Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

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Progressive cortical atrophy after forebrain ischemia in diabetic rats Reviewed

Fumio Kondo, Masato Asanuma, Ikuko Miyazaki, Yoichi Kondo, Ken-ichi Tanaka, Hirohumi Makino, Norio Ogawa

Neuroscience Research 39 ( 3 ) 339 - 346 2001.3

Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. Reviewed

Chiharu Aoki Sogawa, Masato Asanuma, Norio Sogawa, Ikuko Miyazaki, Tohru Nakanishi, Hiroaki Furuta, Norio Ogawa

Acta Medica Okayama 55 ( 1 ) 1 - 9 2001.2

Molecular mechanism in activation of glutathione system by ropinirole, a selective dopamine D2 agonist. Reviewed

Ken-ichi Tanaka, Ikuko Miyazaki, Naoko Fujita, Md Emdadul Haque, Masato Asanuma, Norio Ogawa

Neurochemical Research 26 ( 1 ) 31 - 36 2001

酸化ストレスと神経細胞死. Invited

小川紀雄, 浅沼幹人

Clinical Neuroscience 19 ( 6 ) 665 - 667 2001

フリーラジカルと脳障害. Invited

浅沼幹人, 小川紀雄

Clinical Neuroscience 19 ( 5 ) 555 - 559 2001

Immunophilin ligands prevent H2O2-induced apoptotic cell death by increasing glutathione levels in neuro 2A neuroblastoma cells. Reviewed

Ken-ichi Tanaka, Naoko Fujita, Masato Asanuma, Norio Ogawa

Acta Medica Okayama 54 ( 6 ) 275 - 280 2000.12

Expression of metallothionein-III mRNA and its regulation by levodopa in the basal ganglia of hemi-parkinsonian rats Reviewed

Ikuko Miyazaki, Chiharu Aoki Sogawa, Masato Asanuma, Youichirou Higashi, Ken-ichi Tanaka, Tohru Nakanishi, Norio Ogawa

Neuroscience Letters 293 ( 1 ) 65 - 68 2000.10

Inhibition of Tyrosinase Reduces Cell Viability in Catecholaminergic Neuronal Cells Reviewed

Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

Journal of Neurochemistry 75 ( 4 ) 1771 - 1774 2000.10

Direct interactions of methamphetamine with the nucleus Reviewed

Masato Asanuma, Teruo Hayashi, Sonia V Ordonèz, Norio Ogawa, Jean Lud Cadet

Molecular Brain Research 80 ( 2 ) 237 - 243 2000.9

Bromocriptine markedly suppress levodopa-induced abnormal increase of dopamine turnover in the parkinsonian striatum Reviewed

Norio Ogawa, Ken-ichi Tanaka, Masato Asanuma

Neurochemical Research 25 ( 6 ) 755 - 758 2000.6

フリーラジカルと神経細胞死. Invited

浅沼幹人, 小川紀雄

Clinical Neuroscience 18 ( 4 ) 415 - 417 2000.4

Antioxidants protect against dopamine-induced metallothionein-III (GIF) mRNA expression in mouse glial cell line (VR-2g) Reviewed

Chiharu Aoki Sogawa, Ikuko Miyazaki, Norio Sogawa, Masato Asanuma, Norio Ogawa, Hiroaki Furuta

Brain Research 853 ( 2 ) 310 - 316 2000.1

Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse Reviewed

Yoichi Kondo, Fumio Kondo, Masato Asanuma, Ken-ichi Tanaka, Norio Ogawa

Neurochemical Research 25 ( 2 ) 205 - 209 2000

Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line Reviewed

Ikuko Miyazaki, Emi Iwata-Ichikawa, Masato Asanuma, Motoyuki Iida, Norio Ogawa

Neurochemical Research 24 ( 7 ) 857 - 860 1999.7

Glial Cells Protect Neurons Against Oxidative Stress via Transcriptional Up-Regulation of the Glutathione Synthesis Reviewed

Emi Iwata-Ichikawa, Yoichi Kondo, Ikuko Miyazaki, Masato Asanuma, Norio Ogawa

Journal of Neurochemistry 72 ( 6 ) 2334 - 2344 1999.6

Nitric oxide modulates muscarinic acetylcholine receptor binding in the cerebral cortex of gerbils Reviewed

Marvin Gómez-Vargas, Masato Asanuma, Sakiko Nishibayashi-Asanuma, Emi Iwata, Norio Ogawa

Neurochemical Research 24 ( 5 ) 629 - 635 1999.5

パーキンソン病と活性酸素・窒素種. Invited

浅沼幹人, 小川紀雄

神経研究の進歩 43 ( 2 ) 264 - 274 1999.4

Early treatment with cyclosporin A ameliorates the reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia Reviewed

Yoichi Kondo, Masato Asanuma, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

Neurochemical Research 24 ( 1 ) 9 - 13 1999

Neural transplantation normalizes dopaminegic dysfunction in an animal model of Parkinson's disease. Reviewed

Norio Ogawa, Kiminao Mizukawa, Hitoo Nishino, Masato Asanuma, Mitsutoshi Yamamoto

Journal of Brain Science 25 ( 3-4 ) 133 - 138 1999

Neural transplantation normalizes dopaminergic dysfunction in an animal model of parkinson's disease Reviewed

N. Ogawa, K. Mizukawa, H. Nishino, M. Asanuma, M. Yamamoto

Journal of Brain Science 25 ( 3-4 ) 133 - 138 1999

Language：English Publishing type：Research paper (scientific journal)

Levodopa (L-DOPA) is the most commonly used pharmacotherapy in patients with Parkinson's disease (PD), but is also associated with adverse effects during chronic use and a decreased ability to control PD as the disease progresses. Neural transplantation of dopamine-synthesizing cells is being explored as a possible alternative to L-DOPA for the treatment of PD. In a rodent model of PD, we demonstrated that neural transplantation of dopamine-releasing cells (from fetal midbrain areas) led to normalisation of striatal D1 and D2 dopamine receptors to their non-PD levels at 3 months post-transplantation, which was accompanied by near normalization of rotational behavior. Immunohistochemical evaluation showed that grafted fetal dopaminergic cells survive, synthesize and release dopamine for at least 3 months post-transplantation. Grafting of neuronal cells into the brain therefore represents a promising approach to restoring disturbed motor function characteristic of PD.

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Papers - ASANUMA Masato