Faculty Profiles - WATANABE Toyohiko

Papers - WATANABE Toyohiko

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医療TOPICS 男の更年期

渡辺豊彦

看護実践の科学 28 ( 1 ) 44 - 45 2003.1

Renal cell carcinoma in bilateral native kidneys following failure of transplant graft function: A case report

Toyohiko Watanabe, Katsuji Takeda, Yasuyuki Kobayashi, Toshihiko Asahi

Nishinihon Journal of Urology 65 ( 2 ) 65 - 68 2003

Language：Japanese Publishing type：Research paper (scientific journal)

We report a case of renal cell carcinoma occurring in bilateral native kidneys following failure of transplant graft function. A 50-year-old man with long-standing chronic renal failure secondary to chronic glomerulonephritis had been on hemodialysis for 9 years when a cadaveric renal transplant was performed on January 29, 1995. He then resumed hemodialysis because of graft failure 21 months after the transplantation. He presented with gross hematuria and lower abdominal pain on April 5, 2001. Computerized tomography (CT) demonstrated acquired cystic disease of the kidney (ACDK) in both native kidneys with a 6 cm solid mass in the left kidney. He underwent transperitoneal bilateral nephrectomy with graft removal. Histopathological examination revealed renal cell carcinoma of the clear cell subtype with a maximum diameter of 4.5 cm in the left kidney. Despite the fact that no mass lesion was noted on preoperative CT of the right native kidney, a solitary 1.5×1.2×1.0 cm clear cell carcinoma was found in the upper portion. He has remained free of evidence of recurrence or metastasis for 6 months postoperatively.

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超音波ドプラを用いた非侵襲的ビデオウロダイナミクスの開発 Reviewed

小澤秀夫, 横山光彦, 渡邉雄一, 西口潤, 野崎邦浩, 佐々木克己, 二部野肇, 渡辺豊彦, 公文裕巳, Ding Yew Yoong, Chancellor Michael B.

日本神経因性膀胱学会誌 12 ( 2 ) 200 - 206 2001.12

Language：Japanese Publisher：(一社)日本排尿機能学会

超音波ドプラを用いた尿流動態検査法を開発し,下部尿路閉塞(BOO)診断のためのパタメーター設定を試みた.各排尿において,前立腺部尿道全体の最大流速をV0,尿道括約筋直上の遠位部前立腺部尿道の流速をV1,膜様部尿道の流速をV2とし,これらの部位に対応する機能的断面積を最大尿流率/流速の式により求め,又,尿道括約筋前後の流速比をVRとして求めた.これらのパラメーターとプレッシャーフロースタディーにおける閉塞パラメーター(AG number)との相関を検討した結果,BOOを診断するさいに最も有用なパラメーターはVRであると考えられた

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【Overactive Bladder】Overactive Bladderの治療膀胱腔内注入療法

渡辺豊彦, 小澤秀夫, 公文裕巳

排尿障害プラクティス 8 ( 2 ) 129 - 135 2000.6

看護実践間欠式バルーン・カテーテルによる高齢者の排尿管理

濱田有美, 宮村純子, 日野洋子, 小澤秀夫, 渡辺豊彦, 公文裕巳

Urological Nursing 5 ( 1 ) 82 - 86 2000.1

Language：Japanese Publisher：(株)メディカ出版

高齢者は,夜間多尿のため,夜間に頻回の導尿が必要である.間欠式バルーン・カテーテルを使用することで不眠の解消につながり,また外出時に一定の時間のみに使用し,行動範囲が拡大することが明らかとなった.間欠式バルーン・カテーテルの使用は,清潔間欠自己導尿の有力な補助手段となり得ると共に,高齢者の排尿管理に有用である

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Beneficial effect of intranasal desmopressin for men with benign prostatic hyperplasia and nocturia: preliminary results. Reviewed

Toyohiko Watanabe

Techniques in urology 5 ( 4 ) 191 - 194 1999.12

Publishing type：Research paper (scientific journal)

The aim of this study was to determine the efficacy of intranasal desmopressin in the treatment of nocturnal polyuria in men with benign prostatic hyperplasia (BPH). Twelve men with BPH were treated with intranasal desmopressin at bedtime for nocturnal polyuria. All patients underwent video-urodynamic evaluation. The number of nocturia episodes was the dependent variable. Exclusion criteria included nephrolithiasis, active urinary tact infection, and history of myocardial infarction, congestive heart failure, and angina. Ten of 12 patients improved with the intranasal desmopressin therapy. Nocturia episodes decreased from a median of 3.6 +/- 0.5 episodes/night before treatment to 1.8 +/- 1.1 episodes/night 3 months after therapy (p = .01). The American Urological Association symptom index decreased from 19 +/- 6 before treatment to 12 +/- 6 after therapy (p = .02). Hyponatremia did not occur. We conclude that intranasal desmopressin is a promising therapy for nocturnal polyuria in selected BPH patients.

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治療法紹介薬物療法尿失禁レジニフェラトキシン膀胱腔内注入療法

渡辺豊彦, 小澤秀夫, 公文裕巳

排尿障害プラクティス 7 ( 4 ) 325 - 331 1999.12

EXPERIENCE OF VESICA^<TM> PERCUTANEOUS BLADDER NECK STABILIZATION FOR FEMALE URINARY STRESS INCONTINENCE Reviewed

YOKOYAMA TERUHIKO, OZAWA HIDEO, HASHIMOTO HIDEAKI, WATANABE TOYOHIKO, TSUSHIMA TOMOYASU, KUMON HIROMI

61 ( 7 ) 554 - 557 1999.7

膀胱癌肉腫の1例 Reviewed

横山光彦, 渡辺豊彦, 津島知靖, 公文裕巳, 大枝忠史

西日本泌尿器科 61 ( 2 ) 129 - 131 1999.2

Language：Japanese Publisher：西日本泌尿器科学会

84歳男,肉眼的血尿を主訴とした.膀胱鏡では6.0×5.0cm大の大きな膀胱内腫瘤が後壁から発生していた.膀胱全摘出術と尿管皮膚瘻造設術を施行した.組織学的には膀胱腫瘤は肉腫性組織,骨軟骨肉腫及び移行細胞癌から成っていた.免疫組織化学的検査では,肉腫性領域はビメンチン,S-100,トルイジンブルー染色でのメタクロマジー,及びコラーゲンが陽性であったが,ケラチンとEMAは陰性であった.癌肉腫と診断した.術後15ヵ月間,腫瘍の再発はなく良好な結果を得ている

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High incidence of occult neurogenic bladder dysfunction in neurologically intact patients with thoracolumbar spinal injuries - Comment Reviewed

Perkash, I

JOURNAL OF UROLOGY 159 ( 3 ) 968 - 968 1998.3

Transurethral Balloon Laser Thermotherapy (TUBAL-T) for Symptomatic Benign Prostatic Hyperplasia

NASU Yoshitsugu, WATANABE Toyohiko, SAKURAMOTO Koushi, KUMON Hiromi

19 ( 1 ) 29 - 38 1998.3

Inguinal Cystocele : 下部尿路通過障害のない男性における前立腺症の新しい病態 : 第86回日本泌尿器科学会総会

公文裕巳, 小澤秀夫, 横山光彦, 橋本英昭, 渡辺豊彦, 大森弘之

日本泌尿器科学会雑誌 89 ( 2 ) 373 - 373 1998

超音波カラードプラによる非侵襲性下部尿路機能検査法の構築 : 第86回日本泌尿器科学会総会

横山光彦, 小澤秀夫, 渡辺豊彦, 橋本英昭, 公文裕巳, 大森弘之

日本泌尿器科学会雑誌 89 ( 2 ) 339 - 339 1998

超音波カラードプラによる非侵襲性下部尿路機能検査法の構築

横山光彦, 小澤秀夫, 渡辺豊彦, 橋本英昭, 公文裕巳, 大森弘之

日本泌尿器科学会雑誌 89 ( 2 ) 190 - 190 1998

泌尿器科領域におけるNM441の基礎的・臨床的検討 Reviewed

櫻本耕司, 藤田竜二, 渡辺豊彦

日本化学療法学会雑誌 44 ( Suppl.1 ) 429 - 437 1996.3

Language：Japanese Publisher：(公社)日本化学療法学会

プロドラッグ型新規キノロン系経口合成抗菌薬NM441の活性本体NM394の,尿路感染症由来の教室保存株に対するMICを測定した.グラム陽性菌に対しては,同系薬剤であるciprofloxacin, ofloxacinとほぼ同等の,norfloxacinの1〜3管程度強い抗菌力を示した.グラム陰性菌に対しては,殆ど全ての菌種に強力な抗菌力を示した.NM441を1回100mgないし200mg,1日2回,5〜7日間投与し臨床的有用性を検討した.総合臨床効果は,急性単純性尿路感染症9例全てで著効,急性前立腺炎2例共に有効であった.又,複雑性尿路感染症では有効率88.9%であった.細菌学的効果では,急性単純性尿路感染症,急性前立腺炎の分離菌全てが消失した.複雑性尿路感染症の除菌率は86.2%であった

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Robbins deviceを用いた細菌バイオフィルムの解析緑膿菌バイオフィルムと大腸菌バイオフィルムの比較

小野憲昭, 藤田竜二, 渡辺豊彦

BACTERIAL ADHERENCE研究会講演録 9 78 - 83 1996.1

Language：Japanese Publisher：日本バイオフィルム学会

形成された細菌バイオフィルムの抗菌剤に対する抵抗性に関しては,緑膿菌,大腸菌両菌株に大きな差異はなく,大腸菌バイオフィルムも緑膿菌バイオフィルムと同様に,検討した全ての薬剤に強い抵抗性を示した.特に,高濃度のOFLXの効果は,むしろ緑膿菌バイオフィルムよりも強い抵抗性を示す結果であった

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Clinical studies on advantages and safety of visual laser ablation for patients with benign prostatic hyperplasia Reviewed

Yasutomo Nasu, Toyohiko Watanabe, Hiromi Kumon, Hiroyuki Ohmori

International Journal of Urology 3 ( 1 ) s53 - s54 1996

Language：English Publishing type：Research paper (scientific journal)

Since 1992, we have been performing VLAP using a right-angle laser delivery system (Urolase) for BPH patients with significant underlying nonurological diseases such as diabetes mellitus, cardiovascular, pulmonary, and maligant diseases. Sufficient clinical results have been obtained without major complications during short-term and long-term observation. In this study, we discuss the clinical advantages and safety of VLAP, compared with TURP, through analysis of the clinical procedure for VLAP for patients treated with anticoagulant agents such as waríarin. In our study of 40 patients, 8 patients were treated with anticoagulants for cardiovascular disease. During the procedure and after the operation, no significant complications were encountered except for transient postoperative bleeding. The 8 patients who received simultaneous anticoagulant therapy also underwent TURP to draw a comparison. The time taken for the procedure and the volume of the blood loss were significantly reduced by VLAP. The hemostatic nature of YAG laser energy seems to result in a technical improvement over conventional I URP for patients undergoing anticoagulant therapy. © IUA/CLJ.

DOI： 10.1111/j.1442-2042.1996.tb00087.x

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ラット実験モデルにおけるGracilis Muscle Dynamic Urethral Sphincter Myoplastyの検討

Watanabe Toyohiko, Chancellor Michael B, 公文裕巳, 大森弘之

日本泌尿器科学会雑誌 87 ( 2 ) 351 - 351 1996

Basic and clinical studies on NM441 in urological field

Koushi Sakuramoto, Ryuji Fujita, Toyohiko Watanabe, Tadasu Takenaka, Kouichi Monden, Kazuhiro Hata, Noriaki Ono, Yoshitsugu Nasu, Masaya Tsugawa, Hiromi Kumon, Hiroyuki Ohmori, Katsuichi Nanba, Taiichiro Josen, Satoshi Uno, Bunzo Suyama, Michinao Saegusa, Shunji Hayata

Japanese Journal of Chemotherapy 44 ( 1 ) 429 - 437 1996

Language：Japanese Publishing type：Research paper (scientific journal)

We studied the antibacterial activity and clinical efficacy of NM441, a new oral quinolone, which is the prodrug of the biologically active NM394. 1) Antibacterial activity: We measured the MICs of NM394 against 200 clinical isolates from urinary tract infections(UTI), and compared them with those of ofloxacin(OFLX), ciprofloxacin(CPFX), norfloxacin(NFLX), sparfloxacin(SPFX), lomefloxacin(LFLX) and tosufloxacin(TFLX). The antibacterial activities of NM394 against gram positive bacteria were a little inferior to those of SPFX, LFLX or TFLX, but were comparable to those of OFLX or CPFX. On the other hand, against gram negative bacteria, in general, antibacterial activities of NM394 were superior to those of other new quinolones. 2) Clinical efficacy: According to the criteria of the Japanese UTI Committee, the overall clinical efficacy rate was 100% (9/9) for uncomplicated UTI and was 88.9% (24/27) for chronic complicated UTI. Bacteriologically, 25 of 29 strains (86.2%) were eradicated for chronic complicated UTI. 3) Side effect: Nausea was observed in 1 patient (2.2%), and an abnormal laboratory finding was observed in 1 patient (2.2%), that showed transient eosinophilia.

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複雑性尿路感染症に対するcefluprenamの基礎的・臨床的検討

櫻本耕司, 藤田竜二, 渡辺豊彦

日本化学療法学会雑誌 43 ( Suppl.4 ) 127 - 133 1995.11

Language：Japanese Publisher：(公社)日本化学療法学会

1)尿路感染症由来の14菌種210株に対する本剤の最小発育阻止濃度(MIC)を測定した.グラム陽性菌に対してはIPMにはやや劣るものの,その他の対照薬(CAZ,CPZ,LMOX)より優れた抗菌力を示した.Escherichia coli, Klebsiella pneumoniae, Proteus mirabilisに対しては,本剤が最も優れた成績であった.又,Serratia marcescens, Pseudomonas aeruginosaに対しては,IPMには若干劣るものの,CAZと同等の抗菌力を示した. 2)複雑性尿路感染症14例中UTI薬効評価基準により評価可能であった12例の総合臨床効果は著効2例,有効6例,無効4例で,有効率は66.7%であった.細菌学的効果では分離菌9菌種20株中17株が消失し,除菌率は85.0%であった.副作用及び臨床検査値の異常変動は1例も認められなかった

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