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Efficacy of vitrectomy and inner limiting membrane peeling in age-related macular degeneration resistant to anti-vascular endothelial growth factor therapy, with vitreomacular traction or epiretinal membrane. International journal

Shuhei Kimura, Yuki Morizane, Shinji Toshima, Mika Hosogi, Fumiaki Kumase, Mio Hosokawa, Yusuke Shiode, Atsushi Fujiwara, Fumio Shiraga

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 254 ( 9 ) 1731 - 6 2016.9

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: We assessed the efficacy of vitrectomy and inner limiting membrane (ILM) peeling, followed by anti-vascular endothelial growth factor (VEGF) therapy, anti-VEGF-resistant age-related macular degeneration (AMD) due to vitreomacular traction (VMT) or epiretinal membrane (ERM). METHODS: We identified six patients with anti-VEGF-resistant AMD due to VMT or ERM amongst a total of 588 patients with AMD (821 eyes) referred to Okayama University Hospital between February 2012 and May 2014. These patients underwent vitrectomy to release the VMT (4 cases) or remove the ERM (2 cases), along with ILM peeling. The regimen used for intravitreal injections of anti-VEGF reagents after surgery was based on the severity of exudative changes in each patient. Preoperative and postoperative best-corrected visual acuity (BCVA) and central retinal thickness (CRT) measurements were compared. RESULTS: After vitrectomy and ILM peeling, all six patients responded to anti-VEGF therapy, which was then able to maintain dry retinas. Mean BCVA did not improve significantly (0.49 ± 0.28 before vs. 0.43 ± 0.38 after surgery, P = 0.538). However, mean CR was significantly decreased after surgery, from 423 ± 83.5 μm to 257 ± 75.8 μm (P = 0.0078). CONCLUSIONS: Vitrectomy and ILM peeling followed by anti-VEGF therapy may be a useful therapeutic option for anti-VEGF-resistant AMD with VMT or ERM.

DOI： 10.1007/s00417-016-3314-1

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CLINICAL CHARACTERISTICS OF IDIOPATHIC FOVEOMACULAR RETINOSCHISIS. International journal

Ichiro Maruko, Yuki Morizane, Shuhei Kimura, Yusuke Shiode, Mio Hosokawa, Tetsuju Sekiryu, Tomohiro Iida, Fumio Shiraga

Retina (Philadelphia, Pa.) 36 ( 8 ) 1486 - 92 2016.8

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: To describe the clinical features of idiopathic foveomacular retinoschisis not in association with myopia, glaucoma, optic disk pit, or juvenile retinoschisis. METHODS: Retrospective observational case series. Five eyes of five patients with idiopathic foveomacular retinoschisis were included. RESULTS: The patients were 2 men and 3 women (average age, 75.2 years; range, 71-78 years). The average spherical equivalent was +2.40 diopters (range, +0.88 to +5.75 diopters), and the average axial length was 22.0 mm (range, 21.1-23.1 mm). All patients had retinoschisis from the macula to the optic disk in the affected eye. No patients had retinoschisis in the fellow eye. The average best-corrected visual acuity was 20/44 (68 Early Treatment Diabetic Retinopathy Study letter score). CONCLUSION: Idiopathic foveomacular retinoschisis is not inherited or associated with myopia, vitreomacular traction syndrome, optic pit, or glaucoma but is associated with older age, unilaterality, hyperopia with short axial length, complete posterior vitreous detachment, and weak leakage from the optic disk on fluorescein angiography.

DOI： 10.1097/IAE.0000000000000938

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Novel Technique for Subretinal Injection Using Local Removal of the Internal Limiting Membrane. International journal

Toshio Okanouchi, Shinji Toshima, Shuhei Kimura, Yuki Morizane, Fumio Shiraga

Retina (Philadelphia, Pa.) 36 ( 5 ) 1035 - 8 2016.5

En faceイメージによる脈絡膜血管の深度別検討

藤原篤之, 森實祐基, 木村修平, 熊瀬文明, 塩出雄亮, 細川海音, 土居真一郎, 平野雅幸, 細木三佳, 白神史雄

日本眼科学会雑誌 120 ( 臨増 ) 187 - 187 2016.3

硝子体手術後に遷延する糖尿病黄斑浮腫に対する網膜下眼内灌流液注入

戸島慎二, 森實祐基, 平野雅幸, 木村修平, 熊瀬文明, 細川海音, 塩出雄亮, 土居真一郎, 細木三佳, 藤原篤之, 岡野内俊雄, 白神史雄

日本眼科学会雑誌 120 ( 臨増 ) 220 - 220 2016.3

滲出型加齢黄斑変性に対するアフリベルセプトtreat and extend法の2年成績

細川海音, 森實祐基, 木村修平, 熊瀬文明, 塩出雄亮, 土居真一郎, 平野雅幸, 戸島慎二, 藤原篤之, 細木三佳, 白神史雄

日本眼科学会雑誌 120 ( 臨増 ) 177 - 177 2016.3

剥離した内境界膜に含まれる終末糖化産物の定量評価

的場亮, 森實祐基, 木村修平, 米澤朋子, 須野学, 岡野内俊雄, 高畠隆, 三原研一, 佐々木ミチ, 飯島克昌, 白神史雄

日本眼科学会雑誌 120 ( 臨増 ) 185 - 185 2016.3

網膜中心静脈閉塞症へのラニビズマブ投与(Treat & Extend法)1年の再発に関わる因子

細木三佳, 森實祐基, 木村修平, 熊瀬文明, 細川海音, 塩出雄亮, 平野雅幸, 土居真一郎, 戸島慎二, 藤原篤之, 白神史雄

日本眼科学会雑誌 120 ( 臨増 ) 175 - 175 2016.3

最先端の硝子体手術を検証する難治性黄斑円孔に対する内境界膜翻転法および内境界膜自家移植

森實祐基

日本眼科学会雑誌 120 ( 臨増 ) 10 - 10 2016.3

【OCTを使いこなす2016】網膜硝子体界面症候群

森實祐基

あたらしい眼科 33 ( 2 ) 189 - 195 2016.2

【眼底自発蛍光フル活用】網膜循環障害疾患と眼底自発蛍光

森實祐基

OCULISTA ( 34 ) 61 - 68 2016.1

Language：Japanese Publisher：(株)全日本病院出版会

眼底自発蛍光は、網膜色素上皮細胞や視細胞の機能や代謝状態を反映する。そのため、糖尿病網膜症や網膜静脈および動脈の閉塞症等の網膜循環障害疾患の眼底自発蛍光を検討することは、これらの疾患の病態をより深く理解するために有用であると考えられる。本稿では網膜循環障害疾患に共通してみられる所見として、嚢胞様黄斑浮腫、漿液性網膜剥離、硬性白斑等を取り上げ、その自発蛍光所見の特徴と意義について解説する。また、網膜循環障害疾患の主要な治療法である網膜光凝固における眼底自発蛍光の活用法についても述べる。(著者抄録)

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AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages. International journal

Fumiaki Kumase, Kimio Takeuchi, Yuki Morizane, Jun Suzuki, Hidetaka Matsumoto, Keiko Kataoka, Ahmad Al-Moujahed, Daniel E Maidana, Joan W Miller, Demetrios G Vavvas

PloS one 11 ( 1 ) e0147279 2016

Language：English Publishing type：Research paper (scientific journal)

C-C chemokine receptor 2 (Ccr2) is a key pro-inflammatory marker of classic (M1) macrophage activation. Although Ccr2 is known to be expressed both constitutively and inductively, the full regulatory mechanism of its expression remains unclear. AMP-activated protein kinase (AMPK) is not only a master regulator of energy homeostasis but also a central regulator of inflammation. In this study, we sought to assess AMPK's role in regulating RAW264.7 macrophage Ccr2 protein levels in resting (M0) or LPS-induced M1 states. In both M0 and M1 RAW264.7 macrophages, knockdown of the AMPKα1 subunit by siRNA led to increased Ccr2 levels whereas pharmacologic (A769662) activation of AMPK, attenuated LPS-induced increases in Ccr2 expression in an AMPK dependent fashion. The increases in Ccr2 levels by AMPK downregulation were partially reversed by NF-κB inhibition whereas TNF-a inhibition had minimal effects. Our results indicate that AMPK is a negative regulator of Ccr2 expression in RAW264.7 macrophages, and that the mechanism of action of AMPK inhibition of Ccr2 is mediated, in part, through the NF-κB pathway.

DOI： 10.1371/journal.pone.0147279

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Surgical Outcome of Idiopathic Epiretinal Membranes with Intraretinal Cystic Spaces. International journal

Yusuke Shiode, Yuki Morizane, Shinji Toshima, Shuhei Kimura, Fumiaki Kumase, Mio Hosokawa, Masayuki Hirano, Shinichiro Doi, Kosuke Takahashi, Mika Hosogi, Atsushi Fujiwara, Fumio Shiraga

PloS one 11 ( 12 ) e0168555 2016

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: To investigate the occurrence ratio, localization, and surgical outcomes of intraretinal cystic spaces in idiopathic epiretinal membranes (ERMs). METHODS: We retrospectively reviewed the charts of 432 eyes of 398 consecutive patients with idiopathic ERM who underwent vitrectomy and ERM peeling from January 2012 to September 2015. We selected cases with intraretinal cystic space prior to surgery, detected by spectral-domain optical coherence tomography. We then evaluated the effects of ERM peeling on intraretinal cystic spaces, best corrected visual acuity, and central retinal thickness at 6 months after surgery. RESULTS: Twenty-four eyes (5.5%) showed intraretinal cystic spaces before surgery, present in the inner retinal layer (the inner group) in 9 eyes, in the outer retinal layer (the outer group) in 6 eyes, and in both the inner and the outer retinal layers (the combined group) in 9 eyes. Additionally, 30 eyes with ERM but without any presence of intraretinal cystic space were selected randomly and classified as the no cyst group. At 6 months after surgery, the disappearance rate of cystic spaces was significantly greater for the outer group than for the inner group (83.3% and 11.1%, respectively, P = 0.011). The mean best corrected visual acuity improved significantly after surgery in the inner group, the outer group, and the no cyst group (P < 0.05 for all three groups) but did not improve in the combined group (P = 0.58). The mean central retinal thickness decreased significantly after surgery in the inner group, the combined group, and the no cyst group (P < 0.05). CONCLUSIONS: Intraretinal cystic spaces were observed in 5.5% of preoperative idiopathic ERM cases. Following surgery, the cystic spaces in the outer retinal layer disappeared at higher rates than those in the inner retinal layer, suggesting that the pathophysiologies of these cystic spaces are different.

DOI： 10.1371/journal.pone.0168555

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Successful resolution of stromal keratitis and uveitis using canakinumab in a patient with chronic infantile neurologic, cutaneous, and articular syndrome: a case study. International journal

Masayuki Hirano, Jiro Seguchi, Masahiro Yamamura, Akiko Narita, Hirotaka Okanobu, Ryuta Nishikomori, Toshio Heike, Mio Hosokawa, Yuki Morizane, Fumio Shiraga

Journal of ophthalmic inflammation and infection 5 ( 1 ) 34 - 34 2015.12

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Cryopyrin-associated periodic syndrome (CAPS) is a group of rare autoinflammatory diseases, and of these, chronic infantile neurologic, cutaneous, and articular/neonatal-onset multisystem inflammatory disease (CINCA/NOMID) syndrome has the most severe phenotype. Canakinumab, a monoclonal antibody that targets interleukin-1β, has been shown to be an effective treatment for resolving systemic inflammation. However, its efficacy for treating ophthalmic symptoms of this disorder remains unclear. FINDINGS: A 64-year-old female reported episodes of nonpruritic urticaria, fever, aseptic meningitis, and bilateral sensorineural deafness. Her son had experienced similar symptoms. She was initially referred for ophthalmologic treatment for an infectious corneal ulcer. Examination of her right eye by slit lamp biomicroscopy showed diffuse conjunctival injection, corneal infiltrates, a corneal ulcer, and hypopyon. She was therefore treated aggressively with topical and systemic antibiotics in addition to antifungal medications. However, this was ineffective. Genetic analysis detected the heterozygous germline p.Asp303Asn mutation in the NLRP3 gene in both our patient and her son. She was therefore diagnosed with CINCA/NOMID syndrome based on her clinical manifestations. All of the patient's physical and ophthalmic symptoms were resolved within a few days after the initiation of canakinumab treatment. During an 18-month follow-up period, no adverse events or severe infections were observed. CONCLUSIONS: Our case report indicates that canakinumab is effective not only for the treatment of systemic inflammation but also for treating ophthalmic involvement, such as recurrent stromal keratitis and anterior uveitis.

DOI： 10.1186/s12348-015-0065-9

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