Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

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Iminodipropionitrile投与によって発症させたジスキネジアモデルラットの脳内神経ペプチドの変化 Reviewed

河田義郎, 小川紀雄, 浅沼幹人, 森昭胤

Neurosciences 20 41 - 44 1994.4

Differential effects of chronic l-DOPA treatment on lipid peroxidation in the mouse brain with or without pretreatment with 6-hydroxydopamine Reviewed

Norio Ogawa, Masato Asanuma, Yoichi Kondo, Yoshiro Kawada, Mitsutoshi Yamamoto, Akitane Mori

Neuroscience Letters 171 ( 1-2 ) 55 - 58 1994.4

虚血と神経毒による晩発性脳障害 Invited

小川紀雄, 浅沼幹人, 水川公直

老年期痴呆研究会誌 6 16 - 19 1994.2

Acetylcholinesterase inhibitor ENA-713 protects against ischemia-induced decrease in pre- and postsynaptic cholinergic indices in the gerbil brain following transient ischemia Reviewed

Ken-ichi Tanaka, Norio Ogawa, Kiminao Mizukawa, Masato Asanuma, Yoichi Kondo, Sakiko Nishibayashi, Akitane Mori

Neurochemical Research 19 ( 2 ) 117 - 122 1994.2

Pitfalls in Assessment of c-fos mRNA Expression in the Brain: Effects of Animal Handling Reviewed

Masato Asanuma, Norio Ogawa

Reviews in the Neurosciences 5 ( 2 ) 1994.1

Effect of vagatomy on hyperactivity and increased dopamine turnover induced by intraperitoneal administration of thyrotropin-releasing hormone Reviewed

Norio Ogawa, Masato Asanuma, Yoichi Kondo, Hiroshi Hirata, Naoharu Nakayama, Akitane Mori

Brain Research 633 ( 1-2 ) 167 - 170 1994.1

脳障害過程での免疫系の関与-免疫抑制薬cyclosporine Aを用いた実験的研究- Reviewed

小川紀雄, 浅沼幹人, 近藤洋一

日本神経精神薬理学会雑誌 14 377 - 381 1994

Regional changes in α-tubulin and β-actin mRNA accumulations after transient ischemia in spontaneously hypertensive rat brains

Y. Kondo, N. Ogawa, M. Asanuma, H. Hirata, S. Nishibayashi, A. Mori

Research Communications in Molecular Pathology and Pharmacology 86 ( 2 ) 139 - 153 1994

Language：English Publishing type：Research paper (scientific journal)

Regional changes in the mRNA accumulations for cytoskeletal proteins α- tubulin and β-actin were examined by in situ hybridization and Northern blot analysis in spontaneously hypertensive rat brains at chronic stages after 3 hours of transient ischemia. α-Tubulin mRNA accumulations showed no significant change at 2 weeks after transient ischemia except for a significant decrease in the frontal cortex (9.7%, p &lt
0.01) coinciding with ischemia induced histological changes. β-Actin mRNA level was significantly increased in the parietal cortex (8.5%), septum (10.0%), amygdala (11.0%), CA4 area (5.8%) and the dentate gyrus (7.5%) of the hippocampus at 2 weeks after recirculation compared with a sham-operated control group (p &lt
0.01). The ischemic areas of hippocampal and frontocortical lesions receive afferent neurons from those regions where β-actin mRNA was increased, suggesting that ischemia-induced increases in β-actin mRNA may reflect actin synthesis in these neurons to compensate for lost synaptic connections. Two cytoskeletal mRNA concentrations reacted differently to cerebral ischemia, and did not parallel histological signs of ischemia either temporally or spatially.

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Alterations in the binding of the phosphodiesterase inhibitor, rolipram, after transient ischemia in the gerbil brain Reviewed

Masato Asanuma, Norio Ogawa, Hiroshi Hirata, Yoichi Kondo, Sakiko Nishibayashi, Mitsutoshi Yamamoto, Akitane Mori

Research Communications in Molecular Pathology and Pharmacology 82 ( 3 ) 279 - 285 1993.12

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：P J D PUBLICATIONS LTD

To determine ischemia-induced changes in phosphodiesterase (PDE), changes in the membranous binding sites of rolipram, a cAMP-selective PDE inhibitor, were examined in the gerbil brain following transient 5 min forebrain ischemia. Coinciding with the delayed neuronal death (DND) in the hippocampal CA1 region, affinities for cerebral rolipram bindings decreased on Day 4, when intrinsic cAMP, substrate for PDE, might increase. The number of rolipram binding sites was significantly reduced in the hippocampus on Day 14, despite the lack of change on Day 4. This reduction in rolipram binding was in agreement with the previously reported late onset reduction of muscarinic receptors, progressing more slowly than DND. Slowly progressive mechanisms may be involved in the ischemia-induced reduction of the hippocampal rolipram binding sites which may be PDEs

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ドキサゾシン投与において脳血流増加を認めた脳梗塞合併高血圧症の一例 Reviewed

山本光利, 浅沼幹人, 小川紀雄

臨床と研究 70 ( 9 ) 2975 - 2978 1993.9

Abnormalities in muscarinic cholinergic receptors and their G-protein coupling systems in the cerebral frontal cortex in Alzheimer's disease Reviewed

Norio Ogawa, Kiminao Mizukawa, Masato Asanuma, Ichiro Kanazawa

Archives of Gerontology and Geriatrics 17 ( 2 ) 77 - 89 1993.9

Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain Reviewed

Hsi-hsien Chou, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Akitane Mori

Molecular Brain Research 19 ( 3 ) 211 - 214 1993.8

脊髄小脳変性症/生化学的な進歩 Invited

浅沼幹人, 小川紀雄

Clinical Neuroscience 11 ( 6 ) 626 - 629 1993.6

Regional changes in neuropeptide levels after 5,7-dihydroxytryptamine-induced serotonin depletion in the rat brain Reviewed

Yoichi Kondo, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Ken-ichi Tanaka, Yoshiro Kawada, Akitane Mori

Journal of Neural Transmission 92 ( 2-3 ) 151 - 157 1993.6

Effects of the acetylcholinesterase inhibitor ENA-713 on ischemia-induced changes in acetylcholine and aromatic amine levels in the gerbil brain Reviewed

Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Naoharu Nakayama, Akitane Mori

Archives Internationales de Pharmacodynamie et de Therapie 323 ( 1-2 ) 85 - 96 1993.5

Language：English Publishing type：Research paper (scientific journal) Publisher：ARCH INT PHARMACODYNAMIE

The effects of a new acetylcholinesterase inhibitor, ENA-713, on ischemia-induced changes in acetylcholine, monoamines, and their metabolites, were studied in the gerbil. ENA-713 (0.2 mg/kg) or saline was administered intraperitoneally to gerbils 30 min before induction of cerebral ischemia by bilateral carotid occlusion. Pretreatment with ENA-713 mitigated the ischemia-induced abnormalities of the cholinergic, dopaminergic and serotoninergic systems in the gerbil brain, although it had virtually no effect on acetylcholine, monoamines, or their metabolites in any region of the normal gerbil brain. These findings suggest that ENA-713 has beneficial effects against ischemia-induced cerebral disorders. Thus, ENA-713 seems to be promising as a preventive or therapeutic agent for cerebrovascular dementia due to cerebral ischemia and might be useful for the treatment of Alzheimer-type dementia which is associated with multiple neurotransmitter abnormalities in the brain.

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一過性脳虚血後の晩発性ムスカリン性受容体減少に対する免疫抑制剤Cyclosporin Aの阻止効果 Reviewed

小川紀雄, 浅沼幹人, 近藤洋一, 水川公直, 森昭胤

Neurosciences 19 ( 1 ) 81 - 84 1993.4

The preventive effect of cyclosporin A, an immunosuppressant, on the late onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia Reviewed

Norio Ogawa, Ken-ichi Tanaka, Yoichi Kondo, Masato Asanuma, Kiminao Mizukawa, Akitane Mori

Neuroscience Letters 152 ( 1-2 ) 173 - 176 1993.4

ニユーロトランスミッターのレセプター結合実験法 Invited

浅沼幹人, 小川紀雄

実験医学 11 ( 3 ) 216 - 223 1993.3

脳に対するカルシウム拮抗薬の功罪-カルシウム拮抗薬のドーパミン受容体に対する作用- Invited

浅沼幹人

Clinical Calcium 3 ( 3 ) 97 - 102 1993.3

Amytriptyline投与により無動・姿勢保持障害・歩行障害等の症状改善と同時に前頭葉脳血流低下の著明な改善を認めた進行性核上麻痺の一例 Reviewed

浅沼幹人, 平田洋, 近藤洋一, 小川紀雄

臨床神経学 33 ( 3 ) 317 - 321 1993.3

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